• STAT3 disruption also suppresses endothelial HDAC9 and blocks CM-induced HDAC9 expression, whereas HDAC9 re-expression restores CM-enhanced endothelial proliferation. (oncotarget.com)
  • Thus, targeting JAK1-2 with ruxolitinib blocks a final pathway that is common to multiple pro-angiogenic factors, suppresses EC-mediated PCC proliferation, and may be useful in PDACs with a strong pro-angiogenic signature. (oncotarget.com)
  • The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
  • This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
  • Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
  • Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
  • Tissue injury caused by pancreatitis toxins leads to the release of DAMPs - nuclear proteins (such as histones and HMGB1), nuclear and mitochondrial DNA, heat shock proteins, and ATP (60, 134). (pancreapedia.org)
  • In the cell, T3 binds to a nuclear receptor, resulting in transcription of specific thyroid hormone response genes. (pharmaceuticalintelligence.com)
  • Inhibition of the type I TGF-β receptor with SB505124 does not alter endothelial activation in vitro , but decreases pro-angiogenic gene expression and suppresses angiogenesis in vivo . (oncotarget.com)
  • Its receptor binding site is VEGF-A, which is known to promote vascular generation and leakage and to cause nAMD. (molvis.org)
  • Moreover, patient-derived orthotopic xenografts can exhibit tumor angiogenesis, whereas conditioned media (CM) from KRC-derived pancreatic cancer cells (PCCs) enhance endothelial cell (EC) growth and migration, and activate canonical TGF-β signaling and STAT3. (oncotarget.com)
  • Moreover, ruxolitinib blocks mitogenic EC/PCC cross-talk, and suppresses endothelial p-STAT3 and HDAC9, and PDAC progression and angiogenesis in vivo , while markedly prolonging survival of KRC mice. (oncotarget.com)
  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
  • Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
  • Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
  • Human-derived hepatic cell lines are a valuable alternative to primary hepatocytes for drug metabolism, transport and toxicity studies. (cancerindex.org)
  • Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
  • YAP expression increased following laser exposure, in accordance with vascular endothelial growth factor (VEGF) expression. (molvis.org)
  • Furthermore, LPLI induces the synthesis or release of many molecules, like growth factors, interleukins, inflammatory cytokines and others, which are related to promotive effects of LPLI. (biomedcentral.com)
  • Variability in supply, paucity of donors and cellular instability under in vitro conditions have limited the application of primary human hepatocytes (PHHs) to hepatotoxicity testing. (bvsalud.org)
  • In addition, ATX expression was examined in normal human hepatocytes and liver cancer cell lines. (biomedcentral.com)
  • 0.5 μM) inhibit endothelial nitric oxide synthase activation, leading to reduced endothelial nitric oxide production and attenuated tumor angiogenesis. (oncotarget.com)
  • therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C120183 Eltrapuldencel-T A therapeutic melanoma vaccine consisting of autologous dendritic cells (DCs) pulsed with antigens from lethally irradiated autologous tumor cells derived from a patient-specific, continuously proliferating and melanoma-initiating cell line and suspended in a solution containing the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. (nih.gov)
  • Proinflammtory cytokine tumor necrosis factor alpha (TNF-α) promoted ATX expression and secretion selectively in Hep3B and Huh7 cells, which led to a corresponding increase in lysophospholipase-D activity. (biomedcentral.com)
  • This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. (nih.gov)
  • Angiogenesis is crucial for tumor growth and metastasis. (oncotarget.com)
  • However, it is also fundamental for solid tumor growth and metastasis [ 8 ]. (oncotarget.com)
  • showed changes in genes related to cell growth and possibly carcinogenesis in rat lungs treated with diesel particles. (nih.gov)
  • This prevents both the subsequent translocation of NICD to the nucleus to form a transcription factor complex and the expression of Notch-regulated genes. (nih.gov)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
  • Additionally, autoantibodies to rheumatoid factor (RF) and citrullinated protein are often present. (frontiersin.org)
  • The consequent activation of protein kinase B/Akt, nuclear factor-κB, and mitogen-activated protein kinase signaling cascades mediate the increased secretion of VEGF by tumor cells and the up-regulated VEGF receptor-2 expression in ECs. (oncotarget.com)
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
  • 2) The effect of main constituents on downstream targets in nuclear need more further investigation. (frontiersin.org)
  • This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
  • The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. (nih.gov)
  • Final common mediators of disease, including tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, are well studied and have yielded breakthrough therapeutics. (frontiersin.org)
  • SeV has several features that are important in a vector for a successful vaccine: the virus does not integrate into the host genome, it does not undergo genetic recombination, it replicates only in the cytoplasm without DNA intermediates or a nuclear phase and it is does not cause any disease in humans or domestic animals. (wikipedia.org)
  • therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C116377 Osimertinib A third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. (nih.gov)
  • By contrast, when groups of mice that had received P. acnes were given endotoxin and bled, higher titres of tumour necrosis factor were found in the sera of L mice. (nih.gov)