Urinary thromboxane B2 excretion during acute rejection in cyclosporine treated experimental lung allotransplantation. (medigraphic.com)
Vasoconstrictor2
Thromboxane A2 is also a known vasoconstrictor and is especially important during tissue injury and inflammation. (wikipedia.org)
In addition to these functions, it modulates vascular tone by synthesizing and releasing a number of vasoactive factors that may have vasodilatory effects, such as nitric oxide (NO), prostacyclin (PGI 2 ), and endothelium-derived hyperpolarizing factor, and vasoconstrictor effects, such as thromboxane A 2 and endothelin-1 (ET-1) [ 8 ] . (encyclopedia.pub)
Platelet2
Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets during hemostasis and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation. (wikipedia.org)
This is achieved by activating the thromboxane receptor, which results in platelet-shape change, inside-out activation of integrins, and degranulation. (wikipedia.org)
Receptor2
La selecci n y el cuidado del donador antes de la procuraci n de los rganos juegan un papel primordial en los resultados en el receptor. (medigraphic.com)
En este art culo revisamos aspectos hist ricos y avances recientes en el manejo de estos pacientes incluyendo indicaciones y contraindicaciones, evaluaci n y cuidado del donador y del receptor, t cnica quir rgica y manejo peri- y posoperatorio. (medigraphic.com)
Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets during hemostasis and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation. (wikipedia.org)
Thromboxane A 2 (TXA 2 ), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets as well as increasing platelet aggregation. (wikimili.com)
Low-dose, long-term aspirin use irreversibly blocks the formation of thromboxane A 2 in platelets , producing an inhibitory effect on platelet aggregation . (wikimili.com)
Prostacyclin2
Thus, we have investigated the effect of ethanol on paracrine substances, such as thromboxane and prostacyclin, that act as vasoregulators within the intrauterine tissues. (nih.gov)
The thromboxane:prostacyclin ratio also tended to increase with both 60- and 240-min ethanol exposure, but a statistically significant increase was seen only at a few time points. (nih.gov)
Synthase1
Thromboxane synthase inhibitors inhibit the final enzyme ( thromboxane synthase ) in the synthesis of thromboxane. (wikimili.com)
Some of these mediators such as histamine, neutral proteases including tryptase, chymase and cathepsin-D, as well as arachidonic acid products such as leukotrienes, PAF and thromboxane have important cardiovascular actions. (medscape.com)
The various mechanisms believed to be responsible are pulmonary arterial vasoconstriction and elevated pulmonary artery pressure, resulting in circulatory shear forces and a consequent permeability leak and antidiuresis possibly mediated by increased antidiuretic hormones, which contribute to fluid retention. (medscape.com)
Arterial2
Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). (wikipedia.org)
The coronary arterial plasma withdrawn before stenting induced 21ýý5% and the aspirate plasma after stenting induced 95ýý8% of maximum KCl-induced vasoconstriction. (nih.gov)
Thromboxane inhibitors are broadly classified as either those that inhibit the synthesis of thromboxane, or those that inhibit the target effect of it. (wikimili.com)
TXA22
TXA2 is very unstable in aqueous solution, since it is hydrated within about 30 seconds to the biologically inactive thromboxane B2. (wikipedia.org)
In human studies, 11-dehydrothromboxane B2 levels are used to indirectly measure TXA2 production. (wikipedia.org)
Release1
Serotonin, thromboxane B(2), and TNFýý release into aspirate plasma increased by 1.9ýý0.2 ýýmol/L, 25.6ýý3.1 pg/mL, and 19.7ýý6.1 pg/mL, respectively, during stenting. (nih.gov)
Formation1
Thromboxane is named for its role in blood clot formation ( thrombosis ). (wikimili.com)
Production1
People with asthma tend to have increased thromboxane production, and analogs of thromboxane act as bronchoconstrictors in patients with asthma. (wikimili.com)
Increase2
In the 60-min ethanol exposure, an increase in thromboxane was observed both during and following exposure to ethanol. (nih.gov)
The increase in the thromboxane milieu observed with ethanol exposure may lead, at least in part, to the IUGR which is frequently associated with FAS. (nih.gov)