Vascular cell adhesion regulates vascular endothelial. Medical search. Frequent questions

The vascular endothelium, the innermost layer of blood vessels, provides a dynamic interface between the circulating blood and various tissues/organs and thereby maintaining tissue homeostasis. (nature.com)
Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
Hence, endothelial dysfunction, a predictor of several cardiovascular diseases (CVDs), is caused by imbalance between vasodilating and vasoconstricting agents, including NO, endothelium-derived hyperpolarizing factor, prostacyclin, or vasoconstrictive factors such as thromboxane (TXA 2 ) and endothelin-1 (ET-1) [ 8 ]. (hindawi.com)
In the first phase of the extravasation process, selectins such as L-selectin on leukocytes and E- and P-selectin on endothelial cells lead to a loose connection that permits tethering and rolling of leukocytes on the endothelium under hydrodynamic shear [ 10 ]. (biomedcentral.com)
Yet, endothelium deletion of miR-181a2b2 did not affect body weight, lipid metabolism, anti-inflammatory Ly6C low or the pro-inflammatory Ly6C interm and Ly6C high fractions in circulating peripheral blood mononuclear cells (PBMCs), and pro-inflammatory or anti-inflammatory mediators in both bone marrow (BM) and PBMCs. (unl.edu)
Our study establishes that deficiency of a miRNA specifically in the vascular endothelium is sufficient to profoundly impact atherogenesis. (unl.edu)
Implantation of synthetic grafts without this endothelium barrier may lead to surface protein adsorption followed by platelet adhesion, activation, and aggregation. (biomedcentral.com)
Regardless of the approach chosen, the surface of the prosthesis must enhance the adhesion and proliferation of ECs, to enable restoration of a functional endothelium and, as a result, to reduce clotting processes. (biomedcentral.com)
Therefore, our research focuses on elucidating the mechanisms by which VWF fragments may regulate the permeability of stimulated endothelium. (neurologycongress.com)
Endothelial inflammation increases the adhesiveness of monocytes to the endothelium in addition to increasing vascular permeability, promoting diabetic atherogenesis. (spandidos-publications.com)
Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes). (oskar-bordeaux.fr)
Human CD38, a surface molecule expressed by immature and activated T and B lymphocytes, has been characterized as a molecule transducing activation and proliferation signals, and intervening in adhesion to endothelium via its ligand CD31. (nih.gov)
Atherosclerosis and endothelial dysfunction are diffuse disease processes affecting coronary and peripheral arteries, hence, the physiological basis in assessing endothelium-dependent vasomotion in peripheral vessels. (escardio.org)
Dysfunctional endothelium leads to increased permeability to lipoproteins and up-regulation of leukocyte and endothelial adhesion molecules. (medscape.com)
These mediators are no longer produced when the vascular endothelium is disrupted. (msdmanuals.com)

Inhibition of cancer progression occurs through mir-126s negative control of proliferation, migration, invasion and cell survival, while mir-126 also may support cancer progression through the promotion of blood vessel formation and inflammation at the site of activation. (wikipedia.org)
She completed her graduate training in the lab of Charles Lowenstein M.D. and her work linked the expression of an endothelial microRNA play to vascular inflammation. (utsouthwestern.edu)
The role of NO in vascular homeostasis also comes from the negative regulation on coagulation and inflammation operated by this signaling molecule. (hindawi.com)
Mechanistically, bulk RNA-seq and gene set enrichment analysis of ECs enriched from the aortic arch intima, as well as single cell RNA-seq from atherosclerotic lesions, revealed that endothelial miR-181a2b2 serves as a critical regulatory hub in controlling endothelial inflammation, cell adhesion, cell cycle, and immune response during atherosclerosis. (unl.edu)
Endothelial miR-181a2b2 deficiency regulates multiple key pathways related to endothelial inflammation, cell adhesion, cell cycle, and immune response involved in the development of atherosclerosis. (unl.edu)
Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation. (nih.gov)
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. (escholarship.org)
In addition to its role in promoting endothelial permeability and proliferation, VEGF may contribute to inflammation and coagulation. (mdm2-inhibitors.com)
Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis. (cdc.gov)
The proatherogenic and atheroprotective effects of d-flow and s-flow are mediated in part by the global changes in endothelial cell (EC) gene expression, which regulates endothelial dysfunction, inflammation, and atherosclerosis. (cdc.gov)
Functionally, KLK10 protected against d-flow-induced permeability dysfunction and inflammation in human artery ECs, as determined by NFB activation, expression of vascular cell adhesion molecule 1 and intracellular adhesion molecule 1, and monocyte adhesion. (cdc.gov)
Furthermore, treatment of mice in vivo with rKLK10 decreased arterial endothelial inflammation in d-flow regions. (cdc.gov)
Adhesion proteins control leukocyte migration from the blood stream to the tissue and each step of this migration event is regulated by specific adhesion molecules both on leukocytes and endothelial cells, which increase during inflammation [ 17 ]. (biomedcentral.com)
Under normal conditions VAP-1 is mainly intracellular, but under inflammatory stimulation it is expressed at the cell membrane of activated endothelial cells and is shed into the blood stream, increasing VAP-1 levels in the blood that can serve as a biomarker for inflammation [ 24 ]. (biomedcentral.com)

Mir-126 is a human microRNA that is expressed only in endothelial cells, throughout capillaries as well as larger blood vessels, and acts upon various transcripts to control angiogenesis. (wikipedia.org)
It also suppresses metastatic endothelial recruitment, angiogenesis and colonisation, through interaction with its target genes IGFBP2, PITPNC1, and MERTK. (wikipedia.org)
This issue is of particular relevance since changes in NO release could play an important role in endothelial function maintenance, in addition to regulating proliferation of smooth muscle cells, leukocyte adhesion, platelet aggregation, angiogenesis, thrombosis, vascular tone, and hemodynamics. (hindawi.com)
The ability to form a variety of cell-matrix connections is crucial for angiogenesis to take place. (uea.ac.uk)
Tetraspanin Compact disc151 is expressed in endothelial cells and regulates pathologic angiogenesis highly. (biospraysehatalami.com)
In an investigation of testisin's function in endothelial cells we identified testisin as a novel regulator of physiological hormone-induced angiogenesis and microvascular endothelial permeability. (umaryland.edu)
Together, these data identify testisin as a novel regulator of VE-cadherin adhesions during angiogenesis and indicate a potential new target for regulating neovascular integrity and associated pathologies. (umaryland.edu)
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. (harvard.edu)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)

He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Our findings reveal a critical role for Lyn kinase in modulating inflammatory signals, regulating microvascular permeability and neutrophil recruitment, and in promoting hepatic fibrosis. (nature.com)
Fragments of VWF regulate permeability in endothelial cells and play a role in vascular permeability in a TBI mouse model. (neurologycongress.com)
We used biolayer interferometry, immunofluorescence and immunohistochemistry approaches to analyze vascular permeability during endothelial stimulation. (neurologycongress.com)
A1A2A3 GOF fragment shown to be effective to rescue permeability at 24 hrs in human microvascular endothelial cells under stimulation with IL-1β. (neurologycongress.com)
Based on our experimental data we conclude that VWF is essential to maintain vascular permeability. (neurologycongress.com)
This presentation will help to understand the mechanisms mediated by VWF in the control of vascular permeability. (neurologycongress.com)
The effects of oxLDL‑mediated inflammasome activation on endothelial permeability under HG conditions, in addition to the effects of rosmarinic acid on these oxLDL‑mediated processes, also remain poorly understood. (spandidos-publications.com)
Therefore, the present study aimed to elucidate the mechanisms involved in oxLDL‑induced endothelial permeability and monocyte diapedesis under HG conditions, in addition to the potential effects of rosmarinic acid. (spandidos-publications.com)
In addition, oxLDL‑stimulated ECs under HG conditions exhibited increased phosphorylated VE‑cadherin protein levels and decreased ZO‑1 protein expression levels compared with those in untreated ECs, suggesting increased endothelial permeability. (spandidos-publications.com)
A number of studies have previously suggested that vascular endothelial dysfunction caused by increased junctional permeability is a key event in the development and progression of atherosclerosis and atherosclerotic cardiovascular diseases ( 3 , 4 ). (spandidos-publications.com)
Figure 1 CD151 reinforces vascular stability and regulates vascular permeability. (biospraysehatalami.com)
DHF and DSS are characterized by increased vascular permeability and hemorrhagic manifestations [2], with the former phenotype acknowledged as the hallmark of these severe forms of Dengue. (mdm2-inhibitors.com)
VEGF/vascular permeability factor (VPF) was first recognized and characterized as a potent stimulator of endothelial permeability [4], and was shown to increase vascular permeability 50,000 fold more 312637-48-2 manufacture efficiently than histamine [5]. (mdm2-inhibitors.com)
Moreover, testisin siRNA knockdown increased the paracellular permeability to FITC-albumin across endothelial cell monolayers, which was associated with decreased expression of the adherens junction protein VE-cadherin and increased levels of phospho-(Tyr658)-VE-cadherin, without affecting the levels of the tight junction proteins occludin, claudin-5, or ZO-1. (umaryland.edu)

SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury. (nature.com)
The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)
A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)
Fig. 1: SARS-CoV-2 induced endothelial dysfunction. (nature.com)
SARS-CoV-2 infection alters the balance of endothelial protective molecules and endothelial damaging molecules, leading to endothelial dysfunction. (nature.com)
Endothelial dysfunction during diabetes has been previously reported to be at least in part attributed to increased oxidized low‑density lipoprotein (oxLDL) levels mediated by high glucose (HG) levels. (spandidos-publications.com)
These results suggest that rosmarinic acid can exert a protective effect against oxLDL‑mediated endothelial dysfunction under HG conditions by reducing the interaction between monocytes and ECs in addition to preventing monocyte diapedesis. (spandidos-publications.com)
Chronic metabolic disorders, such as hyperglycemia and dyslipidemia, promote endothelial dysfunction and eventually leakage, resulting in increased monocyte diapedesis ( 5 - 7 ). (spandidos-publications.com)
Endothelial dysfunction during diabetes is closely associated with increased oxidized low-density lipoprotein (oxLDL) levels mediated by high glucose (HG) conditions ( 8 ). (spandidos-publications.com)
Endothelial dysfunction is an early marker of atherosclerosis and levels of vascular relaxation are an indicator of endothelial health. (escardio.org)
Moreover, endothelial dysfunction has been shown in varied populations to be a predictor of cardiovascular events. (escardio.org)
In patients with endothelial dysfunction, this process is disturbed and results in decreased vasodilation, thus demonstrating the dysfunction. (escardio.org)
A lack of vasodilation would suggest decreased release of endogenous vasodilators and therefore, endothelial dysfunction, thus indicating future cardiovascular risk: increased risk for future cardiovascular events and a potential need for revascularisation (5). (escardio.org)
The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia. (diabetesjournals.org)
CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
Potential causes of endothelial dysfunction include sheer stress related to hypertension, oxidized low-density lipoprotein (LDL), homocysteine, and smoking. (medscape.com)
Centre to participate in the study as con- lar endothelial dysfunction, and plays an trols. (who.int)
However, the biomarkers sICAM-1 and sE-selectin (as mechanism of this immune dysregulation markers of endothelial dysfunction) in dia- is still unclear. (who.int)

Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
The local tumour microenvironment is the milieu within which the tumour develops, and includes tumour blood vessels, other cells types (e.g. immune cells, fibroblasts, adipocytes), soluble growth factors and signalling molecules. (otago.ac.nz)
Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive molecules. (nature.com)
Adhesion molecules are important for the extravasation of neutrophils into organs where they may exhibit detrimental effects. (biomedcentral.com)
Therefore, we investigated the in vitro effect of DHEA on the expression pattern of adhesion molecules of human endothelial cells and neutrophils. (biomedcentral.com)
Activated by cytokines and chemokines, leukocytes and endothelial cells express distinct adhesion molecules on their cell surfaces [ 9 ]. (biomedcentral.com)
These adhesion molecules enable the deceleration of blood cells on the endothelial layer in order to enable subsequent diapedesis. (biomedcentral.com)
The importance of adhesion molecules in traumatic and septic diseases has been widely recognized. (biomedcentral.com)
NF-κB is a transcription factor that plays a pivotal role in the highly specific pattern of gene expression observed for immune, inflammatory and acute phase response genes, including interleukin 1, interleukin 8, tumor necrosis factor and certain cell adhesion molecules. (justia.com)
Subsequently, rosmarinic acid treatment significantly reversed oxLDL‑induced overexpression of adhesion molecules and monocyte‑EC adhesion, oxLDL‑induced endothelial junction hyperpermeability and monocyte transmigration through the endothelial monolayer under HG conditions, in a dose‑dependent manner. (spandidos-publications.com)
Functional studies reveal that NOR1 increases monocyte adhesion by inducing the expression of adhesion molecules VCAM-1 and ICAM-1 in endothelial cells. (uky.edu)
MicroRNA (miRNA) molecules, a series of single-stranded non-coding RNA chains measuring 20-25 nucleotides in length, regulate gene expression at the transcriptional level by complementary pairing with target gene mRNA ( 5 ). (spandidos-publications.com)
For example, under conditions, VEGF induces the manifestation of several types of cell adhesion molecules, including E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1), in endothelial cells and promotes the adhesion of leukocytes [11], [12]. (mdm2-inhibitors.com)
Other trophic factors, such as IL-2, TNF-α, and granulocyte-macrophage stimulating factor, cause activated T cells to produce interferon-γ, TNF-α, and TNF-β, leading to stimulation of macrophages and further up-regulation of leukocyte adhesion molecules. (medscape.com)

Transport of NO and ROS by AQPs would be required for cell homeostasis to play a critical role in maintaining endothelial function. (hindawi.com)

RNAi A retrovirus-delivered shRNA system explained previously4 23 was used to knock down expression in human dermal microvascular endothelial cells (HMECs) and human umbilical vein endothelial cells (HUVECs). (biospraysehatalami.com)
MK2 were subjected to a knockdown by interfering RNA, the mRNA and protein levels of HuR in human pulmonary microvascular endothelial cells (HPMECs) were not affected. (biomedcentral.com)
Live cell imaging of in vitro cultured microvascular endothelial cells depleted of testisin by siRNA knockdown revealed that loss of testisin markedly impaired reorganization and tubule-like formation on Matrigel. (umaryland.edu)
RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)

Using a proprotein convertase subtilisin/kexin type 9 (PCSK9)-induced atherosclerosis mouse model, we demonstrated that endothelial cell (EC)-specific deletion of miR-181a2b2 significantly promoted atherosclerotic lesion formation, cell adhesion molecule expression, and the influx of lesional macrophages in the vessel wall. (unl.edu)
Previously, we identified kallikrein-related peptidase 10 (Klk10, a secreted serine protease) as a flow-sensitive gene in mouse arterial ECs, but its role in endothelial biology and atherosclerosis was unknown. (cdc.gov)
Experimental manipulation of DNA methylation in engineered human umbilical vein endothelial cells indicated that the identified differentially methylated probes located at TRIM6 , TLN2, and FLRT2 genes may play a role in endothelial cell adhesion and atherosclerosis. (biomedcentral.com)
According to the current paradigm, atherosclerosis is not a bland cholesterol storage disease, as previously thought, but a dynamic, chronic, inflammatory condition due to a response to endothelial injury. (medscape.com)
Infections and inflammatory conditions also contribute to endothelial injury and atherosclerosis. (medscape.com)

CXCL12 binds the receptor CXCR4 actively counteracting apoptosis and recruiting progenitor cells to the site of injury. (wikipedia.org)
Another approach, in situ endothelialization, is based on colonization with ECs in the patient's body, which is possible through transanastomotic growth, transmural infiltration, and endothelialization with endothelial progenitor cells circulating in bloodstream [ 7 ]. (biomedcentral.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Most type II PNH cells (total lack of GPI-linked protein) are due to a frame shift mutation occurring in the early hematopoietic progenitor cells, resulting in same mutation in all blood cell lines. (medscape.com)

There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
Cell 75:495, 1993), and a series of unique E6-AP homologous proteins have been identified (Huibregtse et al. (justia.com)
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
Endothelial cells (ECs) form a semi-permeable monolayer that separates the bloodstream from underlying tissues and regulate the infiltration of blood cells and proteins through the vessel wall ( 1 , 2 ). (spandidos-publications.com)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
Vascular adhesion protein 1 (VAP-1) is amongst these adhesion proteins. (biomedcentral.com)
Plexins are key cell-surface receptors of the semaphorin family of cell-guidance signalling proteins and can regulate cellular patterning by modulating the cytoskeleton and focal adhesion structures3-5. (ox.ac.uk)
Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. (medscape.com)
This classification was abandoned because of the observation that surface proteins were missing not only in the RBC membrane but also in all blood cells, including the platelet and white cells. (medscape.com)
The common denominator in the disease, a biochemical defect, appears to be a genetic mutation leading to the inability to synthesize the glycosyl-phosphatidylinositol (GPI) anchor that binds these proteins to cell membranes. (medscape.com)
Due to its location on the X chromosome, and due to X inactivation in female somatic cells, only one mutation is required in either males or females to abolish the expression of GPI-linked proteins. (medscape.com)
The absence of these regulating proteins results in uncontrolled amplification of the complement system. (medscape.com)

Among various mechanisms, the uncoupling of nitric oxide synthase (NOS) in vascular cells has also widely been reported to be involved in ROS generation. (hindawi.com)
Furthermore, superoxide anions can modify endothelial function by reducing nitric oxide (NO) biosynthesis and bioavailability [ 7 ]. (hindawi.com)
In physiological conditions, the lumen of the blood vessel is covered with endothelial cells (ECs), which actively counteract the processes of platelet aggregation and blood coagulation through the synthesis and secretion of various bioactive substances e.g.: nitric oxide, heparan sulphate, prostacyclin [ 6 ]. (biomedcentral.com)
It activates endothelial cells and stimulates nitric oxide release. (escardio.org)
High-resolution vascular ultra-sound investigation of the brachial artery before and during reactive hyperaemia (1) shows vasodilatation from the release of nitric oxide as a response to stress induced during increased blood flow. (escardio.org)
Various mechanisms, including endothelial cell nitric oxide and prostacyclin, promote blood fluidity by preventing platelet aggregation and dilating intact blood vessels. (msdmanuals.com)

Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)
Furthermore, we performed neutrophil adhesion assay to assess the adhering capacity after HuR silencing. (biomedcentral.com)

This review focuses on an emerging topic, the functional involvement of AQPs in ROS membrane transport, with specific regard to the movement of hydrogen peroxide and NO into and out of cells, in both health and oxidative stress-induced diseases. (hindawi.com)
Various studies have shown that eating onions can improve vascular function, including lipid profiles and oxidative status. (globalyogajourneys.com)
To investigate this, a recent study evaluated the effects of onion on lipid profile and oxidative status of plasma, vascular reactivity, and NOX activity in mesenteric microvessels of hypercholesterolemic Wistar rats. (globalyogajourneys.com)
To test this hypothesis, we inhibited vascular adhesion protein 1 (VAP-1), a membrane-bound protein expressed on the endothelial cell surface, that mediates leukocyte extravasation and induces oxidative stress. (biomedcentral.com)

In this dissertation, we demonstrate NOR1 expression in endothelial cells and sub-endothelial cells of human atherosclerotic lesions. (uky.edu)
PLXND1 is required for the response of endothelial cells to shear stress in vitro and in vivo and regulates the site-specific distribution of atherosclerotic lesions. (ox.ac.uk)

In addition, intact endothelial monolayer inhibits the proliferation of smooth muscle cells (SMCs), limiting the risk of intimal hyperplasia. (biomedcentral.com)

Endothelial cells derived from human umbilical cord were subjected to an lipopolysaccharide (LPS) challenge. (biomedcentral.com)
The potential functional role of DMPs was verified in a CRISPR/dCas9-Dnmt3a model in human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)

EGFL7 is known to be involved in cell migration and blood vessel formation, making EGFL7 and mir-126 opportune targets for disease, such as cancers, which require the continual formation of blood vessels to supply the tumour with nutrients and cell migration pathways to mediate tissue invasion. (wikipedia.org)
CRK, a protein involved in intracellular signal pathways involved in regulating cellular adhesion, proliferation, migration and invasion. (wikipedia.org)
Cyr61 is cleaved by plasmin within its VWF domain which generates an N-terminal fragment that is not associated with the matrix but retains the ability to induce endothelial cell migration. (rndsystems.com)
Neuropilin-2 (NRP2) is a widely expressed membrane-bound multifunctional non-tyrosine kinase receptor, which has previously been implicated in influencing cell adhesion and migration by interacting with α5-integrin and regulating adhesion turnover. (uea.ac.uk)
The data reported here support a model whereby NRP2 actively promotes EC adhesion and migration by regulating dynamic cytoskeletal remodeling and by stimulating Rab11-dependent recycling of α5-integrin-p-FAK complexes to newly assembling adhesion sites. (uea.ac.uk)
We assessed the effect of CD151 loss on cell migration and survival and found that CD151 silencing did not significantly alter (1) EC motility in Transwell migration (supplemental Physique 3A) and wound healing (data not shown) assays and (2) EC viability after being plated on Matrigel immediately (supplemental Figure. (biospraysehatalami.com)
VEGF was subsequently reported to promote the proliferation, migration, and survival of endothelial cells [6]. (mdm2-inhibitors.com)
We study the dynamic regulation of the actin and tubulin cytoskeletons in the context of cell adhesion, migration, invasion and phagocytosis. (linderlab.de)

In endothelial cells, PLXND1 is a direct force sensor and forms a mechanocomplex with neuropilin-1 and VEGFR2 that is necessary and sufficient for conferring mechanosensitivity upstream of the junctional complex and integrins. (ox.ac.uk)

Increased expression of mir-126 inhibits cell proliferation of non-small cell lung carcinoma cells in vitro and prevents tumour growth through the targeting of EGFL7. (wikipedia.org)
One of them is in vitro endothelialization, i.e. colonization of the prosthesis with the patient's cells before the implantation procedure. (biomedcentral.com)
Similarly, depletion of either Rasip1 or Arhgap29 in cultured ECs blocks in vitro lumen formation, fundamentally alters the cytoskeleton, and reduces integrin-dependent adhesion to ECM . (xenbase.org)
MATERIALS AND METHODS: We examined the effects of IMB5036 on cancer cells by in vitro assays, a molecular docking model and in vivo tumour models. (bvsalud.org)
Cell culture experiments using the type II cell-like cell line, A549, tested whether lipid-soluble cigarette smoke components affected binding and activation of retinoic acid response elements in vitro . (biomedcentral.com)
An in vitro cell culture model shows that lipid-soluble components of cigarette smoke decrease retinoic acid response element activation. (biomedcentral.com)

The diagno- function may play a role in vascular com- sis of type 2 diabetes was established plications such as stroke or ischaemic heart before they were screened for the study disease. (who.int)

Cardiovascular function depends on patent blood vessel formation by endothelial cells (ECs). (xenbase.org)
This study identifies Rasip1 as a unique, endothelial-specific regulator of Rho GTPase signaling, which is essential for blood vessel morphogenesis. (xenbase.org)

Here, we show that human antigen R (HuR), an RNA binding protein which binds preferentially to AU-rich elements (AREs) and stabilizes mRNAs, regulates TNF-α-induced ICAM-1 expression in the MK2/HuR signaling pathway. (biomedcentral.com)

Concomitantly, disturbances in vascular biology provide a pathophysiological basis for identifying individuals at increased risk of future acute cardiovascular events. (escardio.org)
Nevertheless, endothelial function has, for the time being, been demonstrated to be a marker for risk of cardiovascular events in high risk groups only. (escardio.org)
Our results establish a previously undescribed mechanosensor in endothelial cells that regulates cardiovascular pathophysiology, and provide a mechanism by which a single receptor can exhibit a binary biochemical nature. (ox.ac.uk)

MicroRNAs function to regulate the expression levels of other genes by several pre- and post-transcription mechanisms. (wikipedia.org)
The extravasation of leukocytes from the vascular bed into surrounding tissues and organs is part of the host defense mechanisms against invading pathogens. (biomedcentral.com)
However, the mechanisms underlying vascular "tubulogenesis" are only beginning to be unraveled. (xenbase.org)
In this study, we aimed to examine the effects of RCE in endothelial cells challenged with hypoxic exposure and to elucidate the underlying mechanisms. (mdpi.com)
Collectively, these findings identify a novel pathway in endothelial cells underlying monocyte adhesion and expand our knowledge of the epigenetic mechanisms orchestrating NOR1 expression in SMC. (uky.edu)
However, the regulatory mechanisms of HPV infection and consequent immune escape reaction, persistent infection and cell proliferation and the regulatory mechanisms of vascular proliferation are poorly understood and require additional investigation ( 4 ). (spandidos-publications.com)

Both reactive oxidant species from inhaled cigarette smoke and those endogenously formed by inflammatory cells constitute an increased intrapulmonary oxidant burden. (ersjournals.com)
The inflammatory process in patients with stable COPD is dominated by macrophages, CD8+ T‐lymphocytes and neutrophils, and to a lesser extent mast cells, in the bronchial submucosa and alveoli 5 . (ersjournals.com)
Increased production of mediators, such as interleukin (IL)‐8, tumour necrosis factor‐α (TNF‐α) and leukotriene B 4 , which both attract inflammatory cells and increase oxidant production by these cells, has been found. (ersjournals.com)
Cardinal signs of resolution are: (1) limitation/cessation of PMN infiltration, (2) sequestration and counter-regulation of pro-inflammatory chemical mediators, (3) apoptosis of PMN and removal (e.g., by efferocytosis), (4) clearance of pathogens, inflammatory stimuli, and cell debris, and (5) tissue repair. (frontiersin.org)
Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. (escholarship.org)
In response to inflammatory stimuli, NOR1 expression is rapidly induced in endothelial cells through an NF- κ B-dependent signaling pathway. (uky.edu)
KLK10 is a flow-sensitive endothelial protein that serves as an anti-inflammatory, barrier-protective, and anti-atherogenic factor. (cdc.gov)
Changes in dopaminergic neural function can be induced by an acute inflammatory state that, by altering the integrity of the neurovasculature, induces neuronal stress, cell death and causes functional deficits. (biomedcentral.com)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)

Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
Notably, it was a poor substrate of P-glycoprotein and exhibited potent cytotoxicity against drug-resistant tumor cells. (bvsalud.org)
The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
It affects cell proliferation, differentiation and inhibits apoptosis, and its role in tumor development has received attention ( 9 ). (spandidos-publications.com)
At clinical imaging resolutions, this finding is likely to translate to detection at tumor volumes two to three orders of magnitude smaller (0.3-3 × 10(5) cells) than those volumes detectable clinically (10(7)-10(8) cells). (ox.ac.uk)

mir-126* is less abundantly found in organisms than mir-126 and fewer roles in regulating gene expression have been identified. (wikipedia.org)
He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
We have used conditional gene deletion of mouse β-catenin in Sox17-positive embryonic and extra-embryonic endoderm as well as vascular endothelial progenitors to address the function of canonical Wnt signalling in cell lineage formation and patterning. (biologists.com)
The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. (nih.gov)
Targeted gene deletion and radiation chimera analyses have provided insights into the molecular machinery underlying the development of secondary lymphoid organs, emphasizing the importance of crosstalk between hematopoietic and nonhematopoietic cells. (rupress.org)
Transient transfection and chromatin immunoprecipitation assays identify VCAM-1 as a bona fide NOR1 target gene in endothelial cells. (uky.edu)
In smooth muscle cells (SMC), NOR1 was previously established as a cAMP response element binding protein (CREB) target gene in response to platelet-derived growth factor (PDGF) stimulation. (uky.edu)
OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)

Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)

VEGF production by mast cells was examined in KU812 and HMC-1 cells, and was found to be highest when the cells were inoculated with Dengue computer virus and human Dengue virus-immune serum in DLL3 the presence of IL-9. (mdm2-inhibitors.com)
Findings As mast cells are an important source of VEGF, tryptase, and chymase, our findings suggest that mast cell activation and mast cell-derived mediators participate in the development of DHF. (mdm2-inhibitors.com)
Author Summary To clarify the involvement of 312637-48-2 manufacture mast cells in the development of severe Dengue diseases, plasma levels of mast cell-derived mediators, namely vascular endothelial cell growth factor (VEGF), tryptase, and chymase, were estimated in Dengue patients and control subjects in Vietnam. (mdm2-inhibitors.com)
production of VEGF in human mast cells was significantly enhanced in the presence of IL-9 when these cells were inoculated with Dengue computer virus in the presence of human Dengue virus-immune serum. (mdm2-inhibitors.com)
As mast cells are an important source of VEGF, and tryptase and chymase are considered to be specific markers for mast cell activation, mast cells and mast cell-derived mediators might participate in the development of DHF/DSS. (mdm2-inhibitors.com)
Recent studies on Dengue computer virus 312637-48-2 manufacture contamination have exhibited that the serum levels of vascular endothelial cell growth factor (VEGF)-A (formerly VEGF) are elevated in DHF patients [3]. (mdm2-inhibitors.com)
Moreover, VEGF signaling up-regulates. (mdm2-inhibitors.com)

This is followed by polymorphonuclear neutrophil (PMN) recruitment, adhesion to vascular endothelial cells, diapedesis (or transmigration), and accumulation or swarming. (frontiersin.org)
These cellular functions are based on closely regulated and spatially restricted reorganization of the cytoskeleton, and play critical roles during physiological or pathological processes such as diapedesis, wound healing, metastasis, or uptake of pathogens. (linderlab.de)

Finally, we establish a previously unrecognized atherogenic role of NOR1 in positively regulating monocyte recruitment to the vascular wall. (uky.edu)
Decreased expression of VE-cadherin in the neovasculature of Prss21-/- ovaries was also observed without marked differences in endothelial cell content, vascular claudin-5 expression or pericyte recruitment. (umaryland.edu)

The expression of genes through miRNA is regulated by endogenous regulatory pathways, resulting in high stability and biocompatibility ( 5 ). (spandidos-publications.com)

The aim of this study is to examine the role of genetic deficiency of the miR-181b locus in endothelial cells during atherogenesis. (unl.edu)

Neutrophils were freshly isolated from blood of 10 male healthy volunteers, stimulated the same way as endothelial cells and analyzed for surface expression of L-selectin, CD11b and CD18. (biomedcentral.com)
Tissue infiltration by activated innate immune cells, including monocytes, macrophages, and neutrophils, if untreated, leads to rapidly progressive organ injury, that can involve many organ systems. (nature.com)
We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)
This event was accompanied by a decrease in the adhesion of neutrophils towards HPMECs. (biomedcentral.com)

VEGFR-1 is usually expressed 312637-48-2 manufacture on monocyte-macrophage lineages other than endothelial cells, whereas VEGFR-2 is usually expressed primarily on endothelial cells and their progenitors [9], [10]. (mdm2-inhibitors.com)

After two, four and 24 hours, fluorescence activated cell sorter (FACS) analysis for vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and E-selectin was performed. (biomedcentral.com)
ECs were treated with oxLDL under HG conditions in the presence or absence of ROS scavengers mitoTEMPO and NAC, p38 inhibitor SB203580, FOXO1 inhibitor AS1842856 or transfected with the TXNIP siRNA, before protein expression levels of intercellular adhesion molecule 1 (ICAM‑1), vascular cell adhesion molecule‑1 (VCAM‑1), phosphorylated vascular endothelial‑cadherin (VE‑cadhedrin), VE‑cadherin and zonula occludens‑1 (ZO‑1) were measured by western blotting. (spandidos-publications.com)
We found that Gas1 deficiency mainly phenocopies Dhh deficiency especially by inducing VCAM-1 (vascular cell adhesion molecule 1) and ICAM-1 (intercellular adhesion molecule 1) overexpression while Cdon deficiency has opposite effects by promoting endothelial junction integrity. (oskar-bordeaux.fr)
Intercellular adhesion molecule-1 (ICAM-1) and interleukin-8 (IL-8) play an important role in the development of these diseases. (biomedcentral.com)

Throughout the years, ROS and NO have been widely considered to enter cells by freely diffusing through the cell membrane lipid bilayer and not via specific transporters or channels. (hindawi.com)
Testisin (PRSS21) is a membrane anchored serine protease, which is tethered to the cell surface via a glycosylphosphatidylinositol (GPI)-anchor. (umaryland.edu)
Cell Membrane Structures" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Structures which are part of the CELL MEMBRANE or have cell membrane as a major part of their structure. (harvard.edu)
This graph shows the total number of publications written about "Cell Membrane Structures" by people in Harvard Catalyst Profiles by year, and whether "Cell Membrane Structures" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Cell Membrane Structures" by people in Profiles. (harvard.edu)
Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. (harvard.edu)

Cyr61, also known as IGFBP-10 and CCN1, is a 50 kDa matricellular glycoprotein that regulates the growth and adhesion of vascular endothelial cells, fibroblasts, and monocytes. (rndsystems.com)

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. (utsouthwestern.edu)
Endothelial cell-specific deletion of a microRNA accelerates atheroscl" by Dafeng Yang, Stefan Haemmig et al. (unl.edu)

Arteriosclerosis, Thrombosis, and Vascular Biology. (oskar-bordeaux.fr)

Here, they undergo antigen-driven clonal expansion and differentiation into plasma and memory cells. (rupress.org)

Recently, we analyzed serum biomarkers by using samples from the Gulu outbreak and identified associations between cytokines/chemokines, acute-phase reactants, makers of coagulopathy, and markers of endothelial function and patient death, hemorrhage, and viremia ( 10 ). (cdc.gov)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)

and (4) functional validation of top hits in an endothelial cell model via the CRISPR/dCas9-Dnmt3a system. (biomedcentral.com)
The TBARS value endothelial functional status on the other. (who.int)

This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)

We report that pharmacological FAK inhibition prevented TNF-α-induced VCAM-1 expression within heart vessel-associated endothelial cells in vivo, and genetic or pharmacological FAK inhibition blocked VCAM-1 expression during development. (escholarship.org)

Coagulation factors interact on platelet and endothelial cell surfaces to produce thrombin , which converts fibrinogen to fibrin. (msdmanuals.com)

The influence of the luminal surface morphology on platelet adhesion and the attachment of endothelial cells was investigated. (biomedcentral.com)
Initial platelet adhesion is to long strings of von Willebrand factor (VWF) that have been previously secreted by, and anchored to, stimulated endothelial cells. (msdmanuals.com)

PU.1 negatively regulates GATA3 expression, altering the response of the T helper 2 cells. (wikipedia.org)
HOXA9, mir-126 modulates HOXA9 expression in haematopoietic cells. (wikipedia.org)
mir-126 expression is reduced in lung cancer cell lines. (wikipedia.org)
In the present study, we were able to demonstrate effects of DHEA on the expression of every adhesion molecule investigated. (biomedcentral.com)
Thus, we conclude that one mechanism by which DHEA may exert its protection in animal models is via the differential regulation of adhesion molecule expression. (biomedcentral.com)
oxLDL was found to significantly increase the expression of ICAM‑1 and VCAM‑1 in ECs under HG conditions whilst also enhancing the adhesion of monocytes to ECs. (spandidos-publications.com)
The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
These results indicate that MK2 post-transcriptionally regulates TNF-α-induced ICAM-1 expression by altering the cytoplasmic localization of HuR in HPMECs. (biomedcentral.com)
Our previous study showed that mitogen-activated protein kinase (MAPK) p38/ MAPK-activated protein kinase 2 (MK2) regulates the expression of ICAM-1 and IL-8 at the post-transcriptional level in HPMECs after TNF-α stimulation [ 4 ]. (biomedcentral.com)
However, the precise mechanism by which MK2 regulates ICAM-1 and IL-8 expression remains elusive. (biomedcentral.com)
Considering that AREs located in the 3′-UTR of ICAM-1 and IL-8 mRNAs, we hypothesize that the MK2 pathway might regulate the expression of ICAM-1 and IL-8 through HuR in TNF-α-induced HPMECs. (biomedcentral.com)
Testisin expression has been documented in eosinophiles, ovarian cancers, endothelial cells, and spermatozoa where its expression is highest. (umaryland.edu)
Single-cell RNA sequencing (scRNAseq) and scATAC sequencing (scATACseq) study using the partial carotid ligation mouse model showed flow-regulated Klk10 expression at the epigenomic and transcription levels. (cdc.gov)
These findings identify IFN-gamma as a modulator of monocytic CD38 expression and indicate that CD38 plays a specific role in the activation and adhesion processes performed by monocytes. (nih.gov)

Therefore, the author wondered whether the concentration of markers of vascular endothelial injury in maternal peripheral blood (such as VE-cadherin) would be affected through placenta during intrauterine onset. (researchsquare.com)
Whether in coronary or peripheral arteries, response to pharmacological agents and/or to hemodynamic provocation tests is assessed as a measure of endothelial function (2). (escardio.org)
Numerous methods for evaluating the peripheral arterial system have emerged as alternatives to coronary endothelial function testing. (escardio.org)
Impaired peripheral endothelial function has also independently predicted adverse outcomes in specific patient cohorts, such as heart failure cohorts (6). (escardio.org)

Tissue repair and maintenance are important parts of the life cycle of an organism, cells and tissues must remain in homeostasis to ensure survival. (wikipedia.org)

To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells. (spandidos-publications.com)

Objective To study the value of maternal vascular endothelial cadherin (VE-cadherin) level and anti-A/B IgG titer in the prenatal diagnosis of ABO hemolytic disease. (researchsquare.com)

Without stable anchorage to the extracellular matrix (ECM), endothelial cells (ECs) are unable to sense, integrate and disseminate growth factor stimulated responses that drive growth of a vascular bed. (uea.ac.uk)
Rasipl null angioblasts fail to properly localize the polarity determinant Par3 and display defective cell polarity, resulting in mislocalized junctional complexes and loss of adhesion to extracellular matrix ( ECM ). (xenbase.org)

pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. (nature.com)
Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in hematopoietic cells but rather in radioresistant stromal cells needed for the development of secondary lymphoid organs. (rupress.org)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Vascular factors reduce blood loss due to trauma through local vasoconstriction (an immediate reaction to injury) and compression of injured vessels by extravasation of blood into surrounding tissues. (msdmanuals.com)

UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)

Associate Professor Margaret Currie is interested in how the tumour microenvironment affects tumour growth, tumour cell metastasis and tumour response to therapy. (otago.ac.nz)
All the various components of the tumour microenvironment can influence tumour growth and spread and, conversely, tumour cells can influence the local tumour microenvironment. (otago.ac.nz)
The Mackenzie Cancer Research Group has been investigating the contribution of stromal cells and the tumour microenvironment to human tumour biology since the inception of our research group in 1998. (otago.ac.nz)
However, since 2009 Associate Professor Currie's interests have expanded to include the contribution to tumour progression made by tumour infiltrating immune cell populations, breast cancer stem cell-like populations, and obesity-related factors. (otago.ac.nz)
We are culturing human fat cells (adipocytes) and tumour cells together, to find out how adipocytes alter tumour cell phenotype and response to therapy. (otago.ac.nz)

Anatomy50

Organisms9

Diseases13

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes46

Disciplines and Occupations1

Information Science3

Endothelium15

Inflammation14

Angiogenesis10

Permeability15

Dysfunction19

Molecules14

Role in maintaining1

Microvascular4

Atherosclerosis5

Progenitor cells5

Proteins15

Nitric oxide6

Neutrophil adhesion2

Oxidative4

Atherosclerotic lesions2

Proliferation of smooth muscl1

Human umbilical2

Migration8

Integrins1

Vitro6

Play a role in vascular1

Blood vessel2

Binds1

Cardiovascular3

Mechanisms6

Inflammatory9

Tumor6

Gene8

Inhibits2

VEGF7

Diapedesis2

Recruitment2

Pathways1

Atherogenesis1

Neutrophils4

Monocyte1

Intercellular4

Membrane7

Fibroblasts1

MicroRNA2

Thrombosis1

Differentiation1

Cytokines2

Functional2

Diseases1

Vivo1

Coagulation1

Platelet adhesion2

Expression14

Peripheral4

Tissue1

Modulates1

Cadherin1

Extracellular2

Tissues4

Pathway1

Tumour5