Vascular calcification. Medical search. Frequent questions

Sanifit conducted a phase-IIb trial (CaLIPSO) in 274 patients to assess the effect of SNF472 on slowing arterial calcification, a major risk factor for cardiovascular disease in dialysis patients. (menafn.com)
For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. (tmu.edu.tw)
In CHA2DS2-VASc thromboembolic risk score, vascular diseases (V) include either prior myocardial infarction, peripheral arterial disease or aortic plaque, summarizing the patient's atherosclero-tic burden. (romanianjournalcardiology.ro)
One of the principal causes of arterial stiffening with age is vascular calcification. (wikipedia.org)
The aim of this paper is to report the autopsy findings of an Idiopathic Infantile Arterial Calcification-new-born male and describe its follow-up. (nih.gov)
Microscopic investigation revealed a generalized arterial calcification of all organs. (nih.gov)
Idiopathic arterial calcification is primarily a disease of infancy. (nih.gov)
It is characterized pathologically by generalized arterial calcification within the internal elastic lamina, associated with intimal fibrous proliferation. (nih.gov)
Importantly, mice deficient in both MGP and OPN had twice as much arterial calcification as MGP −/− OPN +/+ at 2 wk, and over 3 times as much at 4 wk, suggesting an inhibitory effect of OPN in vascular calcification. (silverchair.com)
At least 13 mutations in the ABCC6 gene have been identified in individuals with generalized arterial calcification of infancy (GACI), a life-threatening disorder characterized by abnormal calcification in the blood vessels that carry blood from the heart to the rest of the body (the arteries). (medlineplus.gov)

Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
Wang XR, Zhang JJ, Xu XX and Wu YG: Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: A systematic review and meta-analysis. (spandidos-publications.com)
San Norberto EM, Revilla Á, Fernández-Urbón A, Gómez-Giralda B, Taylor JH, Vaquero C. Vascular calcification progression in patients with end-stage chronic kidney disease. (minervamedica.it)
It is well established that patients with chronic kidney disease and diabetes have poor cardiovascular outcomes which is thought to be due to increased vascular calcification and atherosclerosis. (manchester.ac.uk)
Calcification of soft tissue and blood vessels is typically a problem associated with aging but it is seen early in life for young patients with chronic kidney disease on dialysis treatments and greatly increases risk of early death due to heart disease. (effectiveselfcare.info)
Vascular calcification could also be linked to the chronic leakage of blood lysates into the vessel wall since red blood cells have been shown to contain a high concentration of calcium. (wikipedia.org)
In an effort to explain this discrepancy, we studied the effects of the VDR activators calcitriol and paricalcitol on aortic calcification in a mouse model of chronic kidney disease (CKD)-stimulated atherosclerotic cardiovascular mineralization. (wustl.edu)
High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease. (bvsalud.org)
In chronic kidney disease (CKD), increases in serum phosphate and parathyroid hormone (PTH) aggravate vascular calcification (VC) and bone loss. (bvsalud.org)
Chronic hypercalcemia may lead to vascular calcification and other soft-tissue calcification. (drugs.com)

Vifor Pharma has announced the acquisition of Sanifit Therapeutics, a Spanish clinical-stage cardio-renal biopharmaceutical company focused on treatments for end-stage kidney disease patients with progressive vascular calcification disorders, and Inositec AG, a Swiss company, developing first-in-class non-dialysis treatments for soft tissue and vascular calcification disorders. (menafn.com)
Raggi P: Cardiovascular calcification in end stage renal disease. (spandidos-publications.com)
BACKGROUND: Intima media thickness (IMT), vascular calcifications and ankle-brachial pressure index (ABPI) were shown to be independent predictors of mortality in end-stage renal disease (ESRD) patients. (minervamedica.it)
Calcification in renal tissue or other organs of the body would cause dysfunction in different ways - disrupting the function of that organ type. (effectiveselfcare.info)
Severe vascular calcifications are becoming more common, due in part to an aging population and the growing prevalence of hypertension, diabetes, and renal insufficiency. (medscape.com)

Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis. (nottingham.ac.uk)

In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification. (tmu.edu.tw)

The long term effect of PhosLo® on the progression of vascular or soft tissue calcification has not been determined. (drugs.com)
Introduction Vitamin K has been suggested to have protective effects against progression of vascular calcification and development of cardiovascular disease (CVD). (lu.se)
However, few well-powered randomised controlled trials have examined whether vitamin K prevents progression of vascular calcification in individuals from the general population. (lu.se)

The aims of this thesis were to characterise the roles of OPG/RANKL/TRAIL in VC,and to measure how insulin and liraglutide affect coronary artery calcification (CAC) in T2DM. (rcsi.com)
All participants had de novo coronary calcifications graded as severe by core laboratory assessment, with a mean calcified length of 47.9 mm by quantitative coronary angiography and a mean calcium angle and thickness of 292.5 degrees and 0.96 mm by optical coherence tomography. (medscape.com)
Instead, the comparator group selected under regulatory guidance was comprised of patients who had received orbital atherectomy for severe coronary calcifications in the earlier, similarly designed ORBIT II trial, which led to FDA marketing approval of that technology. (medscape.com)
A total of 450 men and women aged 52-82 years with detectable coronary artery calcification (CAC), but without manifest CVD, will be randomised (1:1) to receive daily MK-7 (333 μg/day) or placebo tablets for 3 years. (lu.se)

Despite this, thromboembolic risk scores used in atrial fibrillation (AF) patients do not include mitral annular calcification (MAC) as a potential indi-cator of vascular disease. (romanianjournalcardiology.ro)
Treatment of mitral regurgitation (MR) associated with severe mitral annular calcification (MAC) is challenging due to the high risk of fatal atrioventricular groove disruption and significant paravalvular leak. (nih.gov)

The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
Alizarin Red S staining and calcium (Ca) content analysis were carried out to detect calcification in VSMCs. (spandidos-publications.com)
Exosomes derived from HP‑HUVECs promoted the calcification of VSMCs, as assessed by Alizarin Red S staining, alkaline phosphatase activity assays, Ca content measurements and the increased expression of runt‑related transcription factor 2 and osteopontin. (spandidos-publications.com)
Inhibition of STAT1 expression in VSMCs using fludarabine or knockdown of STAT1 expression using small interfering RNA alleviated the calcification of VSMCs. (spandidos-publications.com)
Vascular calcification is an active, regulated process in which vascular smooth muscle cells (VSMCs) differentiate into osteoblast-like cells and deposit a mineralised matrix. (manchester.ac.uk)
Therefore, the initial aim of this study was to determine the effects of farnesyl transferase inhibitors (FTI-277 and manumycin A) on vascular calcification using a well validated in vitro model in which VSMCs are induced to deposit a mineralised matrix in the presence of β-glycerophosphate. (manchester.ac.uk)
The present study investigated the effects of PQS on the calcification of vascular smooth muscle cell (VSMCs). (biomedcentral.com)
The present study used calcification medium containing 3 mM inorganic phosphate (Pi) to induce rat VSMCs calcification. (biomedcentral.com)
We investigated the effects of PQS on VSMCs calcification using alizarin red staining and alkaline phosphatase (ALP) activity assays. (biomedcentral.com)
During VSMCs calcification, PQS inhibited the mRNA and protein expression of Runx2 and BMP2. (biomedcentral.com)
Taken together, these findings suggest that PQS could effectively inhibit VSMCs calcification by ameliorating oxidative stress and regulating osteogenic genes via the promotion of Nrf2 expression. (biomedcentral.com)
The production of reactive oxygen species (ROS) and the oxidative modification of various biomolecules induce the transformation of VSMCs from the contractile type to the osteogenic type, which is accompanied by calcification [ 7 ]. (biomedcentral.com)
Significantly, when vascular smooth muscle cells (VSMCs) were exposed exclusively to high phosphate and calcium , high PTH enhanced while low PTH attenuated calcium deposition through parathyroid hormone 1 receptor (PTH1R) signalling. (bvsalud.org)

Acquisition of Sanifit is for the continued clinical development and commercialization of SNF472, a novel, first-in-class intravenously administered inhibitor of vascular calcification, for the treatment of CUA and PAD in patients with end-stage kidney disease. (menafn.com)
Furthermore, lithium chloride (Wnt activator) reversed the protective effect of STAT1 inhibition on VSMC calcification, while Dickkopf‑1 (Wnt inhibitor) exerted the opposite effect, suggesting that activation of the Wnt/β‑catenin signaling pathway was involved in STAT1‑mediated VSMC calcification. (spandidos-publications.com)

citation needed] Calcification of soft tissue (arteries, cartilage, heart valves, etc.) can be caused by vitamin K2 deficiency or by poor calcium absorption due to a high calcium/vitamin D ratio. (wikipedia.org)
Dietary calcium intake is not associated with accumulation of calcium in soft tissue, and calcification occurs irrespective of the amount of calcium intake. (wikipedia.org)
Intake of excessive vitamin D can cause vitamin D poisoning and excessive intake of calcium from the intestine which, when accompanied by a deficiency of vitamin K (perhaps induced by an anticoagulant), can result in calcification of arteries and other soft tissue. (wikipedia.org)
Such metastatic soft tissue calcification is mainly in tissues containing "calcium catchers" such as elastic fibres or mucopolysaccharides. (wikipedia.org)
citation needed] Intake of too much vitamin D would be evident by anorexia, loss of appetite, or soft tissue calcification. (wikipedia.org)
Radiographic evaluation of suspected anatomical regions may be helpful in early detection of soft tissue calcification. (drugs.com)

The role of osteoprotegerin and receptor activator of nuclear factor kappa-betta ligand in vascular calcification and the influence of insulin and liraglutide on this process in type 2 diabetes mellitus. (rcsi.com)

REN-001 also explored effects on bone mineral density (BMD) and abdominal aortic vascular calcification. (uky.edu)
At dosages sufficient to correct secondary hyperparathyroidism, calcitriol and paricalcitol were protective against aortic calcification, but higher dosages stimulated aortic calcification. (wustl.edu)
At protective dosages, the VDR activators reduced osteoblastic gene expression in the aorta, which is normally increased in CKD, perhaps explaining this inhibition of aortic calcification. (wustl.edu)
Therefore, the skeletal actions of the VDR activators may have contributed to their protection against aortic calcification. (wustl.edu)

For example, small, irregular, linear calcifications may be seen, via mammography, in a ductal carcinoma-in-situ to produce visible radio-opacities. (wikipedia.org)

Breast calcifications are a common mammographic finding, present on over 80% of images, and they are usually benign. (medscape.com)
[ 1 , 2 ] Radiologists who interpret mammograms encounter calcifications on a daily basis (see the images below) and must be able to identify typically benign breast calcifications that do not require biopsy to prevent unnecessary procedures and to reduce patient anxiety. (medscape.com)
High-quality mammography is the best diagnostic tool for the identification of breast calcifications. (medscape.com)

As we have seen in previous weeks, calciphylaxis is a severe and complex syndrome involving vascular calcification, thrombosis, and skin necrosis. (woundeducators.com)

Vascular calcification is a pathology characterized by the deposition of calcium-phosphate in cardiovascular structures, mainly in the form of hydroxyapatite crystals, resulting in ectopic calcification. (revistanefrologia.com)
Other causes included congenital pathology, calcifications, atrophy and gliosis. (bvsalud.org)

These acquisitions are a perfect fit for our expanding nephrology pipeline, which now includes vascular calcification inhibition treatments across various stages of non-dialysis CKD and even non-CKD patient populations. (menafn.com)
Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration. (tmu.edu.tw)

Magnesium helps for prevention and reversal of vascular calcification (VC) - plaque build up along vessel walls of deposits of calcium and cholesterol which leads to stiffening and dysfunction of the vessels. (effectiveselfcare.info)
Calcification is the accumulation of calcium salts in a body tissue. (wikipedia.org)
A common misconception is that calcification is caused by excess amount of calcium in diet. (wikipedia.org)
Metastatic calcification, a systemic elevation of calcium levels in the blood and all tissues. (wikipedia.org)
Extraskeletal calcification, e.g. calciphylaxis Brain, e.g. primary familial brain calcification (Fahr's syndrome) Choroid plexus usually in the lateral ventricles Tumor calcification Arthritic bone spurs Kidney stones Gall stones Heterotopic bone Tonsil stones Pulp stone In a number of breast pathologies, calcium is often deposited at sites of cell death or in association secretions or hyalinized stroma, resulting in pathologic calcification. (wikipedia.org)
Vascular calcification is the deposition of mineral in the form of calcium phosphate salts in the smooth muscle-rich medial layer of large arteries including the aorta. (wikipedia.org)
LEFT: Lobular calcifications: punctate, round or 'milk of calcium' RIGHT: Intraductal calcifications: pleomorph and form casts in a linear or branching distribution. (radiologyassistant.nl)
Cross-sectional analysis of calcium intake for associations with vascular calcification and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. (wakehealth.edu)
Pyrophosphate helps control deposition of calcium (calcification) and other minerals (mineralization) in the body. (medlineplus.gov)

Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)
Vascular smooth muscle cells are sensitive to changes in inorganic phosphate (Pi) levels. (revistanefrologia.com)

Only the dialysis type was the independent predictor for all vascular calcifications markers. (minervamedica.it)
CONCLUSIONS: Dialysis, particularly HD, is an independent risk factor for cardiovascular calcification increase in ESRD patients. (minervamedica.it)
Significantly, even children and adolescents on dialysis develop vascular calcification and have a vastly elevated risk for cardiovascular mortality when compared with the normal age-matched population. (effectiveselfcare.info)

Pi is regulated by parathyroid hormone and 1,25-dihydroxyvitamin D. Changes in the transport of Pi are the primary factor responsible for the regulation of Pi homeostasis and the calcification process. (revistanefrologia.com)

Cholesterol buildup in the blood vessels was wrongly blamed exclusively on fat in the diet and cholesterol from eggs initially and people were instructed to not eat eggs and other cholesterol rich foods but we can make our own cholesterol too, and eventually it was recognized that excess carbohydrates was also a causal factor of vascular calcification. (effectiveselfcare.info)

Calcification may also refer to the processes of normal mineral deposition in biological systems, such as the formation of stromatolites or mollusc shells (see Biomineralization). (wikipedia.org)

King's College London) fuelled her interest in vascular cellular signalling and her subsequent post-doctoral position with Professor Jeremy Pearson at King's College London (KCL) allowed her to pursue this interest in human endothelial cells. (rvc.ac.uk)
Her laboratory specialises in investigating the functional relevance of molecular signalling pathways in human and animal endothelial cells and a range of other vascular cell types. (rvc.ac.uk)
The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)

2 , 5 " ( 17 ) *Medial calcification causes stiffening of the vessel wall but does not include plaque deposits that obstruct the interior of the blood vessel. (effectiveselfcare.info)

Inositec's novel asset INS-3001, is a once-daily subcutaneous treatment for patients with vascular calcification disorders PAD and AVS, which are both major contributors to cardiovascular morbidity and mortality in affected patient populations. (menafn.com)
Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. (tmu.edu.tw)

Previous work from the host laboratory has shown that nitrogen-containing bisphosphonates attenuate vascular calcification by inhibiting farnesyl pyrophosphate synthase, depleting cells of farnesyl pyrophosphate and geranylgeranyl pyrophosphate which are essential for the prenylation and activation of small GTPases such as Ras and Rho. (manchester.ac.uk)

Mice deficient in MGP alone (MGP −/− OPN +/+ ) showed calcification of their arteries as early as 2 weeks (wk) after birth (0.33 ± 0.01 mmol/g dry weight), and the expression of OPN in the calcified arteries was greatly up-regulated compared with MGP wild-types. (silverchair.com)

Mineral balance Dystrophic calcification, without a systemic mineral imbalance. (wikipedia.org)

The aim of the InterVitaminK trial is to investigate the effects of vitamin K supplementation (menaquinone-7, MK-7) on cardiovascular, metabolic, respiratory and bone health in a general ageing population with detectable vascular calcification. (lu.se)

Mammography is limited in evaluating benign calcifications when benign calcifications morphologically overlap with indeterminate or malignant calcifications. (medscape.com)
Although screening mammography remains the only modality demonstrated to reduce death from breast cancer, 70-80% of biopsies performed for suspicious mammographic findings (masses and calcifications) are benign. (medscape.com)
In a study comparing conspicuity of DCIS to benign calcifications on unenhanced breast CT (bCT), contrast-enhanced breast CT (CEbCT), and mammography, DCIS was found to be more conspicuous than benign microcalcifications on CEbCT. (medscape.com)
CEbCT may have an advantage over mammography by reducing false positive examinations when calcifications are analyzed. (medscape.com)

However, the underlying mechanisms of vascular calcification have not been established. (biomedcentral.com)
She is particularly known for her work on mechanisms of vascular endothelial eicosanoid generation and recent studies have identified biological roles for novel fatty acid metabolites in vascular repair and angiogenesis. (rvc.ac.uk)
focus is primarily on vascular cell function with emphasis on understanding molecular control mechanisms. (rvc.ac.uk)

Age-Related Incidence of Pineal Calcification Detected by Computed Tomography" (PDF). (wikipedia.org)

In terms of diagnosis, in this case vascular calcification, an ultrasound and radiography of said area is sufficient. (wikipedia.org)

Synthesis of calcification inhibitors is the main mechanism by which cells are able to prevent vascular calcification. (revistanefrologia.com)

and lack of other trace minerals, zinc, iodine, selenium, or vitamin D ( 12 ) can also be risk factors for vascular calcification. (effectiveselfcare.info)
Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. (tmu.edu.tw)
An apparent conflict exists between observational studies that suggest that vitamin D receptor (VDR) activators provide a survival advantage for patients with ESRD and other studies that suggest that they cause vascular calcification. (wustl.edu)

Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. (tudelft.nl)

F) Brain of neonate 3: pachygyria and severe vascular congestion. (cdc.gov)

Finally, on the basis of the interpretation, the radiologist can make an informed decision about whether the calcifications identified are benign and do not require biopsy or whether the appearance of the calcifications warrants biopsy. (medscape.com)
001). The researchers concluded that the rate of calcification change may help discriminate benign from malignant calcifications. (medscape.com)
Lobular calcifications are almost always benign. (radiologyassistant.nl)

The aim of the present study was to investigate whether exosomes from HUVECs (HUVEC‑Exos) could regulate VSMC calcification and its potential signaling pathway. (spandidos-publications.com)
In conclusion, the present results indicated that exosomal STAT1 derived from HP‑treated HUVECs could promote VSMC calcification, and activation of the Wnt/β‑catenin pathway may be a potential mechanism of the VSMC calcification promoted by exosomes. (spandidos-publications.com)
In hyperphosphataemic CKD, a defective suppression of high PTH exacerbates HP-mediated osteogenic VSMC differentiation and reduces vascular levels of anti-calcifying sclerostin. (bvsalud.org)

DNA damage, especially oxidative DNA damage, causes accelerated vascular calcification. (wikipedia.org)

With INS-3001 daily subcutaneous dosing, patients with earlier stages of vascular calcification can be optimally treated, while end-stage kidney disease patients will benefit from the three times per week dosing regimen of SNF472. (menafn.com)
The presence of MAC, irrespective of se-verity, correlates very well with both vascular disease and thromboembolic risk scores. (romanianjournalcardiology.ro)
This study raises the question whether inclusion of MAC in thromboembolic risk scores as an indicator of vascular disease (V) might increase their predictive value. (romanianjournalcardiology.ro)

Multiple skin calcifications (arrows). (medscape.com)
E) Brain of neonate 2: symmetric cerebellar hypoplasia (arrows) and vascular congestion. (cdc.gov)

Vifor Pharma will be spearheading the vascular calcification field, emphasizing our strategic focus to bring innovative assets to patients with high unmet medical need as we strive to improve lives of people suffering from serious diseases around the world. (menafn.com)

The uneven calcification of the cellular debris explains the fragmentation and irregular contours of the calcifications. (radiologyassistant.nl)

Systemic corticosteroids should be avoided in calciphylaxis as they may exacerbate arteriolar calcification. (woundeducators.com)

Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. (tmu.edu.tw)

Carotid IMT, vascular calcifications analysis values and measurements of the ABPI, were made at baseline and after 1-year of follow-up. (minervamedica.it)

However when there is more fibrosis, as in sclerosing adenosis, the calcifications are usually smaller and less uniform. (radiologyassistant.nl)

Anatomy22

Organisms6

Diseases45

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes19

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science1

Health Care16

Arterial10

Chronic13

Renal5

Atherosclerosis1

Uremic vascular calcification1

Progression3

Coronary4

Mitral annular calcification2

VSMCs13

Inhibitor2

Soft tissue6

Type 2 diabet1

Aortic4

Ductal carc1

Breast calcifications3

Thrombosis1

Pathology2

Inhibition2

Calcium9

Phosphate2

Dialysis3

Parathyroid hormone1

Blood vessels1

Deposition1

Endothelial cells3

Medial1

Mortality2

Bisphosphonates1

Arteries1

Dystrophic1

Bone1

Mammography4

Mechanisms3

Computed tomography1

Ultrasound1

Inhibitors1

Vitamin3

Inflammation1

Severe1

Benign3

VSMC3

Oxidative1

Disease3

Arrows2

Diseases1

Irregular1

Calciphylaxis1

Progenitor1

Carotid1

Fibrosis1