• It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. (abcam.com)
  • It promotes DNA synthesis in endothelial cells, regulates angiogenesis and Vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. (biovision.com)
  • The effect of rosuvastatin and simvastatin therapy (10 mg/kg) for 5 weeks on blood-brain barrier (BBB), blood-retinal barrier (BRB), and cardiac muscle permeability of streptozotocin-induced diabetic rats was studied. (diabetesjournals.org)
  • The size-selective permeability of different vascular beds to a group of fluorescein isothiocyanate dextrans of varying molecular weights was measured. (diabetesjournals.org)
  • Diabetes in humans and in animal models has been found to cause significant alterations in endothelial permeability in various vascular beds ( 2 - 5 ). (diabetesjournals.org)
  • Belik J. The contribution of arterial versus venous vascular permeability in peritoneal fluid formation. (bvsalud.org)
  • peritoneal fluid accumulation is a common finding in many children with abdominal disorders and its generation secondary to increased vascular permeability. (bvsalud.org)
  • The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
  • Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)
  • vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. (bvsalud.org)
  • Changes in vascular permeability are lial cells tethered together by junctional proteins commonly present in certain clinical diseases such as tight and adherens junctions. (bvsalud.org)
  • Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
  • The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. (hindawi.com)
  • The therapeutic effects of diltiazem are believed to be related to its ability to inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. (nih.gov)
  • They grew cardiac, neural and muscle tissue around these electronic scaffolds and were able to probe the living environment in real time. (medgadget.com)
  • Specifically, the team showed that the technology provides "monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs. (medgadget.com)
  • Thyroid hormones affect cardiac output and vascular resistance, and thus can modify kidney perfusion. (medscimonit.com)
  • 4 The deposition of ceramide trihexoside in lysosomes is found predominantly in vascular endothelial cells, smooth muscle cells, cardiac myocytes, leukocytes, fibroblasts, and epithelial cells of ganglion, corneal, and renal origins. (hcplive.com)
  • Cardiac and vascular problems need investigation, lifstyle changes and sometimes specific medication. (abicana.com)
  • The volume of distribution of 40 kDa in cardiac muscle was increased in diabetes, and this change was prevented with statin treatment. (diabetesjournals.org)
  • hs-CRP is an important predictor for cardiovascular events including myocardial infarction, cerebrovascular events, peripheral vascular disease, and sudden cardiac death in individuals without a history of heart disease. (medscape.com)
  • The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
  • BMPR2 functions to inhibit the proliferation of vascular smooth muscle tissue. (wikidoc.org)
  • Improved understanding of vascular biology is crucial for all cardiologists, and particularly interventional cardiologists, as maintenance of a competently functioning endothelium is critical for long-term vascular health. (nature.com)
  • 9. Chan CK, Vanhoutte PM. Hypoxia, vascular smooth muscles and endothelium Acta Pharmaceutica Sinica B. 2013;3(1):1-7. (scielo.br)
  • VCAM-1 (vascular cell adhesion molecule-1) is a specific marker that is commonly found at sites of damaged endothelium, such as the site of an atherosclerotic plaque. (igem.org)
  • Interestingly, these chemosensory GPCRs (csGPCRs) are expressed in several tissues of the body where they are supposed to play a role in biological functions other than chemosensation. (mdpi.com)
  • Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. (thieme-connect.com)
  • Project 1, Developmental Programming Associated with Maternal Diet and Obesity, research continues on Sub-objective 1A, which examines the impact of maternal high fat diet (HFD) and associated maternal obesity on offspring energy homeostasis, adipose tissue development, and metabolism. (usda.gov)
  • One of the predisposing causes for these changes is chronic inflammation resulting from changes in the structure and composition of perivascular adipose tissue. (bvsalud.org)
  • Also, CRP is produced by cells in the vascular wall such as endothelial cells, smooth muscle cells, and also by adipose tissue. (medscape.com)
  • Cells Tissues Organs. (stembook.org)
  • tissue that supports the body's joints and organs). (medlineplus.gov)
  • Fabry disease, or Anderson-Fabry disease, is a rare X-linked hereditary lysosomal storage disorder characterized by deficient enzyme activity of alpha-galactosidase A. This enzyme is a lysosomal hydroxylase that when deficient causes an abnormal systemic accumulation of the glycosphingolipid ceramide trihexoside in various tissue and organs. (hcplive.com)
  • Finally to appraise how tissue function might be affected by endothelial cell hypoxia the contractility of vascular smooth muscle was examined. (bl.uk)
  • Previous study illustrated that CRP participate in venous vascular bridge obstruction postoperatively after CABG. (researchsquare.com)
  • Further analysis by in situ hybridization revealed that CysLT(2) mRNA was expressed in myocytes, fibroblasts, and vascular smooth muscle cells, but not in endothelial cells. (nih.gov)
  • It is constitutively expressed on fibroblasts and, on cellular activation, on vascular smooth muscle cells, monocytes, and neutrophils. (merckvetmanual.com)
  • The female urethra and surrounding vaginal and vulvovestibular tissue are rich in estrogen receptors. (medscape.com)
  • Historically, melatonin has been considered an endocrine hormone released from the epithalamic pineal gland, which then acts on specific G-protein-coupled melatonin receptors in target tissues of both adults and the fetus ( 1 , 2 ). (frontiersin.org)
  • More recently, melatonin has been reported to be synthesized in small amounts by a wide variety of animal cells and tissues as well as diverse organisms, including all kingdoms of living organisms [cf. ( 3 , 4 )], where it presumably has local paracrine and autocrine actions, some of which are probably independent of specific melatonin receptors ( 5 ). (frontiersin.org)
  • Androgen receptors are widely distributed in several tissues, including vascular endothelial and smooth muscle cells. (gla.ac.uk)
  • Mast cells secrete histamine that inhibits vasoconstriction via H2 receptors on smooth muscle cells. (cdc.gov)
  • The pathogenesis of arterial hypertension often involves a rise in systemic vascular resistance (vasoconstriction and vascular remodeling) and impairment of salt excretion in the kidney (inappropriate salt retention despite elevated blood pressure). (nature.com)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
  • [7] When this gene is inhibited, vascular smooth muscle proliferates and can cause pulmonary hypertension, which, among other things, can lead to cor pulmonale, a condition that causes the right side of the heart to fail. (wikidoc.org)
  • The pathophysiology behind hypertension in the elderly is a complex process that is not entirely understood, but it is attributed to an increase in peripheral vascular resistance caused by decreased elasticity and increased stiffness due to smooth muscle hypertrophy in arterial walls. (uspharmacist.com)
  • However, MR is expressed in extrarenal tissues including endothelial and vascular smooth muscle cells, and its activation leads to vascular remodeling, vascular stiffness, and endothelial dysfunction leading to vascular damage, an important pathophysiological process in hypertension and other cardiovascular diseases. (intechopen.com)
  • To establish an experimental animal model to directly modulate smooth muscle cell-derived TFPI on the development of arterial thrombosis, transgenic mice in which a cDNA encoding murine TFPI is expressed from the murine SM22α promoter were generated. (elsevierpure.com)
  • Testosterone interferes with the vascular function by increasing the production of pro-inflammatory cytokines and arterial thickness. (gla.ac.uk)
  • the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage. (bvsalud.org)
  • o acúmulo de líquido abdominal relacionado à doença inflamatória intestinal é mais prová- vel de ser secundária a venosa, em oposição à fuga vascular arterial. (bvsalud.org)
  • Durante a síndrome, observam-se alterações estruturais no sistema cardiovascular, especialmente o remodelamento vascular. (bvsalud.org)
  • Vascular endothelial cells normally provide an efficient barrier against thrombosis, lipid uptake, and inflammation. (nature.com)
  • Both genomic and non-genomic effects facilitate reactive oxygen species (ROS) production (particularly by the enzyme NADPH oxidase), inflammation, and fibrosis, which, in turn, promote tissue remodeling, vascular stiffening, and endothelial dysfunction. (intechopen.com)
  • Finally, aortae from obese male mice displayed an exacerbated inflammation, whereas obese female demonstrated a mild vascular inflammation. (bvsalud.org)
  • Diltiazem produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. (nih.gov)
  • It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, in exercise tolerance studies in patients with ischemic heart disease, reduces the heart rate-blood pressure product for any given workload. (nih.gov)
  • The complement system influence the activity of numerous cells, tissues and physiological mechanism of the body. (dadamo.com)
  • The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE. (bvsalud.org)
  • Moreover, MR is expressed in nonvascular cells in close contact with the vascular wall including immune cells and adipocytes that might influence vascular function and structure. (intechopen.com)
  • In humans, angiotensin-converting enzyme inhibitors, a potent class of antihypertensive agents, lower blood pressure at least partially by favoring enhanced kinin accumulation in plasma and target tissues. (nature.com)
  • Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
  • Studies with MR antagonists and experimental models with cell-specific knockout or overexpression of MR further support a role for aldosterone/MR-mediated oxidative stress-dependent processes in vascular damage. (intechopen.com)
  • This review focuses on the relationship between aldosterone/MR signaling and oxidative stress and the implications in vascular regulation in health and disease. (intechopen.com)
  • It does so by improving the water balance in the body, by helping the tissues in the heart and blood vessels to heal and by helping the nerves to regulate the action of the heart and blood vessels better. (abicana.com)
  • Smooth muscle tumors are very rare in the oral cavity due to the scarcity of smooth muscle in this region, and arise mainly from tunnica media of blood vessels. (bvsalud.org)
  • The secretory products from hypoxia/reoxygenated endothelial cells also affected smooth muscle contractility having an anti-vasoconstrictor or relaxation property, similar to that exerted by PAF. (bl.uk)
  • Diltiazem produces relaxation of coronary vascular smooth muscle and dilation of both large and small coronary arteries at drug levels that cause little or no negative inotropic effect. (nih.gov)
  • CGRP stimulates relaxation of vascular smooth muscle. (cdc.gov)
  • During this syndrome, structural changes are observed in the cardiovascular system, especially vascular remodeling. (bvsalud.org)
  • 1993) A kallikrein-like enzyme in human vascular tissue. (nature.com)
  • It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)
  • CRP can induce the expression of tissue factor and fibrinolytic enzyme activator inhibitor-1 and the promotion of fibrin in vein bridge vascular deposits as it can be synthesized systemically rather than locally. (researchsquare.com)
  • It causes excitation-contraction uncoupling in various myocardial tissues without changes in the configuration of the action potential. (nih.gov)
  • Tissue factor pathway inhibitor (TFPI) is a Kunitz-type protease inhibitor that regulates the extrinsic pathway of coagulation by inhibiting the factor VIIa/tissue factor (TF) catalytic complex. (elsevierpure.com)
  • Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
  • Like other calcium channel antagonists, diltiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect in isolated preparations. (nih.gov)
  • Damaged tissue and the epidermis surrounding it have different electrical charges (positive and negative, respectively), which causes the flow of an endogenous electrical current that stimulates natural healing processes. (nursingcenter.com)
  • TIMP-1 (tissue inhibitor of metalloproteinase-1) is a secreted glycoprotein that blocks metalloproteinase (MMP) activity. (rndsystems.com)
  • Interestingly, obese female mice, but not male, displayed attenuated vascular contractility to different agonists, such difference was blunted by inhibition of Rho-kinase, which was accompanied by a suppressed Rho-kinase activation, measured by Western blot. (bvsalud.org)
  • Thus, melatonin is perhaps best defined as both a pineal hormone and a bioactive amine with cellular targets near its site of synthesis in some tissues. (frontiersin.org)
  • Renal effects of testosterone and the use of testosterone to prevent vascular dysfunction in elderly are also addressed. (gla.ac.uk)
  • This prospective study aimed to test the association between renal cortical perfusion (RCP) estimated in color Doppler sonographic dynamic tissue perfusion measurement (DTPM) with thyroid hormones in 36 patients treated with levothyroxine following total thyroidectomy for resectable thyroid cancer. (medscimonit.com)
  • This small prospective study from a single center showed that the renal cortex's color Doppler sonographic dynamic tissue perfusion measurement had very good intraobserver reproducibility. (medscimonit.com)
  • 1999) Identification of immunoreactive tissue prokallikrein on the surface membrane of human neutrophils. (nature.com)
  • These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
  • Animal studies have shown that CRP can increase the expression of tissue factor (TF) and decrease the expression of TF pathway inhibitors (TFPIs) [10] . (researchsquare.com)
  • The Rho-kinase pathway has a unique role in controlling vascular tone, and in obese male mice, hyperactivation of this system results in worsened vascular constriction. (bvsalud.org)
  • CONCLUSION: In obesity, female mice demonstrate a vascular protective mechanism-suppression of vascular Rho-kinase-to minimize the cardiovascular risk associated with obesity, whereas male mice do not generate any adaptive response. (bvsalud.org)
  • The role of local vascular TFPI in thrombosis and the development of vascular disease is unknown. (elsevierpure.com)
  • However, the microsized particles could only stay in blood circulation and penetrate poorly into tumor tissues, so that the wide application of the particles for in vivo tumor therapy is limited [ 3 ]. (hindawi.com)
  • Tal fato culminou no remodelamento hipertrófico do músculo liso vascular e tecido adiposo perivascular. (bvsalud.org)
  • Although a sex dimorphism on vascular function has already been noted, the underlying processes remain unclear. (bvsalud.org)
  • Intra- and postoperative monitoring of flap microcirculation may provide useful information for better understanding and following-up the ischemia-reperfusion-related alterations in tissue perfusion 6 6. (scielo.br)
  • In animal models, diltiazem interferes with the slow inward (depolarizing) current in excitable tissue. (nih.gov)
  • TF is a transmembrane glycoprotein receptor found in extravascular tissues, including organ capsules and the adventitia of blood vessel walls. (merckvetmanual.com)
  • The tissue factor-factor VIIa complex (TF/FVIIa) activates coagulation factor VIII (FVIII) and upregulates its activity. (researchsquare.com)
  • After treatment, rats were euthanized, and tail tissues were chemically fixed for histological analysis of nerves (PGP9.5, neuropeptide Y, calcitonin gene related protein) and mast cells (avidin, Alcian Blue/Safranin O).2 Single sections were doublestained for nerve fibers and mast cells to permit assessment of the degree of physical overlap. (cdc.gov)
  • Repeated injury and smooth muscle remodeling in resistance arteries is expected to thicken the vessel wall and narrow the lumen and reduce blood flow. (cdc.gov)
  • It's important to determine whether the mutation is specific to one type of vascular cell, for example, endothelial cells that line the lumen of vessels and regulate exchanges between tissue and blood and help prevent clotting, or vascular smooth muscle cells in the vessel wall that regulate the vessel diameter and adjust the blood flow like a faucet would. (medscape.com)
  • When human coronary smooth muscle cells were stimulated with LTC(4), the intracellular calcium concentration increased in a dose-dependent manner, and this action was partially inhibited by nicardipine. (nih.gov)
  • Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
  • The neural and vascular changes from long term vibration are envisioned to generate the persistent vasospastic and neurodegenerative HAVS. (cdc.gov)
  • Dietary Factors and Physical Activity Effects on Health, Development and Function of Organ Systems (skeleton, gastrointestinal and hepatic tissues, immune system, cardiovascular, and muscle, e.g. (usda.gov)
  • VLA-4 (Integrin α4β1 or very late antigen-4) is normally expressed on leukocyte membranes, and it directs the leukocytes to damaged sites in the vascular system. (igem.org)
  • The factors controlling vascular perme- vessels by acting as selective filters. (bvsalud.org)
  • In 1930, American gynecologists Kurzok and Lieb first described the stimulatory effects of seminal fluid on human uterine muscle tissue. (medscape.com)
  • A few years later, von Euler of Sweden independently discovered similar effects of human seminal fluid on smooth muscle tissue. (medscape.com)
  • Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells. (stembook.org)
  • Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 21991-1-AP (PKC alpha antibody at dilution of 1:200 (under 10x lens). (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 21991-1-AP (PKC alpha antibody at dilution of 1:200 (under 40x lens). (ptglab.com)
  • A Non-Aggressive, Highly Efficient, Enzymatic Method for Dissociation of Human Brain-Tumors and Brain-Tissues to Viable Single-Cells. (worthington-biochem.com)
  • C. Characterize the interaction between the microbiome, host health and nutrition to modify physiology and promote health and development (skeleton, gastrointestinal and hepatic tissues, immune system, cardiovascular, and muscle, e.g. (usda.gov)
  • COX-1 is expressed constitutively and is isolated throughout most cell lines in almost all mammalian tissues. (medscape.com)
  • In this mini-review, we briefly comment on the interplay between aging and testosterone levels, the vascular actions of testosterone and its implications for vascular aging. (gla.ac.uk)
  • The volume of distribution of 250-, 70-, and 40-kDa dextrans in the cerebral tissue of diabetic rats were significantly increased. (diabetesjournals.org)