Vascular calcification and aortic stiffness. Medical search. Frequent questions

Aortic stenosis (AS) is commonly caused by degenerative calcification and can be associated with increased arterial stiffness. (nagoya-u.ac.jp)
After adjusting for the other major risk factors for CVD, one study found the odds of vascular diseases increased with every decade of life, demonstrating a strong increase in peripheral arterial disease (PAD), carotid artery stenosis, and abdominal aortic aneurysm (AAA) with advanced age [ 4 ] . (oaepublish.com)
Oral calcium supplementation was associated with lower survival and a greater need for aortic valve replacement in elderly patients with mild to moderate aortic stenosis , a new study finds. (healthybodyart.com)
The researchers, led by Nicholas Kassis, MD, Cleveland Clinic Foundation, Cleveland, Ohio, explain that aortic stenosis is the most common adult valvular disease in the developed world. (healthybodyart.com)
The researchers point out that although it is a disease of the elderly, multiple modifiable risk factors for aortic stenosis have also been identified, including raised cholesterol levels, smoking, and increased serum ionized calcium, parathyroid hormone , and vitamin D3. (healthybodyart.com)
42% women) with mild to moderate native aortic stenosis selected from the Cleveland Clinic Echocardiography Database from 2008 to 2016 and followed for a median duration of 69 months. (healthybodyart.com)
Dysregulated phosphate calcium metabolism is a major determinant in the development of aortic leaflet sclerosis and calcified aortic stenosis, as triggered by impaired renal function, and in primary or secondary hyperparathyroidism , she reports. (healthybodyart.com)
Bergler-Klein points out that osteoporosis and lower bone mineral density have been associated with faster progression of aortic stenosis (AS), but in the present study, the mortality increase with calcium supplementation was independent of the osteoporosis status at entry. (healthybodyart.com)
In 3 of the 16 patients (18.8%), DUS revealed cludes at least vascular physical examination with femoral right iliac artery stenosis requiring a modification in the artery palpation. (health-abstracts.com)
Treatment of Severe Aortic Valve Stenosis: Impact of Patient Sex and Life Expectancy on Treatment Ch. (ecrjournal.com)
In adults with severe aortic stenosis, sex and age differences in symptoms and diagnosis may lead to delays in intervention. (ecrjournal.com)
In adults with severe aortic stenosis (AS) there are two steps in the decision-making process. (ecrjournal.com)
The presence of a stenosis (narrowing) of the aortic valve. (nih.gov)

Increased central (aortic) blood pressure causes increased cardiac after load and pressure load on the central vessels (coronary arteries, carotid arteries and the aorta). (tensiomed.com)
The best way of measuring arterial stiffness is determination of carotid to femoral PWV, and this is recommended in the American Heart Association (AHA), as well as in the European expert consensus document. (jscimedcentral.com)
Also measured is carotid intimal medial thickness, as well as coronary calcification. (deansilvermd.com)
Blad M, Gustafsson N, Engström G, Kennbäck C, Klinge B, Nilsson PM, Jönsson D, Levring Jäghagen E. Defined shapes of carotid artery calcifications on panoramic radiographs correlate with specific signs of cardiovascular disease on ultrasound examination. (lu.se)
Second, pulse wave analysis (PWA), PWA-derived augmentation index (AIx), and carotid-femoral pulse wave velocity (cfPWV) assess for arterial stiffness, a process characterised by functional changes and structural remodelling within the arterial wall, with associated fibrosis and calcification. (biomedcentral.com)
ABSTRACT This study investigated whether breast arterial calcification (BAC) has an association with coronary artery diseases (CAD) in young premenopausal women and evaluated the association of BAC with carotid intima-media thickness and standard CAD risk factors. (who.int)

However, the clinical implications of arterial stiffness indices in AS patients before and after treatment are unknown.MethodsThis single-center observational study enrolled 150 consecutive patients who underwent transcatheter aortic valve implantation (TAVI) for severe AS. (nagoya-u.ac.jp)

Loci for isolated thoracic aortic aneurysm have been identified on chromosomes 11q (AAT1) and 5q (AAT2) and pathogenic variants in the MYH11, ACTA2, MYLK and PRKG1 genes are known causes [13] . (rbht.nhs.uk)

He is developing a treatment strategy for abdominal aortic aneurysms by delivering mesenchymal stem cells or their secreted products to the periadventitial side of the aneurysm to inhibit the matrix degradation commonly seen in the disease progression and promote its regeneration. (pitt.edu)
Ankle-brachial index (ABI), abdominal aortic calcification (AAC), and coronary artery calcification (CAC): the Jackson heart study. (revistaclinicaguayaquil.org)
Kalcifikáciu brušnej aorty (AAC - Abdominal Aortic Calcification) je možné vyhodnotiť pomocou tzv. (clinicalosteology.org)

PWV is a crucial vascular and hemodynamic parameter that is used to assess the stiffness of aorta as a large vessel. (jscimedcentral.com)
I measure endothelial dysfunction and vascular elasticity, as well as central blood pressure and aorta. (deansilvermd.com)
Arterial stiffness refers to a pathological process in which continuous and intermittent distention of the aorta with each heartbeat and during lifespan causes fatigue and fracture of the elastin fibers, and accumulation of collagen, leading to increased stiffening and decreased elasticity of the aorta's wall [ 1 ]. (biomedcentral.com)
Cardiovascular involvement may include inflammation of the aorta, aortic valve insufficiency or disturbances of the heart's electrical conduction system. (findzebra.com)

He is currently studying the biomechanical progression of aortic aneurysms by modeling the mechanical forces that act on the degenerating vessel wall. (pitt.edu)

Our biological age and cardiovascular health are closely connected, with atherosclerosis and arterial stiffness representing a progressive process that eventually leads to the majority of deaths. (healthandscience.eu)
Among the 84 patients presenting with a nor- gree of atherosclerosis and arterial wall calcifications due to mal preoperative physical arterial examination, 12 patients end-stage renal failure, associated cardiovascular risk fac- (14.3%) had an abnormal DUS, revealing atherosclerotic tors and/or hyperparathyroidism. (health-abstracts.com)

This predicts and gives a risk of heart attack and stroke by detecting increasing aortic stiffness, augmentation of the systolic pressure, and changes in the wave. (deansilvermd.com)

Pathogenic vascular calcification, also known as hardening of the arteries , is something which affects millions of people worldwide - especially once you get past a certain age. (zmescience.com)
It has been shown that traditional cardiovascular risk factors such as hypertension, obesity, diabetes, dyslipidemia and metabolic syndrome modify the structural and functional characteristics of arteries reducing their compliance and increasing arterial stiffness. (dovepress.com)
PWV measuring provides us to noninvasively assess arterial stiffness and real age of the arteries and thus the risk of cardiovascular events. (jscimedcentral.com)
The vascular ageing has consistently been found to be related closely to the chronological age as Thomas Sydenham said, "A man is as old as his arteries" [2]. (jscimedcentral.com)
DUS of aortic, iliac and femoral arteries. (health-abstracts.com)
These traits include stiffness of the large arteries, microvascular abnormalities, endothelial dysfunction, and atherosclerosis, phenotypes often apparent prior to established hypertension or organ damage. (biomedcentral.com)

Hispanics with chronic kidney disease are found to be at higher risk of left ventricular hypertrophy than non-Hispanic whites, and have more severe coronary artery calcification than non-Hispanic blacks. (cristudy.org)
The condition is marked by severe calcification causing leaflet immobility and outflow obstruction, a process that occurs over a mean duration of 8 years and leads to dramatically increased mortality if left untreated once symptoms develop. (healthybodyart.com)
Whereas diastolic BP decreased as arterial stiffness became more severe. (e-jcpp.org)
5 m/s), rapid haemodynamic progression or severe valve calcification. (ecrjournal.com)
Measurement of the severity of leaflet calcification by CT also may be helpful, using sex-specific standards for severe calcification, given that women have less calcification and more leaflet fibrosis than men. (ecrjournal.com)
Both echocardiography and computed tomography scanning demonstrated migration of the aortic valve into the left ventricle, causing severe aortic and mitral (secondary) insufficiency. (qxmd.com)

In an accompanying editorial , Jutta Bergler-Klein, professor of medicine and cardiology at the Medical University of Vienna, Austria, notes that calcification is the cardinal process driving a vicious cycle that propagates aortic valve stiffness and obstruction. (healthybodyart.com)
A heart murmur caused by valve stiffness is fairly common in older people. (dotie.eu)

BackgroundArterial stiffness indices are used to assess the material properties of the arterial wall and are associated with cardiovascular events. (nagoya-u.ac.jp)

Any increase of arterial stiffness above 9 m/s, which is not correlated with chronologic age, can suggest and direct us to investigate additional comorbidities such a diabetes, hypertension or chronic renal disease that increase arterial stiffness and hence cardiovascular mortality. (jscimedcentral.com)
Most studies have demonstrated that acute and chronic smoking increase arterial stiffness. (ksep-es.org)

All of these disease share common vascular complications, such as vascular calcification. (zmescience.com)
This mini review fo-cuses on the harmful effects of cigarette smoking on cardiovascular complications and arterial stiffness. (ksep-es.org)
For patients aged 65-80 years, the choice between TAVI and a bioprosthetic SAVR depends on expected longevity, which is greater in women than men, as well as associated cardiac and noncardiac conditions, valvular and vascular anatomy, estimated risk of SAVR versus TAVI and expected complications and patient preferences. (ecrjournal.com)

Retinal vascular pathology may reflect renal disease. (cristudy.org)
This association remains after adjustment for traditional and non-traditional risk factors for chronic kidney disease, suggesting that retinal vascular pathology may reflect renal disease. (cristudy.org)
Jiménez Villodres M. Valor de la excreción fraccionada de fósforo como predictor de fácil manejo de calcificación vascular en pacientes con insuficiencia renal crónica Grado 3. (revistaclinicaguayaquil.org)
Renal transplanta-tion was planned in the right iliac fossa with end-to-lateral The increasing number of renal transplantation (RT) in- vascular anastomoses. (health-abstracts.com)
Among the 16 vascular assessment of a renal graft recipient is warranted patients with abnormal physical arterial examination, 10 and must be performed prior to patient inclusion of the patients (62.5%) had abnormal DUS, including 4 cases of patient on the waiting list [2]. (health-abstracts.com)
Colour Doppler tion is the best clinical predictor of abnormal DUS in preop- sonography is also applied after RT to assess the vascular erative assessment of renal transplant receivers. (health-abstracts.com)

A growing body of evidence suggests that smoking results in macro/microvascular stiffness and accelerates premature mortality independently [ 9 - 12 ]. (ksep-es.org)

Sex Differences in Thoracic Aortic Disease and Dissection: JACC Review Topic of the Week. (ottawaheart.ca)
Risk of aortic dissection, congestive heart failure, pneumonia and acute respiratory distress syndrome in patients with clinical vertebral fracture: a nationwide population-based cohort study in Taiwan. (clinicalosteology.org)
Predicting the risk of rupture or dissection based upon aortic dimension is possible. (rbht.nhs.uk)
Finite element analysis (FEA) can be used to determine ascending thoracic aortic aneurysm (aTAA) wall stress as a potential biomechanical predictor of dissection. (qxmd.com)

Furthermore, it promotes vascular remodeling, including calcification and fibrosis, which in turn precedes the development of hypertension and accelerates the progression of other vascular-related diseases such as atherosclerosis or heart failure [ 7 ] . (oaepublish.com)

Kendrick J, Chonchol M. The role of phosphorus in the development and progression of vascular calcification. (revistaclinicaguayaquil.org)
During the development and progression of CKD, the aortic compliance decreases, reducing systolic volume (SV) buffering capacity, resulting in an exaggerated increase of the systolic blood pressure (SBP) and a drop in diastolic blood pressure (DBP) [ 6 ]. (biomedcentral.com)

However, after supplementing the evaluation with the measurement of central blood pressure, the obtained aortic pressure value was higher than in the first step, referring to increased central pressure load, which can lead to left ventricle hypertension, vascular hypertrophy and can trigger plaque formation. (tensiomed.com)

For example, hydrogen peroxide (H 2 O 2 ) is a classic oxidant stressor that promotes vascular cell calcification by increasing the expression of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) [ 11 ]. (biomedcentral.com)

With the help of this outstanding feature the diurnal changes in both the peripheral and the central aortic blood pressure can be measured simultaneously. (tensiomed.com)
In addition, regular exercise is the best evidence-based strategy for improving or ameliorating central/peripheral arterial stiffness in both nonsmokers and smokers [ 15 , 16 ]. (ksep-es.org)
it is also affected by venous return, peripheral vascular tone, and neurohumoral factors. (msdmanuals.com)

The premature aging is result of accelerated vascular aging (stiffening and PWV increase) and the prevalence of hypertension is more than doubled in the elderly than in the young population. (jscimedcentral.com)
The presence of diabetes and prediabets is associated with increased PWV and synergistically effects vascular stiffness expressed by diabetes and hypertension, too. (jscimedcentral.com)
2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension [corrección publicada en J Hypertens. (revistaclinicaguayaquil.org)
Lack of vitamin K2 also increases the risk of arterial stiffness, according to two studies that are published in American Journal of Hypertension and Nephron. (healthandscience.eu)
Dysfunctional vascular traits represent key pathophysiological processes in the development of hypertension and cardiovascular disease, with both inherited and reversible elements. (biomedcentral.com)
While the effect of hypertension and diabetes on arterial stiffness is quite established, autoimmune dysregulation, underlying most glomerulopathies, was not considered, until recently, as an accelerator of early vascular aging (EVA). (biomedcentral.com)
In this study, we measured pulse wave velocity (PWV, m/sec), a validated marker of arterial stiffness, in CKD secondary to glomerular disorders (CKD-GN) compared with that of CKD secondary to hypertension or diabetes (CKD- HTN/DM). (biomedcentral.com)

F Familial thoracic aortic aneurysm (FTAA) is more common than previously recognised and has an indolent growth pattern that is silent but lethal. (rbht.nhs.uk)
Loeys-Dietz syndrome (LDS) is an aortic aneurysm syndrome characterised by vascular, skeletal, cutaneous, and craniofacial findings. (rbht.nhs.uk)

The aim of this review article is to show the factors that influence the aging and stiffening of the blood vessels, to show our own experiences in PWV and arterial stiffness measurement and compare those findings with the scientific knowledge of other studies. (jscimedcentral.com)

The CRIC study indicates that abnormal calcium and phosphate metabolism, insulin resistance, and declining kidney function are associated with the prevalence of high coronary artery calcification, independent of the traditional risk factors in patients with chronic kidney disease. (cristudy.org)

The risks of all-cause and cardiovascular mortality were also higher in patients supplementing with calcium who did not undergo aortic valve replacement. (healthybodyart.com)

Impact of diabetes on site and pattern of calcification. (revistanefrologia.com)
Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study. (ucdenver.edu)

Taken together, these findings suggest that PQS could effectively inhibit VSMCs calcification by ameliorating oxidative stress and regulating osteogenic genes via the promotion of Nrf2 expression. (biomedcentral.com)
The findings have important translational potential," said Paul Sanders, M.D., professor of nephrology in the UAB Department of Medicine and a co-author, "since they demonstrate the benefit of adequate potassium supplementation on prevention of vascular calcification in atherosclerosis-prone mice, and the adverse effect of low potassium intake. (zmescience.com)

He is a PhD supervisor and researcher in the field of coronary calcification, and Doppler echocardiography in heart failure and valvular heart disease. (umu.se)
With the aid of Doppler ultrasonography, we can estimate the arterial stiffness. (jscimedcentral.com)

The multisystem dysfunction in patients with MELAS syndrome may be due to both parenchymal and vascular OXPHOS defects. (medscape.com)
Furthermore, coupling of the vascular mitochondrial dysfunction with cortical spreading depression might underlie the selective distribution of ischemic lesions in the posterior cortex in these subjects. (medscape.com)
The composite of cardiac death and hospitalization occurrence for HF was significantly higher in the high CAVI group.ConclusionCAVI before TAVI is mainly affected by the AS severity, while CAVI after TAVI is associated with left ventricular diastolic dysfunction and late cardiac events, which may reflect arterial stiffness. (nagoya-u.ac.jp)
Despite the strong link between aging and CVD, surprisingly few studies have directly investigated heart failure and vascular dysfunction in aged models and subjects. (oaepublish.com)
The pathological consequences associated with normal cardiovascular aging include hypertrophy, altered left ventricular (LV) diastolic and systolic function, heart failure, enhanced arterial stiffness, and endothelial dysfunction, all of which can alter the structure and function of the heart and arterial system [ 5 , 6 ] . (oaepublish.com)
Smoking-induced CVD is attributed to endothelial dysfunction or harmful hemodynamic responses, including arterial stiffness [ 8 ]. (ksep-es.org)
alternatively, research trials may employ surrogate markers such as vascular stiffness and endothelial dysfunction-early functional traits known to be predictors of more advanced structural changes and development of cardiovascular disease. (biomedcentral.com)

The present study investigated the effects of PQS on the calcification of vascular smooth muscle cell (VSMCs). (biomedcentral.com)
This study investigated the effects of GLSP on atherosclerosis and aortic calcification and revealed the underlying mechanism. (thno.org)

In this article, we will look closer at some current studies of vitamin K2, Q10, selenium, and omega-3, all of which are essential nutrients that prevent, each in their own way, atherosclerosis, arterial stiffness, and premature death as a result of having high heart age. (healthandscience.eu)

Currently the most active projects Michael Henein's Team is working on are coronary calcification, heart failure and valvular heart disease. (umu.se)

A 76-year-old woman was admitted to the authors' hospital with pulmonary edema five months after the successful implantation of a Perceval sutureless aortic valve (Sorin Group Srl, Saluggia, Italy). (qxmd.com)

In the analyses with preprocedural CAVI, preprocedural echocardiographic aortic valve peak flow velocity was significantly lower in the high CAVI group. (nagoya-u.ac.jp)
To compare pulse wave velocity (PWV), a marker of arterial stiffness, between CKD patients of different etiologies: hypertensive and diabetic nephrosclerosis. (biomedcentral.com)

Aortic calcification - comparison between low, medium, and high Potassium (K) consumption. (zmescience.com)
They found that especially in the case of mice who were eating high-fat foods, potassium levels significantly impacted vascular stiffness. (zmescience.com)
They found that low-potassium mice had a significant increase in vascular calcification. (zmescience.com)
In contrast, the mice fed a high-potassium diet had markedly inhibited vascular calcification. (zmescience.com)

The present study used calcification medium containing 3 mM inorganic phosphate (Pi) to induce rat VSMCs calcification. (biomedcentral.com)
The Key Role of Phosphate on Vascular Calcification. (revistaclinicaguayaquil.org)
Early biochemical changes include altered calcium and phosphate balance, while advanced disease produces reduced bone strength and extraskeletal calcification. (ochsnerjournal.org)

Chronic kidney disease (CKD) manifested as reduced GFR and/or albuminuria, has been known to accelerate arterial stiffness and early vascular aging (EVA). (biomedcentral.com)

The production of reactive oxygen species (ROS) and the oxidative modification of various biomolecules induce the transformation of VSMCs from the contractile type to the osteogenic type, which is accompanied by calcification [ 7 ]. (biomedcentral.com)
In vivo , 8-week-aged male LDLR -/- mice were fed a high-fat diet to induce atherosclerosis along with aortic calcification. (thno.org)

Strengthened by its large sample size and extended follow-up period, our study suggests that calcium supplementation does not confer any cardiovascular benefit, and instead may reflect an elevated overall risk of aortic valve replacement and mortality especially in those not undergoing aortic valve replacement," the authors say. (healthybodyart.com)

Cigarette smoking increases oxidative stress, reduces nitric oxide bioavailability, and changes the extracellular matrix, impairing arterial stiffness. (ksep-es.org)
When vascular endothelial cells are damaged due to prolonged exposure to cardiovascular risk factors, the concentration of inflammatory mediators and the expression of angiotensin II in tissues increases, which results in an increased tendency for vasoconstriction, endothelial cell permeability, platelet aggregation, leukocyte adhesion, and cytokine production. (e-jcpp.org)

Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. (thno.org)
Longer telemeres indicate a reduced risk of heart disease and predict slower vascular aging, and slower aging in general. (deansilvermd.com)
Clinical parameters, DUS results, dications has lead to a larger number of recipients with operative and post-operative parameters at 3 months were vascular disease and more advanced ages [1]. (health-abstracts.com)
Lupus is a collagen vascular disease that causes unique symptoms in each patient. (dotie.eu)
We finally make recommendations regarding planning and reporting of data relating to vascular assessment techniques, particularly when genomic data are also available, to facilitate integration of these tools into cardiovascular disease research. (biomedcentral.com)

The question which etiology contributes more to this vascular phenomenon-hypertensive and diabetic CKD or CKD secondary to immune-mediated glomerulonephritis-remained unclear. (biomedcentral.com)

Aortic valve replacement was performed in almost half of the patients taking calcium, compared with only 11% of those not taking any supplements. (healthybodyart.com)

It has multiple pharmacological effects, but no research on aortic calcification during atherosclerosis was performed. (thno.org)
With no proven pharmacological therapy, aortic valve replacement is the only treatment modality. (healthybodyart.com)

Moreover, arterial stiffness is a major pathological cause of increased systolic blood pressure (BP). (e-jcpp.org)

Identifying susceptible risk factors for valve calcification, which might be modified by noninvasive measures, such as targeted medication or dietary changes, instead of the purely mechanical surgical aortic valve replacement approach, is highly desirable," she adds. (healthybodyart.com)

He is also designing a small diameter tissue engineered vascular graft to treat cardiovascular diseases. (pitt.edu)
Increased arterial stiffness is one of the RISK FACTORS for many CARDIOVASCULAR DISEASES. (bvsalud.org)

Increased stiffness and decreased elastic recoil in the aortic wall lead to reduced coronary perfusion and concentric ventricular hypertrophy [ 9 ]. (biomedcentral.com)

Genetic loci predisposing to coronary artery calcification (CAC) (e.g. chr9p21, COL4A1, ATP2B1 and ABCA4) were identified in CRIC, and found to relate to CAC in independent samples, as well as to myocardial infarction in a general population sample. (cristudy.org)

Arterial calcification can be intimal or medial, each associated with different risk factors. (changingyourbusiness.com)

Anatomy28

Organisms6

Diseases53

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes46

Technology, Industry, Agriculture3

Information Science1

Health Care24

Stenosis13

Carotid6

Transcatheter aortic valve implantation1

Isolated thoracic aortic a1

Abdominal aortic3

Aorta4

Progression of aortic1

Atherosclerosis and arterial2

Systolic pressure1

Arteries6

Severe6

Valve stiffness2

Arterial wall1

Increase arterial stiffness2

Complications3

Renal6

Microvascular1

Dissection4

Fibrosis1

Development and progression2

Left ventricle1

Promotes vascular1

Peripheral3

Hypertension7

Aneurysm2

Blood vessels1

Prevalence1

Cardiovascular mortality1

Diabetes2

Findings2

Doppler2

Dysfunction7

Study investigated2

Premature1

Valvular1

Implantation1

Velocity2

Potassium4

Phosphate3

Chronic kidney1

Induce2

Supplementation1

Increases2

Disease5

Diabetic1

Calcium1

Pharmacological2

Pathological1

Dietary1

Diseases2

Ventricular1

Loci1

Intimal1