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  • endothelial cell
  • Since endothelial dysfunction is considered the first step in the pathogenesis of cerebral aneurysms, a human cerebral vascular endothelial cell model was applied in the study. (hindawi.com)
  • Similarly, the in vitro adhesion of isolated mouse monocytes to tumor necrosis factor α-stimulated murine endothelial cell monolayers and their migration across the cell layers were strongly reduced in P2Y 1 -deficient compared with wild-type endothelial cells, as was the expression of the adhesion molecules P-selectin, Vascular cell adhesion molecule 1, and intercellular adhesion molecule 1. (ahajournals.org)
  • These adhesion molecules are upregulated by proinflammatory cytokines, such as tumor necrosis factor α (TNFα), the effects of which also include the induction of endothelial cell permeability, motility changes, and the secretion of additional cytokines. (ahajournals.org)
  • endothelium
  • It suggested that curcumin could ameliorate diabetic vascular inflammation by decreasing ROS overproduction, reducing leukocyte-endothelium interaction, and inhibiting ICAM-1 and NOX2 expression. (hindawi.com)
  • 2 , - , 4 Members of the selectin family, like P- and E-selectin 5 and the immunoglobulin (Ig) family, notably intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), 4 , 6 promote irreversible adhesion of monocytes to the endothelium and their transmigration into the subendothelial space. (ahajournals.org)
  • IL-10 preserves vascular function, including endothelium-dependent relaxation, during acute inflammation produced by endotoxin ( 4 , 5 ). (diabetesjournals.org)
  • Endothelium-dependent relaxation is impaired in humans with type 1 or type 2 diabetes ( 6 , 7 ) and also in animal models of diabetes ( 8 , 9 ). (diabetesjournals.org)
  • Most likely EPCs enhance the reparative capacity of the endothelium adjacent to the injury by releasing paracrine factors. (ahajournals.org)
  • activation
  • Could also be involved in activation of transcription by the serum response factor. (genecards.org)
  • c-fos is an "early response" gene that undergoes rapid transcriptional activation in response to multiple pathophysiological stimuli (e.g., growth factors, chemical and physical stress, etc. (rupress.org)
  • To better understand the mechanism of LXR on the prevention of atherogenesis, we examined whether activation of LXR affects AT1R expression in vascular smooth muscle cells. (ahajournals.org)
  • 17 Intriguingly, an LXR agonist inhibited nuclear factor-κB activation. (ahajournals.org)
  • Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinases, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation (6,7). (cellsignal.com)
  • We used conditioned growth medium, IL-6-neutralizing antibodies, an inhibitor of the IL-6 receptor, and short hairpin RNA targeting IL-6 to show that US28 activates the IL-6-JAK1-STAT3 signaling axis through activation of the transcription factor nuclear factor κB and the consequent production of IL-6. (sciencemag.org)
  • US28 also elicited STAT3 activation and IL-6 secretion in HCMV-infected cells. (sciencemag.org)
  • Moreover
  • Moreover, the severity of diabetic vascular inflammation reproduced after the plugged leukocyte in microcirculation via the process of phagocytic NADPH oxidase (NOX2 enzyme) mediated superoxide radical formation [ 17 - 19 ]. (hindawi.com)
  • Moreover, in wild-type bone marrow-transplanted chimeric P2Y 1 -deficient mice with an apolipoprotein E-deficient background, a strong reduction of adhesion molecule-dependent leukocyte recruitment was observed after local injection of tumor necrosis factor α and interleukin 1β, excluding a role for the platelet or other hematopoietic cell type P2Y 1 in these events. (ahajournals.org)
  • growth
  • It is unknown whether PPAR expression may be altered in hypertension and play a pathophysiological role by regulating vascular growth. (ahajournals.org)
  • Here, we show increased concentrations of vascular endothelial growth factor and interleukin-6 (IL-6) in supernatants of US28-expressing NIH 3T3 cells. (sciencemag.org)
  • Although it remains uncertain which of these play a significant role in the anticancer action, particular attention has been paid to IκB, a negative regulator of the nuclear factor-κB (NF-κB) transcription factor that seems to play a major role in cancer growth as well as resistance to cytotoxic drugs and radiation. (aacrjournals.org)
  • SBS decreased the number of MDSCs and the level of transforming growth factor β1 (TGF-β1). (biomedcentral.com)
  • mRNA
  • mRNA levels of PPAR-α and PPAR-γ were determined by reverse transcription-polymerase chain reaction. (ahajournals.org)
  • T0901317, a synthetic LXR ligand, decreased AT1R mRNA and protein expression with a peak reduction at 6 hours and 12 hours of incubation, respectively. (ahajournals.org)
  • abnormal
  • In spontaneously hypertensive rats (SHR), blood vessels exhibit abnormal structure due to vascular remodeling. (ahajournals.org)
  • We hypothesized that vasoregulation may be abnormal in leptin-deficient ob/ob mice and that leptin may be important in regulating vascular function. (physiology.org)
  • acute
  • 6. The method according to claim 5, wherein the lung disorders and lung conditions comprise asthma, noneosinophilic asthma, non-specific airway hyper-responsiveness, chronic pulmonary obstructive disease, nosocomial pneumonia, endotoxemia-induced acute respiratory distress syndrome or related conditions. (patentsencyclopedia.com)
  • diabetic
  • Recently, the use of natural plant products has gained more attention among scientists in order to prevent diabetic vascular complications. (hindawi.com)
  • These vascular abnormalities are similar to those observed in obese, diabetic, leptin-resistant humans. (physiology.org)
  • expression
  • 15(S)-HETE induced expression and secretion of interleukin-6 (IL-6), as analyzed by RT-PCR and ELISA, respectively. (ahajournals.org)
  • Serial 5′ deletions and site-directed mutagenesis of IL-6 promoter along with chromatin immunoprecipitation using anti-CREB antibodies showed that cAMP response element is essential for 15(S)-HETE-induced IL-6 expression. (ahajournals.org)
  • Dominant-negative CREB also suppressed balloon injury-induced IL-6 expression, SMC migration from media to intimal region, and neointima formation. (ahajournals.org)
  • 7 However, the expression and function of PPARs in the vascular wall are still unclear. (ahajournals.org)
  • The microRNA suppresses IL-8 and IL-6 expression in these cells. (patentsencyclopedia.com)
  • cells
  • This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. (genecards.org)
  • Vascular cells with genetically or pharmacologically reduced TG2 activity fail to activate β-catenin in response to warfarin. (ahajournals.org)
  • Endothelial progenitor cells (EPCs, defined as sca-1 + flk-1 + lin − mononuclear blood cells) contribute to vascular repair. (ahajournals.org)
  • We conclude that Nox2-derived ROS inactivate SHP-2 and thereby facilitate EPO signaling in EPCs to promote hypoxia-induced mobilization and vascular repair by these cells. (ahajournals.org)