• The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
  • Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl-heidelberg.de)
  • A link between response to S deficiency, ethylene sensing, and LSU-like proteins was emphasized by changes in expression of the genes encoding ethylene receptors and F-box proteins specific for the ethylene pathway. (waw.pl)
  • Typically, EphA receptors bind to glycosylphosphatidylinositol anchor (GPI)-linked ephrin A proteins and EphB receptors bind to transmembrane ephrin B proteins. (silverchair.com)
  • In this study, we show that Vav regulates B cell proliferation following in vitro activation of Ag receptors, but Vav has no apparent role in CD40-, IL-4-, or LPS-induced B cell activation. (ox.ac.uk)
  • vav-/- B cells also responded normally to the polyvalent, repetitive hapten Ag trinitrophenyl (TNP)-Ficoll that effectively cross-links B cell receptors. (ox.ac.uk)
  • CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. (southernbiotech.com)
  • Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling. (thermofisher.com)
  • Moreover, oxidized LDL-induced VAV phosphorylation was substantially lower in WT macrophages comparing to Siglec-E −/− counterparts. (biomedcentral.com)
  • An important consequence of reversible phosphorylation of tyrosine residues on proteins is the creation of binding sites for phosphotyrosine recognizing domains such as Src homology 2 (SH2) and phosphotyrosine binding (PTB) domains [ 1 , 2 ]. (biomedcentral.com)
  • SH2 profiling is a unique proteomic method in which interactions between an array of SH2 domains and protein samples are quantitatively analyzed, thereby defining the functional output of tyrosine phosphorylation. (biomedcentral.com)
  • Association of the proto-oncogene product dbl with G protein betagamma subunits. (embl-heidelberg.de)
  • The proto-oncogene product Vav is required for receptor clustering, proliferation, and differentiation of T cells, and Vav was identified as a substrate in the TCR and B cell receptor signaling pathway. (ox.ac.uk)
  • In addition, the CH domain occurs also in a number of proteins not known to bind actin, a notable example being the vav protooncogene. (embl.de)
  • Since identification of EZH2 in the research of protooncogene product Vav [ 3 ], studies have shown that EZH2 is highly expressed in tumorigenesis, which regulates the expression of tumor suppressor genes, such as in breast cancer, prostate cancer, and lung cancer [ 4 - 6 ]. (hindawi.com)
  • The protooncogene Vav functions as a GDP/GTP exchange factor (GEF) for Rho-like small GTPases involved in cytoskeletal reorganization and cytokine production in T cells. (ox.ac.uk)
  • We have identified a novel pathway that directs Lyn/Src family tyrosine kinase signals to the invadopodia to regulate sarcoma cell invasion via the molecule AFAP-1-like-1 (AFAP1L1), a new member of the AFAP (actin filament-associated protein) family. (nature.com)
  • These results show that a pathway containing Vav and Rac proteins may negatively regulate Notch signaling during early thymic development. (northwestern.edu)
  • Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells. (prelekara.sk)
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. (southernbiotech.com)
  • ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. (thermofisher.com)
  • There is a great interest in studying phosphotyrosine dependent protein-protein interactions in tyrosine kinase pathways that play a critical role in many aspects of cellular function. (biomedcentral.com)
  • A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. (wikidata.org)
  • FN2 is followed by a transmembrane (TM) helix, and an intracellular part consisting of a juxtamembrane (JM) region with several conserved tyrosine (Y) residues, a tyrosine kinase domain, a sterile-α motif (SAM) protein-protein interaction domain, and a C-terminal Psd-95, Dlg and ZO1 domain (PDZ)-binding motif ( Pasquale, 2008 ). (silverchair.com)
  • AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes. (nature.com)
  • Interacts with Vav. (lu.se)
  • Mechanistically, Siglec-E interacts with CD36 to suppress downstream VAV signaling involved in modified LDL uptake. (biomedcentral.com)
  • Biochemically, Vav regulates peptide-specific Ca2+ mobilization and actin polymerization. (ox.ac.uk)
  • Finally, the model revealed the evolutionary kinetics of proteome formation, the phenomenon of protein differentiation and the process of gaining new interactions. (waw.pl)
  • We have previously shown that the MHV68 M2 protein is important for virus reactivation from B cells and, when expressed alone in primary murine B cells, can drive B cell differentiation towards a pre-plasma cell phenotype. (prelekara.sk)
  • Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. (wikipedia.org)
  • and Pirital virus (PIRV) prototype strain VAV-488 ( boldface ) based on a neighbor-joining analysis of nucleocapsid protein gene sequence data. (cdc.gov)
  • Polycomb Group (PcG) proteins are a family of protein complex that regulate gene expression, especially repressing gene transcription [ 1 ]. (hindawi.com)
  • Alternative splicing of gene can generate multiple transcripts and proteins to regulate tissue and organ development [ 17 ]. (hindawi.com)
  • Gene-targeted mice lacking Vav have a severe defect in positive and negative selection of T cell antigen receptor transgenic thymocytes in vivo, and vav−/− thymocytes are completely resistant to peptide-specific and anti-CD3/anti-CD28-mediated apoptosis. (ox.ac.uk)
  • Encoded by human VAV3 Gene (VAV Family), the 847-amino acid VAV-3 Protein exhibits similarity to VAV1 and VAV2. (medindex.am)
  • The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. (wikipedia.org)
  • After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)
  • Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. (embl-heidelberg.de)
  • Vav acts upstream of mitochondrial pore opening and caspase activation. (ox.ac.uk)
  • Activation of PKC with phorbol ester restored peptide-specific apoptosis in vav−/− thymocytes. (ox.ac.uk)
  • Our results indicate that peptide-triggered thymocyte apoptosis is mediated via Vav activation, changes in the actin cytoskeleton, and subsequent activation of a PKC isoform. (ox.ac.uk)
  • The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens. (ox.ac.uk)
  • These results provide the first genetic evidence on the role of the guanine exchange factor Vav in immune responses to viral infections and antigenic challenge in vivo, and suggest that Vav adjusts the threshold for Ag receptor-mediated B cell activation depending on the nature of the Ag. (ox.ac.uk)
  • The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. (wikipedia.org)
  • Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. (avivasysbio.com)
  • Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. (umassmed.edu)
  • The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl-heidelberg.de)
  • Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). (embl.de)
  • A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). (embl.de)
  • Gelation factor (ABP120) is one of the principal actin-cross-linking proteins of Dictyostelium discoideum. (embl.de)
  • Peptide-specific cell death was blocked both by cytochalasin D inhibition of actin polymerization and by inhibition of protein kinase C (PKC). (ox.ac.uk)
  • Like the other Vav proteins, Vav3 is phosphorylated (activated) following ligand binding to a variety of receptor tyrosine kinases (TKs), including EGF receptor, PDGF receptor, insulin receptor, and insulin-like growth factor I receptor. (cytoskeleton.com)
  • The role of Vav in B cell responses to Ag challenge in vivo is not known. (ox.ac.uk)
  • In vivo, vav-/- mice mounted protective antiviral IgM and IgG responses to infections with vesicular stomatitis virus and recombinant vaccinia virus expressing the vesicular stomatitis virus glycoprotein, which harbor repetitive surface epitopes that directly cross-link the Ag receptor and activate B cells in the absence of T cell help. (ox.ac.uk)
  • Taxonomic distribution of proteins containing RhoGEF domain. (embl-heidelberg.de)
  • One of the best statistical representatives of this property is the node degree distribution (distribution of proteins having a given number of interactions). (waw.pl)
  • Old proteins tend to have more interactions than new ones. (waw.pl)
  • According to this model, all proteins gain new interactions with a rate that preferentially increases with the number of interactions (the rich get richer). (waw.pl)
  • Proteins can also gain interactions because of duplication. (waw.pl)
  • Proteins lose their interactions both with and without the loss of partner genes. (waw.pl)
  • The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl-heidelberg.de)
  • The Vav family of Rho/Rac guanosine nucleotide exchange factors comprises three members in mammalian cells. (biomedcentral.com)
  • Vav was found to bind constitutively to PKC-θ in thymocytes. (ox.ac.uk)
  • The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. (embl-heidelberg.de)
  • It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. (embl-heidelberg.de)
  • 1. DamaniaB (2004) Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesis. (prelekara.sk)
  • However, vav-/- mice failed to mount immune responses to the nonrepetitive, T cell-dependent hapten Ag (4-hydroxy-5-iodo-3-nitrophenyl)acetyl (NIP)-OVA. (ox.ac.uk)
  • Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. (univ-amu.fr)
  • The data presented for each entry is based on the UniProt Reference Proteomes but information on individual UniProtKB sequences can still be found by entering the protein accession. (xfam.org)
  • VAV_HUMAN ) or accession (e.g. (xfam.org)
  • Ottinger EA, Shekels LL, Bernlohr DA, Barany G (1993) Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases. (springer.com)
  • An amino-terminal portion conserved among a subset of Dbl family proteins is sufficient for the binding of Gbetagamma. (embl-heidelberg.de)
  • Most genes from the plant-specific family encoding Response to Low Sulphur (LSU)-like proteins are strongly induced in sulphur (S)-deficient conditions. (waw.pl)
  • VAV, a downstream effector implicated in CD36-mediated oxidized LDL uptake, was shown to interact with SHP-1 following oxidized LDL treatment. (biomedcentral.com)
  • We have implemented high throughput methodologies for DNA cloning and automatic, multistep purification of proteins. (waw.pl)
  • Eph and ephrin proteins interact with a number of other ligand/receptor systems to influence how cells translate environmental signals to orchestrate morphogenetic events. (silverchair.com)
  • By performing proximity labeling and proteomic analysis, we identified scavenger receptor CD36 as a cell surface protein interacting with Siglec-E. Further experiments performed in HEK293T cells transiently overexpressing Siglec-E and CD36 and peritoneal macrophages demonstrated that depletion of cell surface sialic acids by treatment with sialyltransferase inhibitor or sialidase did not affect interaction between Siglec-E and CD36 but retarded Siglec-E-mediated inhibition on oxidized LDL uptake. (biomedcentral.com)
  • The obvious benefit of this method is that the low sample requirement allows detection of SH2 binding in samples which are difficult to analyze using traditional protein interaction assays. (biomedcentral.com)
  • Abstract Background: Known protein interaction networks have very particular properties. (waw.pl)
  • Results: The proposed model reproduces the main properties of protein-protein interaction networks very well. (waw.pl)
  • The subcellular localization of EZH2 protein was predicted by using different predictors (CELLO, Euk-mPLoc, WoLF PSORT, and TargetP). (hindawi.com)
  • Suppression of p85Cool-1/betaPix expression restores UbcH7 raft localization and Vav ubiquitination and diminishes Cdc42 activity. (ox.ac.uk)
  • A hallmark of ALS pathology is altered localisation of the transactive response (TAR) DNA binding protein 43 kDa (TDP-43), which is normally found within the nucleus of neuronal and glial cells and is involved in RNA regulation. (bvsalud.org)
  • They exclusively bind membrane-tethered ligands known as ephrin proteins. (silverchair.com)
  • Proteins of the second class are essential for basic life processes and, hence, are always effectively protected against deletion. (waw.pl)
  • One limitation of current SH2 profiling methods is that these assays themselves do not provide the identity of the binding proteins. (biomedcentral.com)
  • The Pfam database is a large collection of protein families, each represented by multiple sequence alignments and hidden Markov models (HMMs) . (xfam.org)