VSMCSMCsVSMCsCalcificationBlood vesselsArteriesChronic kidneyAbstractEndotheliumRestenosisAortic smooth musclRelaxesArterialVasoconstrictionActinLesionStiffnessMigrationContractilityDifferentiationPhysiologicalInhibitsReceptorsRegulationSpecificityCellsTherapeutic targetVesiclesStenosisMuscle TumorsLeiomyomasTissueCell ProliferationNeuralMeSHClinical
VSMC8
- A spectral analysis approach was developed for detailed study of time-resolved, dynamic changes in vascular smooth muscle cell (VSMC) elasticity and adhesion to identify differences in VSMC from young and aged monkeys. (researchwithrutgers.com)
- Vascular smooth muscle cell (VSMC) proliferation and extracellular matrix (ECM) accumulation play key roles in the development and the progression of vascular remodeling such as transplant arteriosclerosis and restenosis. (elsevierpure.com)
- Conclusion-Our results suggest that p38-MAPK/CREB/Rac1 pathway plays a critical role in TNF-α-induced VSMC migration and may be a novel therapeutic target for vascular stenotic lesion. (elsevierpure.com)
- Our results collectively indicate that AP-1 activation is crucial for the mediation of VSMC proliferation in response to vascular injury. (dsmc.or.kr)
- Context As one of the crucial causes leading to cardiovascular disease, atherosclerosis (AS) develops in combination with the dysfunction of soft vascular muscle cells (VSMC). (fgf-4.com)
- Thrombin is a potent vascular smooth muscle cell (VSMC) mitogen. (utmb.edu)
- Our data demonstrate that generation of O 2 /· - and H 2 O 2 is required for thrombin-mediated mitogenesis in VSMC and that p47(phox) is regulated by thrombin in vitro and is associated with vascular lesion formation in vivo. (utmb.edu)
- This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 ( PVT1 ) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. (molcells.org)
SMCs8
- In this study, the effects of JTE-013, a specific antagonist of the migration-inhibitory receptor EDG-5, on Sph-1-P-elicited responses were examined in human umbilical vein endothelial cells (HUVECs) and vascular smooth muscle cells (SMCs), which expressed EDG-5 protein weakly and abundantly, respectively. (nih.gov)
- Morphological, functional, and gene expression studies have established the phenotypic plasticity of smooth muscle cells (SMCs). (tubitak.gov.tr)
- In this study, we intended to investigate the effects of growth factor-rich medium on the protein expression of vascular SMCs in culture. (tubitak.gov.tr)
- Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of macrophage markers with cholesterol exposure. (heart.org)
- Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle cells (SMCs). (jci.org)
- RNA sequencing, proteomics, and myography demonstrated decreased contractile differentiation of SMCs and impaired vascular contractility. (jci.org)
- In the present study, we have evaluated this reciprocal relationship by examining the impact of c-Ha-ras(EJ) oncogene transfection on α-smooth muscle (SM) actin and α 18 -adrenoceptor (ADR) gene expression in vascular (aortic) smooth muscle cells (SMCs). (houstonmethodist.org)
- These results demonstrate that c-Ha-ras(EJ) transfection is associated with alterations in the expression of genes associated with muscle-specific functions in vascular SMCs and implicate c-Ha-ras in the regulation of phenotypic expression in SMCs. (houstonmethodist.org)
VSMCs11
- The proliferation of vascular smooth muscle cells (VSMCs) induced by oxidative injury is one of the main features in diabetes-accelerated atherosclerosis. (hindawi.com)
- Atherosclerosis occurs earlier and with greater severity in the population with diabetes [ 1 - 3 ] and is characterized pathologically by endothelial cell injury, proliferation and migration of vascular smooth muscle cells (VSMCs), and thickening of intima [ 4 , 5 ]. (hindawi.com)
- The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
- The present study investigated the effects of PQS on the calcification of vascular smooth muscle cell (VSMCs). (biomedcentral.com)
- In mammalian visceral organs, vascular smooth muscle cells (VSMCs) originate from an epithelial-to-mesenchymal transition (EMT) of embryonic mesothelial cells (MCs). (ox.ac.uk)
- However, it remains unknown whether adult MCs-derived SM-like cells may acquire specific vascular SM lineage markers and the functionality of differentiated contractile VSMCs. (ox.ac.uk)
- Objective-Migration of vascular smooth muscle cells (VSMCs) contributes to formation of vascular stenotic lesions such as atherosclerosis and restenosis after angioplasty. (elsevierpure.com)
- Excessive proliferation of vascular smooth muscle cells (VSMCs) and neointimal formation are critical steps in the pathogenesis of atherosclerosis and restenosis after percutaneous transluminal angioplasty. (dsmc.or.kr)
- Vascular calcification is driven by aldosterone-sensitive osteogenic transformation of vascular smooth muscle cells (VSMCs). (dissem.in)
- Vascular CYP11B2 may contribute to stimulation of VSMCs osteo-/chondrogenic transformation during hyperphosphatemia. (dissem.in)
- We investigated this question in primary cultured rat aortic vascular smooth muscle cells (VSMCs). (uky.edu)
Calcification8
- Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
- Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
- Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
- Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)
- However, the role and mechanism of PQS in vascular calcification are not unclear. (biomedcentral.com)
- However, the underlying mechanisms of vascular calcification have not been established. (biomedcentral.com)
- For example, hydrogen peroxide (H 2 O 2 ) is a classic oxidant stressor that promotes vascular cell calcification by increasing the expression of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) [ 11 ]. (biomedcentral.com)
- Zhu K, Reiser J. ALKBH1 reduces DNA N6-methyladenine to allow for vascular calcification in chronic kidney disease. (rush.edu)
Blood vessels6
- Vascular smooth muscle is the type of smooth muscle that makes up most of the walls of blood vessels. (wikipedia.org)
- Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. (wikipedia.org)
- Vascular smooth muscle contracts or relaxes to change both the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). (wikipedia.org)
- Thus the main function of vascular smooth muscle tone is to regulate the caliber of the blood vessels in the body. (wikipedia.org)
- Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. (bvsalud.org)
- Smooth muscle tumors are very rare in the oral cavity due to the scarcity of smooth muscle in this region, and arise mainly from tunnica media of blood vessels. (bvsalud.org)
Arteries3
- Arteries have a great deal more smooth muscle within their walls than veins, thus their greater wall thickness. (wikipedia.org)
- These results show that in mesenteric arteries an intact cytoskeleton and force development are not prerequisites for G-protein-coupled receptor-induced activation of PYK2 and paxillin, by tyrosine phosphorylation, in vascular tissue, but are necessary for the translocation of PYK2 and paxillin to the membrane. (manchester.ac.uk)
- Repeated injury and smooth muscle remodeling in resistance arteries is expected to thicken the vessel wall and narrow the lumen and reduce blood flow. (cdc.gov)
Chronic kidney1
- Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
Abstract1
- abstract = "Dynamic remodeling of the actin cytoskeleton occurs during agonist-induced smooth muscle contraction. (manchester.ac.uk)
Endothelium1
- BALB/c aortas (H-2(d)) transplanted into α-TFPI-transgenic (Tg) mice (H-2(b)) regenerated a quiescent endothelium in contrast to progressive IH seen in C57BL/6 wild-type (WT) mice even though both developed aggressive anti-H-2(d) alloresponses, indicating similar vascular injuries. (nih.gov)
Restenosis2
- Excessive proliferation of vascular smooth muscle cells contributes to the progression of pathological conditions, such as vascular inflammation, plaque formation, atherosclerosis, restenosis, and pulmonary hypertension. (wikipedia.org)
- WO9843618A2 ] Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. (epo.org)
Aortic smooth muscl3
- Methods: Human aortic smooth muscle cells (HASMC) were cultured under either proliferating or growth arrest (quiescent) conditions in the presence or absence of ZA for 48 hours, whereupon the effect of ZA on HASMC proliferation, cellular viability, metabolic activity, and membrane integrity were compared. (elsevierpure.com)
- We show that even in absence of exogenous aldosterone, silencing and pharmacological inhibition (spironolactone, eplerenone) of the mineralocorticoid receptor (MR) ameliorated phosphate-induced osteo-/chondrogenic transformation of primary human aortic smooth muscle cells (HAoSMCs). (dissem.in)
- Treatment of human aortic smooth muscle cells with thrombin increased DNA synthesis, an effect that was antagonized by diphenyleneiodonium but not by other inhibitors of cellular oxidase systems. (utmb.edu)
Relaxes1
- Relaxes vascular smooth muscle by stimulating intracellular cyclic GMP. (medscape.com)
Arterial2
- The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
- the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage. (bvsalud.org)
Vasoconstriction3
- Under NE binding alpha-1 receptors cause vasoconstriction (contraction of the vascular smooth muscle cells decreasing the diameter of the vessels). (wikipedia.org)
- Agonists of alpha-2 receptors in the vascular smooth muscle lead to vasoconstriction. (wikipedia.org)
- Mast cells secrete histamine that inhibits vasoconstriction via H2 receptors on smooth muscle cells. (cdc.gov)
Actin10
- Moreover, after a 16-week duration of diabetes, Pggt1b Δ / Δ mice exhibited lower α -smooth muscle actin ( α -SMA) and nitrotyrosine level, Rac1 activity, p47phox and NOXO1 expression, and phospho-ERK1/2 and phosphor-JNK content than wild-type mice. (hindawi.com)
- The goal of this study was to use mice expressing human tissue factor pathway inhibitor (TFPI) on α-smooth muscle actin (α-SMA)(+) cells as recipients of allogeneic aortas to gain insights into the cellular mechanisms of intimal hyperplasia (IH). (nih.gov)
- Ohanian, V, Gatfield, K & Ohanian, J 2005, ' Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle ', Hypertension , vol. 46, no. 1, pp. 93-99. (manchester.ac.uk)
- Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alpha-actin gene transcripts mark the onset of cardiomyocyte differentiation. (silverchair.com)
- The expression of cytoplasmic beta-actin and cardiac, skeletal, and smooth muscle alpha-actins during early avian cardiogenesis was analyzed by in situ hybridization with mRNA-specific single-stranded DNA probes. (silverchair.com)
- The accumulation of large quantities of smooth muscle alpha-actin transcripts in epimyocardial cells preceded the expression of the sarcomeric alpha-actin genes. (silverchair.com)
- At Hamburger-Hamilton stage 12, the smooth muscle alpha-actin gene was selectively down-regulated in the heart such that only the conus, which subsequently participates in the formation of the vascular trunks, continued to express this gene. (silverchair.com)
- This modulation in smooth muscle alpha-actin gene expression correlated with the beginning of coexpression of sarcomeric alpha-actin transcripts in the epimyocardium and the onset of circulation in the embryo. (silverchair.com)
- The specific expression of the vascular smooth muscle alpha-actin gene marks the onset of differentiation of cardiac cells and represents the first demonstration of coexpression of both smooth muscle and striated alpha-actin genes within myogenic cells. (silverchair.com)
- Within vascular smooth muscle cells, smooth muscle α-2 actin forms the core of structures called sarcomeres, which are necessary for muscles to contract. (medlineplus.gov)
Lesion1
- In AVeNEW, patients who received the Covera™ Vascular Covered Stent had 103 reinterventions involving a new lesion compared to 72 reinterventions in the PTA only group at 24 months. (bd.com)
Stiffness1
- The oscillatory behavior suggests that mechanisms governing elasticity and adhesion are coupled and affected differentially during aging, which may link these events to changes in vascular stiffness. (researchwithrutgers.com)
Migration3
- Our results indicate that specific regulation of Sph-1-P-modulated migration responses in vascular cells can be achieved by EDG-5 antagonists and that manipulation of Sph-1-P biological activities by each EDG antagonist may lead to a therapeutical application to control vascular diseases. (nih.gov)
- Introduction: The activation of human vascular smooth muscle cell proliferation, adhesion and migration is essential for intimal hyperplasia formation. (elsevierpure.com)
- ZA was chosen for testing in these experiments because it is clinically used in humans with cancer, and has been shown to modulate rat smooth muscle cell proliferation and migration. (elsevierpure.com)
Contractility1
- KCNQ4 and KCNQ5 regulate vascular smooth muscle excitability and contractility and are implicated as antihypertensive drug targets. (bvsalud.org)
Differentiation1
- The ability of adult MCs to recapitulate EMT and to acquire smooth muscle (SM) markers upon provasculogenic culture suggested they might retain embryonic vasculogenic differentiation potential. (ox.ac.uk)
Physiological2
- Ghorbel MT, Jia H, Swim MM, Iacobazzi D, Albertario A, Zebele C, Holopherne-Doran D, Hollander A, Madeddu P, Caputo M. Reconstruction of the pulmonary artery by a novel biodegradable conduit engineered with perinatal stem cell-derived vascular smooth muscle cells enables physiological vascular growth in a large animal model of congenital heart disease. (rush.edu)
- Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)
Inhibits1
- Inhibits transmembrane influx of calcium ions into smooth muscle, which, in turn, inhibits contraction of the muscle fibers. (medscape.com)
Receptors5
- Vascular smooth muscle is innervated primarily by the sympathetic nervous system through adrenergic receptors (adrenoceptors). (wikipedia.org)
- The adrenergic receptors exert opposite physiologic effects in the vascular smooth muscle under activation: alpha-1 receptors. (wikipedia.org)
- Antagonists of alpha-1 receptors (doxazosin, prazosin) cause vasodilation (a decrease in vascular smooth muscle tone with increase of vessel diameter and decrease of the blood pressure). (wikipedia.org)
- This presynaptic effect is predominant and completely overrides the vasoconstrictive effect of the alpha-2 receptors in the vascular smooth muscle. (wikipedia.org)
- Agonism of beta-2 receptors causes vasodilation and low blood pressure (i.e. the effect is opposite of the one resulting from activation of alpha-1 and alpha-2 receptors in the vascular smooth muscle cells). (wikipedia.org)
Regulation1
- Co-ordinate down-regulation of smooth muscle-specific genes and acquisition of unregulated proliferative characteristics have been proposed as hallmarks of the atherosclerotic process. (houstonmethodist.org)
Specificity1
- The vascular specificity of Itga8-Cre circumvented gastrointestinal effects. (jci.org)
Cells5
- Recent studies have shown that the majority of cells within atherosclerotic plaque, the predominant cause of heart attack and stroke, are vascular smooth muscle cell derived. (wikipedia.org)
- These experiments were designed to test whether zoledronic acid (ZA) would modulate indices of human smooth muscle cell activation, exert differential effects on proliferating versus quiescent cells, and determine whether these effects were dependent on GTPase binding proteins prenylation. (elsevierpure.com)
- Functional vascular smooth muscle-like cells derived from adult mouse uterine mesothelial cells. (ox.ac.uk)
- Signaling mechanisms of heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells. (meharryresearch.org)
- These agents interfere with calcium uptake by smooth muscle cells that are dependent on intracellular calcium for contraction. (medscape.com)
Therapeutic target1
- Vascular smooth muscle cell proliferation as a therapeutic target. (wikipedia.org)
Vesicles1
- Electron micrograph of human omental vein showing longitudinal section of a sympathetic nerve axon containing neurotubules ( n ) in parallel with a smooth muscle cell ( SMC ) with typical pinocytic vesicles ( pv ). (comprehensivephysiology.com)
Stenosis1
- Prospective, Multicenter Clinical Study of the Covera Vascular Covered Stent in the Treatment of Stenosis at the Graft-Vein Anastomosis of Dysfunctional Hemodialysis Access Grafts. (bd.com)
Muscle Tumors4
- The majority of uterine smooth muscle tumors occur in the corpus, but the cervix, vaginal canal, broad ligament, and ovaries may also be involved. (medscape.com)
- There were 49 cases of smooth muscle tumors: 27 leiomyomas and 22 leiomyosarcomas. (bvsalud.org)
- Cases of smooth muscle tumors of the oral cavity were also compiled from 1970 to 2010. (bvsalud.org)
- Nine thousand seven hundred and seventy histopathologic exams were accomplished during this period and only 64 (0,092%) were diagnosed as smooth muscle tumors, that corresponded to 49 cases, being 27 (55%) leiomyomas e 22 (45%) leiomyossarcomas. (bvsalud.org)
Leiomyomas1
- From 27 leiomyomas, 21 (78%) were vascular type and only 6 (22%) were solid, no epithelioid was found. (bvsalud.org)
Tissue3
- Cell death-associated ADAMTS4 and versican degradation in vascular tissue. (rush.edu)
- Vascular and endothelial functions in RA, TA, MA, and CC were assessed by isolated tissue bath with cumulative doses of acetylcholine and sodium nitroprusside. (deu.edu.tr)
- Dose-response relationships and concepts in ligand-receptor binding, demonstrated through hands-on courses using isolated ileum, vas deferens and vascular smooth muscle tissue. (adinstruments.com)
Cell Proliferation1
- Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation. (musc.edu)
Neural2
- The neural and vascular changes from long term vibration are envisioned to generate the persistent vasospastic and neurodegenerative HAVS. (cdc.gov)
- The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. (bvsalud.org)
MeSH1
- Muscle, Smooth, Vascular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Clinical3
- The Covera™ Vascular Covered Stent delivered effective results in two separate clinical trials, one for patients dialyzing with AV grafts and one for patients dialyzing with AV fistulas. (bd.com)
- The VasCore Wound Core Laboratory offers dedicated Wound Core services to supplement clinical, pharmaceutical and device trials, under the leadership of vascular surgeon, Anahita Dua, MD. MSC, who also serves as Medical Director of the Mass General Vascular Lab and Associate Director of the Mass General Wound Center . (massgeneral.org)
- Under the leadership of Kei Yamada, MD of the Mass General Interventional Radiology Department , VascCore provides sophisticated vascular core lab services that implement validated and calibrated image analysis and combines it with clinical and technical expertise in vascular interventions. (massgeneral.org)