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  • stenosis
  • Why Is ABI Effective in Detecting Vascular Stenosis? (hindawi.com)
  • For the purpose of a better understanding of the correlation between vascular stenoses and ABI, a computational model for simulating blood pressure and flow propagation in various arterial stenosis circumstances was developed with a detailed compartmental description of the heart and main arteries. (hindawi.com)
  • The vascular stenosis frequently affects the blood pressure and flow of large and middle-sized arteries. (hindawi.com)
  • 1 - 3 ] developed finite element models including nonlinearities arising from geometry and material properties to analyze the characteristics of blood flow and pressure decrease caused by an arterial stenosis. (hindawi.com)
  • 4 ] and Singh and Shah [ 5 ] analyzed the decreases of instantaneous maximal transvalvular pressure in aortic stenosis using numerical models. (hindawi.com)
  • However, few studies focused on the related detective indexes of the vascular stenosis, such as the ankle-brachial index (ABI). (hindawi.com)
  • ABI, defined as the ratio of systolic pressure in the ankle arteries (the posterior tibial artery in this model) and systolic pressure in the brachial artery (Figure 1 ), was an important noninvasive measurement for the detection of arterial obstructive disease, especially for the lower extremity arterial stenosis [ 8 - 10 ]. (hindawi.com)
  • Graft arteriosclerois (GA), also called allograft vasculopathy, is a pathologic lesion that develops over months to years in transplanted organs characterized by diffuse, circumferential stenosis of the entire graft vascular tree. (jove.com)
  • inflammatory
  • 4) The data suggest the involvement of RAS in the expression of inflammatory proteins at different vascular levels, allowing the creation of a microenvironment suitable for the creation, perpetuation, growth, and destabilization of vascular injury. (hindawi.com)
  • Its role in inflammatory cardiovascular disorders is largely unexplored. (harvard.edu)
  • Colonic histological damage is assessed by using a scoring system that considers loss of crypt architecture, inflammatory cell infiltration, muscle thickening, goblet cell depletion, and crypt abscess. (jove.com)
  • Taken together, these measures can be used to evaluate the intestinal inflammatory response in animal models of experimental colitis. (jove.com)
  • It has been hypothesized that the maladaptive chronic inflammatory responses seen in IBD patients develop in genetically susceptible individuals following abnormal exposure of the intestinal mucosal immune system to enteric bacteria. (jove.com)
  • Recent studies in a rabbit model indicate that aneurysmal damage initiates under specific wall shear stress conditions when smooth muscle cells (SMCs) become pro-inflammatory and produce matrix metalloproteinases (MMPs). (jove.com)
  • theoretical
  • development of simulation models and theoretical analyses, which would begin by exploring the utility of object-oriented (METAMAP) or agent-based (ECHO and SWARM) platforms to model the process of species assembly at three levels: individual organisms, habitat patches, and ecological landscapes or gradients. (ucsb.edu)
  • A theoretical model of avian flight is developed which simulates wing motion through a class of methods known as predictive simulation. (biomedsearch.com)
  • complications
  • 7. Teregulov Yu.E., Teregulov A.E. Stiffness of the arterial system as a risk factor for cardiovascular complications: assessment methods. (pmarchive.ru)
  • We have recently reported the development of a zebrafish model of type I diabetes mellitus and characterized this model to show that diabetic zebrafish not only display the known secondary complications including the changes associated with diabetic retinopathy, diabetic nephropathy and impaired wound healing but also exhibit impaired caudal fin regeneration. (jove.com)
  • chronic
  • In addition, chronic C treatment reverted cardiovascular remodeling but not T. (3) Furthermore, chronic treatment with C was able to completely reverse the expression of NF- κ B and VCAM-1, but T only reduced the expression. (hindawi.com)
  • Interposition of a mouse aorta from one strain into another mouse strain recipient is limited as a model for chronic rejection in humans because the acute cell-mediated rejection response in this mouse model completely eliminates all donor-derived vascular cells from the graft within two-three weeks. (jove.com)
  • Patients with chronic kidney disease (CKD) have significantly increased risk of cardiovascular disease (CVD) compared to the general population, and this is only partially explained by traditional CVD risk factors. (jove.com)
  • systemic
  • Here we provide a method for using spinning disk confocal microscopy of live, anesthetized mice to directly observe drug distribution, cancer cell responses and changes in tumor-stroma interactions following administration of systemic therapy in breast cancer models. (jove.com)
  • arteries
  • What is everyone's opinion about how to model veins or arteries? (newtek.com)
  • Lee RMKW (1985) Vascular changes at the prehypertensive phase in mesenteric arteries from spontaneously hypertensive rats. (springer.com)
  • Particular attention was paid to the analysis of effects of vascular stenoses in different large-sized arteries on ABI in theory. (hindawi.com)
  • The partial occlusion of arteries due to stenotic obstruction is one of the most frequent cardiovascular diseases in human beings. (hindawi.com)
  • Pressure myograph systems are exquisitely useful in the functional assessment of small arteries, pressurized to a suitable transmural pressure. (jove.com)
  • 9-11 The venous pouch arterial bifurcation model in rabbits is formed by a venous pouch sutured into an artificially created true bifurcation of both common carotid arteries (CCA). (jove.com)
  • Mesenteric arteries are mounted on two cannulas connected to a pressurized and sealed system that is maintained at constant pressure of 60 mmHg. (jove.com)
  • Physiology
  • Biomedical Modeling and Simulation on a PC (A Workbench for Physiology and Biomedical Engineering), New York Springer Verlag, 1993, Keener J., Sneyd J.: Mathematical Physiology. (vsb.cz)
  • hypertensive
  • For example, in spontaneously hypertensive rats, these two variables are probably in the normal range which is an indication of the cardiovascular system's ability to adopt its functional and structural parameters for survival. (springer.com)
  • Vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit hyperproliferation and overexpression of cell cycle proteins. (jove.com)
  • Coarctation of abdominal aorta above left kidney artery in rat was used as hypertensive animal model. (jove.com)
  • rats
  • The Fat Preference model presents rats with a series of choices between foods with differing fat content. (jove.com)
  • Like humans, rats have a natural bias toward consuming high fat food, making the rat model ideal for translational studies. (jove.com)
  • 3-5 Several animal models in rats, rabbits, canines and swine are available. (jove.com)
  • human
  • This model is unique in that the zebrafish is capable to regenerate its damaged pancreas and restore a euglycemic state similar to what would be expected in post-transplant human patients. (jove.com)
  • development
  • Avians as a model system of vascular development. (biomedsearch.com)
  • Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. (wisepress.com)
  • Since CKD is characterized by complex derangements of homeostasis, integrative animal models are necessary to study development and progression of CKD. (jove.com)
  • genetic
  • By backcrossing additional genetic changes into the vessel donor, both models can be used to assess the effect of specific genes on GA progression. (jove.com)
  • dietary
  • This study examined the cardiovascular effects of dietary vitamin D deficiency and of vitamin D receptor agonist (paricalcitol) administration in apolipoprotein E knockout mice. (jove.com)
  • To overcome this deficit, a model to quickly and easily test changes in the preference for dietary fat was developed. (jove.com)
  • Responses
  • Three-dimensional co-culture systems are frequently used to explicate tumor-stroma interactions, including their role in drug responses. (jove.com)
  • Therefore, the study of models of infectious colitis offers significant potential for defining potentially pathogenic host responses to enteric bacteria. (jove.com)
  • frequent
  • 13 These limitations have resulted in less frequent use of this aneurysm model in the recent years. (jove.com)
  • blood vessel
  • The combination system was subcutaneously injected into mice using a syringe, and new blood vessel formation was evaluated. (springer.com)
  • study
  • Model study of the oxygen supply to rat myocardium in hypertrophy. (bas.bg)
  • CELLS
  • High cyclic strain induced Rab28 expression of endothelial cells (ECs) through a paracrine control of vascular smooth muscles cells (VSMCs), which at least partly via angiotensin II (Ang II). (jove.com)
  • different
  • 6-8 Comparisons of the different animal models showed the superiority of the rabbit model with regard to hemodynamics and comparability of the coagulation system and cost-effectiveness. (jove.com)
  • studies
  • Models used in those studies were mostly applied to the analysis of hemodynamic effects of stenoses on blood pressure decreases or flow characteristics. (hindawi.com)
  • Mouse models have become increasingly popular in the field of behavioral neuroscience, and specifically in studies of experimental stroke. (jove.com)
  • This unobtrusive and fast procedure for visualizing the microcirculation is attractive to apply in epidemiological studies and to monitor cardiovascular health from early age up to old age. (jove.com)
  • spontaneously
  • Animal models of colitis range from those arising spontaneously in susceptible strains of certain species to those requiring administration of specific concentrations of colitis-inducing chemicals, such as dextran sulphate sodium (DSS). (jove.com)
  • Curette
  • This disposable Explora Model incorporates a long nylon curette with Randall-type cutting edge, stylet and Vacu-Lok syringe that adjusts suction from approximately 15- to 20-inch Hg negative pressure (6 cc to 12 cc). (benetecmed.com)
  • Heart
  • Here is a image of my CV system, I didnt model the heart and lucky didnt have to do any nerves. (newtek.com)
  • Heart Research Center Goettingen, University Medical Center Goettingen, German Center for Cardiovascular Research (DZHK) partner site Goettingen, University of Maryland School of Medicine. (jove.com)