• IgE-mediated release of vasoactive mediators (including histamine). (medscape.com)
  • Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. (hindawi.com)
  • In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
  • Histamine (2-[3H-imidazol-4-yl]ethanamine) is an important chemical mediator that causes vasodilation and increased vascular permeability and may even contribute to anaphylactic reactions [ 1 ]. (hindawi.com)
  • Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases. (nih.gov)
  • Expression of vasoactive intestinal peptide (VIP) receptors in human uterus. (nih.gov)
  • Our study focused on a different mediator, vasoactive intestinal peptide (VIP) and it shows that the vagus nerve releases this peptide during exercise, which helps the coronary vessels dilate allowing more blood to pump through the heart. (news-medical.net)
  • The first and co-corresponding author Dr Julia Shanks says, 'Vasoactive intestinal peptide was first found in the gut and it does help in digestion, but what we now know is that it is also important in exercise. (news-medical.net)
  • The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
  • One model of the mechanism underlying severe disease proposes that weakly cross-reactive antibodies induced during a primary infection facilitate virus entry into Fc receptor-bearing cells during a subsequent secondary infection, increasing viral replication and release of cytokines and vasoactive mediators, culminating in shock. (vumc.org)
  • The endothelins ET-1 ET-2 and ET-3 are vasoactive peptides originally cloned from endothelial cells [1] but also made by various other cell types including Taladegib some tumor cells [2-5]. (exposed-skin-care.net)
  • Treatment of SHRs with rosiglitazone (insulin sensitizer) and/or enalapril (ACE inhibitor) may simultaneously improve hypertension, insulin resistance, and endothelial dysfunction by rebalancing insulin-stimulated production of vasoactive mediators. (diabetesjournals.org)
  • Vascular endothelial growth factor A (VEGFA) is the key mediator of angiogenesis, which leads to numerous kidney diseases. (biomedcentral.com)
  • Vascular endothelial growth factor A (VEGFA), a homodimeric vasoactive glycoprotein, is the key mediator of angiogenesis. (biomedcentral.com)
  • Much experimental work is being conducted in the area of endothelial metabolism of vasoactive substances. (medscape.com)
  • By studying transcriptome- and lipid mediator profiles in MDM of convalescent SARS-CoV-2-infected individuals with previous mild disease, we show that inflammatory gene expression and eicosanoid profiles as well as altered responsiveness to inflammatory cues are maintained at 3-5 months post infection as well as throughout macrophage differentiation. (nature.com)
  • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Comorbidities: Linked by Vascular Pathomechanisms and Vasoactive Mediators? (qxmd.com)
  • or facial vascular reactivity and vasoactive mediators,' the authors write. (rosaceagroup.org)
  • The vascular endothelium has vasodilator, anti-thrombotic and athero-protective properties through the production of vasoactive mediators, such as nitric oxide (NO) and prostacyclin. (edskilling.com)
  • The mediators released have miscellaneous vasoactive effects already discussed, but the dominant symptoms of inhaled allergens are the nasal edema and runny nose caused next to the increased vascular permeability and increased blood flow of nasal blood vessels medicine venlafaxine [url=http://www.stemagen.com/reports/journal5/trusted-online-sinemet-no-rx/]sinemet 110 mg mastercard[/url]. (ehd.org)
  • We are investigating the effects of pulmonary vascular pressures and flows, oxygen tension, and vasoactive mediators on the recruitment of inducible intrapulmonary arteriovenous pathways. (wisc.edu)
  • The second group of receptors reacts with small complement fragments (C4a, C3a, C5a) as well as with C1q, Ba, Bb and factor H. Stimulation of these receptors results in various biological effects (chemotaxis, secretion of vasoactive amines, mediators of the inflammatory and anaphylactic reaction etc. (dadamo.com)
  • Prostaglandins per se don't induce inflammatory signs, but that exacerbate inflammation and pain in the sites of production of mediators of pain, this through activation of specific receptors in the blood vessels and sensitive nerves. (vin.com)
  • The potent vasoconstrictor and proinflammatory mediator endothelin (ET)-1 plays a major role in this cascade. (nih.gov)
  • Damaged epithelial cells release CCL11 to recruit eosinophils which attract more proinflammatory mediators to the damaged region. (knowyourasthma.com)
  • Nitric oxide (NO) is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of the blood flow and the blood pressure. (immundiagnostik.com)
  • The mechanisms of chronic kidney disease progression are not well defined, but may include activation of numerous vasoactive and inflammatory pathways. (medscape.com)
  • Background Endothelin is certainly among the many regional mediators that are essential in pain era as well as the modulation of nociceptor responsiveness to unpleasant stimuli. (exposed-skin-care.net)
  • Prostaglandins (PGs), in addition to being mediators of pain, also play a substantial role in the development of pain and oedema. (vin.com)
  • Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. (hindawi.com)
  • The inflammatory process implies release of numerous of these chemical mediators, from injured tissues or originating of the own inflammatory cells. (vin.com)
  • The control of the pain caused by these mediators is frequently widely employee on the control of the inflammatory process. (vin.com)
  • Chemical mediators are important components of the nociceptive reflex and offer a target of pharmacologic modulation. (vin.com)
  • CNP, DEP and CNP+DEP exposures induced neutrophilia, enlarged macrophages, and released inflammatory mediators, interleukin-12 (IL-12) and osteopontin (OPN), into the bronchial alveolar lavage (BAL) fluid. (cdc.gov)
  • Increased transforming growth factor beta (TGF-beta), an important mediator of fibrosis detected in alveolar macrophages isolated from all particle-exposed rats. (cdc.gov)
  • Our analysis indeed provides strong arguments in favor of this assumption, and we conclude that the main pathomechanisms responsible for this association are excessive generation and spillover into the systemic circulation of inflammatory and vasoactive tissue mediators, dysfunctional β2AdR, and the mutual triggering of symptomatology and disease initiation. (qxmd.com)
  • ECs control blood flow by initiating the vasodilation and vasoconstriction of underlying smooth muscle with the release of various vasoactive factors. (beckman.com)
  • and increase in production and release of inflammatory mediators. (vin.com)
  • An increase in the amount of cyclic GMP within these cells increases mediator release whereas and the increase in cyclic AMP decreases the release. (periobasics.com)
  • The researchers also investigated the role of mediators released by the cardiac vagal nerve. (news-medical.net)
  • The cardiac vagus nerve releases multiple mediators, and previous research has focused on a neurotransmitter, acetylcholine, which has no impact on our ability to exercise,' says Dr Ramchandra. (news-medical.net)
  • When the cross-linkage occurs, the chemical mediators are released within minutes. (periobasics.com)
  • This study was conducted to determine whether treatment with relaxin, an anti-inflammatory and vasoactive hormone, prevents IR. (nih.gov)
  • Mitochondrial activity may also modulate smooth muscle tone by biotransformation of vasoactive mediators. (hal.science)
  • When activated, mast cells rapidly release potent vasoactive and inflammatory substances that cause immediate allergic reactions and can lead to chronic inflammation and tissue remodeling. (nih.gov)
  • The identification and characterization of the signals in the tissue environment that regulate mast cell activation, the intracellular signaling pathways subsequently initiated, and the soluble mediators and extracellular vesicles released by activated mast cells, are key to the understanding of the underlying causes of allergic inflammation and mast cell-related diseases. (nih.gov)
  • Plasma kallikrein (PKal) is a mediator of vascular leakage, inflammation, micro-hemorrhages and neurodegeneration. (oxurion.com)
  • After MSC therapy, PaO 2 /FiO 2 ratio increased, the need for vasoactive drugs reduced, chest CT scan imaging, which initially showed signs of bilateral and peripheral ground-glass, as well as consolidation and fibrosis, improved, and the systemic mediators associated with inflammation decreased. (figshare.com)
  • The cytochrome P450-dependent formation of polyunsaturated fatty acid epoxides is an important biochemical pathway creating mediators of inflammation and blood pressure regulation. (wikipathways.org)
  • Supportive treatment of acute pancreatitis: Gluthation can be effective in preserving the functions of the body from the attack of chemical mediators of inflammation. (bidiphar.com)
  • These symptoms are primarily induced by allergic mediators released from mast cells, basophils, eosinophils, lymphocytes, and epithelial cells. (biomedcentral.com)
  • They are induced by vasoactive mediators, primarily histamine, which are produced by mast cells. (icloudhospital.com)
  • Beta-receptor stimulation not only relaxes airway smooth muscle, but also inhibits mediator release from mast cells in the airways and may alter vascular permeability. (arizona.edu)
  • Histamine is one of the earliest identified mediators of allergy. (wellnessresources.com)
  • Since then, research has determined histamine to be a mediator of autoimmune conditions, gastric acid secretion, and hematopoiesis. (wellnessresources.com)
  • The release of histamine ( hist = because it's made up of histidine residues, amine = because it's a vasoactive amine) causes several allergic symptoms. (davidson.edu)
  • That is why histamine is known as being vasoactive. (davidson.edu)
  • One effect antihistamines have is the inhibition of the histamine-mediated release of inflammatory mediators by leukocytes (Cuss 1999). (davidson.edu)
  • In contrast, many proinflammatory mediators promote the disengagement of the AJ-based contacts, allowing the passage of fluids and leukocytes through a paracellular pathway, that is, between two endothelial cells. (hindawi.com)
  • Vasoconstriction, platelet changes, and neurochemical mediators initiate cerebral ischemia and activate the trigeminal-vascular system. (medicscientist.com)
  • Discovery and development of several highly potent and selective antagonists to platelet-activating factor receptors facilitated experimental studies underscoring the role of this factor as an endogenous mediator in cerebral disorders, particularly cerebral ischemia and trauma. (nih.gov)
  • ATP induces complex reactions, and may either stimulate specific receptors or may be metabolised by a group of ecto-enzymes (Zimmermann 2000) to products including ADP, AMP, and adenosine, which are also potent mediators in the cardiovascular system. (scielo.br)
  • It is also a potent vasoactive agent through its effects on bronchial smooth muscles and nociceptive itch nerves. (wellnessresources.com)
  • The kallikrein-kinin system (KKS) is a metabolic cascade that, when activated, triggers the release of vasoactive kinins. (oxurion.com)
  • Adenosine triphosphate (ATP) is recognised as an important mediator of vasomotor tone in most vascular beds (Kunapuli & Daniel 1998). (scielo.br)
  • Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. (scielo.br)
  • Hence, the aim of the present work was to investigate PKC isozyme specific properties in the pulmonary vasculature following stimulation with vasoactive mediators that are important in the pathogenesis of PAH. (fu-berlin.de)
  • By the aid of this technique, potential associations can be found between functional changes and a variety of substances and mediators released at the site of interest. (medicaljournals.se)
  • Improved response to vasoactive coronary vasodilators such as acetylcholine, nitroglycerin in patients with risk factors for coronary artery disease. (bidiphar.com)
  • Previous research showed that LSG is a cost-effective operation with less perioperative problems in comparison with Roux-en-Y gastric bypass (RYGB). (medscape.com)
  • [ 13 ] In addition to classic vasoactive mediators, neprilysin is an endopeptidase that may have a role in the pathogenesis of HTN by breaking down mediators that cause vasodilation and sodium excretion as bradykinin and natriuretic peptides. (medscape.com)
  • In contrast a variety of different inflammatory mediators, activation of H1 receptors, increased intracellular Ca concentrations and muscarinic effects of acetylcholine increase cGMP levels. (vin.com)
  • Exactly how UFP and NP cause these negative cardiovascular effects is poorly understood, however a variety of mediators and mechanisms have been proposed. (nih.gov)
  • This body of evidence suggests that the KKS plays an important role in the development of DME and that it is a VEGF-independent mediator of the disease. (oxurion.com)
  • Hydrolytic tranformation to vicinal diols eliminates vasoactive actions, however these vicinal diols have been reported to have other biological activites, including PPAR-alpha activation. (wikipathways.org)
  • Data supporting this factor as a mediator of specific pathological sequelae in stroke and neuroinjury are surveyed in this review. (nih.gov)
  • This review provides a comprehensive, overview of the existing knowledge from studies that used skin microdialysis under experimental and clinical inflammatory conditions with the main emphasis on the recovery of inflammatory mediators. (medicaljournals.se)