Vascular endothelial cell dysfunction. Medical search. Frequent questions

The vascular endothelium modulates contractile responses to 5-HT and ET-1 in human subcutaneous resistance arteries but this effect is lost in patients with NPG, indicating a selective defect in agonist mediated release of endothelium derived vasodilators. (bmj.com)
9 Impaired systemic vascular function has been demonstrated in patients with NPG in whom blood flow in the fingers is reduced 10, 11 (both under basal conditions and following cold provocation) and endothelium dependent vasodilatation in the forearm is impaired. (bmj.com)
Other genes associated with essential hypertension are important for the normal function of the lining of blood vessels (the vascular endothelium ). (medlineplus.gov)
ESCs will eventually produce endothelial cells (ECs), which create the thin-walled endothelium that lines the inner surface of blood vessels and lymphatic vessels. (wikipedia.org)
Role of insulin-like growth factors in endothelium differentiation ECs derived from stem cells are the beginning of vasculogenesis. (wikipedia.org)
Important signaling factors for vasculogenesis are TGF-β, BMP4, and VEGF, all of which promote pluripotent stem cells to differentiate into mesoderm, endothelial progenitor cells, and then into mature endothelium. (wikipedia.org)
Not only is VEGF critical for mesoderm cells to become an EC, but also for EPCs to differentiate into mature endothelium. (wikipedia.org)
Normally, the endothelium forms an integral cellular barrier to regulate vascular homeostasis. (surrey.ac.uk)
Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. (imperial.ac.uk)
However, the routes by which macromolecules cross endothelium, the hemodynamic stresses that maintain endothelial physiology or trigger arterial disease, and the dependence of transendothelial transport on hemodynamic stresses are controversial. (imperial.ac.uk)
Albumin-sized tracers dominantly crossed the cultured endothelium via junctions between neighbouring cells, high-density-lipoprotein-sized tracers crossed at tricelluar junctions whilst low-density-lipoprotein-sized tracers crossed through cells. (imperial.ac.uk)
Endothelial inflammation increases the adhesiveness of monocytes to the endothelium in addition to increasing vascular permeability, promoting diabetic atherogenesis. (spandidos-publications.com)
Functional assessment of the vascular endothelium in isolated rat tail arteries and leukocyte differentiation in the spleen and lymph nodes via flow cytometry was also done. (cdc.gov)
Cerebral endothelium is a one cell layer on the inner wall of the vessels and as such is a difficult subject to image. (hindawi.com)
Originally thought to behave as supporting cells for the lung epithelium and endothelium with a singular f. (researchgate.net)
The blood microvascular endothelium consists of a heterogeneous population of cells with regionally distinct morphologies and transcriptional signatures in different tissues and organs. (researchgate.net)
The endothelium appears to be damaged both by AF and various other vascular diseases (e.g. hypertension) that frequently co-exist with the arrhythmia, with similar disruption to endothelial repair (normally effected by endothelial progenitor cells). (bham.ac.uk)
Endothelial cells (ECs) form the endothelium, a layer of single-cell thickness that coats the interior wall of all blood vessels including arteries, capillaries, and veins. (beckman.com)
It has been shown that increased substrate stiffness, mimicking the stiffening that occurs naturally with age, results in increased cell contractility, cell -cell junction width, and endothelium permeability via Rho mediated contractility 2. (cornell.edu)
To date therapeutics to reverse increased vascular stiffness, and in turn prevent endothelial cell dysfunction leading to increased endothelium permeability, have been limited and unsuccessful. (cornell.edu)
As increased stiffness leads to increased permeability via and statins have been shown to decrease RhoA activity, this investigation examined the effect of simvastatin (Zocor®), a common statin, on endothelial cell morphology, cell traction forces, cell-cell junction widths, and endothelium permeability for endothelial cells seeded on 2.5, 5, and 10 kPa polyacrylamide substrates, mimicking the stiffness of healthy and aged vessels respectively. (cornell.edu)
Our data show that simvastatin results in an elongated cell morphology, reduced endothelial cell contractility, enhanced cell-cell junction integrity, and decreased substratestiffness-dependent and thrombin-dependent increased endothelium permeability on physiologically relevant substrate stiffnesses. (cornell.edu)

Effective clearance of inflammatory cells is required for resolution of inflammation. (koreamed.org)
However, many disease-predisposing factors and/or contributing factors have been identified, including inflammation, endothelial cell dysfunction, aberrant vascular wall cell proliferation and mutations in the bone morphogenetic protein-receptor type 2 ( Bmpr2 ) gene [ 1 - 3 ]. (ersjournals.com)
This monolayer of cells is an important endocrine organ, and has been shown to play a major role in regulating blood fluidity, the transfer of solutes and macromolecules, immune responses and inflammation. (beckman.com)
Surface associated glycoproteins of endothelial origin, or derived from pericytes, intravascular leukocytes, and plasma, are other important components of the glycocalyx, constituting a vascular cell surface proteome that is dynamic, tissue-specific, and sensitive to changes in vascular homeostasis, blood infection, and inflammation. (lu.se)
This method facilitates the identification of markers of vascular activation and provides a molecular framework to understand the contribution of vascular dysfunction to the organ pathology of systemic inflammation. (lu.se)
Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis. (cdc.gov)
The proatherogenic and atheroprotective effects of d-flow and s-flow are mediated in part by the global changes in endothelial cell (EC) gene expression, which regulates endothelial dysfunction, inflammation, and atherosclerosis. (cdc.gov)
Functionally, KLK10 protected against d-flow-induced permeability dysfunction and inflammation in human artery ECs, as determined by NFB activation, expression of vascular cell adhesion molecule 1 and intracellular adhesion molecule 1, and monocyte adhesion. (cdc.gov)
Furthermore, treatment of mice in vivo with rKLK10 decreased arterial endothelial inflammation in d-flow regions. (cdc.gov)
Studying the mechanisms underlying increased VDAC1 expression and membrane translocation in pancreatic beta cells, vascular endothelial cells, adipocytes, and macrophages in pathological conditions such as long-lasting hyperglycemia or low-grade inflammation. (lu.se)

Thrombocytopenia is a common feature of hemorrhagic fevers and vascular permeability disorders ( 8 ), but the decrease in platelet counts in acute LF is not low enough to cause spontaneous hemorrhage. (cdc.gov)
LF could be characterized as a disease of enhanced vascular permeability but the underlying pathophysiology remains ambiguous. (cdc.gov)
The effects of oxLDL‑mediated inflammasome activation on endothelial permeability under HG conditions, in addition to the effects of rosmarinic acid on these oxLDL‑mediated processes, also remain poorly understood. (spandidos-publications.com)
Therefore, the present study aimed to elucidate the mechanisms involved in oxLDL‑induced endothelial permeability and monocyte diapedesis under HG conditions, in addition to the potential effects of rosmarinic acid. (spandidos-publications.com)
In addition, oxLDL‑stimulated ECs under HG conditions exhibited increased phosphorylated VE‑cadherin protein levels and decreased ZO‑1 protein expression levels compared with those in untreated ECs, suggesting increased endothelial permeability. (spandidos-publications.com)
A number of studies have previously suggested that vascular endothelial dysfunction caused by increased junctional permeability is a key event in the development and progression of atherosclerosis and atherosclerotic cardiovascular diseases ( 3 , 4 ). (spandidos-publications.com)
Endothelial cells are highly metabolically active and play an important role in many physiological functions, including the control of vasomotor tone, blood cell trafficking, haemostatic balance, permeability, proliferation, and immunity. (hindawi.com)
VEGF promotes vascular permeability and neovascularization, further complicating the micro-aneurysm's clinical significance [ 3 ]. (alliedacademies.org)
In some cases, anti-VEGF therapy may be considered to reduce vascular permeability and inhibit neovascularization. (alliedacademies.org)
Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations and increased vascular permeability correlate with poor disease outcomes. (researchgate.net)
4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
Our data suggest that simvastatin may be beneficial in preventing atherosclerosis beyond its traditional lipid lowering effects b y decreasing monolayer permeability due to vascular stiffening that naturally occurs with aging. (cornell.edu)

Endothelial cells play a central role in controlling vascular function and maintaining vascular integrity. (nii.ac.jp)

In addition, at 48H, BPs linked to inflammatory phenotypes were activated (confirming KEGG results), while BPs linked to extracellular matrix (ECM) structural organisation, endothelial cell proliferation, and collagen metabolism were repressed. (nature.com)
It is well established that insulin-like growth factor (IGF) signaling is important for cell responses such as mitogenesis, cell growth, proliferation, angiogenesis, and differentiation. (wikipedia.org)
Recently I uncovered that ANKHD1 controls cell proliferation by directly binding to and modulating a subset of tumour-suppressor microRNAs (https://www.ncbi.nlm.nih.gov/pubmed/29695508). (sheffield.ac.uk)
These alterations can influence endothelial dysfunction, excessive vasoconstriction, and abnormal cell proliferation of the vascular wall. (ajmc.com)
Our laboratory is focused on (1) the understanding of the role of reactive oxygen species (ROS) in fat development in DIO in mice, and (2) to study the effect of dietary on white adipose progenitor cells proliferation and differentiation. (utah.edu)

Studies have shown that increased Vascular Endothelial Growth Factor (VEGF) production, a response to hypoxia in the diabetic retina, plays a pivotal role in micro-aneurysm formation. (alliedacademies.org)
Given that vascular endothelial growth factor (VEGF) may improve the function of smooth muscle cells and endothelial cells through different mechanisms, it is thus expected that increasing the expression of VEGF may have beneficial effects on erectile function. (nih.gov)
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)
Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease. (nih.gov)
VEGF-D-mediated signaling in tendon cells is involved in degenerative processes. (nih.gov)

The aim of the present study was to identify whether P. gingivalis heat‑shock protein 60 (HSP60) induced the dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. (spandidos-publications.com)
Certain studies show that P. gingivalis lipopolysaccharide (LPS) could induce the expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human umbilical vein endothelial cells (HUVECs) ( 13 , 14 ), which significantly enhances trans-endothelial migration of inflammatory cells. (spandidos-publications.com)
LINC00926 promotes pyroptosis of hypoxia-induced human umbilical vein vascular endothelial cells by recruiting ELAVL1]. (nih.gov)

Endothelial cells (ECs) form a semi-permeable monolayer that separates the bloodstream from underlying tissues and regulate the infiltration of blood cells and proteins through the vessel wall ( 1 , 2 ). (spandidos-publications.com)
Endothelial cells form a semi-permeable barrier between the blood and surrounding tissues within all blood vessels in the body. (beckman.com)

Vanillin and eugenol also increased oxidative stress in the cells. (sciencedaily.com)
TMAO treatment for either 24H or 48H induces reduced cell viability and enhanced oxidative stress. (nature.com)

The team also exposed commercially-available human aortic endothelial cells to the flavorings. (sciencedaily.com)

The effects of sulforaphane on multiple pathways of biochemical dysfunction, increased reactive oxygen species (ROS) formation, hexosamine pathway, protein kinase C (PKC) pathway, and increased formation of methylglyoxal were assessed. (diabetesjournals.org)
Cell viability and reactive oxygen species (ROS) generation were also evaluated. (nature.com)
Adverse stimuli such as pro-fibrotic and pro-inflammatory cytokines or reactive oxygen species, induce endothelial injury and dysfunction. (rug.nl)

The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia. (diabetesjournals.org)
Hyperglycemia increased the formation of ROS-an effect linked to mitochondrial dysfunction and prevented by sulforaphane. (diabetesjournals.org)
CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
Chronic metabolic disorders, such as hyperglycemia and dyslipidemia, promote endothelial dysfunction and eventually leakage, resulting in increased monocyte diapedesis ( 5 - 7 ). (spandidos-publications.com)
To investigate VDAC1 expression in peripheral insulin target tissues such as adipocytes, endothelial, and macrophages under hyperglycemia and inflammatory conditions. (lu.se)

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)

It has been proposed that vascular dysfunction contributes to the pathogenesis of glaucoma and, in particular, NPG as this condition is associated with the presence of widespread cerebrovascular and systemic cardiovascular disease. (bmj.com)
When persistent, this dysfunction can result in endothelial-to-mesenchymal transition (EndMT) which contributes to fibro-proliferative disease. (rug.nl)
Functional failure of smooth muscle cells and endothelial cells in corpus cavernosum contributes to erectile dysfunction (ED) in aging men. (nih.gov)

The impaired homeostasis and platelet dysfunction implicate alterations in the protein C pathway, which might contribute to the loss of endothelial barrier function in fatal infections. (cdc.gov)
Disruption of endothelial homeostasis (damage vs. repair) is thought to be central to this process. (bham.ac.uk)

In the cardiovascular system, mercury induces hypertension in humans and animals that has wide-ranging consequences, including alterations in endothelial function. (hindawi.com)

ESCs have the characteristic properties of a stem cell: self-renewal and differentiation. (wikipedia.org)
Differentiation is the process by which a cell becomes more specialized. (wikipedia.org)
Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)

70%. Severe cases exhibit abnormal coagulation, endothelial barrier disruption, and dysfunctional platelet aggregation but the underlying mechanisms remain poorly understood. (cdc.gov)

We'll be discussing endotheliopathy and platelet dysfunction in Lassa fever. (cdc.gov)
Sarah Gregory] Endotheliopathy and platelet dysfunction are outcomes of Lassa fever. (cdc.gov)
Sarah Gregory] Explain to us what endotheliopathy and platelet dysfunction is. (cdc.gov)

RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)
Endothelial dysfunction during diabetes has been previously reported to be at least in part attributed to increased oxidized low‑density lipoprotein (oxLDL) levels mediated by high glucose (HG) levels. (spandidos-publications.com)
Endothelial dysfunction during diabetes is closely associated with increased oxidized low-density lipoprotein (oxLDL) levels mediated by high glucose (HG) conditions ( 8 ). (spandidos-publications.com)
High blood glucose levels can damage endothelial cells, causing microvascular dysfunction. (alliedacademies.org)
Deletion of the RBP4 receptor STRA6L in CD11c+ immune cells protects mice from diet-induced glucose intolerance and insulin resistance. (utah.edu)
This study aims to investigate the relationship between triglyceride glucose index (TyG) and erectile dysfunction (ED) among United States (US) adult males. (frontiersin.org)
found evidence and they did not require insulin therapy of endothelial cell injury in renal failure for glucose control. (who.int)

For example, an endothelial progenitor cell (EPC) is more specialized than an ESC, and an EC is more specialized than an EPC. (wikipedia.org)
We have shown that chronic inflammatory disease impacts endothelial progenitor cell (EPC) biology, through reducing their circulating numbers and by impairing their function. (rug.nl)

BACKGROUND: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. (koreamed.org)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
Studies using these samples found associations between fatal outcomes and elevated liver enzyme levels, renal dysfunction, cytokine dysregulation, and genetic factors. (cdc.gov)

P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
ECs were treated with oxLDL under HG conditions in the presence or absence of ROS scavengers mitoTEMPO and NAC, p38 inhibitor SB203580, FOXO1 inhibitor AS1842856 or transfected with the TXNIP siRNA, before protein expression levels of intercellular adhesion molecule 1 (ICAM‑1), vascular cell adhesion molecule‑1 (VCAM‑1), phosphorylated vascular endothelial‑cadherin (VE‑cadhedrin), VE‑cadherin and zonula occludens‑1 (ZO‑1) were measured by western blotting. (spandidos-publications.com)
Subsequently, rosmarinic acid treatment significantly reversed oxLDL‑induced overexpression of adhesion molecules and monocyte‑EC adhesion, oxLDL‑induced endothelial junction hyperpermeability and monocyte transmigration through the endothelial monolayer under HG conditions, in a dose‑dependent manner. (spandidos-publications.com)
OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and. (koreamed.org)

This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. (nih.gov)

Coronary Microvascular Dysfunction and Heart Failure With Preserved Ejection Fraction as Female-pattern Cardiovascular Disease: The Chicken or the Egg? (medscape.com)
A variety of observations suggest that coronary microvascular dysfunction (CMD) is related to the pathogenesis of cardiovascular disease, including myocardial ischaemia and heart failure. (medscape.com)

It is a rare but well-described autoimmune connective tissue disorder, which is of unknown etiology and is characterized by a triad of fibrosis, vascular dysfunction, as well as immune dysregulation. (hstalks.com)
However, the biomarkers sICAM-1 and sE-selectin (as mechanism of this immune dysregulation markers of endothelial dysfunction) in dia- is still unclear. (who.int)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)

The remaining cases can be associated with precapillary arterial PH that can result from the obstructive remodeling of the pulmonary vascular bed. (ajmc.com)
Endothelial function is not uniform throughout the arterial system. (hindawi.com)
Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)
Previously, we identified kallikrein-related peptidase 10 (Klk10, a secreted serine protease) as a flow-sensitive gene in mouse arterial ECs, but its role in endothelial biology and atherosclerosis was unknown. (cdc.gov)

peptide 14 or 19 from P. gingivalis HSP60 may have either an anti- or pro-atherogenic role, respectively, in the ApoE(−/-) mouse model of infection-triggered atherosclerosis through distinct mechanisms operating in the polarization of T cells. (spandidos-publications.com)
Vascular dysfunction is the cause of various diseases, such as diabetes, atherosclerosis, and malignancy. (nii.ac.jp)
PURPOSE: This study aimed to investigate the effect of adipose-derived stem cell (ADSC) transplantation on atherosclerosis (AS) and its underlying mechanisms. (koreamed.org)

Interleukin-6, IL-6) in AF with particular reference to circulating progenitor cells (CPCs) as a novel marker of endothelial health/angiogenesis. (bham.ac.uk)

The mechanisms of vascular dysfunction have been investigated in a number of conditions, including hypertension 13 and diabetes, 14 using subcutaneous arteries isolated from biopsies of gluteal fat. (bmj.com)
Knowing that vascular dysfunction is an early event in the development of cardiovascular disease in obese diabetic (OB-T2D) patients, The investigators set their long-term goal to define molecular mechanisms of vascular dysfunction and corrective strategies that target these mechanisms such as physical activity and weight loss. (nih.gov)

Because of its soluble characteristics, elemental mercury is highly diffusible and is able to pass through cell membranes as well as the blood-brain and placental barriers to reach target organs. (hindawi.com)
These well-regulated processes to transfer information between cells occur through direct cell-cell contact, various soluble bioactive factors and through cellular microparticles [ 6 , 7 ]. (ersjournals.com)
ABSTRACT This study assessed changes in serum levels of cytokines IFN and IL-10 (biomarkers of in ammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothe- lial dysfunction) in diabetic patients with and without nephropathy. (who.int)
Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)

We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
Primary human corpus cavernosum smooth muscle cells (CCSMCs) were isolated and cultured in vitro. (nih.gov)
Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. (ersjournals.com)
To develop and test new VDAC1 inhibitors as anti-diabetic drugs in cell-based in vitro models as well as in animal models of diabetes. (lu.se)

This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)

Results: Responses to K + and noradrenaline were similar in patients and controls and were unaffected by endothelial removal. (bmj.com)
Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats. (cdc.gov)
Here, we investigated bleomycin-induced lung injury responses in young and aged mice at single-cell resolution to gain insights into the cellular and molecular contributions of aging to fibrosis. (researchgate.net)
Vascular dysfunction is a hallmark of systemic inflammatory responses such as bacterial sepsis. (lu.se)

Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
Recently, we analyzed serum biomarkers by using samples from the Gulu outbreak and identified associations between cytokines/chemokines, acute-phase reactants, markers of coagulopathy, and markers of endothelial function and patient death, hemorrhage, and viremia. (cdc.gov)

Endothelial cell phenotypes are differentially regulated in space and time, giving rise to the phenomenon of endothelial cell heterogeneity. (hindawi.com)

Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). (nature.com)
Cerebral endothelial dysfunction is mentioned in the pathophysiology of several neurological diseases. (hindawi.com)
Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most. (koreamed.org)
Stem cell research arose from the need to explore new therapeutic possibilities for intractable and lethal diseases. (koreamed.org)
Mesenchymal cells in the lung are crucial during development, but also contribute to the pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most common and deadly form of fibrotic interstitial lung diseases. (researchgate.net)
This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
We therefore believe that investigating the mechanism behind increased VDAC1 expression and its mistargeting to the cell surface in beta cells in pathophysiological conditions can also be of great importance for other human diseases. (lu.se)

For this reason, they are extensively used in a wide range of applications from protein production to bacterial biofilms and endothelial cell experiments. (imperial.ac.uk)
KLK10 is a flow-sensitive endothelial protein that serves as an anti-inflammatory, barrier-protective, and anti-atherogenic factor. (cdc.gov)
We have recently shown that it is possible to restore the normal function of beta-cells by blocking the protein VDAC1 (Voltage-Dependent Anion Channel 1), which is dramatically increased in beta cells of people with T2D. (lu.se)
This protein has been mistargeted to the cell membrane, causing ATP loss that results in cell dysfunctionality. (lu.se)

These results indicated that P. gingivalis HSP60 may induce dysfunction and apoptosis in HUVECs via downregulating the expression levels of VE‑cadherin and eNOS, and promoting the cleavage of caspase‑3. (spandidos-publications.com)

One of the causes of erectile dysfunction is the inability of the penile smooth muscle to relax. (cssbasics.com)
Red Boost contains L-citrulline, which increases nitric oxide production properly to treat erectile dysfunction. (cssbasics.com)
In erectile dysfunction, impaired nitric oxide occurs when the penile smooth muscle does not function properly. (cssbasics.com)
Horny goat weed found in Red Boost is believed to treat erectile dysfunction somewhat. (cssbasics.com)
It has been shown that a higher TyG index is associated with a higher prevalence of erectile dysfunction. (frontiersin.org)
According to the European Multicenter Population Study (EMAS), which conducted the largest study of males with aging populations (40-79), erectile dysfunction prevalence ranged from 6% to 64%, depending on age grouping, and increased with age, averaging 30% ( 3 ). (frontiersin.org)
As of today, the most common treatment of erectile dysfunction involves lifestyle changes that are beneficial to the patient's overall health and sexual function. (frontiersin.org)
Although effective oral and injectable drugs have been introduced for the treatment of erectile dysfunction, these medications have not been demonstrated to restore natural erectile physiology, and in some cases these drugs are contraindicated, intolerable, expensive, or ineffective. (frontiersin.org)
Identifying risk factors for erectile dysfunction, including as smoking, obesity, sedentary lifestyle, and persistent alcohol intake, is crucial for preventing erectile dysfunction ( 6 - 8 ). (frontiersin.org)
Due to the prevalence of erectile dysfunction and its increasing occurrence among young men ( 9 ), prevention of erectile dysfunction, which may be directly related to metabolic psychospiritual culture, should be a priority ( 10 ). (frontiersin.org)

These insights open new horizons for vascular regenerative medicine and challenge current dogmas on the pathophysiology of fibro-proliferative vascular disease. (rug.nl)

Diabetic group ( n = 17): patients with in patients with chronic renal failure and type 2 diabetes without renal involve- under HD, and disturbances in endothelial ment (normoalbuminuria). (who.int)

Flavor additives used in electronic cigarettes and related tobacco products could impair blood vessel function and may be an early indicator of heart damage, according to new laboratory research in Arteriosclerosis, Thrombosis and Vascular Biology , an American Heart Association journal. (sciencedaily.com)
Background: A major clinical feature of severe coronavirus diease 2019 (COVID-19) is microvascular thrombosis linked to endothelial cell activation. (imperial.ac.uk)

Microparticles are plasma membrane vesicle fragments (between 0.1 and 1 μm in size) released from various cell types during activation by agonists or physical or chemical stress, including apoptosis [ 6 , 7 ]. (ersjournals.com)

There is an increased risk of vascular disease in diabetes that is a major cause of patient morbidity and mortality. (diabetesjournals.org)
Diabetes and Vascular Disease Objectives: Describe 3 vascular conditions associated with diabetes. (slideserve.com)
In conclusion, micro-aneurysms are small but significant indicators of vascular compromise, often associated with diabetes mellitus. (alliedacademies.org)
The diagno- function may play a role in vascular com- sis of type 2 diabetes was established plications such as stroke or ischaemic heart before they were screened for the study disease. (who.int)
There are currently no clinical treatments to prevent, reverse, or efficiently cure the progression of rapid beta-cell demise or insulin resistance in diabetes-prone individuals which means that there is a need for novel therapies for these conditions. (lu.se)

It is well established that endothelial cells (EC) play a crucial role in vascular physiology. (rug.nl)

This approach has the advantage of studying vascular dysfunction directly in arteries from patients (rather than animal models) and uses resistance arteries which contribute significantly to maintenance of blood pressure. (bmj.com)

LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway. (nih.gov)

Researchers found all nine flavors were dangerous to cells in the laboratory at the highest levels tested and all the flavorings impaired nitric oxide production in endothelial cells in culture (outside of the body). (sciencedaily.com)
Nonsmokers' cells that were treated with menthol or a clove flavoring also had impaired nitric oxide production, suggesting those flavorings cause damage like that found in active smokers. (sciencedaily.com)

We identified a set of microRNAs (miRNAs) expressed in vascular endothelial cells, which regulate vascular malfunction. (nii.ac.jp)

The discrepancies between studies on TMAO-induced endothelial dysfunction may be attributed to different cell types and animal models used, including different metabolic backgrounds, as well as to distinct TMAO treatment concentrations and durations. (nature.com)

Specifically, does primary CMD lead to ventricular remodelling/diastolic dysfunction and HFpEF or do alterations in myocardial remodelling/diastolic dysfunction observed in HFpEF lead to secondary CMD, i.e. the chicken or the egg? (medscape.com)
This is consistent with a growing body of work from our group showing that women with CMD often have left ventricular (LV) diastolic dysfunction, [ 5 , 11 , 12 ] and are at increased risk of developing HFpEF. (medscape.com)
The exact mechanism(s) contributing to CMD-related diastolic dysfunction, however, remains incompletely understood. (medscape.com)

The further specialized a cell is, the more differentiated it is and as a result it is considered to be more committed to a certain cellular lineage. (wikipedia.org)
My goal is to understand the molecular and cellular mechanisms that cause chronic kidney and vascular disease (CKD / CVD). (sheffield.ac.uk)
There is some sort of etiologic agent, which we do not know what it is, which stimulates or activates the molecular and cellular target cells in a patient, who has the specific genetic background for this disease. (hstalks.com)
Early on, there's a cellular infiltrate in the tissues involved inclusive the skin, as well as the other organs, and this early infiltrate is predominantly with CD4 T-cells in the skin and CD8+ T-cells in the lungs. (hstalks.com)
The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

This compensation can increase endothelial activation. (ajmc.com)
In a previous study, it was reported that oxLDL treatment induced nucleotide‑binding domain and leucine‑rich repeat containing family, pyrin domain‑containing 3 inflammasome activation in endothelial cells (ECs) under HG conditions, in a manner that could be effectively reversed by rosmarinic acid. (spandidos-publications.com)
In the current study, we investigated the extent of endothelial activation in patients receiving hemodialysis who had either mild or severe COVID-19. (imperial.ac.uk)

Aim: Vascular risk factors, and particularly vasospasm, are thought to play a part in the pathogenesis of normal pressure glaucoma (NPG). (bmj.com)
The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)

PH associated with SCD often results from chronic, heightened, left-heart pressure contributing to veinous pulmonary vascular remodeling. (ajmc.com)

Preeclampsia is a pregnancy-specific disorder involving widespread endothelial dysfunction and vasospasm that usually occurs after 20 weeks of gestation and can present as late as 4-6 weeks postpartum. (medscape.com)

Journal Article] Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. (nii.ac.jp)
The TBARS value endothelial functional status on the other. (who.int)

The levels of vascular endothelial (VE)‑cadherin, endothelial nitric oxide synthase (eNOS) and cysteinyl aspartate‑specific protease‑3 (caspase‑3) were measured using western blot analysis. (spandidos-publications.com)

The adverse effects observed with chemical flavor additives on endothelial cells could be early warning signs of future heart disease, researchers say. (sciencedaily.com)
B cells are activated, autoantibodies are produced, and while there's many autoantibodies have been described and some of them have related to specific types of the disease, they have not shown to be pathogenic at this stage. (hstalks.com)
To stress the importance of considering pulmonary complications in sickle cell disease (SCD), researchers compiled an overview on the state of research and available treatment options for patients with SCD associated with pulmonary hypertension. (ajmc.com)
Although rare, pulmonary hypertension (PH) can be a serious complication from sickle cell disease (SCD). (ajmc.com)
BACKGROUND: This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic. (koreamed.org)
Pulmonary hypertension (PH) is a fatal disease with no treatment options, characterised by elevated pulmonary vascular resistanzce and secondary right ventricular failure. (ersjournals.com)

And so during these viral infections (such as Lassa fever), you disturb that endothelial barrier and it becomes porous for various reasons. (cdc.gov)

This study aims to clarify the time-dependent molecular pathways by which TMAO mediates endothelial dysfunction through transcriptomics and metabolomics analyses in human microvascular endothelial cells (HMEC-1). (nature.com)

Bronchoalveolar lavage (BAL), lung gene expression and ex vivo BAL cell challenge were performed to assess lung toxicity. (cdc.gov)

Conclusions: This study has identified dysfunction of the systemic vascular endothelial cell in patients with normal pressure glaucoma. (bmj.com)
Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)

Pulmonary hypertension (PH) is characterised by widespread obstruction and obliteration of pulmonary arterioles, leading to a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. (ersjournals.com)

The results described in this paper indicate that mercury exposure, even at low doses, affects endothelial and cardiovascular function. (hindawi.com)

Anatomy49

Organisms10

Diseases22

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology2

Phenomena and Processes47

Disciplines and Occupations2

Information Science3

Health Care1

Endothelium22

Inflammation10

Permeability12

Role in controll1

Proliferation5

VEGF5

Human umbilical vein3

Form a semi-permeable2

Oxidative2

Aortic endothelial cells1

Reactive oxygen3

Hyperglycemia5

Lung endothelial1

Contributes3

Homeostasis2

Alterations in endothelial1

Differentiation3

Abnormal1

Endotheliopathy and Platelet Dysfunction3

Glucose7

Progenitor cell2

Cytokine4

Adhesion5

Growth Factor1

Microvascular dysfunction2

Dysregulation3

Arterial4

Atherosclerosis3

Angiogenesis1

Mechanisms of vascular dysfunction2

Soluble4

Vitro4

Regulates1

Responses4

Markers3

Phenotypes1

Diseases7

Protein4

Induce1

Erectile dysfunction10

Pathophysiology1

Disturbances1

Thrombosis2

Apoptosis1

Diabetes5

Physiology1

Arteries1

Signaling1

Nitric oxide production2

Regulate vascular1

Metabolic1

Diastolic dysfunction3

Cellular7

Activation3

Pathogenesis2

Chronic1

Vasospasm1

Functional2

Cadherin1

Disease6

Barrier1

Pathways1

Vivo1

Systemic vascular2

Pulmonary vascular1

Cardiovascular1