Muscle, Smooth, VascularMyocytes, Smooth MuscleMuscle, SmoothCells, CulturedAortaAorta, ThoracicPlatelet-Derived Growth FactorRats, Sprague-DawleyMuscle ContractionAngiotensin IIProto-Oncogene Proteins c-sisCalciumCell DivisionRNA, MessengerVasoconstrictionCarotid Artery InjuriesRats, Inbred WKYSignal TransductionVasoconstrictor AgentsTunica IntimaEndothelium, VascularArteriesRabbitsEnzyme InhibitorsMesenteric ArteriesCell MovementPursuit, SmoothDose-Response Relationship, DrugPhosphorylationHyperplasiaCell ProliferationNeointimaCyclic GMPActinsNitric OxideCoronary VesselsGene Expression RegulationPulmonary ArteryVasodilationRats, WistarPotassium ChlorideHypertrophyEnzyme ActivationBlood VesselsPhenylephrineSmooth Muscle MyosinsTime Factorsrho-Associated KinasesMuscle TonusCarotid ArteriesVasodilator AgentsBlotting, WesternTracheaSwineRats, Inbred SHRCyclic GMP-Dependent Protein KinasesImmunohistochemistryReceptors, AngiotensinCattleMuscle ProteinsProtein Kinase CNorepinephrineNitric Oxide SynthaseGene ExpressionMitogen-Activated Protein KinasesUp-RegulationMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Nitric Oxide DonorsNitroprussideEndothelin-1AtherosclerosisGuinea PigsMice, KnockoutMyosin Light ChainsDNACatheterizationMyosin-Light-Chain PhosphataseTransfection15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidrhoA GTP-Binding ProteinMembrane PotentialsEndothelinsReceptor, Angiotensin, Type 1Vascular DiseasesEndoplasmic Reticulum, SmoothReceptor, Platelet-Derived Growth Factor betaAcetylcholineCalcium Channel BlockersReverse Transcriptase Polymerase Chain ReactionMitogensMyosin-Light-Chain KinaseSaphenous VeinHypertensionPyridinesApoptosisStress, MechanicalReactive Oxygen SpeciesCalmodulin-Binding ProteinsCalcium Signaling
Muscle cells2
- Both endothelial and smooth muscle cells appear to play a role in the development and progression of PAH. (nih.gov)
- Prostacyclin is a prostaglandin that is produced by endothelial cells in the lungs and directly relaxes the smooth muscle cells in the pulmonary vasculature. (nih.gov)