Vascular endothelial dysfunction. Medical search. Frequent questions

The vascular endothelium modulates contractile responses to 5-HT and ET-1 in human subcutaneous resistance arteries but this effect is lost in patients with NPG, indicating a selective defect in agonist mediated release of endothelium derived vasodilators. (bmj.com)
9 Impaired systemic vascular function has been demonstrated in patients with NPG in whom blood flow in the fingers is reduced 10, 11 (both under basal conditions and following cold provocation) and endothelium dependent vasodilatation in the forearm is impaired. (bmj.com)
This includes the role of the vascular endothelium in the recruitment of inflammatory leucocytes where they contribute to tissue damage and cytokine release, which are key drivers of acute respiratory distress syndrome (ARDS), in disseminated intravascular coagulation, and cardiovascular complications in COVID-19. (synergy-munich.de)
Here, the Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. (synergy-munich.de)
In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium. (wikipedia.org)
Along with acting as a semi-permeable membrane, the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin, and controlling local angiotensin-II activity. (wikipedia.org)
A feature of endothelial dysfunction is the inability of arteries and arterioles to dilate fully in response to an appropriate stimulus, such as exogenous nitroglycerine, that stimulates release of vasodilators from the endothelium like NO. Endothelial dysfunction is commonly associated with decreased NO bioavailability, which is due to impaired NO production by the endothelium or inactivation of NO by reactive oxygen species. (wikipedia.org)
Atherosclerosis Endothelial activation Nitric oxide endothelial nitric oxide synthase Prostacyclin Endothelium-derived relaxing factor Endothelin Integrin network Endothelial shear stress Sitia, S. (wikipedia.org)
These findings show that maternal exercise alleviates oxidative stress and the impairment of endothelium -dependent vasodilatation via SIRT1 -regulated deacetylation of Nox4, which might contribute to improved vascular function in hypertensive offspring. (bvsalud.org)
Conclusion The upregulation of SGLT1, and the greater SGLT1 and SGLT2-mediated uptake of anthocyanins predominantly in the endothelium at arterial sites at risk in old rats suggest that anthocyanins appear as interesting natural products to protect the endothelial function with increasing age. (unipi.it)
Other genes associated with essential hypertension are important for the normal function of the lining of blood vessels (the vascular endothelium ). (medlineplus.gov)
We will investigate the effects of exenatide on vascular endothelial injury and nitrooxidative stress in hyperglycemia both in vivo and in vitro and explore the role of nitrooxidative stress in endothelium-protective action of exenatide. (hindawi.com)
In conclusion, this study demonstrates that exenatide treatment can alleviate the vascular endothelial injury, as well as attenuating the nitrooxidative stress in hyperglycemia, implying that the endothelium-protective effect of exenatide might be related to the reduction of nitrooxidative stress. (hindawi.com)
Normally, the endothelium forms an integral cellular barrier to regulate vascular homeostasis. (surrey.ac.uk)
Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. (imperial.ac.uk)
However, the routes by which macromolecules cross endothelium, the hemodynamic stresses that maintain endothelial physiology or trigger arterial disease, and the dependence of transendothelial transport on hemodynamic stresses are controversial. (imperial.ac.uk)
Functional assessment of the vascular endothelium in isolated rat tail arteries and leukocyte differentiation in the spleen and lymph nodes via flow cytometry was also done. (cdc.gov)

Oxidative stress and inflammation in the vascular wall are essential mechanisms of atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic diseases, aging, hypertension, etc. (frontiersin.org)
Mechanisms of pathogenesis of atherosclerosis are complex interplay between bloodstream cells and arterial wall components that leads to a chronic state of vascular oxidative stress and inflammation ( Hansson and Hermansson, 2011 ). (frontiersin.org)
In the past decades, unambiguous evidence has been provided that heightened oxidative stress and vascular wall inflammation are the key mechanisms for initiation and progression of atherosclerosis and vascular diseases associated with the risk factors ( Hansson and Hermansson, 2011 ). (frontiersin.org)
Therefore, elucidation of mechanisms underlying oxidative stress and inflammations in the vascular wall will have important impact in understanding atherosclerosis and vascular diseases associated with cardiovascular risk factors and will eventually lead to novel and effective therapeutic modalities. (frontiersin.org)
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. (synergy-munich.de)
Endothelial dysfunction may be involved in the development of atherosclerosis and may predate vascular pathology. (wikipedia.org)
Insulin resistance and endothelial dysfunction have both been implicated in the pathogenesis of hypertension [ 3 - 7 ] and atherosclerosis [ 8 , 9 ]. (hindawi.com)
Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)
On the basis of their evidence review, Dr Thomas Münzel (Johannes Gutenberg University, Mainz, Germany) and colleagues say it's becoming clear that transportation noise is associated with oxidative stress, vascular dysfunction, autonomic imbalance and metabolic abnormalities-potentially contributing to the development of cardiovascular risk factors, such as arterial hypertension and diabetes, as well as progression of atherosclerosis and increased susceptibility to cardiovascular events. (medscape.com)
Despite the vast clinical experience linking diabetes, obesity and the metabolic syndrome to vascular disease, little is understood regarding the mechansims connecting hyperglycemia to atherosclerosis. (lu.se)

Evidence has been provided that activation of the vascular endothelial cells in the presence of the risk factors promotes oxidative stress and vascular inflammatory responses, leading to acceleration of atherosclerotic vascular disease. (frontiersin.org)
Recent research provides emerging evidence supporting an essential role of increased activity of arginases including arginase-I and arginase-II in causing eNOS-uncoupling, which results in vascular oxidative stress and inflammatory responses, and ultimately leading to vascular diseases. (frontiersin.org)
This review article will summarize the most recent findings on the functional roles of arginases in vascular diseases and/or dysfunctions and the underlying mechanisms in relation to oxidative stress and inflammations. (frontiersin.org)
Nitric oxide (NO) suppresses platelet aggregation, inflammation, oxidative stress, vascular smooth muscle cell migration and proliferation, and leukocyte adhesion. (wikipedia.org)
Maternal exercise represses Nox4 via SIRT1 to prevent vascular oxidative stress and endothelial dysfunction in SHR offspring. (bvsalud.org)
Introduction Aging-related endothelial dysfunction and vascular oxidative stress affect early arterial sites at risk. (unipi.it)
Systolic blood pressure (SBP) was assessed by tail-cuff sphygmomanometry, vascular reactivity using organ chambers, protein expression by immunofluorescence, oxidative stress using dihydroethidium, and anthocyanin uptake by Neu reagent. (unipi.it)
Both SGLT inhibitors reduced also ex vivo the age-related vascular oxidative stress. (unipi.it)
This results in hyperglycemia and pancreatic beta-cell dysfunction, especially when repeatedly exposed to oxidative stress. (vitalitymagazine.com)

The team also exposed commercially-available human aortic endothelial cells to the flavorings. (sciencedaily.com)
We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)

The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia. (diabetesjournals.org)
This study aims to clarify the time-dependent molecular pathways by which TMAO mediates endothelial dysfunction through transcriptomics and metabolomics analyses in human microvascular endothelial cells (HMEC-1). (nature.com)

The mechanisms of vascular dysfunction have been investigated in a number of conditions, including hypertension 13 and diabetes, 14 using subcutaneous arteries isolated from biopsies of gluteal fat. (bmj.com)

It has been proposed that vascular dysfunction contributes to the pathogenesis of glaucoma and, in particular, NPG as this condition is associated with the presence of widespread cerebrovascular and systemic cardiovascular disease. (bmj.com)
There is an increased risk of vascular disease in diabetes that is a major cause of patient morbidity and mortality. (diabetesjournals.org)
This mutation has been associated with vascular Behçet disease. (medscape.com)
ORIGINAL RESEARCH-PEYRONIE'S DISEASE: Systemic Vascular Endothelial Dysfunction in Peyronie's Disease by: Julian Halcox, et al. (swan.ac.uk)
In the murine model of HGPS, vascular smooth muscle cell (VSMC) loss is the primary vascular manifestation, which is different from the arterial occlusive disease seen in older patients. (houstonmethodist.org)
Methods and To identify the mechanisms of HGPS vascular disease in humans, we differentiated isogenic endothelial cells (ECs) and results VSMCs from HGPS-induced pluripotent stem cells (iPSCs) and control-iPSCs. (houstonmethodist.org)
Vascular endothelial dysfunction is recognized as a contributor to a wide array of cardiovascular disease states, but the initiating events involved are incompletely defined. (uky.edu)
The adverse effects observed with chemical flavor additives on endothelial cells could be early warning signs of future heart disease, researchers say. (sciencedaily.com)
Endothelial dysfunction, as an early pivotal event in cardiovascular disease, is strongly associated with the pathogenesis of DM [ 1 , 2 ]. (hindawi.com)
CONCLUSIONS There is evidence of persisting abnormal vascular wall morphology and vascular dysfunction at the site of regressed coronary aneurysms in patients with previous Kawasaki disease. (bmj.com)
My goal is to understand the molecular and cellular mechanisms that cause chronic kidney and vascular disease (CKD / CVD). (sheffield.ac.uk)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
BACKGROUND:The onset of many disease processes depends on the function of the endothelial cell (EC) glycocalyx (GCX) which acts as a flow-dependent barrier to cellular infiltration and molecular transport across the blood vessel wall. (iospress.com)
CONCLUSIONS:Regenerating the degraded GCX reverses EC barrier dysfunction and may attenuate the progression of vascular disease. (iospress.com)
In patients with established coronary artery disease, the adverse effects of nighttime noise on vascular function were, as expected, even stronger," Münzel said. (medscape.com)
Central to the development of vascular disease is endothelial dysfunction, which appears well before any clinical sign, but importantly is potentially reversible. (lu.se)

The aim of the present study was to identify whether P. gingivalis heat‑shock protein 60 (HSP60) induced the dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. (spandidos-publications.com)
Certain studies show that P. gingivalis lipopolysaccharide (LPS) could induce the expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human umbilical vein endothelial cells (HUVECs) ( 13 , 14 ), which significantly enhances trans-endothelial migration of inflammatory cells. (spandidos-publications.com)
LINC00926 promotes pyroptosis of hypoxia-induced human umbilical vein vascular endothelial cells by recruiting ELAVL1]. (nih.gov)

and 2) whether statins reduce endothelial inflammation and pro-thrombotic conditions by improving endothelial cholesterol metabolism and trafficking in OSA (Aim 2). (nih.gov)
A large body of scientific evidence supports the critical role of inflammation markers (including adipokines, bioactive mediators secreted directly from adipocytes, and vascular cells within adipose tissue) in the development of systemic inflammation that contributes to vasculopathy and cardiovascular risk within obese individuals [ 1 , 2 ]. (hindawi.com)
The study was designed to evaluate the role of inflammation markers in the development of insulin resistance, microvascular dysfunction, and endothelial dysfunction and eventually the progression to (pre)diabetes and (pre)hypertension. (hindawi.com)
We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
Disturbed lipid and carbohydrate metabolism are manifested by enhanced inflammation and endothelial dysfunction in patients with simply obesity. (medsci.org)
Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)

Frequency of positively stained nuclei was statistically correlated to extent of endothelial dysfunction (p λ 0.01). (uky.edu)
In the current study, we investigated the extent of endothelial activation in patients receiving hemodialysis who had either mild or severe COVID-19. (imperial.ac.uk)

RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)
CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
Researchers found all nine flavors were dangerous to cells in the laboratory at the highest levels tested and all the flavorings impaired nitric oxide production in endothelial cells in culture (outside of the body). (sciencedaily.com)
Dimethylpyrazine/strawberry flavor had that effect even at very low levels, suggesting endothelial cells are especially sensitive to it. (sciencedaily.com)
However, several studies reported controversial results regarding the effects of TMAO on endothelial cells (ECs). (nature.com)
In this study, we aimed to examine the effects of RCE in endothelial cells challenged with hypoxic exposure and to elucidate the underlying mechanisms. (mdpi.com)
The majority of VWF is synthesized by endothelial cells (ECs) and stored in Weibel-Palade bodies (WPB). (imperial.ac.uk)
In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)
During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
Correlations of observations of the GCX with a number of EC functions were sought with an emphasis on studies of trans-endothelial barrier integrity against vessel wall infiltration of cells and molecules from the circulation. (iospress.com)
HM aerosols also caused vascular endothelial dysfunction and increased CD4+, CD8+ and B cells in the spleen. (cdc.gov)
Vascular complications of diabetes: Studies on NFAT (Nuclear Factor of Activated T-cells) as a novel target for the treatment of atherosclersis and vascular dysfunction in diabetes. (lu.se)

Hyperglycemia increased the formation of ROS-an effect linked to mitochondrial dysfunction and prevented by sulforaphane. (diabetesjournals.org)
Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
There is evidence that the endothelial dysfunction induced by hyperglycemia is associated with the enhanced nitrooxidative stress. (hindawi.com)
years of poorly controlled hyperglycemia lead to multiple, primarily vascular, complications that affect small vessels (microvascular), large vessels (macrovascular), or both. (msdmanuals.com)

To demonstrate the importance of GCX as a regulator of trans-endothelial infiltration, assays were performed using ECs with an intact GCX and compared to assays of ECs with an experimentally degraded GCX. (iospress.com)

Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide production and impairs endothelial function in vascular pathologies. (elsevierpure.com)

Since NO maintains low tone and high compliance of the small arteries at rest, a reduction of age-dependent small artery compliance is a marker for endothelial dysfunction that is associated with both functional and structural changes in the microcirculation. (wikipedia.org)
The TBARS value endothelial functional status on the other. (who.int)

ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)

The discrepancies between studies on TMAO-induced endothelial dysfunction may be attributed to different cell types and animal models used, including different metabolic backgrounds, as well as to distinct TMAO treatment concentrations and durations. (nature.com)

12 The relatively small number of studies to have assessed vascular reactivity and blood flow in the systemic circulation of these patients, however, prevents identification of the mechanisms underlying these abnormalities. (bmj.com)
Moreover, regulatory mechanisms of arginases in the vasculature are reviewed and the future perspectives of targeting arginases as therapeutic options in vascular diseases are discussed. (frontiersin.org)
The decreased SkBF and sweating would be associated with the reduction in nitric oxide bioavailability and endothelial functions in skin vasculatures, also with central mechanisms, and so on. (intechopen.com)

The effects of sulforaphane on multiple pathways of biochemical dysfunction, increased reactive oxygen species (ROS) formation, hexosamine pathway, protein kinase C (PKC) pathway, and increased formation of methylglyoxal were assessed. (diabetesjournals.org)

Conclusions: This study has identified dysfunction of the systemic vascular endothelial cell in patients with normal pressure glaucoma. (bmj.com)
Indications of vascular endothelial cell dysfunction in systemic lupus erythematosus. (ox.ac.uk)
These data suggest a degree of endothelial cell dysfunction. (ox.ac.uk)
In addition, at 48H, BPs linked to inflammatory phenotypes were activated (confirming KEGG results), while BPs linked to extracellular matrix (ECM) structural organisation, endothelial cell proliferation, and collagen metabolism were repressed. (nature.com)
Background: A major clinical feature of severe coronavirus diease 2019 (COVID-19) is microvascular thrombosis linked to endothelial cell activation. (imperial.ac.uk)
LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway. (nih.gov)
In addition, the authors say a transcriptome analysis of aortic tissues from animals exposed to aircraft noise revealed changes in the expression of genes responsible for the regulation of vascular function, vascular remodeling, and cell death. (medscape.com)
For this reason, they are extensively used in a wide range of applications from protein production to bacterial biofilms and endothelial cell experiments. (imperial.ac.uk)
These alterations can influence endothelial dysfunction, excessive vasoconstriction, and abnormal cell proliferation of the vascular wall. (ajmc.com)
P-selectin (marker for endothelial cell func- instructions. (who.int)

The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). (iium.edu.my)
Endothelial dysfunction, in particular, can encourage the expression of endothelin-1 (ET-1), a known vasoconstrictor. (ajmc.com)

Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). (nature.com)
This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)

We tested the hypothesis that clinically demonstrated concentrations of 3NT can induce vascular and endothelial dysfunction in vitro. (uky.edu)

The role of ecto-5'-nucleotidase in endothelial dysfunction and vascular pathologies. (medscape.com)

Coronary vascular endothelial function and myocardial ischemia: why should we worry about endothelial dysfunction? (swan.ac.uk)
citation needed] In the coronary circulation, angiography of coronary artery responses to vasoactive agents may be used to test for endothelial function, and venous occlusion plethysmography and ultrasonography are used to assess endothelial function of peripheral vessels in humans. (wikipedia.org)

DESCRIPTION (provided by applicant): The product that will result from this STTR is ABH (2(S)-amino-6-boronohexanoic acid), a potent small molecule inhibitor of the enzyme arginase, for treating vascular complications of diabetes. (sbir.gov)
Using a gene deletion model, we investigated involvement of arginase isoforms arginase 1 and 2 (ARG1 and ARG2) in hypertension and endothelial dysfunction in a mineralocorticoid-salt mouse model. (elsevierpure.com)

is the parent ROS molecule produced by the one electron reduction of oxygen catabolized by various enzymes including NADPH oxidase, cyclooxygenase, lipoxygenases, cytochrome P450 enzymes, enzymes in the mitochondrial electron transport chain ( Yang and Lüscher, 2002 ), and also endothelial NO ⋅ Synthase (eNOS, see below). (frontiersin.org)

vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. (who.int)

It is conceivable that NPG is associated with a generalised vascular defect which produces alterations in both the ocular and systemic circulations. (bmj.com)
Systemic-to-pulmonary communications are usually harmless prenatally because the high pulmonary vascular resistance of the fetus limits left-to-right shunting. (medscape.com)

We propose that endothelial biomarkers and tests of function (e.g. flow-mediated dilatation) should be evaluated for their usefulness in the risk stratification of COVID-19 patients. (synergy-munich.de)
A better understanding of the effects of SARS-CoV-2 on endothelial biology in both the micro- and macrovasculature is required, and endothelial function testing should be considered in the follow-up of convalescent COVID-19 patients for early detection of long-term cardiovascular complications. (synergy-munich.de)
Dyslipidemia and hypertension are well known to contribute to endothelial dysfunction, and lowering blood pressure and LDL has been shown to improve endothelial function, particularly when lowered with ACE inhibitors, calcium channel blockers, and statins. (wikipedia.org)
Current measurements of endothelial function via FMD vary due to technical and physiological factors. (wikipedia.org)
Furthermore, a negative correlation between percent flow mediated dilation and baseline artery size is recognised as a fundamental scaling problem, leading to biased estimates of endothelial function. (wikipedia.org)
A non-invasive, FDA-approved device for measuring endothelial function that works by measuring Reactive Hyperemia Index (RHI) is Itamar Medical's EndoPAT. (wikipedia.org)
Stent implantation has been correlated with impaired endothelial function in several studies. (wikipedia.org)
Sirolimus eluting stents were previously used because they showed low rates of in-stent restenosis, but further investigation showed that they often impair endothelial function in humans and worsen conditions. (wikipedia.org)
Treatment of hypertension and hypercholesterolemia may improve endothelial function in people taking statins (HMGCoA-reductase inhibitor), and renin angiotensin system inhibitors, such as ACE inhibitors and angiotensin II receptor antagonists. (wikipedia.org)
Life style modifications such as smoking cessation have also been shown to improve endothelial function and lower the risk of major cardiovascular events. (wikipedia.org)
Although endothelial dysfunction is involved in the pathophysiology of hypertension , limited studies have characterized how maternal exercise influences endothelial function of hypertensive offspring. (bvsalud.org)
In this study, pregnant spontaneously hypertensive rats and Wistar-Kyoto rats were assigned either to a sedentary lifestyle or to swimming training daily, and fetal histone deacetylase -mediated epigenetic modification and offspring vascular function of mesenteric arteries were analyzed. (bvsalud.org)
Anthocyanins uptake via sodium-glucose co-transporter 1 (SGLT1) are potent inducers of endothelial formation of nitric oxide (NO). Aims This study examined if anthocyanin-rich blackcurrant (ARB) improves the endothelial function in old rats. (unipi.it)
In summary, ARG is involved in murine DOCA-salt-induced impairment of vascular function and hypertension and may represent a novel target for antihypertensive therapy. (elsevierpure.com)
Endothelial function and dysfunction. (univaq.it)
Flavor additives used in electronic cigarettes and related tobacco products could impair blood vessel function and may be an early indicator of heart damage, according to new laboratory research in Arteriosclerosis, Thrombosis and Vascular Biology , an American Heart Association journal. (sciencedaily.com)
This study shows that ACEIs improve brachial FMD which is a marker of endothelial function in patients with endothelial dysfunction caused by various conditions and are superior to CCBs and β-blockers. (unboundmedicine.com)

Aim: Vascular risk factors, and particularly vasospasm, are thought to play a part in the pathogenesis of normal pressure glaucoma (NPG). (bmj.com)

PH associated with SCD often results from chronic, heightened, left-heart pressure contributing to veinous pulmonary vascular remodeling. (ajmc.com)
The remaining cases can be associated with precapillary arterial PH that can result from the obstructive remodeling of the pulmonary vascular bed. (ajmc.com)
Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats. (cdc.gov)
Any intracardiac communication that allows high pulmonary blood flow will lead, over time, to irreversible pulmonary vascular injury, increased pulmonary artery pressures and, ultimately, to right-to-left intracardiac blood flow. (medscape.com)
Over time, any communication that allows a left-to-right shunt causes increased pulmonary vascular flow and, eventually, irreversible vascular injury. (medscape.com)

Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)

This approach has the advantage of studying vascular dysfunction directly in arteries from patients (rather than animal models) and uses resistance arteries which contribute significantly to maintenance of blood pressure. (bmj.com)
We further found that maternal exercise during pregnancy upregulated vascular SIRT1 ( sirtuin 1 ) expression, leading to a low level of H3K9ac ( histone H3 lysine 9 acetylation ), resulting in the transcriptional downregulation of Nox4 in mesenteric arteries of hypertensive fetuses . (bvsalud.org)

Microvascular dysfunction may affect both peripheral vascular resistance and insulin-mediated glucose disposal, thereby contributing to hypertension and insulin resistance, respectively [ 10 ]. (hindawi.com)

Free 3NT is apparently more than a benign biomarker in vivo, and may contribute to vascular endothelial dysfunction through promotion of DNA damage and/or apoptosis. (uky.edu)

The levels of vascular endothelial (VE)‑cadherin, endothelial nitric oxide synthase (eNOS) and cysteinyl aspartate‑specific protease‑3 (caspase‑3) were measured using western blot analysis. (spandidos-publications.com)
These results indicated that P. gingivalis HSP60 may induce dysfunction and apoptosis in HUVECs via downregulating the expression levels of VE‑cadherin and eNOS, and promoting the cleavage of caspase‑3. (spandidos-publications.com)

Endothelial dysfunction can also lead to increased adherence of monocytes and macrophages, as well as promoting infiltration of LDL in the vessel wall. (wikipedia.org)

In addition, it has also shown beneficial effects on both cardiac [ 11 - 13 ] and vascular endothelial functions [ 14 - 19 ]. (hindawi.com)

Results: Responses to K + and noradrenaline were similar in patients and controls and were unaffected by endothelial removal. (bmj.com)

Thus, a second objective of this study is to investigate if NFAT activation leads to early development of endothelial dysfunction and to examine the effects of NFAT blockade on the microvasculature. (lu.se)

Calcium channel blockers and selective beta 1 antagonists may also improve endothelial dysfunction. (wikipedia.org)

Anatomy32

Organisms10

Diseases49

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology2

Phenomena and Processes36

Disciplines and Occupations1

Health Care13

Endothelium17

Atherosclerosis10

Oxidative9

Aortic endothelial cells2

Microvascular endothelial2

Including hypertension1

Disease16

Human umbilical vein3

Inflammation6

Extent of endothelial2

Cells15

Hyperglycemia4

Trans-endothelial1

Nitric oxide production1

Functional2

Abstract1

Metabolic1

Mechanisms3

Pathways1

Cell10

Endothelin2

Diseases2

Vitro1

Pathologies1

Coronary2

Arginase2

20021

Permeability1

Systemic2

Function17

Pathogenesis1

Pulmonary vascular5

Inflammatory1

Arteries2

Peripheral1

Vivo1

ENOS2

Macrophages1

Cardiac1

Responses1

Examine the effects1

Selective1