• In Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology . (nature.com)
  • We particularly use single cell genomics coupled with systems biology approaches, large scale genetic screens, CRISPR genome editing and transgenesis to characterise molecular mechanisms. (edu.au)
  • We are using single cell genomics and a forward genetic screen in zebrafish to discover new genes and molecular mechanisms that control the maturation and function of pericytes and BBB endothelial cells. (edu.au)
  • We are utilising biosensors that report signalling events and multiple imaging modalities to directly observe real-time molecular functions in cells in normal development and disease models in vivo. (edu.au)
  • Her major research interests are focused on the molecular control of endothelial cell function in health and disease. (rvc.ac.uk)
  • Her laboratory specialises in investigating the functional relevance of molecular signalling pathways in human and animal endothelial cells and a range of other vascular cell types. (rvc.ac.uk)
  • The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)
  • focus is primarily on vascular cell function with emphasis on understanding molecular control mechanisms. (rvc.ac.uk)
  • This method facilitates the identification of markers of vascular activation and provides a molecular framework to understand the contribution of vascular dysfunction to the organ pathology of systemic inflammation. (lu.se)
  • Methods in molecular biology (Clifton, N.J. (lu.se)
  • In order to understand what kind of intracellular molecular changes should be expected to occur during the medium change, we analyzed global protein expression changes using nano-LC-MS/MS in smooth muscle cell cultures that were isolated and grown in one medium formulation and temporarily switched to the other. (tubitak.gov.tr)
  • The three physicians "found the molecular switch that regulates how our cells adapt when oxygen levels drop," said Randall Johnson, a member of the Nobel Committee. (npr.org)
  • Current work includes in vitro profiling of human pulmonary artery endothelial cells with heterogeneous PAH-associated molecular defects in order to investigate molecular mechanisms that can exploited therapeutically. (nih.gov)
  • Molecular Biology of the CELL, 4th edition, Alberts et al. (wikidoc.org)
  • Nature Structural & Molecular Biology. (montana.edu)
  • Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism. (nih.gov)
  • He was born in Baltimore, Maryland, and received his bachelor's degree in Molecular and Cell Biology from Johns Hopkins University. (rochester.edu)
  • Humana Press , p. 181-200 (Methods in molecular biology (Clifton, N.J. (lu.se)
  • Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)
  • Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis. (cdc.gov)
  • Always an innovator, Dr Rosai embraced technologies like electron microscopy, immunohistochemistry, and molecular biology to enhance pathologic diagnosis. (who.int)
  • Nishiwaki, Y., Yoshida, M., Masuda, H. and Isobe, M. (2004) Recruitment of bone marrow-derived endothelial progenitor cells to vascular endothelium involves E-selectin dependent mechanism. (scirp.org)
  • Endothelial cells (ECs) form the endothelium, a layer of single-cell thickness that coats the interior wall of all blood vessels including arteries, capillaries, and veins. (beckman.com)
  • The focus of the Pulmonary Vascular Biology Lab, led by Dr. Jason Elinoff, is the interplay between lung vascular endothelium and immune effector cells and their contributions to the development and progression of pulmonary arterial hypertension (PAH). (nih.gov)
  • The endothelium is the thin layer of cells that line the interior surface of blood vessels , forming an interface between circulating blood in the lumen and the rest of the vessel wall. (wikidoc.org)
  • Three scientists who made important discoveries about how cells sense and adapt to different oxygen levels have won the Nobel Prize in physiology or medicine, in the first announcement of Nobel winners for 2019. (npr.org)
  • More specifically, she and her team investigate (i) endothelial progenitor cells, (ii) leukocyte trafficking and (iii) activation of the vasculature during diseases such as heart disease, breast cancer, melanoma and allergy. (sa.gov.au)
  • Dr Bonder's research has culminated in important advances in this area, including (i) identifying the adhesion molecules used by leukocyte subsets and progenitor cells to traffic to inflamed organs, (ii) defining mediators of endothelial progenitor cell function and differentiation and (iii) identifying key surface expressed receptors which regulate major cell survival signals. (sa.gov.au)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Endothelial progenitor cells (EPCs) are bone marrow-derived haematopoietic progenitor cells that have been implicated in vasculogenesis. (scirp.org)
  • These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane. (rupress.org)
  • This work has uncovered unexpected mechanisms in angiogenesis during wound repair and allowed us to study cell-cell adhesion mechanics in developing tissues. (edu.au)
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
  • She is particularly known for her work on mechanisms of vascular endothelial eicosanoid generation and recent studies have identified biological roles for novel fatty acid metabolites in vascular repair and angiogenesis. (rvc.ac.uk)
  • Dr Claudine Bonder is a Heart Foundation Fellow and Head of the Vascular Biology and Cell Trafficking Laboratory at the Centre for Cancer Biology in Adelaide, South Australia. (sa.gov.au)
  • To support research in the Vascular Biology and Cell Trafficking Laboratory, please contact the Royal Adelaide Hospital Research Fund . (sa.gov.au)
  • Flavor additives used in electronic cigarettes and related tobacco products could impair blood vessel function and may be an early indicator of heart damage, according to new laboratory research in Arteriosclerosis, Thrombosis and Vascular Biology , an American Heart Association journal. (sciencedaily.com)
  • Researchers found all nine flavors were dangerous to cells in the laboratory at the highest levels tested and all the flavorings impaired nitric oxide production in endothelial cells in culture (outside of the body). (sciencedaily.com)
  • She co-ordinated the Comparative Physiology and Medicine reserach programme for 3 years (2009-2012) Caroline's major research interest is in endothelial cell signalling. (rvc.ac.uk)
  • The vasculature has a crucial function in normal physiology, enabling the transport of oxygen and nutrients to cells throughout the body. (duke.edu)
  • Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. (unboundmedicine.com)
  • The 2023 Vascular Cell Biology GRS aims to shine a light on new, unpublished research, and harbor discussion and collaboration, in a relaxed and informal environment so that novel and experienced researchers can interact. (grc.org)
  • The 2023 GRS on Vascular Cell Biology promises an exciting program of scientific presentations, mentoring panel, and social interactions that are sure to bring together collaborations that may last decades. (grc.org)
  • Endothelial cell heterogeneity across vascular beds, as well as their metabolism, are increasingly being uncovered thanks to single cell RNA-sequencing and other state-of-the-art tools. (grc.org)
  • Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A. Sci Rep. 2020 May 12;10(1):7849. (rvc.ac.uk)
  • Human-derived hepatic cell lines are a valuable alternative to primary hepatocytes for drug metabolism, transport and toxicity studies. (cancerindex.org)
  • It is a great opportunity to expand your knowledge on the upcoming science in the field of vascular biology, as well as make professional connections that will be relevant to your future. (grc.org)
  • Journal Club: The NAVBO Journal Club is a regular program that brings together NAVBO members to discuss recent, impactful publications in the field of vascular biology. (wikipedia.org)
  • 4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
  • ABSTRACT Allergic contact dermatitis to cement is a delayed-type hypersensitivity reaction in which cytokines interferon-gamma (IFN-) and vascular endothelial growth factor (VEGF) may be involved in persisting erythema and oedema. (who.int)
  • VEGF pour vascular endothelial growth factor) peuvent être impliqués dans des érythèmes ou des oedèmes persistants. (who.int)
  • From her research training during her PhD at Flinders University and post-doctoral position at the University of Calgary (Canada) she has gained expert experience in vascular and cellular biology, immunology, inflammation and imaging. (sa.gov.au)
  • Surface associated glycoproteins of endothelial origin, or derived from pericytes, intravascular leukocytes, and plasma, are other important components of the glycocalyx, constituting a vascular cell surface proteome that is dynamic, tissue-specific, and sensitive to changes in vascular homeostasis, blood infection, and inflammation. (lu.se)
  • This monolayer of cells is an important endocrine organ, and has been shown to play a major role in regulating blood fluidity, the transfer of solutes and macromolecules, immune responses and inflammation. (beckman.com)
  • Atherosclerosis is a disease of large and medium-sized muscular arteries and is characterized by endothelial dysfunction, vascular inflammation, and the buildup of lipids, cholesterol, calcium, and cellular debris within the intima of the vessel wall. (medscape.com)
  • Lymphatics function to drain tissue fluid and traffic immune cells, but are also utilised by tumours to metastasise to lymph nodes and secondary sites in cancer. (edu.au)
  • Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
  • This pathway plays a prominent role in inter- and intracellular communication and subversion can lead to cancer, fibrosis vascular disorders, and immune diseases. (lu.se)
  • In this study, we intended to investigate the effects of growth factor-rich medium on the protein expression of vascular SMCs in culture. (tubitak.gov.tr)
  • Fibrogenic mediators, including Fibroblast Growth Factor-2, Vascular Growth Factor, Transforming Growth Factor â1 (TGF-â1), and Platelet Derived Growth Factor-A, were analyzed using Western Blots and end point ELISA. (cdc.gov)
  • Arteriosclerosis, thrombosis, and vascular biology 2018 6 38 (8): 1913-1925. (cdc.gov)
  • In turn, the cell types specified will play a role in maintaining homeostasis and responding to disease. (grc.org)
  • The society organises several international scientific meetings annually which broadly cover the areas of development of blood and lymphatic vasculature, cardiovascular and lymphatic disease, vascular matrix biology and vascular bioengineering. (wikipedia.org)
  • Although lipid lowering and lifestyle management have reduced the number of deaths from heart disease, coronary artery disease still dominates as the major cause of death in people with heart disease, so we haven't cured the disease yet," said Sessa, who directs Yale's vascular biology and therapeutics program. (constantcontact.com)
  • Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
  • Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
  • Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
  • Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
  • Stem cells as a new treatment for peripheral artery disease: Hype or hope? (iospress.com)
  • Because many of patients with peripheral arterial disease are not eligible for direct or conventional revascularization procedures, because stem cell therapy is being investigated as to its possible role in the treatment of limb ischemia, there is a need to evaluate this treatment and his true appl ication. (iospress.com)
  • The adverse effects observed with chemical flavor additives on endothelial cells could be early warning signs of future heart disease, researchers say. (sciencedaily.com)
  • The scientists studied hypoxia - low oxygen levels - and while many people might know about that condition because of its link to high altitude, Ratcliffe has called hypoxia "an important component of many human diseases including cancer, heart disease, stroke, vascular disease, and anemia. (npr.org)
  • There is an increased risk of vascular disease in diabetes that is a major cause of patient morbidity and mortality. (diabetesjournals.org)
  • Unlike selective pulmonary vasodilators alone, approaches directed at inflammatory vascular remodeling have the potential to arrest or even reverse the disease. (nih.gov)
  • We aim to identify type 2 diabetes-induced, cell type-specific alterations in islet and intestinal cells that explain why the disease develops. (lu.se)
  • The clinical spectrum and prognostic factors of Erdheim-Chester disease and mixed Langerhans cell histiocytosis and Erdheim-Chester disease. (cdc.gov)
  • As a researcher, Dr Rosai advanced our collective knowledge in numerous fields - his publications provide the first descriptions of many entities (including a disease that bears his name, Rosai-Dorfman disease, and the sarcoma of young adults, desmoplastic small round cell tumour), as well as seminal contributions about more than 75 different entities. (who.int)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • When the culture broth extract of P. polonicum (EEPP) was subjected to LPS-induced cytokines expression (ELISA in RAW 264.7 cells), it exhibited inhibition of TNF-α, IL-6 and IL-1ß and this encouraged us to do chemical investigation on EEPP to explore the bioactive components. (bvsalud.org)
  • Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)
  • Both blood and lymphatic capillaries are composed of a single layer of endothelial cells. (wikidoc.org)
  • It is a complex multistep process by which cancer cells detach from a primary tumor and enter into the bloodstream, then migrate through the vascular system as single or cluster of cells, known as circulating tumor cells (CTC), and finally colonize a secondary organ. (tudelft.nl)
  • Although a primary tumor cell releases up to 3-4 million cells/gram every day, fewer than only 0.01% manage metastasize. (tudelft.nl)
  • Here, we describe an experimental protocol to chemically tag and quantify the vascular cell surface proteome in murine models of bacteremia, in a time-resolved and. (lu.se)
  • During medical school, his research focused on the vascular morphology and mural cells of the murine germinal matrix. (rochester.edu)
  • The adherens junction provides strong cell-cell adhesion mediated by the cadherin-catenin complex via its linkage to the actin cytoskeleton ( Wheelock and Johnson, 2003 ). (rupress.org)
  • however, the interrelationship and functional contribution of the individual cadherins in cell adhesion and signaling is poorly understood. (rupress.org)
  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (antibodies-online.com)
  • Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in cerebral vascular smooth muscle cells (VSMCs) generates an Aβ non-clearing VSMC phenotype through transactivation of sterol regulatory element binding protein-2, which downregulates low density lipoprotein receptor-related protein-1, a key Aβ clearance receptor. (nature.com)
  • The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
  • Current work includes detailed genetic analysis of pathways including the CCBE1/VEGFC/VEGFR3 pathway, the Hippo pathway, the role of alternative pre-mRNA splicing and the role of the cell fate regulator Prox1. (edu.au)
  • Directly observing key molecules and pathways as they act to control tissue formation, or as they drive pathological phenotypes, is a major challenge in cell biology. (edu.au)
  • Muller, W.A. (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (scirp.org)
  • Vascular dysfunction is a hallmark of systemic inflammatory responses such as bacterial sepsis. (lu.se)
  • Hence, the prevailing view is that N-cadherin's primary function in ECs is to promote heterotypic cell interactions with mural cells. (rupress.org)
  • King's College London) fuelled her interest in vascular cellular signalling and her subsequent post-doctoral position with Professor Jeremy Pearson at King's College London (KCL) allowed her to pursue this interest in human endothelial cells. (rvc.ac.uk)
  • Using single cell RNA sequencing, we aim to identify which cellular processes are affected by type 2 diabetes and in which islet and small intestinal cell type this occurs. (lu.se)
  • Vascular networks in all organs are the product of coordinated signals during development which specify cell identity. (grc.org)
  • To investigate the role of N-cadherin in vascular development, N-cadherin was specifically deleted from endothelial cells in mice. (rupress.org)
  • Embryonic development occurs with precisely timed morphogenetic cell movements directed by complex gene regulation. (duke.edu)
  • Other topics include the development of computational models for root and shoot growth, as well as chemical tools and synthetic systems to understand auxin biology. (cshlpress.com)
  • Contrary to previous studies, we found that N-cadherin localizes to endothelial cell-cell junctions in addition to its well-known diffusive membrane expression. (rupress.org)
  • Joint Meeting of the European Society for Microcirculation (ESM) European Vascular Biology Organisation (EVBO). (karger.com)
  • This buildup results in plaque formation, vascular remodeling, acute and chronic luminal obstruction, abnormalities of blood flow, and diminished oxygen supply to target organs. (medscape.com)
  • On the basis of experimental data, preliminary clinical studies have established the safety and feasibility of stem cells implantation in case of critical limb ischemia. (iospress.com)
  • Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)
  • Recent technological advances have provided insights into mechanistic details of auxin signaling and its many roles in plant biology. (cshlpress.com)
  • hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
  • In this research, I will collaborate with my primary host institute (Pouyan Boukany, Chemical Engineering, TU Delft) and secondary support institute (Amin Doostmohammadi, Neils Bohr Institute, University of Copenhagen) to study the migration of cancer cells in a model in-vitro system mimicking the vascular network. (tudelft.nl)
  • Therefore, the in-vitro cell culture systems can be used for mechanistic studies and screening tests for MWCNT and similar fibrogenic nanoparticle s. (cdc.gov)
  • The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia. (diabetesjournals.org)
  • CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
  • Cells and tissues are constantly experiencing changes in oxygen availability," Johnson said. (npr.org)
  • This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)
  • Endothelial cells form a semi-permeable barrier between the blood and surrounding tissues within all blood vessels in the body. (beckman.com)
  • Basement membrane (BM) is a sheet-like extracellular matrix that underlies most tissues and acts as a barrier to invading cells. (duke.edu)
  • In a study published in 2006 in the journal Cell, researchers in France found that resveratrol protects mice against diet-induced insulin resistance and obesity. (lifeextension.com)
  • The researchers also studied the cell-signaling pathway in the mitochondria of these mice. (lifeextension.com)
  • RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)
  • This pathway is basally active in mesenteric artery endothelial cells, but, after exposure to intermittent hypoxia to mimic sleep apnea, nuclear factor of activated T cells c3 nuclear translocation and CSE expression are decreased, concomitant with decreased CSE-dependent vasodilation. (unboundmedicine.com)
  • Despite a significant progress made in the cancer biology, what makes these few cells to cause metastasis bypassing the complex vascular network remains unknown. (tudelft.nl)
  • During the Expo, engineering students Alana Hayes '24 and Ryan Jaworski '25 and biology students Elia Haghbin '26, Eliza Hogan '24, Grace Lombardi '25, and Elizabeth Ricci '23 presented phase one of their original research, "Developing a Human Blood Vessel Using 3D Bioprinting and Cell Culturing Techniques. (fairfield.edu)
  • The Journal of Vascular Research /European Society for Microcirculation (JVR/ESM) Award aims to spotlight important and growing fields of research with high impact for vascular biology and the microcirculation, with the goal of giving an award to one of the most prominent researchers in the field. (karger.com)
  • Angiography reveals a highly vascular lesion with vessels oriented parallel to one another. (medscape.com)