• The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
  • A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells (VSMCs), which are the main source of extracellular matrix (ECM) proteins. (biomedcentral.com)
  • Interestingly, a recent single-cell RNA sequencing study of IAA revealed cluster-specific, differentially expressed genes in the VSMCs. (biomedcentral.com)
  • The phenotypic modulation of VSMCs is characterized by the downregulation of contractile genes and upregulation of matrix metalloproteinases (MMPs), which have been suggested to occur before aneurysm formation in animal models [ 12 ]. (biomedcentral.com)
  • Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)
  • The two latter particularly related to ISR though a phenotypic change of the vascular smooth muscle cells (VSMCs) from a contractile to a proliferative state under the induction of platelet-derived growth factor (PDGF), resulting in accumulation of VSMC in the intimal arterial layer [ 4 - 6 ]. (hindawi.com)
  • For instance, the miRNA-143/145 cluster coordinates the phenotypic modulation of VSMC through a cooperative network of transcription factors, such as Kruppel-Like Factor 5 (KLF5), Kruppel-Like Factor 4 (KLF4), and the potent transcriptional coactivator myocardin (MYOCD), to promote differentiation and suppress VSMCs proliferation [ 9 , 10 ]. (hindawi.com)
  • Thereby, deficiency of miRNA-145/143 promotes the synthetic phenotype of VSMCs. (hindawi.com)
  • VSMCs were transfected with the miR-128-5p mimic and inhibitor, and the migration, phenotypic modulation, and proliferation of VSMCs were investigated. (hindawi.com)
  • AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
  • The migration, phenotypic transformation, and proliferation of VSMCs lead to vascular wall remodeling, which is mediated by activation of extracellular regulated protein kinases 1/2 (ERK1/2) signalling [ 9 ]. (hindawi.com)
  • Inhibition of TGF-β or BMP signalling in VSMCs decreases the manifestation of VSMC-specific genes and transforms VSMCs from a fully differentiated or 'contractile' phenotype to a dedifferentiated or 'synthetic' state4-6. (healthyconnectionsinc.com)
  • Platelet-derived growth factors (PDGFs) acting via their tyrosine kinase receptors are major mitogens for many cell types of mesenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs)[ 1 - 4 ]. (biomedcentral.com)
  • This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 ( PVT1 ) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. (molcells.org)
  • This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). (hindawi.com)
  • It has been shown that inflammation caused by oxidized low-density lipoprotein (ox-LDL) contributes to the occurrence and development of AS [ 1 ], which can promote vascular smooth muscle cell (VSMC) migration, proliferation, and transformation from a contractile to a synthetic phenotype [ 2 - 6 ]. (hindawi.com)
  • Mutations in molecules of the TGF-β or BMP signalling pathways are found among individuals with vascular disorders indicating the essential part of TGF-β or BMP pathways in vascular homeostasis1 2 Both TGF-βs and BMPs are known to be critical modulators of the vascular clean muscle mass cell (VSMC) phenotype3-5. (healthyconnectionsinc.com)
  • Figure 1 miR-21 is critical for the modulation of the VSMC phenotype by BMP The function of miRNAs was tested by transfecting PASMCs with 'anti-miRs': 2′-construct (Ad-miR-21)9 PF-2545920 increased SMA protein and mRNA levels in PASMCs (Fig. 1c and Supplementary Fig. 5). (healthyconnectionsinc.com)
  • It is also thought to be involved in VSMC phenotypic modulation and is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns[ 18 ]. (biomedcentral.com)
  • Bone is a very dynamic and heterogeneous tissue formed by two components which are in close relationship with each other during the bone remodeling process: extracellular matrix (ECM) and bone cells. (biomedcentral.com)
  • The dynamics of cell-extracellular matrix interactions in normal and pathological situations. (mcgill.ca)
  • The Reinhardt laboratory is interested in components and mechanisms involved in the biogenesis, function and pathological aspects of the extracellular matrix and its interactions with cells. (mcgill.ca)
  • We are interested how extracellular matrix proteins instruct cells to differentiate, migrate, and proliferate, and how cells sense normal and pathologically altered extracellular matrix. (mcgill.ca)
  • Extracellular matrix and vascular dynamics in the kidney of a murine model for Marfan syndrome. (mcgill.ca)
  • Their role in enhancing migratory and proliferative responses and extracellular matrix (ECM) synthesis in these cells makes them key regulators of critical biological and pathological functions including tissue remodelling, scarring and fibrosis. (biomedcentral.com)
  • SMC phenotype switching is critical in the development of various vascular disorders, such as hypertension, intima/media thickening ( Figure 1 ), atherosclerosis and aortic aneurysms. (rochester.edu)
  • Background: Smooth muscle cells (SMC) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the atherosclerotic plaque. (stanford.edu)
  • Atherosclerosis is a disease of large and medium-sized muscular arteries and is characterized by endothelial dysfunction, vascular inflammation, and the buildup of lipids, cholesterol, calcium, and cellular debris within the intima of the vessel wall. (medscape.com)
  • ICOS also has been uncovered to function in vascular ailments this kind of as atherosclerosis. (trpvantagonists.com)
  • Nevertheless, strong correlations have been found between heart disease, atherosclerosis, hypertension, fibrosis, and regeneration efficiency with senescent cell burden and its proinflammatory sequelae. (oaepublish.com)
  • It targets CD117, which then prevents cell migration and proliferation in endothelial cells. (wikipedia.org)
  • Under growth permissive conditions, cells demonstrating restored splicing factor expression also demonstrated increased telomere length, re-entered cell cycle and resumed proliferation. (beds.ac.uk)
  • The mitotic index and apoptotic index were assessed by quantitative morphometric evaluation of proliferating cell nuclear antigen expression and in situ terminal transferase mediated fluorescein deoxy UTP nick finish labeling,two established markers of proliferation and apoptosis. (trpvantagonists.com)
  • KLF4 plays roles in cell proliferation, differentiation and survival. (trpvantagonists.com)
  • ICOS belongs to your CD28 and CTLA 4 cell surface receptor family members, and it plays an im portant purpose in cell cell signaling, immune responses, and regulation of cell proliferation. (trpvantagonists.com)
  • CD28 is important for T cell proliferation and survival, selleckchem cytokine manufacturing, and T helper sort two advancement. (trpvantagonists.com)
  • Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty Rats. (unc.edu)
  • Long-term effect of PROLI/NO on cellular proliferation and phenotype after arterial injury. (unc.edu)
  • We also show that N-cadherin is important for endothelial cell proliferation and motility. (rupress.org)
  • Single-cell transcriptomic analyses revealed that loss of Smad3 altered SMC transition cell state toward two fates: a SMC phenotype that governs both vascular remodelling and recruitment of inflammatory cells, as well as a chondromyocyte fate. (stanford.edu)
  • In the cardiovascular system, miRNAs regulate basic functions in almost all cell types including cardiac muscle, endothelial cells, smooth muscle, inflammatory cells, and fibroblasts and, therefore, play a pivotal role in the pathogenesis of several cardiovascular diseases (CVDs). (hindawi.com)
  • Considerable evidence from basic and clinical experiment has demonstrated that pulmonary vascular remodeling caused by impairment of endothelial cells (ECs), pulmonary artery spasm, adhesion and mligration of inflammatory cells to the pulmonary artery wall, adventitial fibrosis, intimal occlusive fibrosis, and fibrinoid necrosis are typical pathological features in many forms of PH. (imrpress.com)
  • Thus, development of strategies targeting particular subsets of inflammatory cells and providing well-timed resolution of inflammation may be crucial for proper healing and recovery. (springer.com)
  • Vascular SMCs exist in diverse phenotypes and exhibit phenotypic plasticity, e.g. changing from a quiescent/contractile phenotype to an active, myofibroblast-like, frequently called a "synthetic" phenotype. (rochester.edu)
  • In-stent restenosis (ISR) is one of the main complications in patients undergoing percutaneous coronary angioplasty, and microRNAs participate in the contractile-to-synthetic phenotypic switch of vascular smooth muscle cells, a hallmark of restenosis development. (hindawi.com)
  • We aim to reveal new molecular targets for pharmacologic modulation of specific cyclic nucleotide signaling in the treatment of cardiovascular diseases. (rochester.edu)
  • Smooth muscle cells (SMCs), the major cell type in atherosclerotic plaques, are vital in coronary artery diseases (CADs). (stanford.edu)
  • He is also designing a small diameter tissue engineered vascular graft to treat cardiovascular diseases. (pitt.edu)
  • Studies have shown that exosomes microRNAs from different cells or tissue sources play an important role in cardiovascular diseases including PH and is expected to become a new way to treat PH. (imrpress.com)
  • Myeloid immune cells are important mediators in the pathology of many diseases, especially in diseases associated with chronic inflammation (DACI). (brainmap.ro)
  • The concerted activity of these experts on myeloid cell biology (either basic or clinical research) MYE, bioinformatics INFO, and bio-banking BANK, will transform complex molecular information into standardised and applicable biomarkers, which have the potential to improve clinical decision making in a number of socio-economically important diseases. (brainmap.ro)
  • A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. (edu.sa)
  • After adjusting for the other major risk factors for CVD, one study found the odds of vascular diseases increased with every decade of life, demonstrating a strong increase in peripheral arterial disease (PAD), carotid artery stenosis, and abdominal aortic aneurysm (AAA) with advanced age [ 4 ] . (oaepublish.com)
  • In addition to its pro-pruritic effect, several studies acknowledge a role for the H1R on immune cells in mediating inflammatory effects of allergic skin diseases with antagonism of the H1R by several drugs demonstrating anti-inflammatory properties in different experimental models of AD [ 15 - 19 ]. (springeropen.com)
  • Many of the properties of adiponectin suggest the potential for cardiovascular benefit, including insulin sensitization, induction of nitric oxide production to limit obesity-induced endothelial dysfunction, reduction of endothelial cell activation, inhibition of generation of reactive oxygen species and apoptosis, and promotion of endothelial cell repair (10). (technuc.com)
  • The mechanisms of early aortic valve dysfunction are still unclear, but evidence suggest that valvular endothelial cells (VEC) and monocytes (Mo) play key roles in the process. (brainmap.ro)
  • The main goal of this project is to reveal the molecular signatures of VEC and Mo upon their interaction in HG conditions, to evaluate the role of key molecules in cell dysfunction and to propose novel mechanisms of early valvular dysfunction in diabetes. (brainmap.ro)
  • Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. (oaepublish.com)
  • Despite the strong link between aging and CVD, surprisingly few studies have directly investigated heart failure and vascular dysfunction in aged models and subjects. (oaepublish.com)
  • Noteworthy, there are yet no attempts to target Fn14 with agonistic Fc effector function silenced antibodies to unleash the proinflammatory and cell death-enhancing activities of this receptor for tumor therapy. (bvsalud.org)
  • We and others have shown that the proinflammatory phenotype in diabetes is characterized by elevated plasma C-reactive protein (CRP), cytokines, chemokines, adhesion molecules, monocytic activity, etc. ( 4 - 6 ). (diabetesjournals.org)
  • This rescue was independent of cell cycle traverse and also independent of SIRT1, SASP modulation or senolysis. (beds.ac.uk)
  • Loss of N-cadherin in endothelial cells results in embryonic lethality at mid-gestation due to severe vascular defects. (rupress.org)
  • As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor combinations mediate specific cellular functions. (biomedcentral.com)
  • During EndMT, ECs lose their ability to express endothelial markers, such as vascular endothelial cadherin (VE-cadherin), platelet endothelial cell adhesion molecule (PECAM-1, also known as CD31) and von Willebrand Factor (vWF). (bmbreports.org)
  • Platelet-derived growth factor (PDGF) signalling is essential for many key cellular processes in mesenchymal cells. (biomedcentral.com)
  • Through genetic depletion and pharmacological inhibition, we aim to demonstrate the causative role and address the underlying mechanism of these PDEs in SMC pathology and vascular remodeling using in vitro and in vivo approaches. (rochester.edu)
  • Un rôle majeur des prostaglandines dans l'hématopoïèse, ainsi mis en évidence, a pu être étendu à la souris chez qui un traitement par la prostaglandine PGE2 provoque la multiplication des CSH in vivo et in vitro, un résultat qui génerera très probablement des applications cliniques. (hypotheses.org)
  • Methodologically, the lab employs a wide spectrum of techniques ranging from in vitro biochemical and biophysical assays, to cell biology methods with primary cells and transformed cell lines, to light and electron microscopic techniques, to in vivo studies with genetically modified mouse models. (mcgill.ca)
  • Physiologically relevant platform for an advanced in vitro model of the vascular wall: focus on in situ fabrication and mechanical maturation. (mcgill.ca)
  • They use data science, systems biology, and traditional molecular biology approaches to discover novel disease pathways in human cells and in mice. (virginia.edu)
  • He is developing a treatment strategy for abdominal aortic aneurysms by delivering mesenchymal stem cells or their secreted products to the periadventitial side of the aneurysm to inhibit the matrix degradation commonly seen in the disease progression and promote its regeneration. (pitt.edu)
  • Here he also utilizes mesenchymal stem cells or their products incorporated in a biodegradable scaffold that undergoes substantial in vivo remodeling to develop a native-like blood vessel. (pitt.edu)
  • This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs), which are activated by secreted, active transforming growth factor beta 1 (TGFβ) to migrate to bone-resorptive sites and differentiate into osteoblasts (see below). (biomedcentral.com)
  • 1). Conclusion: Serum adiponectin levels were inversely associated with cross-sectional measures of thoracic and lumbar vertebral vBMD, inflammation, and visceral adiposity in African Americans but not with vascular AZD6244 CP after adjustment for covariates. (technuc.com)
  • PDCD4 is a critical target of miR-21 in vascular smooth muscle Because miR-21 has been shown to target the tumour suppressor gene and to downregulate its expression in cancer cells10-12 we asked whether PDCD4 mediates the effect of miR-21 in SMCs. (healthyconnectionsinc.com)
  • The construction of the blood-brain barrier (BBB), which is a natural barrier for maintaining brain homeostasis, is the result of a meticulous organisation in space and time of cell-cell communication processes between the endothelial cells that carry the BBB phenotype, the brain pericytes, the glial cells (mainly the astrocytes), and the neurons. (mdpi.com)
  • It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)
  • ALVAREZ MIGUEL, INES Remodeling of vascular smooth muscle ion channels involved in purinergic signaling in essential hypertension . (uva.es)
  • Pulmonary hypertension (PH) is a chronic and progressive disease characterized by enhanced pulmonary vascular resistance and elevated pulmonary artery pressure resulted from pulmonary vascular remodeling and vasoconstriction [ 1 ]. (imrpress.com)
  • Pulmonary vascular remodeling is the result, and, likely, contributes to increased pulmonary vascular pressures by increasing pulmonary vascular resistance [ 6 , 7 ]. (imrpress.com)
  • Hyperglycemia contributes to vascular complications of diabetes. (diabetesjournals.org)
  • In the vasculature specifically, aging contributes to decreasing vascular compliance. (oaepublish.com)
  • This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation. (frontiersin.org)
  • The down-regulation of both VE-cadherin and p120ctn was confirmed in cultured endothelial cells using small interfering RNA to knockdown N-cadherin. (rupress.org)
  • The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology. (beds.ac.uk)
  • Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC phenotype can modulate coronary artery disease (CAD) risk. (stanford.edu)
  • miR-21 downregulates PDCD4 (designed cell loss of life 4) which in turn acts as a negative regulator PF-2545920 of clean muscle PF-2545920 mass contractile genes. (healthyconnectionsinc.com)
  • Notably, amid the dif ferentially expressed mRNAs predicted to become targeted through the differential miRNAs, had been some genes previously ex perimentally identified to get concerned in aneurysm forma tion or loss of vessel cells, this kind of as TGFBR1, MMPs and IL18 and so on. (trpvantagonists.com)
  • Loss of CRP2 attenuated Ang II-induced AAA incidence and severity, accompanied by preserved smooth muscle α-actin expression and reduced elastin degradation, matrix metalloproteinase 2 (MMP2) activity, deposition of collagen, particularly collagen III (Col III), aortic tensile strength, and blood pressure. (biomedcentral.com)
  • Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells. (unc.edu)
  • Thus rules of miRNA biogenesis by ligand-specific SMAD proteins is critical for control of the vascular clean muscle mass cell phenotype and potentially for SMAD4-self-employed responses mediated from the TGF-β and BMP signalling pathways. (healthyconnectionsinc.com)
  • The structure and structure-based modulation of ADAM17 are also described for better understanding of the various ADAM17 regulatory pathways in different cell types or tissues. (frontiersin.org)
  • Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. (mdc-berlin.de)
  • Fn14 expression is upregulated in non-hematopoietic cells during tissue injury and is also often highly expressed in solid cancers. (bvsalud.org)
  • Therefore, this article reviews the role of microRNAs from different cells or tissue sources in the occurrence and development of PH. (imrpress.com)
  • PCNA or TUNEL optimistic cells were quantified in 40 randomly picked high power fields of every tissue area. (trpvantagonists.com)
  • Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
  • In 1930, American gynecologists Kurzok and Lieb first described the stimulatory effects of seminal fluid on human uterine muscle tissue. (medscape.com)
  • A few years later, von Euler of Sweden independently discovered similar effects of human seminal fluid on smooth muscle tissue. (medscape.com)
  • Nitric oxide inhibits neointimal hyperplasia following vascular injury via differential, cell-specific modulation of SOD-1 in the arterial wall. (unc.edu)
  • This was paralleled by barrier maturation with junctional proteins regularly distributed at the cell borders. (bvsalud.org)
  • Application of cytomix in immature human intestinal organoid cultures resulted in reduced barrier function that was accompanied with cell fragmentation, cell death and overall loss of junctional proteins, demonstrating a high susceptibility of the organoid culture to inflammatory stimuli. (bvsalud.org)
  • In differentiated organoid cultures, cytomix induced a hierarchical sequence of changes beginning with loss of cell adhesion, redistribution of junctional proteins from the cell border, protein degradation which was accompanied by loss of epithelial barrier function. (bvsalud.org)
  • EVs are a natural carrier system that can transfer nucleic acids, proteins, and lipids between donor and recipient cells in an autocrine, paracrine, and endocrine manner. (imrpress.com)
  • ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
  • A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
  • It is estimated that as much as 10% of the cell surface proteins undergo ectodomain shedding. (frontiersin.org)
  • Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. (mdc-berlin.de)
  • In the skin, H1Rs are expressed on vascular smooth muscle cells, endothelial cells, neurons, and different immune cells such as monocytes, neutrophils, DCs, and T and B cells where their activation drives the typical symptoms of immediate hypersensitivity responses, comprising edema and pruritus [ 10 ]. (springeropen.com)
  • Endothelial cells express two classic cadherins, VE-cadherin and N-cadherin. (rupress.org)
  • however, the function of N-cadherin in endothelial cells remains poorly understood. (rupress.org)
  • Contrary to previous studies, we found that N-cadherin localizes to endothelial cell-cell junctions in addition to its well-known diffusive membrane expression. (rupress.org)
  • To investigate the role of N-cadherin in vascular development, N-cadherin was specifically deleted from endothelial cells in mice. (rupress.org)
  • These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane. (rupress.org)
  • The adherens junction provides strong cell-cell adhesion mediated by the cadherin-catenin complex via its linkage to the actin cytoskeleton ( Wheelock and Johnson, 2003 ). (rupress.org)
  • N-cadherin is normally concentrated at cell-cell contact sites in most cell types where it is expressed. (rupress.org)
  • He also serves as a Director of the Center for Vascular Remodeling and Regeneration, the Co-Director of the Center for Medical Innovation, the Acting Director of the University's GRID Institute, as well as the Director of the Vascular Bioengineering Laboratory. (pitt.edu)
  • This buildup results in plaque formation, vascular remodeling, acute and chronic luminal obstruction, abnormalities of blood flow, and diminished oxygen supply to target organs. (medscape.com)
  • The occurrence and development of PH is closely related to pulmonary vascular remodeling and abnormal function. (imrpress.com)
  • However, the mechanism of pulmonary vascular remodeling has not been fully elucidated, there is still a lack of effective drugs to prevent and reverse pulmonary vascular remodeling. (imrpress.com)
  • Intercellular communication, a key process in pulmonary vascular remodeling, is originally believed to be achieved by either direct cell-to-cell contact or paracrine effects. (imrpress.com)
  • PDGF-BB is required in the ontogeny of kidney mesangial cells and has been shown to be essential for development of the vasculature and vascular integrity[ 15 ]. (biomedcentral.com)
  • Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
  • Members of the ADAM family contribute to various physiological and pathophysiological processes by modulation of molecules like growth factors or cytokines. (frontiersin.org)
  • To better understand the epigenetic and transcriptional mechanisms that mediate these cell state changes, and how they relate to risk for coronary artery disease (CAD), we have investigated the causality and function of transcription factors (TFs) at genome wide associated loci. (stanford.edu)
  • Our working hypothesis is that diabetic conditions (high glucose-HG) alters normal VEC-Mo interaction by progressively inducing molecular changes and function alteration in both cell types. (brainmap.ro)
  • Its part, primarily during the context of cancer, is extensively studied, and various research have explored the function of KLF4 in vascular smooth muscle cell and vas cular endothelial cell. (trpvantagonists.com)
  • Mapping cytoskeletal protein function in cells by means of nanobodies. (scriptiebank.be)
  • Hence, the prevailing view is that N-cadherin's primary function in ECs is to promote heterotypic cell interactions with mural cells. (rupress.org)
  • Immunologically, AD is driven by TSLP-secretion by keratinocytes and epithelial cells which modulate dendritic cell (DC) and basophil function to preferentially induce a Th2 immune response. (springeropen.com)
  • A recent review has shown that CD28 influence the ath erosclerosis development by co stimulating T cell with CD80 86. (trpvantagonists.com)
  • Age, and its associated physiological and pathological consequences, exacerbate CVD incidence and progression, while modulation of biological age with interventions track with cardiovascular health. (oaepublish.com)
  • These infiltrating cells secrete various inflammatory cytokines, such as tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. (molcells.org)
  • The importance of these communications for the establishment, maturation and maintenance of this unique phenotype had already been suggested in the pioneering work to identify and demonstrate the BBB. (mdpi.com)
  • High expression of miR-21 has also EPHB2 been observed in the vascular wall of balloon-injured rat carotid arteries-an model recapitulating smooth muscle phenotype switch7. (healthyconnectionsinc.com)
  • ECs have the capacity to undergo a dynamic cellular phenotypic switching, termed the endothelial to mesenchymal transition (EndMT), in response to local environmental cues throughout the vascular system. (bmbreports.org)
  • At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. (biomedcentral.com)
  • Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions. (diabetesjournals.org)
  • Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production. (unc.edu)
  • We discuss the current knowledge about sex differences in migraine and its comorbidities, and focus on the potential role of mast cells (MCs) in both. (frontiersin.org)
  • The anti-pruritic effects are mediated by a reduction of histamine-dependent release of pruritogenic pro-inflammatory mediators such as bradykinins, serotonin, prostaglandins, and substance P by mast cells which all can confer an itching sensation. (springeropen.com)