• Furthermore, the compounds 1-3 were subjected to screening of anti-cancer activity against different cell lines followed by brief analysis of apoptotic and anti-angiogenic potentials of the potent hit against non-small cell lung carcinoma cell line. (biomedcentral.com)
  • This abnormally implanted placenta may result in poor uterine and placental perfusion, yielding a state of hypoxia and increased oxidative stress and the release of anti-angiogenic proteins along with inflammatory mediators into the maternal plasma. (wikipedia.org)
  • While the etiology of PE is still unclear, clinical phenotypes have been associated with high circulating levels of anti-angiogenic proteins such as soluble Fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng). (alliedacademies.org)
  • We used deep proteomic profiling to define the molecular phenotype of human retinal and choroidal endothelial cells at the protein level. (elsevier.com)
  • Here, we described the generation of an immortalized human mesenchymal bone marrow-derived cell line and we investigated the angiogenic phenotype of our cellular model by inhibiting SIRT1 by both the genetic and pharmacological level. (hindawi.com)
  • Furthermore, the compounds 1-3 were subjected to screening of anti-cancer activity against different cell lines followed by brief analysis of apoptotic and anti-angiogenic potentials of the potent hit against non-small cell lung carcinoma cell line. (biomedcentral.com)
  • Taken together, all these findings of the direct and indirect angiogenic investigations nominated S. triloba as a highly potent antiangiogenic plant that may have chemotherapeutic and/or chemoprevention potentials. (biomedcentral.com)
  • Conclusions: This work describes the different protein expression profiles of human retinal and choroidal vascular endothelial cells, and provides multiple candidates for further study as novel treatments or drug targets for posterior eye diseases. (elsevier.com)
  • Vascular cell seeding of scaffolds and the design of bioactive polymers for in situ arterial regeneration have yielded promising results. (pubmedcentralcanada.ca)
  • Since then, strategies to create a suitable material for a vascular graft have focused on three areas of research: coatings and surface chemical modifications of synthetic materials, biodegradable scaffolds and biopolymers. (pubmedcentralcanada.ca)
  • Furthermore, we observed a consistent reduction of tubule-like formation and migration and we found that SIRT1 inhibition reduced the hypoxia induced accumulation of HIF-1α protein and its transcriptional activity in hMSCs. (hindawi.com)
  • In most cases, damage caused by diabetes, stroke, hypoxia and other cellular insults to vascular endothelial cells is repaired through effective balance of TIE2 with other angiogenic proteins. (novusbio.com)
  • Myeloperoxidase (MPO) is a highly abundant protein within the neutrophil that is associated with lipoprotein oxidation, and increased plasma MPO levels are correlated with poor prognosis after myocard. (bioportfolio.com)
  • Under normoxic condition, HIF-1α rapidly decreases since it is bound to the tumour suppressor Von Hippel-Lindau (VHL) protein, which in turn results in HIF-1α ubiquitynation and becomes a target for the proteosome. (biomedcentral.com)
  • Protein transduction exploits the ability of some cell-penetrating peptide (CPP) sequences to enhance the uptake of proteins and other macromolecules by mammalian cells. (freepatentsonline.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • While synthetic polymers have been extensively studied as substitutes in vascular engineering, they fall short of meeting the biological challenges at the blood-material interface. (pubmedcentralcanada.ca)
  • The VHL gene encodes a ubiquitously expressed messenger RNA of 4,700 nucleotides and the protein-coding region is contained in three exons. (biomedcentral.com)
  • The VHL gene encodes a 213 amino acid protein that does not closely resemble any other human protein. (biomedcentral.com)
  • The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by CSK. (wikipedia.org)
  • Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • We first assessed the expression of SIRT1 in hMSCs under basal and hypoxic conditions at both RNA and protein level. (hindawi.com)
  • Smith, JR , David, L , Appukuttan, B & Wilmarth, P 2018, ' Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs ' American Journal of Ophthalmology . (elsevier.com)
  • In this study, human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAPs) were applied in an in vivo model of dental pulp regeneration in order to compare their regenerative potential and confirm their previously demonstrated paracrine angiogenic properties. (hindawi.com)
  • Plasma angiogenic proteins were evaluated as potential PD biomarkers of response to lenvatinib in a dose-escalation phase 1 study. (biomedcentral.com)
  • Pre-eclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine. (wikipedia.org)
  • While historically both high blood pressure and protein in the urine were required to make the diagnosis, some definitions also include those with hypertension and any associated organ dysfunction. (wikipedia.org)
  • Women with a history of PE have an increased risk of hypertension, and cardiovascular and renal disease Therefore, this raises the possibility of measuring circulating angiogenic proteins in the blood and the urine as a diagnostic and screening tool for PE. (alliedacademies.org)
  • however, recent studies demonstrate that failure of effective vascular remodeling in pre-eclampsia is associated with the erroneously low production of soluble TIE2. (novusbio.com)
  • Within a given microenvironment, the angiogenic response is determined by a net balance between pro- and anti-angiogenic regulators released from activated ECs, monocytes, smooth muscle cells and platelets. (biomedcentral.com)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • Results: Human retinal and/or choroidal vascular endothelial cells expressed 5042 nonredundant proteins. (elsevier.com)
  • Chow-fed 17-wk-old female Apoe mice treated with 4-PBA-supplemented drinking water for 5 wk exhibited smaller lesions as well as increased plasma levels of heat shock protein (HSP) 25, the mouse homolog of human HSP27, compared with controls. (bioportfolio.com)
  • 4 isoforms of the human protein are produced by alternative initiation. (mybiosource.com)
  • This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
  • Peptide sequences were assigned to fragment ion spectra, and proteins were inferred from openly accessible protein databases. (elsevier.com)
  • Other elements that define an ideal biomaterial necessary to the design of a vascular graft are bio-compatibility, infection resistance, suturability and off-the-shelf availability. (pubmedcentralcanada.ca)
  • Dr. Pardi's research focuses on structure-function studies of proteins, nucleic acids and nucleic aicd-protein complexes. (colorado.edu)