Vascular cell adhesion molecule 1. Medical search. Frequent questions (1)

Intercellular adhesion molecule 1 (ICAM-1), interleukin (IL)-8, and IL-6 levels in the supernatant of VSMCs were measured with enzyme-linked immunosorbent assay 0 and 24 h after grouping. (geneticsmr.com)
A nitric oxide (NO) detection kit was used to determine the concentration of NO. Western blotting analysis was performed to determine the levels of intercellular cell adhesion molecule (ICAM)‑1, vascular cell adhesion molecule (VCAM)‑1, endothelin‑1, caspase‑3, Bax, Bcl‑2, Toll‑like receptor 4 (TLR4), p65 and p‑p65. (spandidos-publications.com)
IgG antibody titres against H pylori and M pneumoniae and plasma levels of soluble E-selectin, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 were determined. (bmj.com)
After two, four and 24 hours, fluorescence activated cell sorter (FACS) analysis for vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and E-selectin was performed. (biomedcentral.com)

This assay has high sensitivity and excellent specificity for detection of Vascular Cell Adhesion Molecule 1 (VCAM1). (uscnk.com)
No significant cross-reactivity or interference between Vascular Cell Adhesion Molecule 1 (VCAM1) and analogues was observed. (uscnk.com)
Matrices listed below were spiked with certain level of recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) and the recovery rates were calculated by comparing the measured value to the expected amount of Vascular Cell Adhesion Molecule 1 (VCAM1) in samples. (uscnk.com)
Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Vascular Cell Adhesion Molecule 1 (VCAM1) were tested 20 times on one plate, respectively. (uscnk.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Vascular Cell Adhesion Molecule 1 (VCAM1) were tested on 3 different plates, 8 replicates in each plate. (uscnk.com)
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Vascular Cell Adhesion Molecule 1 (VCAM1) and their serial dilutions. (uscnk.com)
The microtiter plate provided in this kit has been pre-coated with an antibody specific to Vascular Cell Adhesion Molecule 1 (VCAM1). (uscnk.com)
Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Vascular Cell Adhesion Molecule 1 (VCAM1). (uscnk.com)
After TMB substrate solution is added, only those wells that contain Vascular Cell Adhesion Molecule 1 (VCAM1), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (uscnk.com)
VCAM1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 682 amino acids (25-698 a.a) and having a molecular mass of 75.4kDa (Migrates at 70-100kDa on SDS-PAGE under reducing conditions). (angioproteomie.com)
Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. (wikipedia.org)
Immunohistochemical analysis of paraffin-embedded human breast cancer, using VCAM1 / CD106 (GTX110684) antibody at 1:250 dilution. (genetex.com)
Non-transfected (-) and transfected (+) 293T whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with VCAM1 / CD106 antibody [N1N2], N-term (GTX110684) diluted at 1:20000. (genetex.com)

The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. (wikipedia.org)
Certain melanoma cells can use VCAM-1 to adhere to the endothelium, VCAM-1 may participate in monocyte recruitment to atherosclerotic sites, and it is highly overexpressed in the inflamed brain. (wikipedia.org)
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. (genetex.com)
The vascular endothelium, the innermost layer of blood vessels, provides a dynamic interface between the circulating blood and various tissues/organs and thereby maintaining tissue homeostasis. (nature.com)
Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
In the first phase of the extravasation process, selectins such as L-selectin on leukocytes and E- and P-selectin on endothelial cells lead to a loose connection that permits tethering and rolling of leukocytes on the endothelium under hydrodynamic shear [ 10 ]. (biomedcentral.com)
Nishiwaki, Y., Yoshida, M., Masuda, H. and Isobe, M. (2004) Recruitment of bone marrow-derived endothelial progenitor cells to vascular endothelium involves E-selectin dependent mechanism. (scirp.org)
It is involved in the adhesion of lymphocytes, monocytes and eosinophils to activated endothelium. (beckman.com)

Cryo-EM structures of the human Sec61 complex inhibited by various small-molecule inhibitors. (biorxiv.org)

Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. (jci.org)
It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis. (wikipedia.org)
Vascular endothelial cells serve a key role in the pathogenesis of atherosclerosis by regulating vascular tension, platelet adhesion, inflammation and fibrinolysis ( 5 ). (spandidos-publications.com)
At the onset of atherosclerosis, LDL is deposited on vascular endothelial cells to be oxidized to form ox-LDL, which is then absorbed by macrophages to form foam cells. (spandidos-publications.com)
Therefore, the study of ox-LDL-mediated endothelial cell dysfunction can further clarify the pathogenesis of atherosclerosis and provide a more theoretical basis for the treatment and prevention of atherosclerosis. (spandidos-publications.com)
2022 : 7541411 Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis. (genetex.com)
PURPOSE: This study aimed to investigate the effect of adipose-derived stem cell (ADSC) transplantation on atherosclerosis (AS) and its underlying mechanisms. (koreamed.org)
Natural products from traditional Chinese medicine have shown promising therapeutic potential against atherosclerosis by means of regulating the expression of specific genes, stabilizing arterial plaques and protecting vascular endothelial cells. (bvsalud.org)
They can participate in the occurrence and development of atherosclerosis through inflammation, oxidative stress, lipid metabolism, cell proliferation and migration, macrophage polarization and autophagy respectively. (bvsalud.org)
Vascular toxicity caused by cancer treatment can present as vasospasm, arterial thrombosis, and accelerated atherosclerosis. (bvsalud.org)
The proatherogenic and atheroprotective effects of d-flow and s-flow are mediated in part by the global changes in endothelial cell (EC) gene expression, which regulates endothelial dysfunction, inflammation, and atherosclerosis. (cdc.gov)

OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and. (koreamed.org)
This work uses a model of experimental T1DM to investigate the intervention of insulin in a model of murine PCM induced by Paracoccidioides brasiliensis , analyzing the process of cell migration (adhesion molecules expression, leukocyte phenotyping), molecular mechanisms (production and secretion of cytokines), intracellular mechanisms (signaling pathways) and phagocytic and microbicidal activities in alveolar macrophages. (usp.br)
Functionally, KLK10 protected against d-flow-induced permeability dysfunction and inflammation in human artery ECs, as determined by NFB activation, expression of vascular cell adhesion molecule 1 and intracellular adhesion molecule 1, and monocyte adhesion. (cdc.gov)

The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
Effective clearance of inflammatory cells is required for resolution of inflammation. (koreamed.org)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

We demonstrated for the first time that gene silencing of endothelial E-selectin using siRNA transfection in human umbilical vein endothelial cells (HUVECs) causes inhibition of EPC adhesion under flow conditions. (scirp.org)

Moreover, full EBs of the iPS 4.1 cell line after oxidative stress induction by SNAP was protected at day-8 samples. (nih.gov)
Oxidative stress has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD) 1 - 5 . (ersjournals.com)
Several reviews have summarised the available data on the presence (table 1 ⇓ ) and consequences (table 2 ⇓ ) of oxidative stress in the lungs of "healthy" smokers and smokers with COPD 1 - 5 , 9 . (ersjournals.com)
14,15 Conversely, its pro-oxidant activity may enhance cellular defence against oxidants by stimulating the redox-regulated signal transduction pathway which leads to the gene expression of anti-oxidative enzymes such as heme oxygenase-1 (HO-1) and glutathione peroxidase (GPx). (rsc.org)

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. (jci.org)
Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells. (oregonstate.edu)
Confocal image of the same artery showing expression of vascular cellular adhesion molecule-1 (VCAM-1, in red). (lu.se)

The 1G11 antibody inhibits T lymphocyte adhesion to TNF-stimulated endothelial cells. (beckman.com)
The same antibody molecule can cross-react with related antigens if their epitopes are similar enough to those of the original antigen. (msdmanuals.com)

The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily. (wikipedia.org)
Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. (wikipedia.org)
VCAM-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural information available in the PDB for UniProt: P19320 (Vascular cell adhesion protein 1) at the PDBe-KB. (wikipedia.org)
Furthermore, second messenger inhibitors implicated essential and complimentary roles of phosphatidylinositol-3-kinase and protein kinase C in mediating Tpo-induced adhesion. (ox.ac.uk)
This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. (genetex.com)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)

VCAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. (wikipedia.org)
Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)
The Sec61 complex also mediates membrane integration of many proteins, including most cell surface receptors and cell adhesion molecules. (biorxiv.org)
Cell surface receptors containing an immunoglobin domain. (embl.de)
Killer cell inhibitory receptors. (embl.de)

Thrombopoietin (Tpo), the ligand for c-mpl and a principal regulator of megakaryocytopoiesis and platelet production, has been demonstrated to stimulate the growth and differentiation of megakaryocyte as well as multipotent hemopoietic progenitor cells. (ox.ac.uk)
Unlike the ability of these cytokines to synergistically enhance growth of Mo7e as well as normal progenitor cells, no synergy was observed with regard to their ability to enhance adhesion. (ox.ac.uk)
Thus, Tpo might play an important role in early hemopoiesis, at least in part through its ability to promote adhesion through activation of adhesion molecules on hemopoietic progenitor cells. (ox.ac.uk)
Endothelial progenitor cells (EPCs) are bone marrow-derived haematopoietic progenitor cells that have been implicated in vasculogenesis. (scirp.org)

The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. (wikipedia.org)
Upregulation of VCAM-1 in endothelial cells by cytokines occurs as a result of increased gene transcription (e.g., in response to tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1)) and through stabilization of messenger RNA (mRNA) (e.g. (wikipedia.org)
Activated by cytokines and chemokines, leukocytes and endothelial cells express distinct adhesion molecules on their cell surfaces [ 9 ]. (biomedcentral.com)
ABSTRACT This study assessed changes in serum levels of cytokines IFN and IL-10 (biomarkers of in ammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothe- lial dysfunction) in diabetic patients with and without nephropathy. (who.int)

The inflammatory process in patients with stable COPD is dominated by macrophages, CD8+ T‐lymphocytes and neutrophils, and to a lesser extent mast cells, in the bronchial submucosa and alveoli 5 . (ersjournals.com)
The CD106 antigen, also known as Vascular Cell Adhesion Molecule-1 (VCAM-1), is an adhesion molecule which binds to integrin α4/β1 (VLA‑4) and integrin α4/β7 on lymphocytes. (beckman.com)

86 : 104712 Cordycerebroside A suppresses VCAM-dependent monocyte adhesion in osteoarthritis synovial fibroblasts by inhibiting MEK/ERK/AP-1 signaling. (genetex.com)

BACKGROUND: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. (koreamed.org)
found evidence and they did not require insulin therapy of endothelial cell injury in renal failure for glucose control. (who.int)

Muller, W.A. (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (scirp.org)

F) plasminogen activator inhibitor 1. (cdc.gov)

This effect goes along with reduced amounts of infiltrating immune cells in organs such as lung and liver. (biomedcentral.com)
Ongoing projects focus on glial cells (astrocytes and microglia) and how they coordinate with immune cells from the blood to affect bystander brain injury in the days after stroke. (stanford.edu)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)
Brinkman et al5 examined whether the presence and foods.1,2 However, much less is known about the poten- severity of AD was predictive of the occurrence and mag- tial influence that skin challenges have on the systemic nitude of early and late asthmatic responses to inhaled immune response, in particular whether sensitization allergens. (cdc.gov)
However, the biomarkers sICAM-1 and sE-selectin (as mechanism of this immune dysregulation markers of endothelial dysfunction) in dia- is still unclear. (who.int)
Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)
Higher magnification of the same region, showing very high levels of VCAM-1 and adhesion of immune cells (arrows) at the plaque edges, also areas of turbulent blood flow. (lu.se)

Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways. (ox.ac.uk)
In the present study, we have characterized the ability of TNFalpha in inducing eosinophil accumulation in rat skin and have shown the inhibitory effects of anti-alpha4 integrin and anti-vascular cell adhesion molecule-1 (VCAM-1) antibodies on this response. (ox.ac.uk)
In contrast, the intravenous administration of an anti-alpha4 integrin MoAb, HP2/1 (3.5 mg/kg), or an anti-VCAM-1 MoAb, 5F10 (2 mg/kg), greatly inhibited the 111In-eosinophil accumulation induced by TNFalpha (the responses detected at 10(-11) mol/site were inhibited by 78% and 50%, respectively). (ox.ac.uk)

Short interfering RNA (siRNA) is a powerful technique that can suppress gene expression in a variety of cells including mammalian cells. (scirp.org)
Our experiments have shown the importance of E-selectin in EPC adhesion to HUVECs and the potential utility of gene silencing of E-selectin in EPC recruitment. (scirp.org)

These data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes. (jci.org)

The universally conserved heterotrimeric Sec61 complex (SecY in prokaryotes) plays essential roles in biosynthesis of more than one third of proteins in all species (for review, see ref. 1 - 4 ). (biorxiv.org)
In eukaryotes, secretory proteins are first translocated into the ER by the Sec61 complex before reaching the cell surface by vesicular trafficking. (biorxiv.org)
Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. (embl.de)
We use basic and clinical research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. (stanford.edu)
This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
Acute phase reactants are plasma proteins whose levels dramatically increase (called positive acute phase reactants) or, in some cases, decrease (called negative acute phase reactants) in response to the elevated circulating levels of interleukin (IL)-1 and IL-6 that occur when infection or tissue damage occurs. (msdmanuals.com)
Serum amyloid A and alpha-1 acid glycoprotein are transport proteins, and fibrinogen is a coagulation factor. (msdmanuals.com)

Cell Counting Kit‑8 assay was used to detect cell viability. (spandidos-publications.com)
When vesicles predominate, perilesional skin may be examined with direct immunofluorescence, and serum may be evaluated with indirect immunofluorescence on healthy human skin and/or desmoglein 1/desmoglein 3 enzyme-linked immunosorbent assay to exclude pemphigus foliaceus or pemphigus vulgaris. (medscape.com)
Fluorescence immunobinding assay analysis showed that significant reduction of E-selectin surface expression in HUVECs (activated with IL-1β (10 U/mL) for 4 h) transfected with siRNA against E-selectin, but not in HUVECs transfected with LacZ siRNA (control). (scirp.org)

In view of the accelerated vascular disease observed in patients with diabetes, and the enhanced expression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE). (jci.org)
Soluble VCAM-1 antigen was elevated in human diabetic plasma. (jci.org)
The genesis of diabetic nephropathy (DN) in type 2 diabetes mellitus is clearly multifactorial, involving hypertension, hyperglycemia, hyperinsulinemia, and hyperlipidemia [ 1 - 6 ]. (hindawi.com)
Type 1 diabetes mellitus is characterized by destruction of insulin producing-pancreatic cells and, among its symptoms, an impaired immunological function has been observed in many studies having diabetic patients described as more susceptible to infections and complications resulted of them. (usp.br)
sICAM-1 and sE-selectin were signi cantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis. (who.int)
Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)
Role of the incretin hormone GIP in the development of diabetic vascular complications - good or bad? (lu.se)

After analysis of full embryoid bodies (EBs) and cardiac marker (VCAM and cardiac troponin I) positive cells of three lines at 6 conditions (32 different conditions altogether), we found significant SI/R injury-induced cell death in both full EBs and VCAM+ cardiac cells at later stage of their differentiation. (nih.gov)

Kakkar, A.K. and Lefer, D.J. (2004) Leukocyte and endothelial adhesion molecule studies in knockout mice. (scirp.org)

The diagno- function may play a role in vascular com- sis of type 2 diabetes was established plications such as stroke or ischaemic heart before they were screened for the study disease. (who.int)

TNF-α-activated endothelial cells promote VSMC proliferation and secretion of ICAM-1 and IL-8 by elevating IL-6 release. (geneticsmr.com)
Compared with the ox‑LDL group, S/V treatment significantly increased the cell viability, NO concentration and Bcl‑2 expression, decreased the levels of IL‑1β, IL‑6 and TNF‑α and reduced the expressions of MALAT1, ICAM‑1, VCAM‑1, cleaved‑caspase‑3, Bax, TLR4 and p‑p65. (spandidos-publications.com)
27 (11) : 1509-1522 CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells. (genetex.com)

Cell viability in simulated ischemia/reperfusion (SI/R)-induced injury and a known cardiocytoprotective NO-donor, S-nitroso-n-acetylpenicillamine (SNAP) was tested. (nih.gov)

Increased production of mediators, such as interleukin (IL)‐8, tumour necrosis factor‐α (TNF‐α) and leukotriene B 4 , which both attract inflammatory cells and increase oxidant production by these cells, has been found. (ersjournals.com)

Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells. (oregonstate.edu)
Fasudil decreased significantly Rho-kinase activity in peripheral blood mononucleated cells (PBMC), myocardium and aortic wall to similar levels as in the sham group. (portlandpress.com)

CD106 also exists on the surface of some subpopulations of mesenchymal stem cells (MSC). (wikipedia.org)
CD106 antigen is present on activated endothelial cells, tissue macrophages, dendritic cells and bone marrow fibroblasts. (beckman.com)
Recent studies shown that CD106 identifies a unique subpopulation of Mesenchymal Stem Cells (MSCs) with powerful immunosuppressive activity. (beckman.com)

Endothelial cells derived from human umbilical cord were subjected to an lipopolysaccharide (LPS) challenge. (biomedcentral.com)

Quercetin glycosides from diet are slightly absorbed via the intestinal epithelial cells, although most of them return into the digestive tract by the action of specific transporter systems. (rsc.org)
Phase II enzymes present in the intestinal epithelial cells and the liver cells facilitate their metabolic conversion to glucuronide and sulfate conjugates. (rsc.org)
BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. (koreamed.org)

According to the World Health Organization, an estimated 17.5 million people died of cardiovascular disease in 2012, of which 7.4 million died of ischemic heart disease and 6.7 million died of stroke ( 1 ). (spandidos-publications.com)
With HIV disease, the CD4 count is often less than 300 cells/µL. (medscape.com)
Thus, COVID-19 is deemed as a (micro)vascular and endothelial disease. (nature.com)
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents an ongoing public health burden leading to extensive morbidity and mortality worldwide [ 1 ]. (nature.com)

In the present study we demonstrate that Tpo can stimulate the adhesion of the Mo7e progenitor cell line to fibronectin (Fn) as well as vascular cell adhesion molecule-1 through activation of very late antigen (VLA)-4 and VLA-5, adhesion molecules previously demonstrated to be involved in regulation of steady state hemopoiesis. (ox.ac.uk)
Thus, we conclude that one mechanism by which DHEA may exert its protection in animal models is via the differential regulation of adhesion molecule expression. (biomedcentral.com)

Stem cell-derived cardiac myocytes are potential sources for testing cardiocytoprotective molecules against ischemia/reperfusion injury in vitro. (nih.gov)
Here we performed a systematic analysis of two different induced pluripotent stem cell lines (iPSC 3.4 and 4.1) and an embryonic stem cell (ESC) line-derived cardiac myocytes at two different developmental stages. (nih.gov)

The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction. (jci.org)
Phytocannabinoids like ∆(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) show a beneficial effect on neuroinflammatory and neurodegenerative processes through cell membrane cannabinoid receptor (CBr)-dependent and -independent mechanisms. (nih.gov)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts. (jci.org)
ELISA was performed to detect the levels of IL‑1β, IL‑6 and TNF‑α. (spandidos-publications.com)
Single-cell RNA sequencing (scRNAseq) and scATAC sequencing (scATACseq) study using the partial carotid ligation mouse model showed flow-regulated Klk10 expression at the epigenomic and transcription levels. (cdc.gov)

It is a 110 kDa cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. (beckman.com)

Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1: role of activation of very late antigen (VLA)-4 and VLA-5. (ox.ac.uk)
and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)

Cytoadherence characteristics of Plasmodium falciparum isolates in Thailand using an in vitro human lung endothelial cells model. (ajtmh.org)
Using an in vitro model of human lung endothelial cells, we studied different characteristics of Plasmodium falciparum isolates as potential factors for malaria severity in 2 Thai patient groups: 27 with complicated malaria and 42 with uncomplicated malaria. (ajtmh.org)
Therefore, we investigated the in vitro effect of DHEA on the expression pattern of adhesion molecules of human endothelial cells and neutrophils. (biomedcentral.com)

It has been hypothesized that this fibrin cuff serves as a barrier to oxygen diffusion, with resulting tissue hypoxia and cell damage. (medscape.com)

The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)

The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. (embl.de)

VCAM-1 is also upregulated if vWF (Von Willebrand Factor) is given in knock-out (KO) ADMATS13 mice but not on mice without KO. (wikipedia.org)
We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)

As part of a study on the SAR of phytocannabinoids, we have investigated the effect of the oxidation modification in the resorcinol moiety of cannabigerol (CBG) on CB(1), CB(2) and PPARγ binding affinities, identifying cannabigerol quinone (VCE-003) as a potent anti-inflammatory agent. (nih.gov)
VCE-003 protected neuronal cells from excitotoxicity, activated PPARγ transcriptional activity and inhibited the release of pro-inflammatory mediators in LPS-stimulated microglial cells. (nih.gov)
Both reactive oxidant species from inhaled cigarette smoke and those endogenously formed by inflammatory cells constitute an increased intrapulmonary oxidant burden. (ersjournals.com)
The typical plaque is characterized by a large central lipid core, an abundance of inflammatory cells, a thin fibrous cap, and a paucity of smooth muscle cells [ 5 ]. (hindawi.com)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)

The aim of this study was to investigate the influence of activated endothelial cells on the proliferation and secretion of vas-cular smooth muscle cells (VSMCs). (geneticsmr.com)

Qinghaosu derivatives were more efficient than other antimalarial drugs, but a positive correlation was observed between the 50% inhibitory concentrations of halofantrine and quinine and the number of adhesive parasitized red blood cells, suggesting their influence on cytoadherence. (ajtmh.org)
Several natural and synthetic small molecules specifically inhibit the Sec61 channel, generating cellular effects that are potentially useful for therapeutic purposes, but their inhibitory mechanisms remain unclear. (biorxiv.org)

Finally, Tpo stimulated adhesion of primitive (CD34+ CD38-) human bone marrow cells to fibronectin, predominantly through activation of VLA-5, whereas no such effect could be observed on CD34+ CD38+ bone marrow cells. (ox.ac.uk)
Here we present near-atomic-resolution structures of the human Sec61 channel inhibited by a comprehensive panel of structurally distinct small molecules- cotransin, decatransin, apratoxin F, ipomoeassin F, mycolactone, cyclotriazadisulfonamide (CADA) and eeyarestatin I (ESI). (biorxiv.org)
1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)

Anatomy55

Organisms10

Diseases8

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Health Care1

Intercellular4

VCAM113

Endothelium8

Small-Molecule Inhibitors1

Atherosclerosis11

Intracellular3

Inflammation3

Inhibition1

Oxidative4

Expression of vascular3

Antibody2

Protein7

Receptors5

Progenitor cells4

Cytokines4

Lymphocytes2

Monocyte adhesion1

Endothelial cell injury2

Leukocyte-endothelial cell1

Plasminogen1

Immune8

Integrin3

Gene2

Monocytes1

Proteins7

Assay3

Diabetic7

Differentiation1

Knockout mice1

Role in vascular1

ICAM3

Viability1

Interleukin1

Aortic2

CD1063

Umbilical1

Epithelial3

Disease4

Regulation2

Cardiac2

Receptor3

Levels3

Surface sialoglycoprotein1

Antigen2

Vitro3

Tissue1

Molecular2

Immunoglobulin1

Mice2

Inflammatory5

Secretion1

Inhibitory2

Human3