• [ 1 ] Spinal cord hemorrhage is most commonly caused by trauma, vascular malformations, or bleeding diatheses. (medscape.com)
  • With trauma, shear forces acting upon the spinal cord and surrounding structures may lead to hemorrhage and vascular damage. (medscape.com)
  • Autopsy studies demonstrate the hemorrhagic necrosis of the spinal cord that is caused by trauma. (medscape.com)
  • Part Four: Spine and Spinal Cord" includes chapters on congenital spinal anomalies, degenerative disk disease, spinal cord and spinal tumors, trauma, vascular disorders, and spinal infection/inflammation. (ajnr.org)
  • Their stem cell experience has focused on the healing of brain trauma, spinal cord injury, cerebral vascular diseases, multiple sclerosis and myelitis, among other illnesses. (mediescapes.com)
  • Spinal cord and nerve injury can be due to trauma, vascular disease such as a blood clot, some infectious and inflammatory diseases, degenerative diseases and some cancers. (lortsmith.com)
  • Individuals who have developed Paget's disease are also likely to suffer from certain complications, such as the bones in the affected areas being inclined to breakage or fracture owing to even slight trauma. (herbs2000.com)
  • These fellowships include pediatric neurosurgery , trauma/neurocritical care, functional and stereotactic surgery, surgical neuro- oncology , radiosurgery, neurovascular surgery, skull-base surgery, peripheral nerve and complex spinal surgery. (wikipedia.org)
  • Yet, we couldn´t find any reported case of a trauma patient, that describes a late onset complete paraplegia of the lower limbs caused by spinal chord ischaemia without a spinal (chord) injury. (fortunejournals.com)
  • Spinal ischemia in traumatized patients is rarely described, and when it occurs, it is usually associated with direct trauma to the spine and consecutive vascular injury. (fortunejournals.com)
  • To date, no case has been described in the literature in which traumatized patients developed vascular myelopathy with a time delay without the presence of direct spinal trauma or direct vertebral vascular injury. (fortunejournals.com)
  • Three major routes of spread are: (1) hematogenous spread from a distant infection, (2) direct inoculation from trauma, (3) direct inoculation following invasive spinal diagnostic procedures and from spinal surgery. (wheelessonline.com)
  • Traumatic spinal cord injury (SCI) is perhaps the most devastating orthopedic injury, and with prolonged survival being the rule, rehabilitation of these injuries has an increasingly important role. (medscape.com)
  • The increasing prevalence of various leg ulcers and increased accident rate of injuries driving the global market for a vascular boot during the forecast period. (futuremarketinsights.com)
  • The increased number of spinal cord surgeries performed due to the increased rate of spinal cord injuries supplements the market growth. (futuremarketinsights.com)
  • Europe accounts for the second highest share of the vascular foot market owing to the increased prevalence of vascular-related injuries in the region. (futuremarketinsights.com)
  • But also the adult locomotor and neurological rehabilitation (Cerebral Vascular Accident, spinal cord injuries, Parkinson's disease, etc. (apprentus.com)
  • [9] During the Middle Ages in Al-Andalus from 936 to 1013 AD, Al-Zahrawi performed surgical treatments of head injuries, skull fractures, spinal injuries, hydrocephalus , subdural effusions and headache. (wikipedia.org)
  • Injuries of the spine or the spinal chord were not apparent. (fortunejournals.com)
  • spinal cord injuries, Alzheimer's and Parkinson's can prevent men from having erections. (thestoneclinic.co.in)
  • Saulius Ročka consults on vascular and oncological diseases of the brain and spinal cord, epilepsy, hydrocephalus, treatment of various brain injuries. (hila.lt)
  • International experts show how to generate state-of-the-art images and define diagnoses from crucial clinical/pathologic MR imaging correlations for neurologic, neurosurgical, and psychiatric diseases spanning fetal CNS anomalies to disorders of the aging brain. (chipsbooks.com)
  • Spinal cord hemorrhage usually presents as sudden, painful myelopathy, which may reflect the anatomic level of the hemorrhage. (medscape.com)
  • Myelopathy is a clinical diagnosis with localization of the neurological findings to the spinal cord, rather than the brain or the peripheral nervous system, and then to a particular segment of the spinal cord. (bvsalud.org)
  • Myelopathy can be the result of primary intrinsic disorders of the spinal cord or from secondary conditions, which result in extrinsic compression of the spinal cord. (bvsalud.org)
  • After performance of damage control surgery at the day of the accident, the patient presented a complete sensoric and motoric deficit 7 days after surgery, the MRI showed a vascular myelopathy. (fortunejournals.com)
  • Treatment of vascular myelopathy or spinal ischemia primarily involves improving spinal perfusion. (fortunejournals.com)
  • If successful, this procedure would be an alternative for patients who may not be able to have DBS because of vascular problems, mood disorders or aversion to brain surgery. (michaeljfox.org)
  • Dr. Dawson's discoveries have led to innovative approaches and enhanced the development of new agents to treat neurologic disorders, such as Parkinson's disease and Alzheimer's disease as well as other neurodegenerative disorders. (hopkinsmedicine.org)
  • Neurosurgery or neurological surgery , known in common parlance as brain surgery , is the medical specialty concerned with the surgical treatment of disorders which affect any portion of the nervous system including the brain , spinal cord and peripheral nervous system . (wikipedia.org)
  • Turkish neurosurgeons successfully treat dejenrative spinal disorders, vascular diseases of the brain and the spinal cord, hydrocephalus, and neuro oncology cases. (doctorhealthturkey.com)
  • Intramedullary spinal cord tumors, both primary CNS and metastatic (especially renal cell carcinoma), can also bleed and lead to hematomyelia. (medscape.com)
  • More common causes are aneurysms of the aorta or ischemia after aortic surgery, compression of vascular structures by tumors, thrombosis or embolism and arterio-venous malformations. (fortunejournals.com)
  • Among them, isolated spinal artery aneurysms are uncommon and a limited number of cases have been reported in the literature. (elsevierpure.com)
  • Conclusion: Isolated spinal artery aneurysms represent a rare cause of intracranial SAH. (elsevierpure.com)
  • California Stem Cell Treatment Center products are also being used for the experimental treatment of patients who suffer from a variety of serious diseases or conditions, including cancer, arthritis, stroke, ALS, multiple sclerosis, macular degeneration, Parkinson's disease, COPD, and diabetes. (biopharminternational.com)
  • Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia. (harvard.edu)
  • In addition, the patients may experience collapse of the vertebra or vascular changes that may have an effect on the spinal cord resulting in paraplegia. (herbs2000.com)
  • This 2-volume set is divided into 5 parts: Principles of MR Imaging (191 pages), Brain (892 pages), Skull Base (274 pages), Spine and Spinal Cord (373 pages), and Advanced Applications (150 pages). (ajnr.org)
  • The Spinal Cord Injury Rehabilitation (SCIRehab) project , a 5-year project led by the Rocky Mountain Regional Spinal Injury System (RMRSIS) at Craig Hospital, used practice-based evidence (PBE) research to identify the rehabilitation interventions most strongly associated with positive outcomes. (medscape.com)
  • Predictors and outcomes of spinal cord injury following complex branched/fenestrated endovascular aortic repair in the US Aortic Research Consortium. (harvard.edu)
  • Outcomes following thoracic endovascular aortic repair for blunt thoracic aortic injury stratified by Society for Vascular Surgery grade. (harvard.edu)
  • The most common cause of spinal cord hemorrhage is traumatic injury. (medscape.com)
  • Therefore, a sensory level to light touch may be absent unless both of these are involved (e.g., a complete injury that involves all spinal cord tracts). (emcrit.org)
  • What are the Evidence about Electrical Stimulation for Pressure Ulcer Prevention and Treatment in Spinal Cord Injury? (novapublishers.com)
  • Remember that animals with paralysis may have a spinal cord injury and should be handled very gently. (lortsmith.com)
  • There are many possible causes of paralysis, but is usually associated with an injury of the spinal cord or nerves supplying the limb. (lortsmith.com)
  • Our four basic research programs focus on a wide range of conditions including Parkinson's disease, ALS, cancer, diabetes, heart failure, stroke and spinal cord injury among many more. (hopkinsmedicine.org)
  • In addition, she sees patients with stroke and neurovascular diseases in her stroke clinic as well as patients discharged from the neurological ICU in the Outcomes clinic. (stanford.edu)
  • A neurotechnology that stimulates the spinal cord instantly improves arm and hand mobility, enabling people affected by moderate to severe stroke to conduct their normal daily activities more easily, report researchers from the University of Pittsburgh and Carnegie Mellon University today in Nature Medicine. (news-medical.net)
  • Dementia in people who have risk factors or symptoms of a stroke is often vascular dementia. (msdmanuals.com)
  • Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. (harvard.edu)
  • For perfusion, three longitudinal vessels form an anastomotic network that supplies the spinal cord: two posterior spinal arteries, and the anterior spinal artery. (medscape.com)
  • The blood flow to the posterior spinal arteries originates from intradural vertebral arteries, which are from medullary segments of the posterior inferior cerebellar arteries and segmental radiculopial arteries. (medscape.com)
  • The posterior spinal arteries give rise to the "vasocorona," which eventually branches into peripheral arteries and mainly supplies the white matter of the spinal cord. (medscape.com)
  • Spinal cord stimulation for ischemic heart disease and peripheral vascular disease [med. (emf-portal.org)
  • Sept. 6, 2022 - A team of authors published a study estimating the budget impact for the National Health Service in England of screening trials for spinal cord stimulation for neuropathic pain. (neuromodulation.com)
  • Sept. 1, 2022 - The device company Nevro announced positive coverage updates from U.S. healthcare insurance providers concerning the treatment of painful diabetic neuropathy with spinal cord stimulation. (neuromodulation.com)
  • Aug. 31, 2022 - Researchers in Sweden used a large population sample from a national registry to analyze changes in sick leave and disability pension in patients from 2006-2017, before and after they were implanted with spinal cord stimulation for chronic pain, compared to a reference group. (neuromodulation.com)
  • Aug. 30, 2022 - A column gives an overview of spinal cord stimulation. (neuromodulation.com)
  • Deep brain stimulation is a game changer for many Parkinson's disease (PD) patients. (michaeljfox.org)
  • These investigators made a splash earlier this year when they published in Scientific Reports that spinal cord stimulation in pre-clinical models improved motor symptoms and showed neuronal protection. (michaeljfox.org)
  • The Michael J. Fox Foundation (MJFF) did not fund that study, but we have funded research from this same group of investigators to test spinal stimulation in a more advanced model. (michaeljfox.org)
  • While deep brain stimulation has helped many people living with Parkinson's disease, there are limitations to its use. (michaeljfox.org)
  • Spinal stimulation could extend this therapeutic approach to many more. (michaeljfox.org)
  • Spinal stimulation uses the same technique, but rather than blocking the signals where they begin, the therapy blocks them further downstream. (michaeljfox.org)
  • Spinal cord stimulation is already used to treat chronic pain. (michaeljfox.org)
  • The same enhancements could be used in spinal stimulation. (michaeljfox.org)
  • Summary of intramedullary spinal cord hemorrhage etiologies, with history and associated clues, common imaging findings, and representative management. (medscape.com)
  • Columbia researchers have discovered how a genetic defect leads to spinal muscular atrophy (SMA), a critical piece of information about the disease that neurologists have been seeking for decades. (news-medical.net)
  • Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy. (ox.ac.uk)
  • OBJECTIVE: Spinal muscular atrophy (SMA) is a major inherited cause of infant death worldwide. (ox.ac.uk)
  • Spinal Cord Ischemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Spinal Cord Ischemia" by people in Harvard Catalyst Profiles by year, and whether "Spinal Cord Ischemia" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Spinal Cord Ischemia" by people in Profiles. (harvard.edu)
  • Preoperative Spinal Drain Placement is Associated with Reduced Risk of Spinal Cord Ischemia in Patients Undergoing Thoracic Endovascular Aortic Repair for Aortic Dissection. (harvard.edu)
  • Spinal ischemia underlies 6% of acute myelopathies [1]. (fortunejournals.com)
  • Fibrocartilaginous emboli are described in up to 5.5% of cases for unexplained and sudden onset spinal ischemia [2]. (fortunejournals.com)
  • The prognosis of spinal ischemia depends on the severity of the neurologic deficit that presents at the beginning [5]. (fortunejournals.com)
  • Hematomyelia more commonly involves the cervical rather than thoracic or lumbar spinal cord. (medscape.com)
  • Nerves to the cervical cord are located closest to the middle of the cord, whereas nerves to the sacrum are located farthest towards the edges of the spinal cord. (emcrit.org)
  • Lhermitte's sign (an electric-shock sensation elicited by neck flexion that runs down the spine and sometimes into the limbs) suggests involvement of the posterior columns of the cervical spinal cord. (emcrit.org)
  • Evaluating for a sensory level using a pin to detect pain sensation is more sensitive to detect a spinal level originating from a lesion in the spinothalamic tract. (emcrit.org)
  • Motor weakness may be used to evaluate the level of a spinal lesion that involves the corticospinal tract. (emcrit.org)
  • Thus, a central spinal cord lesion may cause neurologic deficits in a descending order. (emcrit.org)
  • and vascular spinal cord lesion. (ed.ac.uk)
  • The pial surface and superficial regions of the spinal cord are drained by radial veins and the coronal venous plexus. (medscape.com)
  • The occurrence of two episodes of venous thromboembolism within a short time frame in this case, in conjunction with known associations between other vascular anomalies and venous thromboembolism, raises the question of whether BRBNS may be associated with a prothrombotic state. (bvsalud.org)
  • Whereas arterial occlusion in the spinal region quickly becomes symptomatic by neurological deficits, venous outflow obstruction may be clinically unnoticed for much longer and usually manifests as a slowly progressive neurological deficit. (fortunejournals.com)
  • and lesions in the spinal cord. (ed.ac.uk)
  • They occur in diseases of the brain or peripheral nervous system, acute infectious diseases (ARI, acute respiratory infections), lesions of ENT organs or structures of the eye. (vsebolezni.com)
  • Researchers at the Francis Crick Institute and UCL have shown that hundreds of proteins and mRNA molecules are found in the wrong place in nerve cells affected by Motor Neuron Disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS). (news-medical.net)
  • Alzheimer Disease Alzheimer disease is a progressive loss of mental function, characterized by degeneration of brain tissue, including loss of nerve cells, the accumulation of an abnormal protein called beta-amyloid. (msdmanuals.com)
  • Two patients did not undergo resection or transplantation and died of progressive disease. (stanford.edu)
  • Following transplantation, 5 patients were alive at the end of the follow-up period and one died of recurrent disease. (stanford.edu)
  • The increasing demand for vascular boots for patients with arterial thrombolytics is expected to drive market growth during the forecast period. (futuremarketinsights.com)
  • Patients with partial cord involvement may fail to display a sensory level. (emcrit.org)
  • Each year in the U.S., 5,000 patients receive a diagnosis of ALS, an incurable neurodegenerative disease that will likely kill them within two to five years. (news-medical.net)
  • Results: Both patients presented with an atypical intracranial SAH and were also found to have spinal SAH caused by a ruptured posterior spinal aneurysm. (elsevierpure.com)
  • The warning letter cited an FDA inspection of the clinic which found that it was processing adipose tissue (body fat) into stromal vascular fraction (a cellular product derived from body fat) and administering the product both intravenously or directly into the spinal cord of patients to treat a variety of serious diseases or conditions, including Parkinson's disease, amyotrophic lateral sclerosis (ALS), chronic obstructive pulmonary disease (COPD), heart disease, and pulmonary fibrosis. (biopharminternational.com)
  • Patients affected by Paget's disease experience bone pain in the bones that have developed this condition. (herbs2000.com)
  • MATERIAL AND METHOD: Patients diagnosed with FAVA and managed between September 2019 and May 2022 in department of pediatric surgery & vascular anomalies of Xi'an international medical center hospital were retrospectively reviewed. (bvsalud.org)
  • Patients with stage I disease underwent radical resection and obtained a cure. (bvsalud.org)
  • Patients with stage II disease received radical resection and possible Achilles lengthening, having an outcome of cure. (bvsalud.org)
  • Personalized treatment was required in patients with stage III disease, including radical/partial/staged resection, Achilles lengthening/tenotomy, joint capsulotomy, neurolysis/neurectomy, tendon transfer, stretching exercises, and oral sirolimus/alpelisib. (bvsalud.org)
  • Efficacy and safety of sirolimus thus need to be evaluated in large prospective phase III trials.METHODSThe Vascular Anomaly-Sirolimus-Europe (VASE) trial, initiated in 2016, is a large multicentric prospective phase III trial (EudraCT 2015-001703-32), which evaluates efficacy and safety of sirolimus for 2 years in pediatric and adult patients with symptomatic slow-flow vascular malformations. (bvsalud.org)
  • METHODS: Development and integrity of the capillary bed was examined in skeletal muscle and spinal cord of SMA mice, and muscle biopsies from SMA patients and controls, using quantitative morphometric approaches on immunohistochemically labeled tissue. (ox.ac.uk)
  • Skeletal muscle biopsies from human patients confirmed the presence of developmentally similar, significant vascular depletion in severe SMA. (ox.ac.uk)
  • INTERPRETATION: Our results indicate that vascular defects are a major feature of severe forms of SMA, present in both mouse models and patients, resulting in functional hypoxia of motor neurons. (ox.ac.uk)
  • Blood flows from the anterior spinal artery into medullary branches of the intradural vertebral arteries, and subsequently into segmental radiculomedullary arteries. (medscape.com)
  • Spinal infections involve pyogenic or granulomatous infections of the vertebral column, intervertebral discs, the dural sac or the epidural space. (wheelessonline.com)
  • Spine infections are rare infections that can involve the intervertebral disc space (discitis), the vertebral bones, the spinal canal or adjacent soft tissues. (wheelessonline.com)
  • The most common primary spinal infection is pyogenic vertebral osteomyelitis. (wheelessonline.com)
  • Severe pulmonary hypertension due to chronic echinococcal pulmonary emboli treated with targeted pulmonary vascular therapy and hepatic resection. (medscape.com)
  • The duration of seizures from 30 minutes to a week the disease may be episodic or chronic. (vsebolezni.com)
  • Generally, people affected by Paget's disease do not have any symptoms, at least in the initial stages of developing this chronic bone disorder, and it is interesting to note that it is often identified when the X-rays of the patient are taken for diagnosing other medical conditions. (herbs2000.com)
  • In addition, the pressure in the spinal canal can be reduced by means of a lumbar drain. (fortunejournals.com)
  • Note that the spinal cord level doesn't line up precisely with the corresponding vertebrae, especially caudal to the thoracic spine. (emcrit.org)
  • Primary spinal infections are described as infections of the vertebrae that are not secondary to an operation. (wheelessonline.com)
  • It is believed that a viral infection may possibly set off Paget's disease in individuals having inherited the propensity of the genes to develop this disease by possessing these specific genes. (herbs2000.com)
  • Monkeypox (mpox) is a disease caused by infection with Monkeypox virus (MPXV), an Orthopoxvirus (OPXV) in the same genus as Variola virus , which causes smallpox. (cdc.gov)
  • Nearly one million people in the United States are living with Parkinson's disease, making it the second-most common neurodegenerative disease after Alzheimer's. (news-medical.net)
  • In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell. (news-medical.net)
  • Blue rubber bleb nevus syndrome (BRBNS) is a rare condition characterised by vascular malformations mostly of the skin and gastrointestinal tract and less commonly of the central nervous system, liver, thyroid, spleen and lungs. (bvsalud.org)
  • Erection is the result of a joint work of the vascular and hormonal nervous system. (thestoneclinic.co.in)
  • While it is established that cardiovascular disease (CVD) is typically associated with middle or old age, atherosclerosis often initiates in early childhood when deposits of cholesterol form fatty streaks in the intima of large arteries. (umc.edu)
  • The vascular boot market is estimated to secure a valuation of US$ 1.1 billion in 2023 and is estimated to rise to US$ 1.5 billion by 2033. (futuremarketinsights.com)
  • and subacute combined cord affection. (ed.ac.uk)
  • Subcortical ischemic vascular cognitive impairment and dementia: Dementia results from tissue damage in the area of the brain under the cortex (the convoluted outer surface of the cerebrum, which is the largest part of the brain). (msdmanuals.com)
  • Spinal nerves and corresponding sensory dermatomes are shown above. (emcrit.org)
  • Autonomic nerves run within the grey matter, near the center of the cord. (emcrit.org)
  • Vascular diseases: they cause clogging in the arteries and veins, which can hinder the arrival of blood to the penis. (thestoneclinic.co.in)
  • Smoking affects the body's vascular system and the muscles of the walls of the veins and arteries, altering the quality of the body's blood circulation. (thestoneclinic.co.in)
  • The first step towards diagnosis and therapy is recognizing that the patient has some sort of spinal cord pathology. (emcrit.org)
  • Read Carefully before Using The Public Health Service Act (Section 308 (d)) provides that the data collected by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC), may be used only for the purpose of health statistical reporting and analysis. (cdc.gov)
  • The NAMCS is a national probability sample survey conducted by the Division of Health Care Statistics, National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC). (cdc.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The central perfusion region receives blood supply from the anterior spinal artery, which forms the central sulcus artery and courses into the ventral median sulcus and supplies the grey matter of spinal cord. (medscape.com)
  • The last part of the book ("Part Five: Advanced Applications") deals with advanced applications with chapters on the fetal spine and brain, diffusion and diffusion tensor imaging, perfusion imaging, clinical functional MR imaging, psychiatric disease, MR spectroscopy, and contrast agents. (ajnr.org)
  • MRI diagnostic showed an anterior hyperintense area in the region of the anterior spinal cord in the sagittal T2- weight, correspondingly hyperintense areas are often found in the axial layers [4, 5]. (fortunejournals.com)
  • At mid- and late-symptomatic time points, the extent of the vascular architecture observed in two distinct mouse models of SMA was ∼50% of that observed in control animals. (ox.ac.uk)
  • Problems with the joints, (such as arthritis), bones (such as deformities), circulation (such as peripheral vascular disease), or even pain can make it difficult to walk properly. (medlineplus.gov)
  • One of the main symptoms of this disease is a pronounced intense headache. (vsebolezni.com)
  • It is worth mentioning here two main factors - the affected bones as well as the severity of the condition determine the symptoms of Paget's disease. (herbs2000.com)
  • must be free of disease symptoms. (what-when-how.com)
  • In adults, Paget's disease generally has an effect on the older skeletal bone and, according to rough estimate, approximately one per cent of the adult population in the United States, suffers from Paget's disease. (herbs2000.com)
  • Acute flaccid myelitis (AFM) is characterized by rapid onset of flaccid weakness in one or more limbs and distinct abnormalities of the spinal cord gray matter on magnetic resonance imaging (MRI). (cdc.gov)
  • Terms in the spinal cord MRI report such as "affecting gray matter," "affecting the anterior horn or anterior horn cells," "affecting the central cord," "anterior myelitis," or "poliomyelitis" would all be consistent with this terminology. (cdc.gov)
  • Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles. (news-medical.net)
  • Researchers at Nagoya University in Japan have discovered a receptor, sigma-1 receptor, and a protein, ATAD3A, that are associated with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease. (news-medical.net)
  • New research offers clues about the biology of cells in the spinal cord that die off in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. (news-medical.net)
  • Abnormal gait may be caused by diseases in different areas of the body. (medlineplus.gov)
  • Thus, abnormal vascular development and resulting hypoxia may contribute to the pathogenesis of SMA. (ox.ac.uk)
  • CAA is caused by accumulation of beta-amyloid (an abnormal protein) in blood vessels in brain, Most people with Alzheimer disease have CAA, but it also occurs in the brains of many healthy older people. (msdmanuals.com)