• Although TNF-a and LPS increase levels of both mRNA and protein in murine models, they do not appear to affect mRNA in human endothelial cells, while IL-4 increases P-selectin transcription in both species. (wikipedia.org)
  • The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 ( PSGL-1 ) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan . (wikipedia.org)
  • P-selectin is expressed on the surface of both stimulated endothelial cell and activated platelet and helps cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively. (wikipedia.org)
  • Many studies have postulated that increased production of cell adhesion molecules (CAMs) on the vascular endothelium (blood vessel lining) plays a role in the development of arterial plaque, with the suggestion from both in vitro and in vivo studies that the CAM production is increased by dyslipidemia (abnormal lipid levels in the blood). (wikipedia.org)
  • Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the platelet releases α- and dense granules and the inner walls of the granules are exposed on the outside of the cell. (wikipedia.org)
  • P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. (wikipedia.org)