Loading...
  • tumors
  • 1 In general, the growth and spread of tumors has been shown to be dependent on the development of increased vascularization in the tumor vicinity in order to maintain sufficient oxygenation. (labcorp.com)
  • heparin
  • In 1986, Napoleone Ferrara and Jean Plouet (Fig. 7.1), both postdoctoral fellows in Denis Gospodarowicz's laboratory in San Francisco, detected a stimulating activity of endothelial cells in the culture medium of bovine and mouse pituitary cells that was eluted from a heparin-sepharose column at much lower ionic strength than fibroblast growth factors [122, (springer.com)
  • stimulate
  • Conversely, growth factor agonists have been successfully used to stimulate collateral vessel formation and reduce ischemic symptoms from macrovascular disease in the coronary arteries and peripheral limbs. (diabetesjournals.org)
  • contrast
  • In contrast, recent data suggest that vascular collateralization resulting from ischemia-induced growth factor release in tissues compromised by macrovascular disease may be important in reducing clinical symptoms and tissue damage. (diabetesjournals.org)
  • Role
  • We aimed to elucidate the role of these angiogenic factors in placentation and to evaluate the predictive value of their protein concentrations and genetic variations in pregnancy complications.METHODSWe performed a systematic search of PubMed, and retrieved original articles. (biomedsearch.com)