DiseasesIsolated systolic hypComplicationsMortalityMyocardialOutcomesAcuteInterventionsSciencesBoneTissueHypothesisContractilityImagingIncidenceClinicalHeart FailureBiological systemsDiseaseAtherosclerosisPredictive ModelsSurvivalDependenceHFpEFSimulationPrematureTherapeuticGlucoseDifferencesDiagnosticFunctionAssessmentFattyExperimentsResearchLeftHighSignificant
Diseases6
- Dysregulation or dysfunction of the insulin signalling path- ways often underlies the molecular ætiology of diseases such as diabetes, obesity, and Alzheimer's. (sun.ac.za)
- In turn, these diseases are the harbingers of various co-morbidities such as cardio-vascular disease, chronic inflammation, and dementia. (sun.ac.za)
- Therefore, brown adipose tissue is now being considered as a novel target to combat obesity and related diseases such as type 2 diabetes and cardiovascular disease. (einthovenlaboratory.com)
- Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
- In this review, we will discuss the role of NAD + depletion in instigating SASP and its downstream signaling and regulatory mechanisms that lead to the premature onset of atherosclerotic cardiovascular diseases in cancer survivors. (oaepublish.com)
- Association between cardiovascular diseases and dementia among various age groups: a population-based cohort study in older adults. (ottawaheart.ca)
Isolated systolic hyp1
- One of the hypotheses being investigated is that aberrant vascular stiffness changes are involved in the genesis of certain cardiovascular pathologies (e.g., preeclampsia, isolated systolic hypertension in elderly). (pitt.edu)
Complications3
- Although alterations in the methionine metabolism cycle (MMC) have been associated with vascular complications of diabetes, there have not been consistent results about the levels of methionine and homocysteine in type 2 diabetes mellitus (T2DM). (biomedcentral.com)
- Hyperglycemia contributes to vascular complications of diabetes. (diabetesjournals.org)
- Late cardiovascular complications such as myocardial infarction and structural heart defects were observed in childhood cancer survivors treated at St. Jude Children's Research Hospital. (oaepublish.com)
Mortality3
- Heart Failure (HF) is the only cardiovascular disease for which incidence, prevalence, morbidity, mortality, and costs are not decreasing. (frontiersin.org)
- This serves as a plausible mechanistic link between the previously described association between particulate matter air pollution and increased cardiovascular morbidity and mortality. (wikipedia.org)
- Also, the ADDITION-Europe Simulation Model Study shows early diagnosis reduces the risk of suffering cardiovascular events and mortality ( 2 ), which also spurs research associated with early diagnosis. (frontiersin.org)
Myocardial3
- We quantified alterations in myocardial function in a mathematical model of the human LV that is based on the finite element method. (frontiersin.org)
- We therefore explored a physics-based mathematical [finite element (FE)] model of the normal human LV to test the hypothesis that reduced subendocardial contractility combined with compensatory high subepicardial contractility may help in preserving LVEF independent of changes in myocardial geometry and material properties. (frontiersin.org)
- Changes in myocardial blood flow in a canine model of left sided breast cancer radiotherapy. (ottawaheart.ca)
Outcomes2
- Construction of machine learning-based models for cancer outcomes in low and lower-middle income countries: A scoping review. (cdc.gov)
- Long-Term Survival, Cardiovascular, and Functional Outcomes after Minimally Invasive Coronary Artery Bypass Grafting in 566 Patients. (ottawaheart.ca)
Acute1
- In human experimental studies using an exposure chamber setup, DE has been linked to acute vascular dysfunction and increased thrombus formation. (wikipedia.org)
Interventions3
- Technical Recommendations for Computed Tomography Guidance of Intervention in the Right Ventricular Outflow Tract: Native RVOT, Conduits and Bioprosthetic Valves: A White Paper of the Society of Cardiovascular Computed Tomography (SCCT), Congenital Heart Surgeons' Society (CHSS), and Society for Cardiovascular Angiography & Interventions (SCAI). (ottawaheart.ca)
- Journal of the Society for Cardiovascular Angiography and Interventions. (ottawaheart.ca)
- Cardiovascular Interventions, 16(8), e012527. (ottawaheart.ca)
Sciences1
- Dr. Shroff has been serving as the Principal Investigator on a NIH-NHLBI pre-doctoral training grant (Cardiovascular Bioengineering Training Program) since 2005 and the Coulter Translational Research Partnership II Program since 2013, and Co-Director on a NIH-NHLBI post-doctoral training grant (Training Program in Imaging Sciences in Translational Cardiovascular Research) since 2016. (pitt.edu)
Bone1
- Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. (e-enm.org)
Tissue2
- The computational results simulating the effects of transmural alterations in the ventricular tissue replicate the phenotypic patterns of LV dysfunction observed in clinical practice. (frontiersin.org)
- Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. (imperial.ac.uk)
Hypothesis2
- In particular, data for LVEF, strain and displacement are consistent with previous clinical observations in patients with HFpEF, and substantiate the hypothesis that increased subepicardial contractility may compensate for subendocardial dysfunction and play a vital role in maintaining LVEF. (frontiersin.org)
- To verify this hypothesis, mathematical modeling of methionine metabolism was required to predict the levels of homocysteine derived from given amounts of methionine. (biomedcentral.com)
Contractility1
- We hypothesized that transmural variations in myofiber contractility with existence of subendocardial dysfunction and compensatory increased subepicardial contractility may underlie preservation of LVEF in patients with HFpEF. (frontiersin.org)
Imaging3
- In autumn 2009 I took up my current position as Reader in Cardiovascular Imaging and Centre Lead in the new Advanced Cardiovascular Imaging Centre funded through the NIHR Cardiovascular Biomedical Research Unit. (researchgate.net)
- Objectives To assess the feasibility of extracting radiomics signal intensity based features from the myocardium using cardiovascular magnetic resonance (CMR) imaging stress perfusion sequences. (researchgate.net)
- Cardiovascular Imaging. (ottawaheart.ca)
Incidence1
- The cumulative cardiovascular disease (CVD) incidence of those who survived more than 10 years and reached age over 18 years was 45.5% relative to 15.7% of the age- and sex-matched controls. (oaepublish.com)
Clinical5
- Our consortium aims to investigate novel non-invasive tools to quantify microvascular health and rarefaction in both organs, as well as surrogate biomarkers for cerebral and/or cardiac rarefaction (via sublingual capillary health, vascular density of the retina, and RNA content of circulating extracellular vesicles), and to determine whether microvascular density relates to disease severity.Methods/design: The clinical research program of CRUCIAL consists of four observational cohort studies. (unav.edu)
- The Vascular Nephrology Group was initiated by Anton Jan van Zonneveld and Ton Rabelink in 2004 and research topics are centred around the understanding and clinical translation of molecular mechanisms in vascular injury and repair, secondary to adverse metabolic- or hemodynamic risk factors such as encountered in diabetes, chronic kidney disease or kidney transplantation. (einthovenlaboratory.com)
- 50%), better clinical models and pipelines for targeted therapies are urgently required. (hrb.ie)
- In the Fall 2019 Quarter, he taught a special study course (BioE 297: Physics-Based Modeling and In Silico Clinical Trials). (ucsf.edu)
- Integration of GWAS with "omic" data, patient characteristics, and clinical correlates into predictive models could decrease radiation-induced side effects while increasing therapeutic efficacy. (e-roj.org)
Heart Failure1
- Introduction: Microvascular rarefaction, the functional reduction in perfused microvessels and structural reduction of microvascular density, seems to be an important mechanism in the pathophysiology of small blood vessel related disorders including vascular cognitive impairment (VCI) due to cerebral small vessel disease and heart failure with preserved ejection fraction (HFpEF). (unav.edu)
Biological systems1
- In addition to basic and translational research, Dr. Shroff and colleagues have developed and continue to develop novel, simulation-based material (i.e., mathematical models of biological systems and associated "virtual experiments") for education and engineering design. (pitt.edu)
Disease5
- Mathematical modelling of insulin signalling is indispensable in the effort to un- derstand the dynamics of the insulin signalling cascade and how malfunctions therein lead to disease. (sun.ac.za)
- Cardiovascular disease remains number one cause of premature death in women. (einthovenlaboratory.com)
- Despite advances in the diagnosis, prevention and treatment of cardiovascular disease, the risk of coronary artery disease in women increases dramatically after menopause. (einthovenlaboratory.com)
- For disease models in living animals, DISEASE MODELS, ANIMAL is available. (lookformedical.com)
- IMPORTANCE: High salt intake is associated with hypertension, which is a leading modifiable risk factor for cardiovascular disease. (cdc.gov)
Atherosclerosis1
- Recently, we reported that the nucleus-mitochondria positive feedback loop formed by p90 ribosomal S6 kinase (p90RSK) and phosphorylation of S496 on ERK5 (a unique member of the mitogen-activated protein kinase family that is not only a kinase but also a transcriptional co-activator) were vital signaling events that played crucial roles in linking mitochondrial dysfunction, nuclear telomere dysfunction, persistent SASP induction, and atherosclerosis. (oaepublish.com)
Predictive Models1
- Evaluating the Feasibility of Machine-Learning-Based Predictive Models for Precancerous Cervical Lesions in Patients Referred for Colposcopy. (cdc.gov)
Survival1
- Machine learning models for predicting one-year survival in patients with metastatic gastric cancer who experienced upfront radical gastrectomy. (cdc.gov)
Dependence2
- and using reference values derived by valid and biologically meaningful statistical models, taking into account the dependence of lung function with age. (ersjournals.com)
- Mathematical modeling predicted the dependence of solute clearances on the extent to which solutes were taken up by the carbon block and were bound to plasma proteins.RESULTS: By itself, the conventional system provided clearances of the tightly bound solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) of only 18±10 and 19±11 ml/min, respectively (mean±sd). (stanford.edu)
HFpEF1
- We aim to recruit 75 VCI patients, 60 HFpEF patients, 60 patients with severe aortic stenosis (AS) undergoing surgical aortic valve replacement as a pressure overload HFpEF model, and 200 elderly participants with mixed comorbidities to serve as controls. (unav.edu)
Simulation2
- The model building and simulation were performed using NONMEM® (ver. (biomedcentral.com)
- It is demonstrated that the model is in much better agreement with the simulation data than the classical Stokes solution, improving the prediction in 63% of the studied cases. (imperial.ac.uk)
Premature1
- Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. (oaepublish.com)
Therapeutic1
- 3) Cardiovascular actions of relaxin and its therapeutic potential in the context of three pathologies: (i) relaxin-induced maternal vascular remodeling and associated functional benefits in preeclampsia, (ii) relaxin-induced left atrial remodeling and suppression of atrial fibrillation, and (iii) relaxin-induced left ventricular remodeling and associated functional benefits in the setting of diastolic dysfunction. (pitt.edu)
Glucose1
Differences1
- Cox proportional hazard model was used to analyze travel time differences for colon versus rectal cancer patients. (cdc.gov)
Diagnostic1
- Furthermore, to compare the diagnostic performance of radiomics models against standard-of-care qualitative visual assessment of stress perfusion images, w. (researchgate.net)
Function1
- 2) The role of pulsatile arterial load (vascular stiffness in particular) in cardiovascular function. (pitt.edu)
Assessment1
- Application of Cardiovascular Computed Tomography to the Assessment of Patients With Hypertrophic Cardiomyopathy. (ottawaheart.ca)
Fatty1
- The aim of the current study was to predict changes in plasma methionine and homocysteine concentrations after simulated consumption of methionine-rich foods, following the development of a mathematical model for MMC in Zucker Diabetic Fatty (ZDF) rats, as a representative T2DM animal model. (biomedcentral.com)
Experiments1
- The model is validated using a large set of numerical simulations covering a wide range of flow regimes representative of those used in laboratory experiments. (imperial.ac.uk)
Research1
- Nature Cardiovascular Research. (elsevierpure.com)
Left2
- Aims Left ventricular systolic dysfunction (LSVD) is a heterogeneous condition with several factors influencing prognosis. (researchgate.net)
- Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. (ucsf.edu)
High1
- Here, we focused on the fact that a high-fat diet affects the metabolism of both methionine and homocysteine in a diabetic rat model [ 14 ]. (biomedcentral.com)
Significant1
- ATSDR acknowledges that a considerable amount of judgment may be required in establishing whether an end point should be classified as a NOAEL, 'less serious' LOAEL, or 'serious' LOAEL, and that in some cases, there will be insufficient data to decide whether the effect is indicative of significant dysfunction. (cdc.gov)