Vascular receptors. Medical search. Frequent questions

Vascular endothelial growth factor (VEGF) is an essential angiogenic factor for formation of the embryonic vasculature, and also has important roles in pathological conditions such as diabetic retinopthy, rheumatoid arthritis and cancer. (figshare.com)
Although the signalling pathways induced by VEGF have been well-studied, the precise molecular mechanisms remain to be determined, particularly with respect to the relative contribution of the individual receptors. (figshare.com)
Two main VEGF receptors are expressed in endothelial cells: VEGFR-1 and VEGFR-2. (figshare.com)
We have previously demonstrated that a failure of pulmonary endothelial cell survival induced by vascular endothelial growth factor (VEGF) receptor blockade results in lung alveolar septal cell apoptosis and emphysema. (nih.gov)
Because apoptosis and oxidative stress may be pathobiologically linked, we hypothesized that oxidative stress has a central role in alveolar septal cell apoptosis and emphysema induced by VEGF receptor blockade. (nih.gov)
When compared with control animals, rats treated with the VEGF receptor blocker SU5416 showed increased alveolar enlargement, alveolar septal cell apoptosis, and expression of markers of oxidative stress, all of which were prevented by the superoxide dismutase mimetic M40419. (nih.gov)
Oxidative stress and apoptosis, which cause lung cellular destruction in emphysema induced by VEGF receptor blockade, may be important mediators common to human and experimental emphysema. (nih.gov)
Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. (jci.org)
Vascular endothelial growth factor (VEGF) is a secreted endothelial cell-specific mitogen. (jci.org)
To evaluate whether VEGF may play a role in angiogenesis, we have determined the spatial and temporal patterns of expression of VEGF and VEGF receptors during natural angiogenic processes taking place within the female reproductive system. (jci.org)
We propose that excessive expression of VEGF during gonadotropin-induced ovulation may contribute to the development of ovarian hyperstimulation syndromes by virtue of the vascular permeabilization activity of this factor. (jci.org)
42 (10): 10611067 Abstract Background Vascular endothelial growth factor (VEGF) helps control tumour growth via causing new capillaries growth in tumours. (wichita.edu)
Four cardiac hormones [i.e. vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide (KP) and atrial natriuretic peptide (ANP)] that eliminate up to up to 86% of human small-cell lung cancers growing in mice were investigated for their effects on VEGF and the VEGFR2/KDR/Flk-1 receptor. (wichita.edu)
Conclusion Four cardiac hormones are the first dual inhibitors of VEGF and the VEGFR2/KDR/Flk-1 receptor. (wichita.edu)
During angiogenesis, a highly regulated process, the most potent pro-angiogenic signaling cascades are initiated by vascular endothelial growth factor (VEGF) binding to EC-resident VEGF receptors (VEGFR) like VEGFR1, VEGFR2 and VEGFR3 [ 9 ]. (biomedcentral.com)
The loss of myoferlin results in lack of proliferation, migration, and nitric oxide (NO) release in response to vascular endothelial growth factor (VEGF). (elsevierpure.com)
Western blotting and surface biotinylation experiments show that loss of myoferlin reduces the expression level and autophosphorylation of VEGF receptor-2 (VEGFR-2) in native ECs. (elsevierpure.com)
The aim of this study was to investigate the effect of CO on angiogenesis and vascular endothelial growth factor (VEGF) receptor-2 phosphorylation. (aston.ac.uk)
Here, we report the surprising finding that exposure to CO inhibits vascular endothelial growth factor (VEGF)-induced endothelial cell actin reorganisation, cell proliferation, migration and capillary-like tube formation. (aston.ac.uk)
We analysed the mRNA expression levels of all known vascular endothelial growth factor (VEGF) ligands and receptors in human endometrium collected in the menstrual and proliferative phases of the menstrual cycle. (amsterdamumc.org)
Changes in VEGF ligands and receptors were associated with elevated expression of the hypoxia markers HIF1alpha and CA-IX in the menstrual and early proliferative phases. (amsterdamumc.org)
In cultured cells, the overexpression of Spred-1 or Spred-2 strongly suppressed vascular endothelial growth factor-C (VEGF-C)/VEGF receptor (VEGFR)-3-mediated ERK activation, while Spred-1/2-deficient cells were extremely sensitive to VEGFR-3 signaling. (elsevierpure.com)
Vascular endothelial growth factor (VEGF) plays a significant role in both physiologic and pathologic angiogenesis and plays a part in improved permeability across both blood-retinal and blood-brain barriers. (molecularcircuit.com)
VEGF Features Three years of intense analysis provides uncovered the complete biochemistry of VEGF and its own receptors. (molecularcircuit.com)
The present study assessed, by immunohistochemistry, the microvessel density in the synovium of these arthritides and in normal controls, in relation to the expression of the angiogenic factors vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) and the apoptosis-related proteins bcl-2 and p53. (ox.ac.uk)
More importantly, using the novel 11B5 MAb, the activated "VEGF/flk-1(KDR)-receptor" microvessel density was assessed. (ox.ac.uk)
Background Vascular endothelial growth factor (VEGF) is produced by bladder cancer cell lines in vitro and expressed in human bladder tumor tissues. (johnshopkins.edu)
ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)

Ultrasound (US) molecular imaging by examining the expression of vascular endothelial growth factor receptor 2 (VEGFR2) on uterus vascular endothelium was applied to evaluate the endometrial receptivity. (thno.org)
The sst 2 gene was expressed in the proliferating angiogenic sprouts of human vascular endothelium. (beatingcancercenter.com)
Despite its importance, there are very few studies focusing on the quantification of such dynamics in the vascular endothelium . (bvsalud.org)
We conclude that estrogen action(s) within the vascular endothelium in the endometrium may be mediated via direct binding to the ERβ isoform and that these cells could therefore be a target for agonists or antagonists that selectively target the β form of the ER. (elsevierpure.com)
The vascular endothelium is formed by a sheet of endothelial cells tethered together by junctional proteins such as tight and adherens junctions. (bvsalud.org)

In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
Background and Aims: Activation of the antitumor immune response using programmed death receptor-1 (PD-1) blockade showed benefit only in a fraction of patients with hepatocellular carcinoma (HCC). (elsevierpure.com)
Specific blockade of vascular endothelial receptor 2 (VEGFR-2) using a murine antibody significantly delayed primary tumor growth but failed to prolong survival, while anti-PD-1 antibody treatment alone conferred a minor survival advantage in one model. (elsevierpure.com)
Long-term effects of ETA receptor blockade on blood pressure and kidney function in spontaneously hypertensive rats (SHRs) on a high-salt diet are unknown. (silverchair.com)
In conclusion, the renal ET system contributes in a blood-pressure-independent manner to the regulation of urinary protein excretion and renal vascular hypertrophy in SHR-S. Lower doses of the ETA antagonist were more effective, indicating that a potential additional blockade of the ETB receptor using higher doses of LU 135252 seems to oppose the beneficial effects of a sole ETA blockade. (silverchair.com)

The EGF receptor tyrosine kinase inhibitor AG1478 (0.25-1 μM) was without effect. (aspetjournals.org)
Pazopanib is a vascular endothelial receptor tyrosine kinase inhibitor with anti-angiogenesis and anti-tumor activity in several preclinical models. (johnshopkins.edu)

G protein-coupled receptors can activate Erk MAPK pathways through a variety of mechanisms, including stimulation of Src, phosphoinositide-3 kinase (PI-3-K), protein kinase C (PKC), or the epidermal growth factor (EGF) receptor tyrosine kinase. (aspetjournals.org)
Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. (drugbank.com)
The molecular mechanism by which vascular endothelial receptors (VEGFRs) control vessel growth and function in physiological and pathological settings is under intensive study, but questions remain. (helsinki.fi)
Liu H, Chen Y, Yan F, Han X, Wu J, Liu X, Zheng H. Ultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 Expression for Endometrial Receptivity Evaluation. (thno.org)
There have recently been considerable advances in GPCR signaling especially recognition of the extended role for GPCR transactivation of tyrosine and serine/threonine kinase growth factor receptors. (edu.au)
Phosphorylation of vascular endothelial growth factor receptor 2 (pVEGFR2) via PI3K/Akt signaling plays a key role in mediating cellular processes involved in repair, such as mitogenesis, angiogenesis, and vascular permeability. (biomedcentral.com)
Product Description google The human Vascular Endothelial Growth Factor receptor 1 (VEGFR1) Kit is a sandwich ELISA. (biosensis.com)
Specificity Human Vascular Endothelial Growth Factor receptor 1 Human sVEGFR1 isoforms, possibly primate sVEGFR1 (untested), homology to mouse, rat, chicken sVEGFR1 proteins less than 80% across the immunogen used. (biosensis.com)
For the quantification of Vascular endothelial growth factor receptor 1, soluble (sVEGFR-1) in Culture Supernatant, Serum, Plasma (EDTA). (biosensis.com)
The angiogenic pathway "vascular endothelial growth factor/flk-1(KDR)-receptor" in rheumatoid arthritis and osteoarthritis. (ox.ac.uk)
Vascular growth during implantation normal non-pregnant controls, 20 normal and placentation is critical for successful pregnant controls, 20 patients with mild gestation. (who.int)

The mechanism of activation of the transient receptor potential vanilloid 4 (TRPV4) channel by 4α-phorbol esters was investigated by combining information from chemical modification of 4α-phorbol-didecanoate (4α-PDD, 2a ), site-directed mutagenesis, Ca 2+ imaging, and electrophysiology. (acs.org)
CGRP release was induced by either 60 mM K + (for depolarization-induced stimulation) or 100 nM capsaicin (for transient receptor potential vanilloid 1 (TRPV1) -induced stimulation) and measured using an enzyme-linked immunosorbent assay. (lu.se)

It was found that phosphorylation of the human A2AAR could be induced in HUVECs by treatment with PMA or by stimulation of endogenous histamine H1 receptors. (gla.ac.uk)
Mast cells secrete histamine that inhibits vasoconstriction via H2 receptors on smooth muscle cells. (cdc.gov)

The presence of sst 2 receptors on proliferating angiogenic vessels was confirmed by immunohistochemical staining and in vivo scintigraphy. (beatingcancercenter.com)

The RAS consists of two counterregulatory axes, divided into the conventional axis and includes angiotensin II (Ang II), angiotensin-converting enzyme (ACE), Ang II type 1 receptor (AT 1 R), and the nonconventional axis composed of Ang1-7 ACE2, Ang II type 2 receptor (AT 2 R), and Mas receptor (MasR) [ 13 ]. (hindawi.com)
We studied the effect of T3 on the angiotensin (Ang) II type 1 receptor (AT 1 R) expression in vascular smooth muscle cells. (elsevierpure.com)

The use of transgenic and gene knockout animals, gene manipulated cells, pharmacological LPA receptor agonists and antagonists have provided many insights into the biological significance of LPA and individual LPA receptors in the progression of atherosclerosis and vascular diseases. (edu.au)

Via six widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological responses, contributing to inflammation, thrombosis and atherosclerosis. (edu.au)

The VEGFR2 receptor is the main receptor mediating VEGFs cancer-enhancing effects. (wichita.edu)
Vessel dilator, LANP, KP and ANP decreased the VEGFR2 receptor by 77%, 89%, 88% and 67% in human small-cell lung cancer cells and by 48%, 92%, 64% and 71% in human prostate cancer cells. (wichita.edu)
These results were confirmed with the cardiac hormones also decreasing the VEGFR2 receptor measured by Western blots. (wichita.edu)

Vascular dilatation is critically impaired in many diseases and is encountered by an upregulated endothelin receptor A (ETA) in the vasculature in association with a decline in nitric oxide bioavailability. (nih.gov)
Endothelin receptor antagonist CPU0213 and ingredients from plant origins such as CPU86017, p-benzyl-tetra-hydro-berberine are effective in attenuating vascular abnormality by normalizing changes of biomarkers in the vascular wall. (nih.gov)
Vascular derived endothelin receptor A controls endothelin-induced ret" by Olivia J Marola, Gareth R Howell et al. (jax.org)
Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death. (jax.org)
Marola O, Howell G, Libby R. Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death. (jax.org)

Analysis of phosphorylation-dependent interactions downstream of VEGFR-1 in mammalian cells, which is generally hindered by the lack of ligand-induced receptor phosphorylation, was enabled by the development of chimeric receptors. (figshare.com)
These results show that in mesenteric arteries an intact cytoskeleton and force development are not prerequisites for G-protein-coupled receptor-induced activation of PYK2 and paxillin, by tyrosine phosphorylation, in vascular tissue, but are necessary for the translocation of PYK2 and paxillin to the membrane. (manchester.ac.uk)

Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. (drugbank.com)

Endothelial inflammation leading to vascular dysfunction is a major contributor to the development of atherosclerosis. (gla.ac.uk)
This review provides a comprehensive presentation of LPA with the highlight of the distinct role of its receptors in cell and animal models that relate to atherosclerosis and vascular diseases, and therefore provides new opportunities to reduce the burden of cardiovascular diseases. (edu.au)

Our results suggest that downregulation of AT 1 R gene expression may play an important role for T3-induced vascular relaxation. (elsevierpure.com)
Expression of the D1 and D5 receptors was decreased in both adult and senescent rats compared to the young rats, suggesting an age-related decline in these receptors. (unicam.it)
Of the D2-like receptors, the expression of the D2 receptor was decreased as a function of age, while the D3 receptor was unchanged in the senescent rats compared to the young rats. (unicam.it)
Expression of the D4 receptor was increased in adult, but was unchanged in the senescent rats compared to young animals. (unicam.it)
The above data suggest that reduction in the D1, D2 and D5 receptor expression may contribute to the deficiency in the dopamine-mediated vasorelaxation and hence blood flow in the mesenteric vascular tree in aging. (unicam.it)
The different sensitivity to aging of sympathetic neuroeffector junctions labeled by TH and of dopamine D2-like receptors that are known to be prejunctional, suggests that age-related changes of dopamine receptor expression in the mesenteric vasculature reflect more complicated mechanisms than simple up- or down-regulation phenomena. (unicam.it)
Functional studies demonstrate NOR1 as a constitutively active ligand-independent nuclear receptor whose transcriptional activity is dependent on both expression level and posttranslational modifications. (uky.edu)
Two periods of elevated mRNA expression of ligands and receptors were observed, separated by a distinct drop at cycle days (CDs) 9 and 10. (amsterdamumc.org)
These results indicate that INF-γ selectively increases P2X 4 -receptor gene expression, leading to an up-regulation of purinergic signaling in vascular endothelial cells. (elsevierpure.com)
The aim of the present experiments was to compare the spatial and temporal pattern of expression of estrogen receptor β (ERβ) with that of ERα in full thickness endometrial samples (from the superficial to the basal zone) obtained from both women and rhesus macaques. (elsevierpure.com)
Vibration white finger is likely driven by somatosympathetic reflex activation, increased á2c adrenergic receptor expression and endothelin-1 release. (cdc.gov)

IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
Molecular and vascular mechanisms were probed in mesenteric arteries and cultured vascular smooth muscle cells (VSMCs) from C57BL/6J, nondiabetic lean db/m, and diabetic obese db/db mice as well as in human microvascular endothelial cells (HMECs). (gla.ac.uk)
However, the molecular mechanisms of vascular relaxation by T3 are incompletely characterized. (elsevierpure.com)
The aim of this study was to examine how VM-specific mutations affect the molecular characteristics of TIE2-receptor downstream signaling and cellular functions. (oulu.fi)
Because no effective treatment has been available for VMs, a better understanding of the molecular basis of their pathology should enable the development of more potent and non-invasive treatments as well as provide a better understanding of vascular morphogenesis in general. (oulu.fi)
This data provides new information on the pathological mechanisms behind abnormal vascular morphogenesis and should assist the development of new molecular treatment strategies for VM patients. (oulu.fi)

The chimeric receptors were significantly activated in response to ligand, thereby enabling studies of this signalling with the putative effectors PKB/Akt, PLC and ERK1.2. (figshare.com)
Antagonism of EDN receptors (EDNRA and EDNRB, also known as ET-A and ET-B) prevented RGC death in mouse models of chronic ocular hypertension, and intravitreal injection of EDN ligand was sufficient to drive RGC death. (jax.org)
Estrogen action is dependent upon the presence of specific ligand-activated receptors in target tissues. (elsevierpure.com)

SERMs bind to estrogen receptors and activate estrogen pathways in some tissue while blocking its effects in other types of tissue. (rxlist.com)

Herein, using a proteomic analysis of endothelial cell (EC) caveolae/lipid raft microdomains we identified myoferlin in these domains and show that myoferlin is highly expressed in ECs and vascular tissues. (elsevierpure.com)

The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides such as N-Formylmethionine-leucyl-phenylalanine (FMLP) but also the polyunsaturated fatty acid metabolite of arachidonic acid, lipoxin A4 (LXA4). (wikipedia.org)
The human FPR2 gene encodes the 351 amino acid receptor, FPR2, within an intronless open reading frame. (wikipedia.org)
The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)
IFN-γ did not affect P2X 4 -receptor mRNA stability, but increased P2X 4 -receptor gene transcription in a cycloheximide- insensitive manner. (elsevierpure.com)
Estrogen receptor beta gene variant is associated with vascular dementia in elderly women. (cdc.gov)

An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
Epigallocatechin gallate (EGCG), an inhibitor of STAT1-mediated signaling, and AG490, a Janus kinase (JAK) inhibitor, impaired P2X 4 -receptor mRNA up-regulation by IFN-γ. (elsevierpure.com)

The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)

Diabetic vasculopathy is characterized as a compromised vascular dilatation, implicated in many diabetic complications. (nih.gov)
We aimed to determine whether chemerin reduces vascular insulin signaling and whether there is interplay between chemerin/ChemR23, insulin resistance, and vascular complications associated with type 2 diabetes (T2D). (gla.ac.uk)
Our novel in vivo findings highlight chemerin/ChemR23 as a promising therapeutic target to limit insulin resistance and vascular complications associated with obesity-related diabetes. (gla.ac.uk)
The rise in blood pressure and vascular complications present in IMQ mice were also observed in the CTR mice recipients of IMQ microbiota. (ugr.es)

The renal vascular responses to graded Ang II (30, 100, 300, and 1000 ng kg −1 .min −1 ) infusion using A779 or its vehicle were measured at constant renal perfusion pressure. (hindawi.com)
No significant differences were detected between the groups in renal blood flow (RBF) or renal vascular resistance (RVR) responses to Ang II infusion when MasR was not blocked. (hindawi.com)
In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)

CCX832 treatment of db/db mice decreased body weight, insulin, and glucose levels as well as vascular oxidative stress. (gla.ac.uk)
CCX832 also partially restored vascular insulin responses in db/db and high-fat diet-fed mice. (gla.ac.uk)

How Do Selective Estrogen Receptor Modulators Work? (rxlist.com)
Selective estrogen receptor modulators (SERM) are a class of medications used to relieve postmenopausal symptoms and to prevent bone loss ( osteoporosis ) associated with menopause . (rxlist.com)
Selective estrogen receptor modulators work by modulating the activity of estrogen receptors, proteins in cells that are activated by estrogen. (rxlist.com)
Selective estrogen receptor modulators have both estrogen agonistic and antagonistic properties, depending on the type of tissue. (rxlist.com)
Selective estrogen receptor modulators may also be combined with estrogen for postmenopausal women with an intact uterus, who are undergoing estrogen replacement therapy. (rxlist.com)
How are selective estrogen receptor modulators used? (rxlist.com)
What are side effects of selective estrogen receptor modulators? (rxlist.com)

Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin resistance. (gla.ac.uk)
In conclusion, gut microbiota plays a role in the TLR7-driven increase in Th17 cell, endothelial dysfunction, vascular inflammation, and hypertension. (ugr.es)
Extracellular nucleotides are involved in the development of vascular inflammation. (elsevierpure.com)

In addition, the observed dependence of some of these effects on a specific tyrosine residue within VEGFR-2 suggested that the chimeric receptors couple to downstream effectors in a manner analogous to that of the full-length receptors. (figshare.com)
moreover if VEGFR-3 is involved in vascular permeability. (helsinki.fi)
Our data showed that VEGFR-3 loss-of-function is accompanied by increased vascular leakage in the retina, in solid tumors, and in the ear skin. (helsinki.fi)
In vascular smooth muscle cells (SMCs), VEGFR-1 is inducibly expressed by vascular injury and participates in neointimal development. (cusabio.com)

However, a series of subsequent studies cloned two genes that encoded receptor-like proteins with amino acid sequences very similar to that of FPR. (wikipedia.org)
C5a2 or C5L2), which has the structure of G protein receptors but apparently does not couple to G proteins and is of uncertain function. (wikipedia.org)
Both receptor subtypes were detected on Western blots using proteins extracted from uterine samples obtained throughout the menstrual cycle. (elsevierpure.com)

Ohanian, V, Gatfield, K & Ohanian, J 2005, ' Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle ', Hypertension , vol. 46, no. 1, pp. 93-99. (manchester.ac.uk)
These receptors are present on phagocytic cells, mast cells, and lung epithelial and smooth muscle cells. (medscape.com)
CGRP stimulates relaxation of vascular smooth muscle. (cdc.gov)
Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. (bvsalud.org)

Early studies suggested that these formyl oligopeptides operated by a Receptor (biochemistry) mechanism. (wikipedia.org)
Together, these data suggest EDN ligands cause RGC death via a mechanism initiated by vascular mural cells. (jax.org)

coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)

Dopamine D1-D5 receptor protein immunoreactivity and tyrosine hydroxylase (TH) immunoreactivity were investigated on the mesenteric arterial tree by immunohistochemistry. (unicam.it)
The D2-like (D2, D3 and D4) receptors as well as TH immunoreactivity were localized only on the adventitia-media transitional zone of mesenteric arterial tree. (unicam.it)
The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)

N-formyl peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species. (wikipedia.org)

PDGFB, a major attractant of vascular mural cells, was found to be strongly attenuated due to chronic activation of Akt, which also increases EC survival, by the TIE2 mutant receptors. (oulu.fi)
Deletion of Ednra from the full body, and then specifically from vascular mural cells, prevented EDN1-induced vasoconstriction and RGC death. (jax.org)

Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. (drugbank.com)

It is worth testing the activity of these agents further for the potential in relieving abnormal vascular activity, reducing the risk of morbidity and mortality in patients at risk. (nih.gov)

An apparent conflict exists between observational studies that suggest that vitamin D receptor (VDR) activators provide a survival advantage for patients with ESRD and other studies that suggest that they cause vascular calcification. (wustl.edu)

This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
Changes in vascular permeability are commonly present in certain clinical diseases and when occurring in the lung or brain lead to serious consequences related to impaired gas exchange and cerebral function, respectively. (bvsalud.org)

The density of various dopamine receptors and TH immunoreactivity was compared between young (6-month-old), adult (15-month-old) and senescent (24-month-old) Fischer 344 rats by computer-assisted microdensitometry. (unicam.it)

This receptor was initially named the formyl peptide receptor (i.e. (wikipedia.org)
The three receptors had been given various names but are now termed formyl peptide receptor 1 (i.e. (wikipedia.org)
FPR1) for the first defined receptor, FPR2, and Formyl peptide receptor 3 (i.e. (wikipedia.org)
FPR2 and FPR3 are termed formyl peptide receptors base on the similarities of their amino acid sequences to that of FPR1 rather than any preferences for binding formyl peptides. (wikipedia.org)

The analysis of CGRP release data was combined with immunohistochemistry in order to study the cellular localization of CB1, cannabinoid receptor type 2 (CB2), CGRP and receptor activity modifying protein 1 (RAMP1), a subunit of the functional CGRP receptor, in the TG. (lu.se)

IFN-γ increased P2X 4 -receptor mRNA and protein, accompanied by an increase in ATP-triggered membrane current. (elsevierpure.com)

T3 causes arterial relaxation and reduction of systemic vascular resistance, resulting in an increase in cardiac output. (elsevierpure.com)
the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage. (bvsalud.org)
o acúmulo de líquido abdominal relacionado à doença inflamatória intestinal é mais provável de ser secundária a venosa, em oposição à fuga vascular arterial. (bvsalud.org)

[ 6 ] These receptors play a role in C3a-mediated and C5a-mediated anaphylactic reactions. (medscape.com)
Finally, we establish a previously unrecognized atherogenic role of NOR1 in positively regulating monocyte recruitment to the vascular wall. (uky.edu)
TIE2 has a crucial role in vascular development, remodeling and quiescence. (oulu.fi)
Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. (lu.se)

Evidence suggests that C1q binds a receptor present on phagocytic cells, termed C1qRP. (medscape.com)
The C3a receptor binds C3a and C4a. (medscape.com)

It is possible RGC death is a consequence of vascular mural cell-induced vasoconstriction and its pathological sequelae. (jax.org)

To identify novel effectors downstream of these receptors, their intracellular domains were used as bait to screen yeast two-hybrid cDNA libraries. (figshare.com)

Both chimeric receptors were able to activate these effectors. (figshare.com)

Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)

Diseases1

Chemicals and Drugs5

Phenomena and Processes1

VEGF28

Endothelium5

Blockade5

Tyrosine kinase in2

Growth11

Transient receptor potential2

Histamine2

Angiogenic1

Angiotensin2

Antagonists1

Protein-coupled receptors1

VEGFR23

Endothelin receptor5

Phosphorylation2

Angiogenesis1

Atherosclerosis2

Expression11

Molecular6

Ligand3

Pathways1

Tissues1

Gene5

Regulation2

Mechanisms1

Complications4

Renal vascular3

Mice2

Estrogen7

Inflammation3

VEGFR4

Proteins3

Smooth Muscle4

Mechanism2

Neuronal1

Mesenteric arterial3

GPCR1

Mural cells2

Transmembrane1

Abnormal vascular1

Survival1

Diseases2

Rats1

Peptide4

CGRP1

MRNA1

Arterial3

Role4

Binds2

Vasoconstriction1

Downstream1

Activate1

Physiological1