Vascular endothelial vascular development embryonic cell differentiation. Medical search. Frequent questions

The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
Embryonic blood cell development occurs via well-defined developmental stages which are recapitulated in vitro by differentiation of embryonic stem cells. (nih.gov)
Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. (wjgnet.com)
In addition to the new in vitro systems, in recent years there were also significant advances in the development of new animal models that allows studying the entire cell cycle of human malaria. (wjgnet.com)
Thanks to recent progresses, stem cells have been extensively employed to study Plasmodium liver and blood cycle in vitro . (wjgnet.com)
In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)
In order to more effectively study epicardial EMT in vitro, we developed several new methods for the in vitro study of coronary vessel development. (arizona.edu)
From 3D cell culture, 2D cell coating to animal injection, VitroGel makes it possible to bridge the in vitro and in viv o studies with the same platform system. (thewellbio.com)
Un rôle majeur des prostaglandines dans l'hématopoïèse, ainsi mis en évidence, a pu être étendu à la souris chez qui un traitement par la prostaglandine PGE2 provoque la multiplication des CSH in vivo et in vitro, un résultat qui génerera très probablement des applications cliniques. (hypotheses.org)
In vivo and in vitro experiments demonstrate that not only vascular endothelial cells growth factor (VEGF) enhances EC fate commitment, but also basic fibroblast growth factor (bFGF) further facilitates EC differentiation [ 17 , 18 , 19 ]. (biomedcentral.com)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
Likewise, while the number of transplanted HSCs is well known to directly impact engraftment efficiency, there are currently no established clinical protocols to successfully expand donor-harvested HSCs, nor to differentiate embryonic or induced pluripotent stem cells (iPSCs) into functional HSCs in vitro. (grantome.com)
These observations imply that current in vitro differentiation strategies are missing critical cues which are essential to unlock or maintain full HSC potential in vivo. (grantome.com)
This study aims to characterize the role of biomechanical modulation of the hemogenic vascular niche in HSC formation in vivo and in vitro, with the overall goal of identifying the signaling pathway(s) connecting select biophysical forces to the gene regulatory network controlling HSC commitment. (grantome.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

2007 Abnormal vascular growth during specific phases of lung advancement may take into account insufficient alveolar septation which plays a part in the lung hypoplasia quality of bronchopulmonary dysplasia (Abman 2001 Vascular Endothelial Development Element (VEGF) (Del Moral et al. (immune-source.com)
2002 While VEGF and Ang are well-established mediators in vascular biology (Breier et al. (immune-source.com)
2009 While Wnt Norfloxacin (Norxacin) signaling is Norfloxacin (Norxacin) essential for endothelial differentiation and in the central anxious system it really is unclear whether Wnt signaling interacts with VEGF and Ang to market pulmonary vascular advancement. (immune-source.com)
Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
Several growth factors such as fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF), promote cell proliferation and differentiation. (medscape.com)
We further demonstrated that atRA regulated vascularization via upregulating vascular endothelial growth factor-A (VEGF-A) secretion in embryonic pancreas and treatment with VEGF-A was able to partially rescue vascularization and β-cell differentiation in DEAB-treated embryonic pancreas cultures. (bath.ac.uk)
4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
A protein called Vascular endothelial growth factor (VEGF) had been suggested to help guide and align the angioblasts as the embryo develops. (elifesciences.org)
Mesodermal progenitor cells are further differentiated into ECs by utilizing a combination of human vascular endothelial growth factor A165 (VEGF), basic fibroblast growth factor (bFGF), 8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt monohydrate (8Bro) and melatonin (Mel) for 48 h. (biomedcentral.com)
Hence, we hypothesized that manipulating Wnt signaling together with VEGF, bFGF, 8Bro and Mel improves differentiation of hiPSCs into human ECs above previously published protocols. (biomedcentral.com)
It promotes GBM angiogenesis by inducing angiogenic factors such as vascular endothelial growth factor (VEGF), plasminogen activator inhibitor (PAI-I) and insulinlike growth factor-binding protein 7 (IGFBP7), contributes to GBM progression by inducing metalloproteinases (MMPs), "pro-neoplastic" integrins (αvβ3, α5β1) and GBM initiating cells (GICs) as well as inducing a GBM mesenchymal phenotype. (tmu.edu.tw)
Prophylactic utilization of inhibitors of VEGF expression in sufferers with hepatic cirrhosis might protect against the development of cancer. (dehydrogenase-signal.com)
ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
RÉSUMÉ Nous avons évalué la valeur pronostique de l'endostatine et du facteur de croissance endothéliale vasculaire (VEGF) dans le sérum pour le diagnostic de la prééclampsie. (who.int)

Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)
Vascularization or vasculogenesis is defined as the differentiation of epithelial progenitor cells (EPCs) into mature epithelial cells to enable the formation of new blood vessels. (naturalnews.com)
The exocrine pancreas, which is composed of acinar and ductal epithelial cells, accounts for nearly 98% of the adult pancreatic mass (12). (pancreapedia.org)

Proteins of this family play a central role during prenatal development, postnatal growth, and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. (biofargo.com)
EPO supports the proliferation and differentiation of erythroid progenitor cells and is critical for their survival [ 1 ]. (biomedcentral.com)

Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. (drugbank.com)
Regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells are also involved in Notch signaling including regulation of blood vessel sprouting, branching during normal and pathological angiogenesis, and the physiological responses of vascular smooth muscle cells ( 4 , 6 , 7 , 21 - 23 ). (frontiersin.org)
While both processes result in new blood vessel formation, vasculogenesis occurs mainly during embryonic development and is facilitated by EPCs, while angiogenesis takes place via "sprouting" of endothelial cells , which allows new blood vessels to take shape from already existing blood vessels. (naturalnews.com)
While the general molecular principles of angiogenesis and peripheral nerve development have been described, how these two processes are coordinated to form the intranervous vascular system is virtually unknown. (elifesciences.org)
During development and in the adult, new blood vessels are formed from pre-existing ones by a process called angiogenesis. (elifesciences.org)
High cell proliferation, angiogenesis and/or necrosis are histopathological features of this cancer, which has no efficient curative therapy. (tmu.edu.tw)
Peripherally administered EPO crosses the blood-brain barrier and activates in the brain anti-apoptotic, anti-oxidant and anti-inflammatory signaling in neurons, glial and cerebrovascular endothelial cells and stimulates angiogenesis and neurogenesis. (biomedcentral.com)
A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. (thermofisher.com)

Furthermore, we found that expression of HoxD8 was significantly induced by Prox1 in MESECs, a finding confirmed in human umbilical vein endothelial cells (HUVECs) and human dermal LECs (HDLECs). (elsevierpure.com)
We show that primary human umbilical vein endothelial cells (HUVECs) readily uptake the nanoparticles with and without specific antibody targets. (frontiersin.org)

However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)
Furthermore, titration of hhex with a dexamethasone-inducible hhex -VP16GR fusion construct suggested that endogenous hhex activity during gastrulation is essential for the formation of ventral pancreatic progenitor cells. (xenbase.org)
In this study, we identify a population of vascular progenitor c-Kit+/Sca-1- cells available in large numbers and derived from immuno-privileged embryonic stem cells (ESCs). (ox.ac.uk)
Human induced pluripotent stem cells (hiPSCs) are cultured under serum-free conditions and induced into mesodermal progenitor cells via stimulation of Wnt signaling for 24 h. (biomedcentral.com)
These results highlight the potential benefit of progenitor cells to generate other cell types that contribute to heart regeneration. (ca.gov)
In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. (thermofisher.com)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Notch signaling is highly conserved cell signaling pathway, which is involved in diverse embryonic organs or tissue development as well as regeneration ( 1 - 10 ). (frontiersin.org)
The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. (thermofisher.com)

The FUNGENES project aimed to achieve a detailed basic understanding of stem cell self-renewal and differentiation. (europa.eu)
In some cases, "master" genes have been described which control differentiation versus self-renewal. (justia.com)
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
Pluripotent stem cells (PSCs) harbor several attractive features for regenerative medicine: they are capable of self-renewal and have the capacity to differentiate to the tissue lineage of all three germ layers. (ca.gov)
Mesenchymal stem cells (MSCs) are widely regarded to be promising cell sources for bone tissue engineering, due to their multi-lineage differentiation potential and extensive self-renewal capacity [ 5 ]. (biomedcentral.com)
Therefore, the identification of novel modifiers of de novo production of HSCs with long-term self-renewal and differentiation capacity is a major unmet clinical need. (grantome.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. (techscience.com)
The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
Finally, the researchers reported that the mRNA levels of endothelial markers - namely, the platelet endothelial adhesive factor-1 (CD31), the endothelial cell-specific molecule-1 (ESM-1), and the vascular von Willebrand factor (vWF) in mouse 4T1 mammary tumor tissue - significantly increased after epimedin C treatment. (naturalnews.com)
Pulmonary hypoplasia (PH) or aplasia is a rare condition that is characterized by incomplete development of lung tissue, which can be unilateral or bilateral. (medscape.com)
Although the exocrine differentiation appeared normal, development of islet tissue was impaired. (bath.ac.uk)
Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)
Blood vessel formation plays an essential role in adult tissue function as well as during embryonic development (16). (pancreapedia.org)
Multiple studies have made use of RGD hydrogel in different tissue and cell types. (thewellbio.com)
It is a highly specific chemotactic and mitogenic factor for many cell types, and appears to be involved in remodeling damaged tissue, such as ulcer healing, vascular repair, traumatic brain injury (TBI). (biofargo.com)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway. (ox.ac.uk)
We also define an efficient and controlled differentiation protocol yielding fully to differentiated ECs and SMCs in sufficient numbers to allow the repopulation of a tissue engineered vascular graft. (ox.ac.uk)
Our data show that ESC-derived c-Kit+/Sca-1-cells can be differentiated through a Klf4/β-catenin dependent pathway and are a suitable source of vascular progenitors for the creation of superior tissue-engineered vessels from decellularised scaffolds. (ox.ac.uk)
Therefore, ECs are of interest in regenerative medicine to support revascularization of ischemic tissues and to line artificial vascular structures in tissue engineering approaches [ 3 ]. (biomedcentral.com)
The precise control of tissue-specificity of gene expression is essential for successful development and depends on distal cis -regulatory elements such as enhancers which interact with promoter elements in physical space. (amegroups.org)
While adult stem cells have yet failed to convincingly regenerate myocardial tissue, human embryonic stem cells (hESCs) have proven to be a potential and unlimited source for cardiomyocyte regeneration. (ca.gov)
It is possible that the transplanted cells fail to physiologically couple with the host tissue, or they may modify the substrate such that a pro-arrhythmic focus is created. (ca.gov)
Biological scaffolding, either alone or in combination with cells for tissue regeneration, has the potential to revolutionize the repair of injured tissues and to replace tissues lost through disease and injury. (genengnews.com)
Bioscaffolding materials may originate from multiple animal, tissue, and cell sources, as well as from synthetic polymers. (genengnews.com)
While many types of matrices have been successfully applied in the clinic, fundamental questions remain about how to combine and manipulate cells with scaffolding to generate functional tissue constructs that avoid immunogenicity. (genengnews.com)
Approaches to scaffolding technology that were discussed at the meeting ranged in complexity from tissue repair products consisting of bovine type 1 collagen knee implants to the highly complex such as the use of whole acellular lung matrix (ACM) to support the development of engineered lung tissue from embryonic stem cells. (genengnews.com)
Tissue engineers working at the laboratory for stem cells and tissue engineering at Columbia University's Fu Foundation School of Engineering are applying a biomimetic approach to developing tissue replacements. (genengnews.com)
They are involved in various cellular processes, including tissue development, immune responses, and maintenance of tissue integrity. (pharmiweb.com)
The molecules are found on the cell surface, where they facilitate adhesion to neighboring cells or the extracellular matrix, creating stable cell structures and supporting tissue organization. (pharmiweb.com)
They play a vital role in tissue development, maintaining tissue integrity, and organizing complex cellular structures. (pharmiweb.com)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)

vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. (who.int)

Thus, mesonephros is a challenging model for studies on epithelial differentiation and organogenesis, regulation of apoptosis, sex determination and stem cell differentiation. (ehu.eus)
Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
They can trigger apoptosis, a process of programmed cell death, when a cell becomes irreparably damaged or poses a risk of becoming cancerous. (pharmiweb.com)

dubious - discuss] In his Nobel seminar, Yamanaka cited the earlier seminal work of Harold Weintraub on the role of myoblast determination protein 1 (MyoD) in reprogramming cell fate to a muscle lineage as an important precursor to the discovery of iPSCs. (wikipedia.org)
Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
We have used conditional gene deletion of mouse β-catenin in Sox17-positive embryonic and extra-embryonic endoderm as well as vascular endothelial progenitors to address the function of canonical Wnt signalling in cell lineage formation and patterning. (biologists.com)
Sox17 lineage tracing in the definitive endoderm (DE) shows a cell-autonomous requirement for β-catenin in midgut and hindgut formation. (biologists.com)
Hence, upon differentiation of hESCs towards cardiac lineage, a distinct fluorescent color is expressed sequentially at each stage of cardiovascular development. (ca.gov)
In particular, the ETS factor, Ets variant 2 (ETV2), is closely linked to development of the vascular lineage [ 19 ]. (biomedcentral.com)

During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
Note: When using high concentrations of antibody, background binding of this dye to erythroid cell subsets (mature erythrocytes and precursors) has been observed. (bdbiosciences.com)
Simultaneously, SC precursors (SCP) derive from the neural crest cells and migrate from the neural tube around embryonic day E10.5 to contact axons and differentiate into immature SC (iSC) around E15/E16 ( Woodhoo and Sommer, 2008 ). (elifesciences.org)
A key step in the de novo formation of the embryonic vasculature is the migration of endothelial precursors, the angioblasts, to the position of the future vessels. (elifesciences.org)
In the developing embryo, definitive HSCs arise from a unique population of mesodermal precursors termed hemogenic endothelium (HEC) through a process known as endothelial-to-hematopoietic transition (EHT). (grantome.com)
Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

These results show essential roles of R-Ras GAP in development and differentiation: its expression is needed for embryonic development of blood vessel barriers, whereas its down-regulation facilitates NGF-induced neurite formation of PC12 cells via maintaining activated R-Ras. (elsevierpure.com)
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. (scbdd.com)
Collectively our results provide significant advancements in our understanding of EMT regulation during cardiac development. (arizona.edu)
Endothelial cells (ECs) form the inner lining of all blood vessels of the body play important roles in vascular tone regulation, hormone secretion, anticoagulation, regulation of blood cell adhesion and immune cell extravasation. (biomedcentral.com)
It is involved in important biological functions including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. (tmu.edu.tw)

so that as a cargo receptor proteins that directs Wnt ligands through the Golgi apparatus towards the cell surface area by getting together with the lipid-modified domains in the ligands (Banziger et al. (immune-source.com)
These results provide the first direct evidence for a role of Wnt proteins during coronary vessel development. (arizona.edu)
We have employed gene editing technology to generate new hESC lines, in which fluorescent reporter proteins are expressed only in cardiac cells. (ca.gov)
The transforming growth factor β (TGFβ) superfamily is a large group of structurally related proteins including TGFβ subfamily members Nodal, Activin, Lefty, bone morphogenetic proteins (BMPs) and growth and differentiation factor (GDF). (tmu.edu.tw)
Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)

We have used RT-PCR to screen pluripotent murine embryonic stem cells to identify receptor tyrosine kinases (RTKs) potentially involved in the determination or differentiation of cell lineages during early mouse development. (silverchair.com)
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. (drugbank.com)
Notch signaling regulates cell-fate determination during activation by signal sending and receiving, affected through ligand-receptor crosstalk. (frontiersin.org)
We show that, while the axon guidance molecule Netrin-1 promotes nerve invasion by blood vessels via the endothelial receptor UNC5B during embryogenesis, myelinated Schwann cells negatively control intra-nervous vascularization during post-natal period. (elifesciences.org)
Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)

The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)
C3H/10T1/2 is a clonal mouse embryo line used in the developmental determination of vertebrate stem cell lineages and their subsequent differentiation. (naturalnews.com)
C3H/10T1/2 cells can be induced to differentiate into multiple stem cell lineages. (naturalnews.com)
These unique clones allow for to study into specific epicardial cell lineages and phenotypes. (arizona.edu)

The iPSC technology was pioneered by Shinya Yamanaka and Kazutoshi Takahashi in Kyoto, Japan, who together showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells. (wikipedia.org)
Its major objective was to produce a gene expression atlas covering the development of ES cells into all three germ layers (ecto-, meso-, and endoderm) and into somatic cells. (europa.eu)
Understanding the genetic pathways underlying differentiation of ES cells to somatic cells would contribute to future therapeutic strategies for degenerative diseases such as heart disease, diabetes and Parkinson's. (europa.eu)
Second, it is a source of multiple stem cells including somatic cells in the male gonad, vascular endothelial cells, and hematopoietic stem cells. (ehu.eus)

We also show the presence of normal lamellar bodies and the secretion of surfactant into the cell culture medium in the organoids of lentiviral infected cells. (nature.com)
2006 With Nkx2-1 exception of Dorsal a Drosophila non-acylated Wnt ligand it really is predicted that Wnt ligands require Wls for secretion to the cell surface (Ching et al. (immune-source.com)
2009 In disrupted eye development via a mechanism that involves anomalous secretion of the Wnt4 ligand (Kim et al. (immune-source.com)
How endothelial cell differentiation can be regulated at the amount of Wnt secretion and whether promotes endothelial cell differentiation in the developing lung are currently unfamiliar. (immune-source.com)

Although many differentiation protocols in the literature have been successful in mimicking lung development from stem cells, there has not been an examination of how a specific mutation impacts the differentiation process including its effects on the early endoderm, as well as the proximal and distal lung epithelial cell populations in the lung organoids. (nature.com)
ventral pancreatic precursor 1 ( vpp1 ) is a marker gene that is differentially expressed in a cell population within the dorsal endoderm in a pattern partially overlapping with that of hematopoietically expressed homeobox ( hhex ) during gastrulation. (xenbase.org)
L) Statistic analysis of phospho- histone H3-positive cells on the whole surface of bisected vegetal endoderm , as demarcated by the red dashed lines in J and K. As the distribution of phospho-histone H3-positive cells across the whole vegetal endoderm sur - face did not show obvious bias, for simplicity, we counted the whole area rather than only putative vpp1 -positive area. (xenbase.org)

Promotes proliferation, survival, migration and differentiation of endothelial cells. (drugbank.com)
1996 For instance Wnt5a induces proliferation and migration of endothelial cells (Cheng et al. (immune-source.com)
Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (scbdd.com)
Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. (scbdd.com)
Vascular endothelial growth factor has been proposed to serve as a chemoattractant for the angioblasts and to regulate this medial migration. (elifesciences.org)
L1CAM plays a role in neural development, axon guidance, and cell migration. (pharmiweb.com)

citation needed] Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line. (wikipedia.org)
Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)
Endothelial cells form a semi-permeable barrier between the blood and surrounding tissues within all blood vessels in the body. (beckman.com)
In addition, repair or replacement cells or tissues should not provoke immune reactions in the host. (genengnews.com)
As a type of MSCs derived from dental tissues, human dental pulp stem cells (hDPSCs) are easily and readily isolated from extracted teeth. (biomedcentral.com)
Ig-superfamily CADMs are involved in a wide range of biological processes and are critical for the development and functioning of various tissues and organs in the body. (pharmiweb.com)
They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
On examination of the oral cavity, the vascular malformations of the mucosa and the adjacent soft tissues are usually readily apparent. (medscape.com)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

It thoroughly investigated the unique ability of mouse embryonic stem cells to develop into cells of any organ ("pluripotency"), created new tools for functional genomic studies and thus provided key knowledge to understanding the commitment of cells to differentiate into cells of a particular germ layer. (europa.eu)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)

Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)
We found that the addition of DEAB blocked vascularization and suppressed β-cell differentiation. (bath.ac.uk)
Using mouse genetic models, the authors show that Schwann cells regulate vascularization of the sciatic nerve and are required for a decrease in vascular density postnatally. (elifesciences.org)

[ 4 ] The effect of stretch of the lung parenchyma induces and promotes lung development. (medscape.com)
Studies have demonstrated that severe oligohydramnios decreased lung cell size, alters cell shape and may also negatively affect Type I cell differentiation which ultimately induces pulmonary hypoplasia. (medscape.com)
Equally, Nodal promotes GICs, induces cancer metabolic switch and supports GBM cell proliferation, but is negatively regulated by Lefty. (tmu.edu.tw)

For lung development to proceed normally, physical space in the fetal thorax must be adequate, and amniotic fluid must be brought into the lung by fetal breathing movements, leading to distension of the developing lung. (medscape.com)
Maintenance of fetal lung volume plays a major role in normal lung development. (medscape.com)
The present study examined how maternal vitamin A deficiency affects fetal islet development. (bath.ac.uk)
We found that maternal vitamin A deficiency during pregnancy affected fetal pancreas development. (bath.ac.uk)
The findings explain why maternal vitamin A deficiency affects fetal islet development and support an essential role of retinoid signaling in regulating vascularized islet development. (bath.ac.uk)
Ideally, the differentiation protocol avoids animal-derived components such as fetal serum and yields ECs at efficiencies that make further sorting obsolete for most applications. (biomedcentral.com)

While heterozygotes are normal, homozygous mice die at E12.5-13.5 of massive subcutaneous and intraparenchymal bleeding, probably due to underdeveloped adherens junctions between capillary endothelial cells. (elsevierpure.com)
In the pancreas of neonatal mice, only a few endocrine cell clusters were formed, and these cell clusters lacked capillary endothelial cells. (bath.ac.uk)
The vascular malformations can be further subdivided into arterial, venous, capillary, and lymphatic malformations. (medscape.com)

We have started pre-clinical studies of transplanting cardiovascular progenitors (at different stages of development) and mature cardiomyocytes in animal models. (ca.gov)
Furthermore, we have shown that transplantation of immature cardiovascular progenitors may generate cardiomyocytes in addition to supporting cells such as vascular endothelial cells and fibroblasts. (ca.gov)

All these diseases are characterised by the irreversible loss of functional cells. (europa.eu)
Stem cells are undifferentiated cells which can give rise to a succession of mature functional cells. (justia.com)
Because of the functional and structural similarities between the mesonephric and metanephric kidneys, it is not surprising that many molecules regulating metanephric development are also activated during mesonephric development. (ehu.eus)
In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. (frontiersin.org)
They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
To become functional, blood vessels mature and specialize by recruitment of mural cells and form a network of arteries, capillaries, and veins. (elifesciences.org)
When seeded ex vivo on a decellularised vessel, c-Kit+/Sca-1-derived cells recapitulated the native vessel structure and upon in vivo implantation in the mouse, markedly reduced neointima formation and mortality, restoring functional vascularisation. (ox.ac.uk)
We are in the process of developing imaging modalities to investigate the extent of structural and functional integration of the transplanted cells into the host heart. (ca.gov)
Requirements for scaffolding include biocompatibility, hemocompatability, and the use of nontoxic materials that are durable, functional, and able to support cell growth. (genengnews.com)

We showed that Krüppel-like transcription factor 4 (Klf4) regulates the choice of differentiation pathway of these cells through β-catenin activation and was itself regulated by the canonical Wnt pathway activator lithium chloride. (ox.ac.uk)
How developmental trajectories are encoded in the genome and how the interplay between intrinsic and extrinsic processes regulates development is one of the major questions in developmental biology. (amegroups.org)

culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)
On the other hand, BMPs target GICS and induce differentiation and sensitivity to chemotherapy. (tmu.edu.tw)

In particular, FUNGENES identified genes controlling the development of pluripotent embryonic stem (ES) cells into heart cells (cardiomyocytes), nerve cells (neurons), smooth muscle cells, vascular endothelial cells, fat cells (adipocytes), liver cells (hepatocytes) and insulin-producing cells of the pancreas. (europa.eu)
Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)

Upon introduction of reprogramming factors, cells begin to form colonies that resemble pluripotent stem cells, which can be isolated based on their morphology, conditions that select for their growth, or through expression of surface markers or reporter genes. (wikipedia.org)
Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
These conditions include growing the cells to high or low density, changing media, introducing or removing cytokines, hormones and growth factors, creating an environment which suits differentiation toward a specific cell type, such as providing a suitable substrate. (justia.com)
Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. (drugbank.com)
We found that R-Ras GAP is down-regulated during neurite formation in rat pheochromocytoma PC12 cells by nerve growth factor (NGF), which is blocked by the transient expression of R-Ras gap or dominant negative R-ras cDNA. (elsevierpure.com)
BMP2 is a cytokine and growth factor that stimulates the differentiation of myoblasts to osteoblasts. (naturalnews.com)
The tunability of the hydrogel gives the ability to create an optimized environment for cell growth. (thewellbio.com)
Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
The malformations have a normal endothelial cell growth cycle that affects the veins, the capillaries, or the lymphatics, and they do not involute. (medscape.com)
Vascular growth during implantation normal non-pregnant controls, 20 normal and placentation is critical for successful pregnant controls, 20 patients with mild gestation. (who.int)

After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
Since the researchers already knew that vasculogenesis plays a pivotal role in bone formation, they used a bone morphogenetic protein 2 (BMP2)-induced ectopic bone formation model and mice 4T1 breast cancer cells co-implanted with luciferase-labeled C3H/10T1/2 cells (4T1 + C3H/10T1/2-Luc) model for their study. (naturalnews.com)
Embryonic mouse models have demonstrated that ROCK protein inhibitor decreases the number of terminal lung buds. (medscape.com)
Mitochondria not only serve as power plants in cells but also act as crucial regulators in many biological processes, including reactive oxygen species (ROS) signaling, redox balance, calcium homeostasis, protein quality control, and programmed cell death ( 3 , 4 ). (frontiersin.org)
8-Bromoadenosine 3′, 5′-cyclic monophosphate (8Bro) is an activator of cyclic AMP-dependent protein kinase, also known as protein kinase A (PKA), and was recently shown to support the differentiation of hiPSCs into ECs [ 20 ]. (biomedcentral.com)
The "molecule" could for instance be a cancer cell or a viral protein. (igem.org)
Detailed site-specific glycan analysis of a wide variety of SARS-CoV-2 variants provides useful information toward the understanding of the role of protein glycosylation on viral protein structure and function and development of effective vaccines and therapeutics. (cdc.gov)

Activin promotes GBM cell proliferation while GDF yields immune-escape function. (tmu.edu.tw)

However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
We previously identified binding motifs for the commonly expressed AP-1 transcription factor family in open chromatin regions specific for early stages of blood specification and thus aimed to study the role of AP-1 for hemangioblast differentiation. (nih.gov)
In the mouse germline ablation of Wls resulted in embryonic death due to abnormalities in axis specification (Fu et al. (immune-source.com)
The forkhead box (FOX) and ETS transcription factor families have been shown to be important in endothelial specification and establishment. (beckman.com)
These observations suggest that, beyond its role in liver development, hhex controls specification of a vpp1 -positive endodermal cell population during gastrulation that is required for the formation of the ventral pancreas . (xenbase.org)

Among numerous physiological tasks, the vascular network transports oxygen and nutrients and eliminates waste products, all critical for organ survival and cellular homeostasis. (elifesciences.org)

Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. (wikipedia.org)

Endothelial cells (ECs) form the endothelium, a layer of single-cell thickness that coats the interior wall of all blood vessels including arteries, capillaries, and veins. (beckman.com)
We found, in mice, that the sciatic nerve invasion by blood vessels begins around embryonic day 16 and continues until birth. (elifesciences.org)
The cells that make up these blood vessels develop from cells called angioblasts-but first, during development these angioblasts must move to the place where the vessels will form. (elifesciences.org)
Endothelial cells form the inner lining of all blood vessels of the mammalian organism. (biomedcentral.com)

2009 Conditional deletion of revealed roles in pancreas and craniofacial development (Carpenter et al. (immune-source.com)
However, the prenatal effects of maternal vitamin A deficiency on pancreas development have not been clearly determined. (bath.ac.uk)
Over time, the pancreas has evolved from relative obscurity, to possessing the most studied cell in the world, the beta cell. (pancreapedia.org)

Thyroid transcription factor 1 (TTF-1) is thought to be the earliest embryologic marker associated with cells committed to pulmonary development. (medscape.com)
D) A 3-dimensional reconstruction of (A). CD31: an endothelial marker, also known as anti-platelet/endothelial cell adhesion molecule-1 (PECAM). (pancreapedia.org)
Furthermore, the majority of hiPSC-ECs express the vascular endothelial marker CD184 (CXCR4). (biomedcentral.com)

Notch signaling is a highly conserved signaling system that is required for embryonic development and regeneration of organs. (frontiersin.org)
However, no study has yet confirmed the delivery of a pure population of stem cells capable of robust regeneration of the injured myocardium. (ca.gov)
A major challenge to clinical translation of stem cells for heart regeneration is the lack of data on the integration of the transplanted cells into the host heart. (ca.gov)

These research provide a fresh platform for understanding the molecular systems underlying regular pulmonary vasculature development as well as the dysmorphic pulmonary vasculature advancement connected with congenital lung disease. (immune-source.com)
Epithelial to mesenchymal transition (EMT) is an essential process during embryogenesis for the development of organ systems, including the heart and its vasculature. (arizona.edu)

It is also clear that pro-mitotic factors such as C-MYC/L-MYC or repression of cell cycle checkpoints, such as p53, are conduits to creating a compliant cellular state for iPSC reprogramming. (wikipedia.org)
Delivering exogenous genetic materials encoding Notch into cells can reestablish downstream signaling and rescue cellular functions. (frontiersin.org)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD CompBead to ensure that BD CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
This manuscript focuses on the cellular and molecular mechanisms underlying intra-nervous vascularisation of peripheral nerves during embryogenesis and early postnatal development. (elifesciences.org)
The development of multi-cellular organisms from a single fertilized egg requires to differentially execute the information encoded in our DNA. (amegroups.org)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)
Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
The proposed research will elucidate how biomechanical forces resulting from the onset of embryonic circulation cue the cellular commitment and vascular remodeling necessary for HSC formation via Rho-Yap activation. (grantome.com)

These molecules are essential for embryonic development, wound healing, immune cell recognition, and many other physiological functions. (pharmiweb.com)

signaling pathways which mediate vascular Norfloxacin (Norxacin) advancement had been downregulated from first stages of advancement. (immune-source.com)
2007 pathways are important in pulmonary vascular advancement and lung development (Chinoy et al. (immune-source.com)
Defining the molecular signaling pathways that mediate productive HSC formation in vivo will reveal new targets for optimizing the directed expansion and/or differentiation of adult-type HSCs for clinical use. (grantome.com)

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. (wikipedia.org)
Pluripotent stem cells hold promise in the field of regenerative medicine. (wikipedia.org)
Induced pluripotent stem cells were first generated by Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University, Japan, in 2006. (wikipedia.org)
Unlike the first generation of iPSCs, these second generation iPSCs produced viable chimeric mice and contributed to the mouse germline, thereby achieving the 'gold standard' for pluripotent stem cells. (wikipedia.org)
They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)

During lymphatic development, Prox1 plays central roles in the differentiation of blood vascular endothelial cells (BECs) into lymphatic endothelial cells (LECs), and subsequently in the maturation and maintenance of lymphatic vessels. (elsevierpure.com)
Here, we identified FoxC2 and angiopoietin-2 (Ang2), which play important roles in the maturation of lymphatic vessels, as novel targets of Prox1 in mouse embryonic-stem-cell-derived endothelial cells (MESECs). (elsevierpure.com)
Among the superfamily of cell adhesion molecules, in this article, we mainly focus on Ig-Superfamily CADMs: the members of the Immunoglobulin superfamily of cell adhesion molecules, which play diverse roles in immune responses, neural development, and cell signaling. (pharmiweb.com)

However, since the generation of embryonic stem cells involves destruction (or at least manipulation) of the pre-implantation stage embryo, there has been much controversy surrounding their use. (wikipedia.org)
Lung development is a complicated process that involves the specialization of multiple bronchiolar and alveolar epithelial populations. (nature.com)
This mechanism involves specialized endothelial cells named tip cells. (elifesciences.org)

The fibroblasts were engineered so that any cells reactivating the ESC-specific gene, Fbx15, could be isolated using antibiotic selection. (wikipedia.org)

During early stages of embryogenesis, by a process called vasculogenesis, a part of the mesoderm differentiates into endothelial cells, forms a lumen, and deposits a basal lamina to create a vascular plexus de novo. (elifesciences.org)

NCAM is crucial for neural development and plays a role in axon guidance, synapse formation, and neural plasticity. (pharmiweb.com)

A subset of epicardial cells undergoes EMT, migrates into the developing heart, and differentiates into cardiac fibroblast, vascular endothelial, and smooth muscle cells. (arizona.edu)

Here we show that FOS and JUN together bind to and activate a core set of vascular genes in the hemogenic endothelium and that upon global inhibition of AP-1 by expression of a dominant negative FOS peptide the balance between endothelial and hematopoietic fate is shifted towards blood. (nih.gov)
Moreover, we demonstrate that in the hemogenic endothelium AP-1 is required for de novo binding of TEAD4, a transcription factor connected to Hippo signaling, to vascular genes. (nih.gov)
In endothelium, Delta-like ligand 4 (DLL4) is one of main ligands to send a signal to Notch in the adjacent cell ( 4 , 6 ) ( Figure 1A ). (frontiersin.org)

They hypothesized that genes important to embryonic stem cell (ESC) function might be able to induce an embryonic state in adult cells. (wikipedia.org)

Thanks to the expression of specific receptors, tip cells can sense the microenvironment, and respond to guidance cues to lead the angiogenic sprout. (elifesciences.org)

FUNGENES identified the gene subsets that are active in self-renewing cells, during the exit from pluripotency and at specific stages of mouse ES cell differentiation. (europa.eu)
This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
Embryonic development is tightly controlled at the level of gene expression. (amegroups.org)
Therefore, we have developed a novel method where cardiac cells of interest harbor an antibiotic resistant gene. (ca.gov)

We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)
Despite more than a decade of research, current protocols rely primarily on enforced expression of transcription factors to help steer cells into an ?HSC-like? (grantome.com)

Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)

While mechanical properties of the niche, including sheer stress and circumferential stretch, are increasingly recognized as important stem cell cues in many contexts, the mechanism(s) by which mechanotransduction drives commitment to hemogenic fate and HSC productionduring vertebrate development remain largely unexplored. (grantome.com)

On the other hand deletion of in mesenchymal cells from the developing lung didn't alter branching morphogenesis or early mesenchymal differentiation. (immune-source.com)
We conclude that epithelial modulates Wnt ligand actions crucial for pulmonary vascular differentiation and peripheral lung morphogenesis. (immune-source.com)
Epithelial-mesenchymal interactions are critical for induction and coordination of vascular development in organs undergoing branching morphogenesis including the lung (Del Moral et al. (immune-source.com)

These findings provide novel mechanistic insights into vascular and hematopoietic development. (nih.gov)

In popular media, the term Regenerative Medicine, or Stem Cell Therapy, are becoming buzz words. (stemcellsgroup.com)

The enhanced osteogenic differentiation of hDPSCs due to ETV2 overexpression was partially reversed by treatment with inhibitors of ERK/MAPK or PI3K-AKT signaling. (biomedcentral.com)

3. developed new embryonic stem cell-based approaches to screening of small candidate molecules for therapeutic applications in human diseases. (europa.eu)

Notably, after the endothelial-to-hematopoietic transition TEAD4 binding is no longer persisting. (nih.gov)

Good for adhesion cells or cells requiring stronger cell-matrix interactions. (thewellbio.com)
VCAMs are involved in mediating the adhesion of leukocytes to vascular endothelial cells, facilitating the recruitment of immune cells during inflammation. (pharmiweb.com)
PECAM-1 is expressed on the surface of platelets and endothelial cells and is involved in cell adhesion and signaling during immune responses. (pharmiweb.com)

This pathway plays a prominent role in inter- and intracellular communication and subversion can lead to cancer, fibrosis vascular disorders, and immune diseases. (lu.se)

Our prior work revealed that Runx1 expression is strongly upregulated after initiation of the embryonic heartbeat, and HSC production is coordinated with the onset of vigorous circulatory flow and sheer stress. (grantome.com)

Anatomy68

Organisms15

Diseases10

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes56

Disciplines and Occupations1

Information Science3

Vitro17

VEGF14

Epithelial cells3

Proliferation and differentiation2

Angiogenesis8

Human Umbilical Vein Endothelial Cells2

Progenitor7

Signaling pathway2

Self-renewal7

Tissue29

Permeability1

Apoptosis3

Lineage6

Precursors6

Regulation5

Proteins7

Receptor5

Lineages4

Somatic cells4

Secretion4

Endoderm3

Migration6

Tissues11

Differentiate4

Vascularization3

Induces3

Fetal6

Capillary3

Progenitors2

Functional9

Regulates2

Induce differentiation2

Cardiomyocytes2

Growth10

Protein7

Promotes1

Specification5

Survival1

Neurons1

Blood vessels4

Pancreas3

Marker3

Regeneration3

Vasculature2

Cellular9

Physiological1

Pathways3

Pluripotent stem5

Roles3

Involves3

Fibroblasts1

Vasculogenesis1

Neural1

Differentiates1

Endothelium3

Hypothesized that genes1

Angiogenic1

Gene6

Transcription2

Myocytes1

Commitment1

Morphogenesis3

Hematopoietic development1

Regenerative medicine1

Osteogenic1

Molecules1

Notably1

Adhesion3

Plays1

RUNX11