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  • mice
  • To investigate the involvement of NOD2 in the pulmonary vascular response to hypoxia, we subjected wild-type and NOD2-deficient mice to chronic normobaric hypoxic conditions. (oncotarget.com)
  • Pulmonary vascular remodeling in NOD2-deficient mice was characterized by increased PASMC proliferation. (oncotarget.com)
  • 2000
  • Thus, hemodynamic forces affecting ECs may play a role in both the development and prevention of vascular disease (Pohlman and Harlan, 2000). (springer.com)
  • mechanisms
  • 1,2 Thus, understanding the molecular mechanisms that control hyperplastic growth and the locomotion of vascular cells should aid in the development of novel therapeutic strategies to reduce neointimal thickening. (ahajournals.org)
  • Objective: The aim of this study was to determine the roles of AMPK alpha in the development of vascular neointima hyperplasia and to elucidate the underlying mechanisms. (rti.org)
  • 7 Although the molecular basis of the mechanisms involved for the development of vascular disease in diabetes mellitus is poorly understood, several lines of evidences demonstrate impairment in endothelium-dependent relaxation of diabetic blood vessels. (ahajournals.org)
  • Pathway
  • The infection of rat carotid arteries with recombinant adenovirus encoding SM22α inhibited neointimal hyperplasia via suppression of the Raf-1-MEK1/2-extracellular signal-regulated kinase 1/2 signaling pathway. (ahajournals.org)
  • Similarly, DLL4 activity was suppressed when the basal activin-like kinase-1-Smad1/5/9 pathway was inhibited, showing that these pathways are interdependent. (ahajournals.org)
  • A role for the Notch pathway in regulating vascular development was initially suggested based on findings from the analysis of several targeted mouse mutants in Notch pathway components. (biologists.org)
  • modulation
  • Moreover, the proto-oncogene c- myc plays a key role in p27 sequestration through modulation of the level of cyclin D and E proteins. (ahajournals.org)
  • occlusive
  • These findings might have important implications for the development of novel therapeutic strategies targeting the fibroproliferative/migratory component of vascular occlusive disorders. (ahajournals.org)
  • formation
  • COX-2 inhibitors increase CRMP-1 expression by inhibiting Sp1-DNA complex formation and enhancing DNA binding of C/EBPα at the promoter. (aacrjournals.org)
  • However, the role of SS in the vascular remolding and neointimal formation has not been completely clarified, especially disturbed flow in vivo. (biomedcentral.com)
  • Ligand-dependent complex formation between the Angiotensin II receptor subtype AT2 and Na+/H+ exchanger NHE6 in mammalian cells. (embl.de)
  • 22 In our recent study, we have demonstrated via microarray analysis that miR-221 and miR-222 are upregulated in vascular walls with neointimal lesion formation. (ahajournals.org)
  • neointimal hyperplasia
  • The vascular sections were embedded in paraffin blocks for morphometric analysis to evaluate neointimal hyperplasia, and anti-CD31 immunohistochemical staining was for endothelialization ratio. (biomedcentral.com)
  • However, the upstream SS of the stenosis can promote vascular re-endothelialization after balloon injury compared with normal SS, verified by endothelialization ratio (0.36 ± 0.03 vs 0.32 ± 0.03, P = 0.017), thereby attenuate neointimal hyperplasia (64,851 ± 3995 vs 68,335 ± 3867, P = 0.018). (biomedcentral.com)
  • cell cycle
  • CDK-dependent pRb hyperphosphorylation releases E2F transcription factors, thus contributing to the expression of several growth and cell cycle-regulatory genes with functional E2F-binding sites in their promoters. (ahajournals.org)
  • Arterial
  • Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: a "set up" for vascular disease. (springer.com)
  • Regeneration of arterial endothelium after injury is critical for the maintenance of normal blood flow, cell trafficking, and vascular function. (embopress.org)
  • development
  • This is at least partly due to a progressive impairment of the cellular processes regulating cardiac and vascular homeostasis, finally leading to the development of cardiovascular pathologies. (hindawi.com)