MucousEndothelial growth factorEndotheliumCell MembraneEpiretinal membranesEpimacular membranesSystemic vascular rBasement membranesAorticCardiacImpaired vascular healthInterventional CardiologyRetinalReceptorsMacularAtherosclerosisPeripheralVesiclesVesselsTumorRegulateCognitiveSheathHereditary hemorrhagic teExtravasationGlycoproteinRare vascularSurface membraneCardiovascularComplicationsIdiopathic2020GrowthPlateletProteinsHemorrhageDisordersCollagenPhosphatidylserineCerebralProgressivelyCellsVitreousVasodilationInsulin resistanceStructuresMuscleLeakEndoglinFibrosisProteinGraftConcentrationFractionPathwaySurgeryNutrient
Mucous3
- irritates eyes, respiratory tract and mucous membranes. (ihcworld.com)
- Donovanosis is a bacterial infection of the skin and mucous membranes in the genital region. (health.mil)
- VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. (bvsalud.org)
Endothelial growth factor3
- The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)
- This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. (nih.gov)
- The most widely studied serum markers for PE, to date, are vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). (hindawi.com)
Endothelium6
- During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane. (tamu.edu)
- Vascular complications are responsible for the excess mortality associated with diabetes ( 1 ), and impaired endothelium-dependent vasodilation has been described in humans and in animal models of the disease ( 2 - 6 ). (diabetesjournals.org)
- PSMA is a cell surface glycoprotein receptor present on tumor vascular endothelium of many types of cancer [6, 7]. (aiche.org)
- The basement membranes are complex structures that support layers of endothelium and epithelium. (medscape.com)
- Angiogenesis is a process by which new vessels are formed from pre-existing ones when the physiological conditions of the vascular endothelium are altered. (bvsalud.org)
- Heartworm disease, caused by Dirofilaria immitis, causes changes in the vascular endothelium of the pulmonary arteries due to obstruction, friction, and hypoxia. (bvsalud.org)
Cell Membrane6
- Cell Membrane Structures" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- Structures which are part of the CELL MEMBRANE or have cell membrane as a major part of their structure. (harvard.edu)
- This graph shows the total number of publications written about "Cell Membrane Structures" by people in Harvard Catalyst Profiles by year, and whether "Cell Membrane Structures" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Cell Membrane Structures" by people in Profiles. (harvard.edu)
- PPC is a phospholipid, and an essential nutrient found in certain foods and in every cell membrane in your body. (betterlife.com)
- Studies suggest that healthy red blood cell membrane omega-3 fatty acid concentration is associated with emotional well-being. (vitacost.com)
Epiretinal membranes6
- all of which pertain to clinico-anatomic descriptions of pathologic findings produced by epiretinal membranes of varying severity and differing morphologic characteristics. (medscape.com)
- Epiretinal membranes can be associated with various ocular conditions, such as posterior vitreous detachments (PVD), retinal tears, retinal detachments , retinal vascular occlusive diseases, ocular inflammatory diseases, and vitreous hemorrhage . (medscape.com)
- Idiopathic and postdetachment membranes are the most common epiretinal membranes and, as such, are the focus of this article. (medscape.com)
- Epiretinal membranes are avascular, fibrocellular membranes that proliferate on the surface of the retina and can lead to varying degrees of visual impairment. (medscape.com)
- Modern vitrectomy specimens have shown that epiretinal membranes comprise glial cells, retinal pigment epithelial cells, macrophages, fibrocytes, and collagen cells. (medscape.com)
- Kofod M, Christensen UC, la Cour M. Deferral of surgery for epiretinal membranes: Is it safe? (medscape.com)
Epimacular membranes2
- However, a large proportion of cases do not occur in the context of any associated disease or known history and therefore are classified as idiopathic epimacular membranes (IEMM). (medscape.com)
- Charles S. Epimacular Membranes. (medscape.com)
Systemic vascular r2
- The pathogenesis of arterial hypertension often involves a rise in systemic vascular resistance (vasoconstriction and vascular remodeling) and impairment of salt excretion in the kidney (inappropriate salt retention despite elevated blood pressure). (nature.com)
- In patients with cardiovascular disease, diltiazem hydrochloride injection administered intravenously in single bolus doses, followed in some cases by a continuous infusion, reduced blood pressure, systemic vascular resistance, the rate-pressure product, and coronary vascular resistance and increased coronary blood flow. (nih.gov)
Basement membranes4
- Ssels are demarked by collagen IV immunolabeling of vascular basement membranes. (c-mycinhibitor.com)
- To improve the comprehensibility of electron micrographs, endothelial cells (E) have been transparently highlighted in BD-3 Protein Rat yellow, though basement membranes were transparently highlighted in red. (c-mycinhibitor.com)
- The autoantibodies bind to their reactive epitopes in the basement membranes and activate the complement cascade, resulting in tissue injury. (medscape.com)
- This binding of antibodies can be visualized as the linear deposition of immunoglobulin along the glomerular basement membrane and, less commonly, the alveolar basement membranes, by direct immunofluorescent techniques. (medscape.com)
Aortic3
- Cations stimulated aortic muscle membrane aggregation with increasing potency according to their effective charge, e.g. (mcmaster.ca)
- Convincing data have been presented to show that production of reactive oxygen species (ROS) occurs in nonphagocytic cells, including endothelial cells ( 8 ), vascular smooth muscle cells ( 9 ), and aortic adventitial fibroblasts ( 10 ), and superoxide anion has a variety of biological functions that accompany induction of gene expression ( 11 ), cellular proliferation ( 12 ), apoptosis ( 13 , 14 ), and hypertrophy ( 15 ). (diabetesjournals.org)
- A, B) Aortic computed-tomography angiogram (A) and 3-dimensional reconstruction (B) show the periprosthetic collection and vascular leak (arrows). (cdc.gov)
Cardiac4
- In the Sheikh Zayed Tower at The Johns Hopkins Hospital, specialists in every branch of cardiac care - cardiology , cardiac surgery , vascular medicine , and radiology - work collaboratively in a hospital setting designed to foster innovative treatments and accelerate the science of medicine. (hopkinsmedicine.org)
- At the Johns Hopkins Heart and Vascular Institute, cardiac specialists swiftly translate laboratory discoveries into new treatments, with the ultimate goal of saving more lives from heart disease, the leading cause of death in the United States. (hopkinsmedicine.org)
- Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
- Diltiazem inhibits the influx of calcium (Ca 2+ ) ions during membrane depolarization of cardiac and vascular smooth muscle. (nih.gov)
Impaired vascular health1
- The PCA-derived vascular biomarker cluster was positively associated with linoleic acid, n-6PUFA:n-3PUFA ratio and inversely associated with EPA.ConclusionSpecific erythrocyte membrane fatty acid compositions are associated with impaired vascular health and IR in adults with T1D. (swan.ac.uk)
Interventional Cardiology2
- The North American interventional cardiology and peripheral vascular devices market is consolidated with five key players that contributed to a collective share of 91% in 2013. (marketsandmarkets.com)
- The increasing volume of peripheral intervention and DVT/PE treatment procedures are expected to lure new entrants in the North American interventional cardiology and peripheral vascular devices market in the coming years. (marketsandmarkets.com)
Retinal7
- Earlier reports proposed that glial cells (primarily fibrous astrocytes) from the inner layers of the neurosensory retina proliferated through breaks in the internal limiting membrane (ILM) produced after a retinal tear or a posterior vitreous detachment. (medscape.com)
- Membranes associated with retinal breaks, previous retinal detachments, or cryopexy are composed mainly of dispersed RPE cells, while cells of glial origin predominate in the IEMM. (medscape.com)
- The incidence of associated PVD in cases of IEMM range from 75-93%, and PVD is present in virtually all eyes with retinal breaks or retinal detachments and subsequent epiretinal membrane formation. (medscape.com)
- PVD can lead to retinal breaks that may liberate RPE cells that initiate membrane formation. (medscape.com)
- Bovey EH, Uffer S. Tearing and folding of the retinal internal limiting membrane associated with macular epiretinal membrane. (medscape.com)
- Karacorlu M, Ozdemir H, Senturk F, Karacorlu SA, Uysal O. Correlation of retinal sensitivity with visual acuity and macular thickness in eyes with idiopathic epimacular membrane. (medscape.com)
- Liu H, Zuo S, Ding C, Dai X, Zhu X. Comparison of the Effectiveness of Pars Plana Vitrectomy with and without Internal Limiting Membrane Peeling for Idiopathic Retinal Membrane Removal: A Meta-Analysis. (medscape.com)
Receptors2
- Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
- Angiogenic factors and their receptors are important regulators of placental vascular development [ 13 ]. (hindawi.com)
Macular4
- Very dense epiretinal membrane with associated macular distortion. (medscape.com)
- To evaluate expression of proangiogenic matrix metalloproteinases (MMP) 2 and 9 at distinct intervals after verteporfin photodynamic therapy (PDT) in human choroidal neovascular membranes (CNV) secondary to age-related macular degeneration (AMD). (bmj.com)
- Surgical treatment of lamellar macular hole associated with epimacular membrane. (medscape.com)
- Macular pucker: to peel or not to peel the internal limiting membrane? (medscape.com)
Atherosclerosis2
- Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
- 2022 : 7541411 Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis. (genetex.com)
Peripheral1
Vesicles1
Vessels4
- In ischemia-affected regions, the vascular Cx43 expression seems to become condensed in vessels displaying FITC-albumin extravasation (arrow heads). (c-mycinhibitor.com)
- Corkscrew vascular loops and feeder vessels are seen. (medscape.com)
- CNV without previous therapy disclosed MMP-2, MMP-9 in RPE-Bruch's membrane, vessels and stroma in different intensities. (bmj.com)
- It is characterized by the prominence of skin blood vessels, such as vascular spiders. (bvsalud.org)
Tumor3
- The objective of this study is to design a new class of liposomes that can target tumor vasculature via Prostate-Specific Membrane Antigen (PSMA) and rapidly and extensively release therapeutic agents intracellularly by using the pH-sensitive peptide GALA conjugated to lipid moieties to destabilize the integrity of intracellular endosomes and achieve better tumor killing outcomes. (aiche.org)
- Histologically, the tumor was composed of polygonal cells exhibiting diffuse hemorrhage, multifocal necroses, and vascular invasion. (nih.gov)
- Most of the tumor cells contained melanin pigments with Fontana-Masson positivity and ultrastructurally suspicious, membrane-bound premelanosomes. (nih.gov)
Regulate3
- Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation. (tamu.edu)
- Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. (harvard.edu)
- They regulate the excitability of cells and contribute to their resting membrane potential [ 1 , 2 ]. (ersjournals.com)
Cognitive1
- Furthermore, omega-3 fatty acids are important components of neuronal cell membranes and are essential to cognitive function. (vitacost.com)
Sheath1
- Vascular sheath between the hyaloid membrane and the vitreous humour. (dictionary.com)
Hereditary hemorrhagic te3
- It is involved in angiogenesis and angiogenesis-related diseases, including the rare vascular pathology known as hereditary hemorrhagic telangiectasia type 1. (bvsalud.org)
- G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations. (cdc.gov)
- Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia. (cdc.gov)
Extravasation1
- Taking our in vitro results back into mouse models, we present evidence that pericyte relaxation contributes to the opening of the gaps between pericytes and to the enlargement of the LERs in the vascular BM, facilitating PMN extravasation. (tamu.edu)
Glycoprotein1
- Endoglin, alias CD105, is a human membrane glycoprotein highly expressed in vascular endothelial cells. (bvsalud.org)
Rare vascular1
- Those with the rare vascular type of EDS are at greater risk for rupture of a major organ or blood vessel. (medlineplus.gov)
Surface membrane2
- 1999) Identification of immunoreactive tissue prokallikrein on the surface membrane of human neutrophils. (nature.com)
- Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
Cardiovascular3
- The growth in this market can be attributed to a large number of approvals for vascular closure devices, high prevalence of cardiovascular diseases, increasing prevalence of obesity, increasing focus of market players on large-bore vascular closure devices, growing geriatric population, favorable reimbursement scenario for interventional radiology procedures, and rising focus on effective blood loss management in patients during surgeries. (marketsandmarkets.com)
- Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
- Whether you are interested in a preventive heart screening, a consultation, or treatment for an existing cardiovascular condition, rest assured that you will receive the highest quality of care from our heart and vascular physicians. (ohiohealth.com)
Complications2
- Controlling these factors reduces the risk of acute vascular complications and death from CVD [ 1 , 7 ]. (hindawi.com)
- Superoxide anion can modulate vascular smooth muscle tone and is potentially involved in diabetic vascular complications. (diabetesjournals.org)
Idiopathic4
- Idiopathic Epiretinal Membrane and Vitreomacular Traction Preferred Practice Pattern(®) Guidelines. (medscape.com)
- Long-term anatomical and functional results in patients undergoing observation for idiopathic nontractional epiretinal membrane. (medscape.com)
- Hosoda Y, Ooto S, Hangai M, Oishi A, Yoshimura N. Foveal Photoreceptor Deformation as a Significant Predictor of Postoperative Visual Outcome in Idiopathic Epiretinal Membrane Surgery. (medscape.com)
- Surgical removal of idiopathic epiretinal membrane with or without the assistance of indocyanine green: a randomised controlled clinical trial. (medscape.com)
20203
- Terumo Corporation (Japan) is a leading player in the vascular closure devices market, with a market share of 33.4% in 2020. (marketsandmarkets.com)
- Abbott (US) accounted for the high share of the vascular closure devices market in 2020. (marketsandmarkets.com)
- Cardinal Health (US) held the third position in the vascular closure devices market in 2020. (marketsandmarkets.com)
Growth3
- In contrast, the need for highly skilled professionals, risks associated with vascular closure devices and stringent regulatory framework may challenge market growth to a certain extent. (marketsandmarkets.com)
- The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
- Similarly, sEng is a truncated form of receptor for two subtypes of transforming growth factor beta (TGF β ) specifically, TGF β 1 and TGF β 2 which are highly expressed by vascular endothelial cells and syncytiotrophoblasts. (hindawi.com)
Platelet2
- We provide a comprehensive overview of the proteases acting on the platelet membrane. (frontiersin.org)
- Furthermore, a circulating form of endoglin, also named as soluble endoglin, whose levels are abnormally increased in different pathological conditions, such as preeclampsia, seems to act as an antagonist of membrane-bound endoglin and as a competitor of the fibrinogen-integrin interaction in platelet-dependent thrombus formation. (bvsalud.org)
Proteins1
- Using mouse models and intravital microscopy, we show that migrating PMNs expand and use the low expression regions (LERs) of matrix proteins in the vascular basement membrane (BM) for their transmigration. (tamu.edu)
Hemorrhage2
- Finally, vitreous hemorrhage, inflammation, or both associated with a PVD also may stimulate epiretinal membrane formation. (medscape.com)
- Goodpasture disease is a term used to describe glomerulonephritis, with or without pulmonary hemorrhage, and the presence of circulating anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
Disorders1
- Affects nervous system and may cause vascular system disorders. (ihcworld.com)
Collagen1
- The principal component of basement membrane is type IV collagen, which acts as a support structure and is composed of building blocks that are linked end-to-end. (medscape.com)
Phosphatidylserine2
- Phosphatidylserine-exposing platelets, usually located around a thrombus, provide a negatively charged membrane surface, which supports coagulation factor binding and the formation of tenase and prothrombinase complexes ( 6 , 7 ). (frontiersin.org)
- Upon activation, platelets release plasma-membrane derived microparticles (PMPs) exposing phosphatidylserine (PS) on their surface. (lu.se)
Cerebral1
- Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in cerebral vascular smooth muscle cells (VSMCs) generates an Aβ non-clearing VSMC phenotype through transactivation of sterol regulatory element binding protein-2, which downregulates low density lipoprotein receptor-related protein-1, a key Aβ clearance receptor. (nature.com)
Progressively2
- When the pH is lowered below 6.0, membrane aggregation progressively increased with a concomitant decrease in cation-induced aggregation. (mcmaster.ca)
- 4-5 Early lesions are small, painless nodules that grow into characteristic "beefy red" highly vascular ulcers and progressively expand. (health.mil)
Cells12
- An epiretinal membrane (ERM) is a collection of collagenous cells that occurs on the inner surface of the central retina. (medscape.com)
- These cells, once in contact and attached to the retina, may proliferate and form sheets of membranes over the surface of the retina. (medscape.com)
- The source of the cells producing these membranes has been the source of great debate. (medscape.com)
- These cells are found in varying proportions in accordance with the etiology of the membrane. (medscape.com)
- A sagittal section of this stage is shown in figure 2 A . The foregut is here more inclosed, and the notochord, nt , having separated from the entoderm, en , is seen as a distinct layer of cells extending from the foregut to the blastopore. (gutenberg.org)
- Further analysis by in situ hybridization revealed that CysLT(2) mRNA was expressed in myocytes, fibroblasts, and vascular smooth muscle cells, but not in endothelial cells. (nih.gov)
- The lens capsule arises at about the same period as the hyaloid membrane , and is a product of the cells of the lens. (dictionary.com)
- Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. (harvard.edu)
- During medical school, his research focused on the vascular morphology and mural cells of the murine germinal matrix. (rochester.edu)
- This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. (ersjournals.com)
- They span the membrane of cells, allowing the selective permeation of K + ions from one side of the membrane to the other, usually from the inside of the cell to the outside. (ersjournals.com)
- 30 nm in diameter, establish direct membrane-to-membrane contact with endothelial cells in specialized areas of irregular endothelial basement membrane and enriched with vesicular activity. (elifesciences.org)
Vitreous2
- [ 2 ] They hypothesize that the presence of ILM tears and folds are more likely when the epiretinal membrane forms prior to a posterior vitreous detachment, resulting in the subsequent cleavage plane being between the ILM and the inner retina rather than at the ILM surface. (medscape.com)
- the delicate, pellucid, and nearly structureless membrane enclosing the vitreous humor of the eye. (dictionary.com)
Vasodilation1
- An immediate effect of alcohol ingestion is vasodilation in some vascular beds. (medscape.com)
Insulin resistance2
- PurposeThe aim of this study was to assess the relationship between specific erythrocyte fatty acids levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).MethodsWe analysed baseline pretreatment data in a subset of 23 patients with T1D from a previously publis. (swan.ac.uk)
- PurposeThe aim of this study was to assess the relationship between specific erythrocyte fatty acids levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).MethodsWe analysed baseline pretreatment data in a subset of 23 patients with T1D from a previously published randomised controlled trial consisting of comprehensive erythrocyte-derived fatty acid profiles and a panel of inflammation-associated endothelial markers. (swan.ac.uk)
Structures2
- The thyrohyoid membrane refers to the two structures it connects: the thyroid cartilage and the hyoid bone. (wikipedia.org)
- It may also be known as the hyothyroid membrane, where the two structures are reversed. (wikipedia.org)
Muscle1
- Our results indicate that cation-induced membrane aggregation can also be used to isolate a plasma membrane-enriched fraction from vascular smooth muscle. (mcmaster.ca)
Leak1
- In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
Endoglin1
- These studies suggest that membrane-bound endoglin and circulating endoglin are important components involved in vascular homeostasis and hemostasis. (bvsalud.org)
Fibrosis1
- This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
Protein2
- After college, he conducted research on the human nuclear membrane protein Emerin. (rochester.edu)
- This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. (genetex.com)
Concentration1
- The patterns of aggregation of microsomal membranes and further purified plasma membranes were almost identical whereas the aggregation of the heterogeneous mitochondrial membrane-enriched fraction was distinctly different in the initial rate of aggregation, its pH dependence, and metal ion concentration dependence. (mcmaster.ca)
Fraction1
- In line with these results, studies using various enzyme inhibitors, such as DPI, allopurinol, rotenone, N G -monomethyl- l -arginine, and indomethacin, suggest that the predominant source of superoxide anion in vascular particulate fraction is NADH-dependent membrane-bound oxidase. (diabetesjournals.org)
Pathway1
- Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway. (harvard.edu)
Surgery1
- Rahman R, Stephenson J. Early surgery for epiretinal membrane preserves more vision for patients. (medscape.com)
Nutrient1
- By supporting vascular health, fish oils promote oxygen and nutrient delivery to the brain. (vitacost.com)