Vascular inflammation vascular system models cardiovascular. Medical search. Frequent questions

Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. (frontiersin.org)
We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. (frontiersin.org)
The abnormal morphology and dysfunction of mitochondria have been proven as the principal mechanisms in the pathogenesis of cardiovascular diseases, such as heart failure, myocardial infarction, atherosclerosis, and hypertension ( 4 - 6 ). (frontiersin.org)
So mitochondria-targeted therapy is suggested to be a potential treatment strategy for cardiovascular diseases. (frontiersin.org)
However, clinical trials of these agents for cardiovascular diseases were hardly approved to carry out, even less to evaluate their clinical effectiveness and safety. (frontiersin.org)
Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
What excites you about this field, in particular, and do you see this as the future for treatment of cardiovascular diseases? (escardio.org)
The exposure to low doses of these materials may modify the progression of existing pathophysiological conditions including cardio-vascular diseases (CVD). (cdc.gov)
Prolonged inactivity is particularly harmful for people with cardiovascular diseases and other chronic health problems, such as diabetes, hypertension, obesity or cancer. (fapesp.br)
The funds from this ARC will be used to 1) initiate collaborative studies in mouse models on mechanisms of obesity-linked cardiovascular diseases and 2) support research where basic science and clinical research labs perform molecular analyses on tissues and cell samples isolated from patient populations. (bu.edu)
Premature cardiovascular disease (CVD) is a serious long-term complication of chronic systemic inflammatory diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). (bmj.com)
Despite advances in disease-modifying and biological therapy for these diseases, we lack specific strategies aimed at retarding development of premature CVD and have limited knowledge of whether individual drugs offer vascular protection. (bmj.com)
Vascular endothelium actively participates in inflammatory reactions in the majority of chronic respiratory diseases. (intechopen.com)
Nowadays, the connection between chronic obstructive pulmonary disease (COPD) and some cardiovascular and cerebrovascular diseases has been well established. (intechopen.com)
Some of these drugs have reduced inflammation, delayed the onset of age-related diseases and extended the life span of rodents. (worldhealth.net)
Interplay of infection, immunity, and inflammation in the initiation and progression of atherosclerotic cardiovascular diseases (ASCVD) in people with HIV (PWH). (nih.gov)
We aim to understand how early changes in the endothelium and vascular wall are related to the initiation and development of vascular diseases, with a particular focus on nitric oxide signalling. (ox.ac.uk)
Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). (biomedcentral.com)
PGRN has been introduced among the secreted growth factors as one related to wound healing, inflammation, and human embryonic development, as well as a wide variety of autoimmune diseases. (biomedcentral.com)
Many types of cardiovascular diseases (CVDs) are associated with complex immune responses that can significantly contribute to their progression and remission. (biomedcentral.com)
RationaleDuring the last decennium t a more focused attention has been directed to the presence of chronic inflammation in cardiovascular diseases (CVD), but mainly to the high impact that this one has in generating and. (medandlife.org)
Provided herein are methods for the prevention and treatment of cardiovascular diseases and disorders in a subject diagnosed as having suffered a cerebrovascular injury by administering agents that contain or induce the expression of microRNA-126. (justia.com)
Post-stroke neurological deficits increase the risk of cardiovascular diseases roughly by three times, and the ischemic brain transmits indirect cell death signals to the heart. (justia.com)
We work at biochemical and physiological levels, employing clinical knowledge, genetically engineered animal models, surgically, dietarily or chemically-induced disease models, and multi-omics approaches to identify new therapeutic targets for human diseases including diabetes, fatty liver diseases, liver cancer, and cardiovascular diseases. (zhao-sun-lab.org)
Chronic low-grade inflammation is an important pathogenic factor in the development of type 2 diabetes and cardiovascular diseases ( 1 ). (diabetesjournals.org)
Multimorbidity, defined as the co-existence of two or more chronic diseases within an individual [ 1 ], is one of the major problems for the health care systems of industrial nations. (biomedcentral.com)
Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery disease (CAD), valvular heart disease, diabetes mellitus, and hypertension. (medscape.com)

Our research efforts are currently directed to evaluate the cardiovascular effects, including vascular inflammation, blood cell coagulation status, atherosclerosis, as well as the related molecular mechanisms associated with respiratory exposure to different types of nanosized materials using animal models. (cdc.gov)
Since these types of oxidative modifications are considered to play a role in atherogenesis, we further evaluated the effects of SWCNT respiratory exposure on atherosclerosis progression in ApoE-/- transgenic mice, a widely used model of human atherosclerosis. (cdc.gov)
In their own study, the team examined tissue samples from human patients with atherosclerosis and found that their vascular endothelial cells bore far more GPNMB than the cells of those without the disease. (worldhealth.net)
To test this idea, the team used a mouse model of atherosclerosis and then eliminated GPNMB-positive cells from the rodents, using genetic modification. (worldhealth.net)
Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group. (ox.ac.uk)
MiR-126 facilitates vascular re-modeling, decreases fibrosis in multiple organs, and has been reported to be beneficial in the treatment of atherosclerosis and re-stenosis. (justia.com)
In the vasculature, activation of STAT1 and STAT3 promotes inflammatory response ( 5 ), increases neointimal formation ( 6 ), and accelerates the development of atherosclerosis ( 7 ), a chronic disease characterized by inflammation in the artery wall ( 8 ). (diabetesjournals.org)
Atherosclerosis, the underlying cause of cardiovascular disease, is conceptualised as a lipid-driven inflammation. (ox.ac.uk)
Engelen SE, Robinson AJB, Zurke YX, Monaco C. Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed? (ox.ac.uk)

Recently, we demonstrate that lung instillation of single wall carbon nanotube s (SWCNTs) is associated with a dose-dependent increase in oxidative vascular damage manifested by heme oxygenase-(HO-I) gene activation and mitochondrial alterations. (cdc.gov)
Here, we review these societal and structural factors and then link them with biological processes such as telomere shortening, allostatic load, oxidative stress, and tissue inflammation. (frontiersin.org)
Repetitive apneic episodes disrupt the normal physiologic function and trigger sympathetic activation, vascular endothelial dysfunction, increased oxidative stress, inflammation, increased platelet aggregability, and metabolic dysregulation. (hindawi.com)
Chronic exposure to tobacco smoke and the products of combustion of tobacco leads to chronic system inflammatory reaction, oxidative stress, endothelial dysfunction and morpho-functional damage of target organs. (intechopen.com)
Infiltration and retention of LDL in the artery wall, especially in regions of disturbed flows in vascular niches such as branches and curves, followed by their oxidation (OxLDL) under conditions of oxidative stress, is held to be a key-initiating event that causes early atherogenesis. (zhao-sun-lab.org)
The fundamental regulation of LPPs in cellular and subcellular functions including lipid metabolism, mitochondria function, oxidative stress, inflammation, and fibrosis has become an area with tremendous opportunity for advancement in metabolic and cancer research. (zhao-sun-lab.org)

Statins are known to improve pulmonary arterial hypertension (PAH) by their anti-inflammatory and anti-proliferative effects in animal models. (escardio.org)
OSA is a risk factor for cardiovascular disorders including hypertension, congestive heart failure (CHF), myocardial ischemia, arrhythmias and infarction, and cerebrovascular conditions including stroke [ 3 ]. (hindawi.com)
BACKGROUND: Pulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH), is a type of pulmonary vascular disease characterized by abnormal contraction and remodeling of the pulmonary arterioles, manifested by pulmonary vascular resistance (PVR) and increased pulmonary arterial pressure, eventually leading to right heart failure or even death. (bvsalud.org)
Most importantly, there is astrong evidence from clinical studies and experimental animal models that uric acid is associated with hypertension and other CVDs. (gout-aware.com)
Obesity and its comorbidities, including hypertension, hyperlipidemia and type 2 diabetes mellitus, have a devastating impact on vascular function leading to conditions that promote cardiovascular disease. (bu.edu)
In human subjects, studies have shown that endothelial dysfunction, recognized as impairments in flow-mediated dilation or endothelial-dependent vasodilation in response to acetylcholine, is predictive of cardiovascular events in patients with hypertension, coronary artery disease, peripheral artery disease, etc. (bu.edu)
The mechanistic relationship between renal functional decline and increasing rates of cardiovascular disease and mortality is complex and not fully explained by the frequent co-existence of conventional CVD risk factors such as diabetes, hypertension or dyslipidemia [ 8 ]. (biomedcentral.com)
We investigated the effects of olmesartan on the changes in serum ACE2 and Ang-(1-7) levels as well as kidney and vascular function in patients with type 2 diabetes and hypertension. (biomedcentral.com)

Lastly, we focus on the impact of inflammation on the immune system and the molecular mechanisms by which the inflamed immune microenvironment promotes the formation of atherosclerotic plaques. (frontiersin.org)
We propose that racial residential segregation and discrimination increases tissue inflammation and cytokine production, resulting in dysregulated immune signaling, which promotes plaque formation and cardiovascular disease. (frontiersin.org)
Unlike Celiac which is an autoimmune condition triggered by the protein gluten (gliadan to be specific) non celiac gluten sensitivity (NCGS) has been hypothesized to be an innate immune response which causes GI distress and inflammation. (robbwolf.com)
Led by Brian O'Rourke, Ph.D. , Robert L. Levy Professor in Cardiology and a professor of medicine, this team will study how the immune system and mitochondria (part of a cell that converts energy) cause variable heartbeats in people with COVID-19 that continue for a long time after the initial viral infection. (heart.org)
Endocrine functions of white adipocytes, and other WAT-resident cells in the stromal vascular fraction, are performed by the release of a variety of adipokines (adipose-associated cytokines) which affect the functioning of the brain, liver, pancreas and immune system 9 . (nature.com)
These cells accumulate as we age, as the immune system becomes less efficient at clearing such cells from the body. (worldhealth.net)
To develop their senolytic vaccine, the researchers selected a specific target, or "antigen," on senescent cells - a sort of bullseye for the immune system to aim at. (worldhealth.net)
Contributions of the microbiome/virome towards inflammation/chronic immune activation and dysfunction. (nih.gov)
This study provides new insight into the role of the innate immune system in uremic cardiomyopathy. (biomedcentral.com)
Notably, the innate and adaptive immune responses under physiological conditions are typically regulated with high sensitivity to avoid the exacerbation of inflammation, but any dysregulation can probably be associated with CVDs. (biomedcentral.com)
Therefore, immune cells are typically expected to play a vital role in regulating the immune system responses in the heart. (biomedcentral.com)
These processes cause immune system cells to release inflammatory mediators called cytokines, which in their own turn produce changes in the walls of blood vessels, eventually resulting in accumulation of diseased tissue known as plaques. (lifeextension.com)
The overall theme of our research is the regulation of energy homeostasis, lipid metabolism, lipid peroxidation, inflammation and cell death in mammalian systems, with special emphasis on adipose tissue, liver, immune system, and blood vessels. (zhao-sun-lab.org)
The immune system is integral to the cardiovascular health and disease. (ox.ac.uk)
The results will contribute to our understanding of the role of vascular immune cells in cardiovascular health and disease and it will explore the fundamental molecular mechanisms regulating vascular tissue immune cell responses. (ox.ac.uk)
However, some of the fluid, along with certain cells and cellular debris (eg, from the immune response to local infection, cancer, inflammation) enters the lymphatic system. (msdmanuals.com)
Lymph nodes also are key participants in the immune system because they are packed with lymphocytes, macrophages, and dendritic cells that are poised to respond to any antigens transported from tissues in the lymph. (msdmanuals.com)
The goal of this study was to investigate the impact of multiple exposomal factors (genetics, lifestyle factors, environmental/occupational exposures) on pulmonary inflammation and corresponding alterations in local/systemic immune parameters. (cdc.gov)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
Black seed might have effects in the body that help boost the immune system, fight cancer, prevent pregnancy, reduce swelling, and lessen allergic reactions by acting as an antihistamine. (medlineplus.gov)

They can regulate many biological processes that are critical in disease , including coagulation, proliferation and survival, inflammation, neurotransmission and pain. (anaspec.com)

The mechanisms involved in this process include inflammation, vascular matrix remodeling, endothelial cell apoptosis and proliferation, vasoconstriction, vascular smooth muscle cell proliferation and hypertrophy. (bvsalud.org)
We propose projects to define the molecular mechanisms by which metabolic disease impacts vascular function and vice versa . (bu.edu)
Led by Joseph Loscalzo, M.D., Ph.D. , chair of the department of medicine, this team will bring together experts from different fields with access to and expertise in a variety of new technologies, including computational biology, network science and systems biology, to study the specific mechanisms that cause cardiovascular complications in people with COVID-19. (heart.org)
Studying the mechanisms of endothelial dysfunction in brain blood vessels of patients with smoking habits and COPD can be very important for preventing acute vascular events. (intechopen.com)
Despite its significance, many WAT-related pathophysiogical mechanisms in humans are still not understood, largely due to the reliance on non-human animal models. (nature.com)
The novel system provides a promising tool for wide-ranging applications in mechanistic research of WAT-related biology, in studying of pathophysiological mechanisms in obesity and diabetes, and in R&D of pharmaceutical industry. (nature.com)
She is particularly known for her work on mechanisms of vascular endothelial eicosanoid generation and recent studies have identified biological roles for novel fatty acid metabolites in vascular repair and angiogenesis. (rvc.ac.uk)
focus is primarily on vascular cell function with emphasis on understanding molecular control mechanisms. (rvc.ac.uk)
Mechanisms of HIV infection related atherosclerotic cardiovascular disease. (nih.gov)
The cannabinoid system consists of a complex array of receptors, substances with agonist/antagonist properties for those receptors, biosynthetic machineries and mechanisms for cellular uptake and degradation for. (medandlife.org)
Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. (diabetesjournals.org)
This study was designed to characterize the molecular mechanisms by which AMPK suppresses vascular inflammation. (diabetesjournals.org)
The exact mechanisms by which cardiovascular risk factors predispose to AF are not understood fully but are under intense investigation. (medscape.com)

Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)

Racist and discriminatory federal, state, and local housing policies significantly contribute to disparities in cardiovascular disease incidence and mortality for individuals that self-identify as Black or African American. (frontiersin.org)
Hyperuricemia per se was a significant risk factor for determining the development or severity of CAD in some studies [4-8], but uric acid was not an independent factor for CAD and related cardiovascular mortality. (gout-aware.com)
Interestingly, not only high levels of uric acid, but an increase in uric acid level 6 months after a coronary event was also associdred with high cardiovascular and all-cause mortality. (gout-aware.com)
Low-dose weekly methotrexate (MTX), the most widely used disease-modifying drug for rheumatoid arthritis (RA), reduces disease-associated cardiovascular mortality. (bmj.com)
Inflammation, Epigenetics, Aging, Epidemiology The population is aging worldwide not only due to gains in early-life survival but also due to progress with declining late-life mortality (1). (deepdyve.com)
Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)
Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)

With the PHENOMIN project launched in 2011 (part of the call for projects entitled National Infrastructures in Biology and Health), the objective of the iCS was to create a national infrastructure specialized in the development, analysis and conservation of mouse models. (igbmc.fr)
Caroline is a Professor of Vascular Cell Biology and is Head of Comparative Biomedical Sciences. (rvc.ac.uk)
Caroline was appointed to a Lectureship position at the Royal Veterinary College in late 1997 and now holds a personal Chair in Vascular Cell Biology. (rvc.ac.uk)
Caroline is an internationally recognised expert in vascular cell signalling and biology with 20 years' experience in the field. (rvc.ac.uk)
The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)
Overall, this project aims to investigate the biology and regulation of vascular lymphocytes and how they function in health and disease. (ox.ac.uk)
Finally, we will invite speakers to talk about aspects of personalized or stratified medicine based on systems biology approaches for better care and future drug development. (lu.se)

We hypothesised that MTX specifically protects the vascular endothelium against inflammatory injury via induction of AMPK-regulated protective genes. (bmj.com)
Conclusions These data suggest that MTX therapeutically conditions vascular endothelium via activation of AMPK-CREB. (bmj.com)
We have developed transgenic models to increase tetrahydrobiopterin levels in the endothelium and other cell types, by overexpression of GTP cyclohydrolase 1 (GTPCH), the rate-limiting enzyme in its synthesis. (ox.ac.uk)

This ARC will coordinate activities of basic science labs and clinical research labs to assess the interrelationship between metabolic dysfunction and vascular disease. (bu.edu)
The ARC takes a well integrated approach to understand the functional interrelationships between metabolic disease and vascular dysfunction. (bu.edu)
A number of novel hypotheses will be evaluated by the ARC: 1) The metabolic-regulatory and vascular-protective actions of polyphenols (i.e. resveratrol) are mediated, in part, by their ability to upregulate adiponectin expression in a SIRT1-dependent manner. (bu.edu)
3) Vascular dysfunction within adipose tissue leads to inflammation and metabolic dysfunction. (bu.edu)
The metabolic abnormalities of type 2 diabetes, including hyperglycemia, dyslipidemia, and insulin resistance, activate the Janus kinases/signal transducer and activator of transcription (JAK/STAT) signaling pathway, a major intracellular inflammatory cascade that transmits the intracellular signaling to the nucleus ( 2 ), promoting inflammatory response, inducing insulin resistance ( 3 ), and accelerating the development of cardiovascular complications ( 4 ). (diabetesjournals.org)
supports the concept that metabolic reprogramming, inflammation, and genome instability (including epige- netic changes) underlie many of the other hal marks and foster multiple hallmark functions. (who.int)

Together with the local atherogenic disturbed flow, LPPs induce vascular dysfunction and inflammation to promote atherogenesis. (zhao-sun-lab.org)

Considering the limitation of studies investigating the relationship between T. gondii and cardiovascular biomarkers, this study was focused on assessing the association of T. gondii to nine cardiovascular biomarkers. (mdpi.com)
Given the complexity of the aging process, different measures of biologic aging (BA) and of successful aging have been constructed to better reflect an individual's rate of aging by combining clinical biomarkers representative of different physiologic systems (4-7). (deepdyve.com)

Obesity promotes a chronic inflammatory state, which contributes to the development of insulin resistance and cardiovascular disease. (bu.edu)
The projects involve genetic, physiological and clinical studies that focus on the central theme of defining how obesity and insulin resistance lead to biochemical changes in endothelial cell that impair function and promote inflammation. (bu.edu)
lipid- and inflammation-mediated insulin resistance in skeletal muscle and vasculature. (rvc.ac.uk)

Primary emphasis has been on imaging markers of inflammation or angiogenesis. (mirm-pitt.net)
MiRNAs regulate both transcriptional and post-transcriptional gene expression as well as regulate several circuits involved in tissue repair, inflammation, hypoxia-response, and angiogenesis. (justia.com)
MicroRNA-126 (miR-126) is endothelial cell (EC) specific and plays a key role in regulating EC function, controlling angiogenesis, and maintaining vascular integrity. (justia.com)
Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. (mdpi.com)

These abnormalities accelerate the processes that lead to vascular disease, including inflammation, thrombosis and atherosclerotic plaque formation. (ox.ac.uk)
In previous work, we have used both clinical studies and experimental models to explore the role of endothelial nitric oxide synthase and its regulation by tetrahydrobiopterin in vascular disease, in particular the inflammation associated with atherosclerotic plaque formation. (ox.ac.uk)
The development of a method to reliably identify high-risk atherosclerotic plaques is seen as one of the major quests of contemporary cardiovascular medicine. (nature.com)
In contrast, our study demonstrates that autofluorescence in the NIR range uniquely characterizes atherosclerotic plaques with intraplaque hemorrhage and may allow classification of atherosclerotic plaques into lesions of low or high risk for future cardiovascular events. (nature.com)
This mouse model was instrumental for the description of NIRAF as a potential indicator of an atherosclerotic plaque's risk in causing future cardiovascular events. (nature.com)
Besides establishing fluorescence emission tomography (FLECT) as a preclinical tool for the detection of plaques with intraplaque hemorrhage and its potential use in testing and monitoring of plaque-stabilizing drugs, our report has the potential to support technical developments for imaging technologies that will ultimately allow to risk stratify atherosclerotic plaques in patients and, in particular, to identify plaques that are prone to cause cardiovascular events. (nature.com)

While endothelial PARs help in the regulation of vascular tone and permeability, those in smooth muscles mediate contraction, proliferation and hypertrophy. (anaspec.com)

The major causes of death in stroke-related moralities are a consequence of neurological damage and/or cardiovascular complications. (justia.com)
Besides liver-related complications, patients with NAFLD have higher-than-usual risk for cardiovascular disease (CVD). (zhao-sun-lab.org)
Describe cardiovascular symptoms and complications associated with post-COVID conditions. (cdc.gov)
Today I'll present an overview of post-COVID conditions as an introduction of the main presentation on evaluating and supporting patients with cardiovascular symptoms and complications following COVID-19. (cdc.gov)

This ARC is intended to promote translational research by bringing basic and clinical research laboratories together to study the cardiovascular consequences of obesity and diabetes. (bu.edu)
Role of inflammation in both normal wound healing and impaired wound healing associated with diabetes. (uic.edu)
2) Simulation systems for glucose, insulin and physiological variable dynamics in Type 1 and Type 2 diabetes and assessment of medication and lifestyle changes in regulating blood glucose levels. (uic.edu)
Dr. Alonso's primary academic interest is redesigning the system in which care is provided to children and adolescents with type 1 diabetes. (cuanschutz.edu)
Dr. Albers develops mathematical models of physiology, machine learning models, and their associated inference methods to support the extraction and creation of new knowledge from data related to diabetes, to support clinician-centric decision support, and to support patient-centric decision support for chronic disease self-management. (cuanschutz.edu)
He also works with model-based control, e.g., like the artificial pancreas project, but in the context of type-2 diabetes, cystic fibrosis related diabetes, and within the intensive care unit unrelated to diabetes. (cuanschutz.edu)
The multi-site randomized controlled pragmatic trial includes 320 sedentary subjects with at least two of the following NCDs, either manifested or in a pre-stage with evident risk factors: Cardio-vascular disease, Diabetes mellitus type 2, knee/ hip osteoarthritis and obesity. (biomedcentral.com)

Regulation of hepatic lipid and glucose metabolism in mouse models. (uic.edu)
Additionally, CGRP might be important in processes such as control of fetoplacental vascular tone, regulation of calcium metabolism and insulin secretion, acetylcholine receptor synthesis, peripheral nerve regeneration, and neurogenic inflammation. (bachem.com)
To date, there have been few effective modalities in the treatment of cardiovascular disease and/or disorder subsequent to stroke, including in subjects with a glucose metabolism disorder. (justia.com)
We are interested in understanding the regulation of cholesterol metabolism, inflammation and vascular functions under physiological and pathological conditions. (zhao-sun-lab.org)

Uric acid has potential to cause cardiovascular disease. (gout-aware.com)

Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is Th at Link? (krasgmu.ru)

Endothelial function is not uniform throughout the arterial system. (hindawi.com)
Arterial inflammation can be extinguished. (robbwolf.com)

As components of neurogenic inflammation in the processes of tissue remodeling in emphysema, we describe the distribution and activity of the substance P, neurokinin-1 and its receptor, tissue metalloproteinases and their tissue inhibitors in the lungs during the entire experimental period, the modeling of COPD in rats with a smoking model. (intechopen.com)

The laboratory's mission is to apply engineering principles to develop technologies that will improve the diagnosis and treatment of cardiovascular disease. (mirm-pitt.net)
The present disclosure provides experimental support regarding the treatment of cardiovascular disease or disorder subsequent to stroke, using a novel composition. (justia.com)

Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. (eurekamag.com)

There is a progressive decrease in sympathetic activity, blood pressure (BP), stroke volume, heart rate, cardiac output, and systemic vascular resistance, during deeper NREM sleep stages [ 4 ]. (hindawi.com)
For cardiac failure, congenital heart disease, valvular and vascular disease, efforts have been focused on developing novel biodegradable materials that are mechanically appropriate for replacing or augmenting the soft and elastic tissue of the cardiovascular system. (mirm-pitt.net)
With inflammation imaging we have shown the ability for these targeted microbubbles to detect cardiac transplant rejection as well as "ischemic memory", where a temporarily blocked coronary artery does not cause cardiac damage, but does leave behind a temporary state of inflammation. (mirm-pitt.net)
We assessed cardiac response in two experimental models of CKD and tested macrophage and chemokine implication in monocytopenic CCR2 −/− and anti-CXCL10 treated mice. (biomedcentral.com)
The latest findings indicate that full spectrum grape extract can help support cardiac health by maintaining youthful endothelial function, regulating platelet aggregation, and reducing inflammation. (lifeextension.com)

We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
1-4 The ability of red grape constituents to fight inflammation is opening new doors in treatment of chronic age-related disorders, including both the prevention and treatment of cancer. (lifeextension.com)
Transcriptome-wide association studies further reveal 12 genes to prioritize for functional follow-up, including targets of drugs investigated for vascular and cognitive disorders. (rhu-shiva.com)

The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells. (eurekamag.com)

In just the past decade, striking new findings have been made on how components of red grapes (including both skin and seeds) affect vascular health, ranging from increasing vital nitric oxide (critical in maintaining endothelial function) to protecting against heart muscle damage. (lifeextension.com)

The primary research interests of the Wagner Laboratory in the McGowan Institute for Regenerative Medicine are in the area of cardiovascular engineering with projects that address medical device biocompatibility and design, tissue engineering, and targeted imaging. (mirm-pitt.net)
The materials and processes developed in this effort, while designed for cardiovascular application, are amenable to numerous regenerative medicine areas directly or with modifications in molecular design or processing. (mirm-pitt.net)

these systems integrate engineered human tissues into physiological microenvironment supplied by a vasculature-like microfluidic perfusion. (nature.com)

the Northwestern Mutual Professor of Cardiovascular Medicine, this team will look into why blood vessels continue to be unhealthy in people who have COVID-19 and they will explore whether the use of a dietary supplement called Lp299v can restore normal blood vessel function to improve the health of people after COVID-19 infection. (heart.org)
The process, known as lipid peroxidation, is a powerful stimulant of inflammation in blood vessels, eventually leading to plaque formation. (lifeextension.com)
Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. (mdpi.com)

Since our nanoparticle is relatively nonspecific for the target organ, it is known to be extremely safe, and thus can be the first clinical oriented drug delivery system in the field of cardiology. (escardio.org)
This work has spanned from in vitro models to clinical studies. (mirm-pitt.net)
Pre-clinical and animal models for HIV-associated HLBS comorbidities. (nih.gov)
Determine which clinical assessments and tests are needed for a patient with cardiovascular symptoms. (cdc.gov)

Endothelial cell function has long been viewed as a barometer of overall cardiovascular health. (bu.edu)

a professor of microbiology and immunology, this team will study the role of the viral mRNA and protein found in pulmonary vascular endothelial cells during a COVID-19 infection. (heart.org)

In all types of CVDs, inflammation has been further documented as one of the critical events in the initiation and spread of the pathological processes. (biomedcentral.com)
Cardiovascular disease involves a cascade of aberrant biological processes, but one area of interest even amongst the medical establishment is LDL oxidation. (lifeextension.com)
We found significant enrichment of PVS loci in genes involved in early-onset leukodystrophies and expressed in fetal brain vascular endothelial cells, supporting involvement of developmental processes. (rhu-shiva.com)

The normal physiologic interactions are disrupted by OSA, and the cardiovascular and cerebrovascular systems are therefore impacted [ 4 , 5 ]. (hindawi.com)
The present disclosure provides a method for the treatment or prevention of a cardiovascular disorder or disease in a subject who has suffered cerebrovascular injury, the method comprising administering a therapeutically effective amount of a miR-126 containing agent or an agent that induces expression of miR-126 to the subject in need thereof. (justia.com)

The Japanese Coronary Artery Disease Study group demonstrated that elevated serum uric acid was an independent predictor for cardiovascular events in patients with severe coronary artery stenosis in their 3 year follow-up [4]. (gout-aware.com)
Another study in 2,796 patients with non-diabetic CAD also showed an association between serum uric acid and increased cardiovascular events, independent of renal function [9]. (gout-aware.com)

But because cells throughout the body can become senescent, different senescent cells look different than one another, senior author Dr. Tohru Minamino, a professor at Juntendo University Graduate School of Medicine and the director of cardiovascular medicine at Juntendo University Hospital in Tokyo, told Live Science in an email. (worldhealth.net)
King's College London) fuelled her interest in vascular cellular signalling and her subsequent post-doctoral position with Professor Jeremy Pearson at King's College London (KCL) allowed her to pursue this interest in human endothelial cells. (rvc.ac.uk)

An ever growing body of evidence shows that components of red grapes can have powerful effects on vascular health, reducing platelet aggregation and lipid peroxidation while improving endothelial function. (lifeextension.com)

We also analyzed the content of neurokinin system markers, the localization, and markers of tissue metalloproteinases in human lung tissue structures. (intechopen.com)
The components of red grapes prevent the consequences of oxidant damage in a large number of human tissue models far better than vitamins C, E, and beta-carotene. (lifeextension.com)
The student will benefit from the availability of in-house state-of-the-art single cell technologies including transcriptomics and proteomics approaches using dissociative methods but also spatial methodologies including spatial transcriptomics and CyTOF Hyperion for tissue imaging in human and mouse models of atherogenesis. (ox.ac.uk)
Most of the fluid and its constituents is taken up by tissue cells or reabsorbed into the vascular tree, depending on the balance of hydrostatic and oncotic pressures. (msdmanuals.com)

Even mild chronic kidney disease (CKD) with isolated albuminuria has been associated with a 2- to 4-fold increased risk of cardiovascular events [ 1 ]. (biomedcentral.com)

LDL transports lipids (fats) from the digestive system to tissues. (lifeextension.com)

Targeting inflammation ameliorates cardiovascular outcomes. (ox.ac.uk)

In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. (frontiersin.org)

Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways. (eurekamag.com)
CGRP expression is widely distributed in the central and peripheral nervous system. (bachem.com)

Studies have confirmed that prostaglandins and their receptors play important roles in the occurrence and development of PAH through vasoconstriction, vascular smooth muscle cell proliferation and migration, inflammation, and extracellular matrix remodeling. (bvsalud.org)
These G-protein coupled receptors (GPCR) are seen as contributors to different pathways including those of the circulatory and cardiovascular system, nervous system, gastrointestinal system, airways and also the skin. (anaspec.com)

Nanoparticle exposure and systemic/cardiovascular effects - experimental data. (cdc.gov)
In this respect, epidemiological and experimental studies have suggested an association between respiratory exposure to ambient ultrafine particles and the progression of cardiovascular disease. (cdc.gov)
Importantly, the ARC is translational, and it strives to meaningfully involve mechanistic studies in experimental systems with measures of vascular cell function in patients. (bu.edu)

We are currently taking in vitro and in vivo approaches, including our unique transgenic mouse models that express natural antibodies (Abs) specifically target LPPs to explore modes of LPPs regulation during atherogenesis. (zhao-sun-lab.org)
To carry out these legislative mandates, ATSDR's Division of Toxicology (DT) has developed and coordinated a mixtures program that includes trend analysis to identify the mixtures most often found in environmental media, in vivo and in vitro toxicological testing of mixtures, quantitative modeling of joint action, and methodological development for assessment of joint toxicity. (cdc.gov)

This amount of inactivity was sufficient to cause vascular alterations, an increase in inflammation markers, and a rise in postprandial blood sugar. (fapesp.br)

Many studies have further demonstrated that SARS-CoV-2 (COVID-19) has dramatically increased the risks of CVDs due to inflammation, so PGRN has drawn much more attention among scholars. (biomedcentral.com)
Lysosomes play a pivotal role in the inflammation process, and PGRN is one of the key regulators in their functioning, which contributes to the immunomodulatory mechanism in the pathogenesis of CVDs. (biomedcentral.com)

Atherogenesis results from hypercholesterolemia, systemic chronic inflammation, and aortic cell dysfunctions. (zhao-sun-lab.org)

Independent risk factors for development of proven drug therapy, preferably a combination of doxycycline chronic Q fever were valvular surgery, vascular prosthesis, and hydroxychloroquine for 18-24 months. (cdc.gov)

Aims Premature cardiovascular events complicate chronic inflammatory conditions. (bmj.com)
Methods/results In the (NZW×BXSB)F 1 murine model of inflammatory vasculopathy, MTX 1 mg/kg/week significantly reduced intramyocardial vasculopathy and attenuated end-organ damage. (bmj.com)
Additionally, the laboratory has been involved with a variety of projects involving blood-contacting devices, for instance, to develop a membrane system to scavenge deleterious host antibodies and to evaluate a bead-packed column to preferentially adsorb pro-inflammatory cytokines from patients at risk for septic shock. (mirm-pitt.net)

by organisms spread through the lymphatic system from the primary site of infection. (msdmanuals.com)
In the Netherlands, development of chronic Q fever after Coxiella burnetii however, an equal distribution of endocarditis and vascular infection, we performed a case-control study. (cdc.gov)
Indication of vascular infection on PET/CT, relied on results of serologic testing and PCR. (cdc.gov)

Nowhere are the "blessings of the grape" so evident as in prevention of cardiovascular disease. (lifeextension.com)
Routine cross-notification between the veterinary and human health surveillance systems should be part of any zoonotic disease prevention and control programme, and close collaboration between the two health sectors is particularly important during epidemiological and outbreak investigations. (who.int)

Anatomy50

Organisms11

Diseases45

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes45

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science5

Health Care6

Diseases27

Atherosclerosis9

Oxidative6

Hypertension8

Immune20

Coagulation1

Mechanisms13

Role in regulating car1

Mortality7

Biology7

Endothelium3

Metabolic6

Dysfunction1

Biomarkers2

Insulin resistance3

Angiogenesis4

Atherosclerotic6

Regulation of vascular tone1

Complications4

Diabetes7

Metabolism4

Cause cardiovascular1

Myocardial infarction1

Arterial2

Neurogenic inflammation1

Treatment of cardiovascular disease2

Increased cardiovascular disease risk1

Cardiac5

Disorders3

Systemic inflammation1

Nitric oxide1

Regenerative Medicine2

Physiological1

Blood vessels3

Clinical4

Endothelial cell1

Pulmonary vascular1

Processes3

Cerebrovascular2

Uric acid2

Professor2

Lipid peroxidation1

Tissue4

Risk of cardiovascular1

Lipids1

Outcomes1

Mitochondria1

Peripheral2

Receptors2

Experimental3

Vivo2

Alterations1

CVDs2

Aortic1

Valvular1

Inflammatory3

Infection3

Prevention2