Variation polymorphism genetic. Medical search. Frequent questions

Differences in the severity of an illness or response to treatments may also be manifestations of genetic variations caused by SNPs. (wikipedia.org)
SNPs within a coding sequence do not necessarily change the amino acid sequence of the protein that is produced, due to degeneracy of the genetic code. (wikipedia.org)
SNPs occur in non-coding regions more frequently than in coding regions or, in general, where natural selection is acting and "fixing" the allele (eliminating other variants) of the SNP that constitutes the most favorable genetic adaptation. (wikipedia.org)
The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). (routledge.com)
Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. (routledge.com)
In this study, 74 single nucleotide polymorphisms (SNPs) were identified. (nih.gov)
As a living information and communications system, the genome encodes patterns in single nucleotide polymorphisms (SNPs) reflecting human adaptation that optimizes population survival in differing environments. (scirp.org)
The $45-million project will identify and analyse single nucleotide polymorphisms (SNPs). (newscientist.com)
We focused on 8 single-nucleotide polymorphisms (SNPs) in 2 candidate genes important in the innate immune response to influenza infection and for which national prevalence estimates were available: the gene for tumor necrosis factor superfamily, member 2 (official symbol TNF ) and the mannose-binding lectin gene (official symbol MBL2 ). (cdc.gov)
Single nucleotide polymorphisms (SNPs) in the Gγ-globin gene promoter in BCL11A regions and HBS1L-MYB intergenic polymorphism (HMIP) are thought to be associated with Hb F levels. (scirp.org)
The SeqStudio instrument is easy to use across a broad range of applications, including de novo , targeted, and plasmid Sanger sequencing, CRISPR-Cas9 genome editing confirmation, cell line authentication, and detection of single nucleotide polymorphisms (SNPs). (thermofisher.com)
That project looked at nearly 10 million single nucleotide polymorphisms (SNPs). (bigthink.com)
While CNVs usually cover large DNA sequence variations, single nucleotide polymorphisms or SNPs are random, single base substitutions found throughout the genome. (jove.com)
Both CNV and SNPs are immensely valuable in genetic screening studies and kinship analysis. (jove.com)
The study was based on SNPs (single nucleotide polymorphisms), which are thought to influence school attainment. (sciencedaily.com)
SNPs are small variations in the genetic code which may be linked to particular traits, abilities or disease risks. (sciencedaily.com)
Single-nucleotide polymorphisms (SNPs) in the glucocorticoid receptor (GR) gene influence the sensitivity to glucocorticoids and are related to both microbial colonization and susceptibility to develop auto-immune disease. (eur.nl)
This method searches a person's DNA (genome) for small variations, called single nucleotide polymorphisms (SNPs). (news-medical.net)
We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). (medsci.org)
Single nucleotide polymorphisms (SNPs) denote the single nucleotide variations occurring at specific sites in the genome with substantial frequency within the population [ 1 , 9 , 10 ]. (medsci.org)
Variations in toxicity and response to therapy are observed among patients despite similar clinicopathologic characteristics which are attributed to single nucleotide polymorphisms (SNPs). (researchsquare.com)
So, the aim of this review was to investigate the effect of single nucleotide polymorphisms (SNPs) on response rate and toxicity in HNSCCs. (researchsquare.com)
Among the European ancestry sample, they discovered 19 single nucleotide polymorphisms (SNPs) that were significantly associated with general addiction risk and 47 genetic variants linked to specific SUDs - nine for alcohol, 32 for tobacco, five for cannabis, and one for opioids. (medscape.com)
ABSTRACT Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon--ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. (who.int)

Single-nucleotide polymorphisms may fall within coding sequences of genes, non-coding regions of genes, or in the intergenic regions(regions between genes). (wikipedia.org)
These findings suggest that variation in the ACE and AGTR1 genes and their interaction may not only contribute to susceptibility of coronary artery disease as previously found but also modify the disease process, thus contributing to interindividual differences in severity of the disease. (bmj.com)
Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. (routledge.com)
This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. (routledge.com)
Polymorphisms in other genes likely have smaller effects on clopidogrel activation. (medlineplus.gov)
We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. (cdc.gov)
Limited analysis of 2 genes important to the innate immune response found no association between genetic variants and fatal influenza infection. (cdc.gov)
Different genotypes of several genetic polymorphisms of certain genes, at least in part, might be accounted for susceptibility to COVID-19 infection. (degruyter.com)
Studying twins allows for researchers to examine the entirety of genetic influence, including how genes interact with one another, how rare variants influence a person, and how the interplay between genes and the environment takes place. (bigthink.com)
In other words, the scoring system examines interaction between genes, and estimates the difference between genetic influences and common variance. (bigthink.com)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)
Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)
Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (snpedia.com)
Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (snpedia.com)
Genes can have multiple variations known as polymorphisms, which may contribute to some of this variability [Grassman et al. (cdc.gov)
Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes. (lu.se)

Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. (routledge.com)
Genetic samples were obtained from several ongoing studies, including many funded by NIA: the Health and Retirement Study, the Age, Gene/Environment Susceptibility Reykjavic Study, and the SardiNIA Study of Aging, as well as dozens of other cohorts. (nih.gov)
To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)
Based on meta-analysis the association between ESR2 rs3020450 polymorphism and cancer susceptibility was estimated and a case-control design was used to verify this result in ovarian cancer. (cancerindex.org)
The pooled analysis indicated no significant correlation between the ESR2 rs3020450 polymorphism and the cancer susceptibility. (cancerindex.org)
In this review we define the field of occupational and environmental health (OEH) research as the study of interactions between the following domains: environment (the exposome), 4 individual (genetic) susceptibility (the (epi)genome), and biological outcomes (the responsome) 5 ( figure 1 ). (bmj.com)
The fact that genetic factors account for about 60% of the overall susceptibility to RA highlights the importance of research into genetic aberrations of this disease [ 3 , 6 - 8 ]. (medsci.org)
Studies of population genetics have also created opportunities for strain identification and molecular taxonomy and for exploring the relationship between genetic diversity and properties of medical relevance such as virulence, resistance to drugs, antigenic variation, susceptibility to potential vaccines, and host and vector specificity. (bio.net)
Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). (cancerindex.org)
The study of biomarkers of genetic susceptibility in the context of workplace exposures can provide information about gene-environment interactions. (cdc.gov)
For example, the fat mass and obesity-associated (FTO) gene polymorphism affects the susceptibility to obesity but accounts for less than 0.5% of the overall variance in body mass index (BMI). (medscape.com)

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. (routledge.com)
According to King's College researchers, genetic determinants had more to do with academic achievement than "grit," or any other personality trait. (bigthink.com)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
Few studies have been conducted on the epidemiology of waterpipe smoking behavior and its genetic determinants. (who.int)

This is an interesting development in behavior genetics," said NIA Director Richard J. Hodes, M.D. "It extends our understanding of the connection between the genetic components of cognition and years of formal education. (nih.gov)
But David Bentley, head of genetics at the Wellcome Trust's Sanger Centre near Cambridge, argues that individual variation is even more important. (newscientist.com)
Wonil Chung, Omer Weissbrod and Margaux Hujoel were awarded as semifinalists for the Charles J. Epstein Trainee Award for Excellence in Human Genetic Research for the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)
Major technological advances in the last few years have increased our knowledge of the role that genetics has in occupational diseases and our understanding of genetic components and the interaction between genetics and environmental factors. (cdc.gov)
Specifically, the role of genetic information in occupational disease is discussed in Chapter 2, followed in Chapter 3 by a presentation of how genetics is incorporated into occupational health research. (cdc.gov)

A recent study suggested that the A allele of the 3′UTR biallelic polymorphism in the LBP-1c / CP2 / LSF gene was associated with reduced AD risk. (bmj.com)
They found that the A allele of a G/A polymorphism located in the 3′UTR was associated with sporadic AD in samples diagnosed predominantly by clinical, rather than pathological, criteria. (bmj.com)
Based on meta-analysis and case-control pooled results, ARP and PARP were evaluated respectively in allele (21.95% and7.97%), heterozygote (36.99% and 12.11%) and dominant model (36.84% and 12.97%) of rs3020450 polymorphism in ovarian cancer. (cancerindex.org)
The authors reported correlation between the frequency of the Del allele of the ACE Ins/Del polymorphism and prevalence and mortality rates of COVID-19 in 33 countries (25 European, three north-African and five Middle East countries). (degruyter.com)
We could distinguish six different GR haplotypes of which two carried the BclI polymorphism: haplotype 1, which consists of the minor allele of BclI in combination with the common variant of TthIIII and haplotype 2, which carries the minor allele of BclI as well as the minor allele of TthIIII. (eur.nl)
However, haplotypes carrying the minor allele of the BclI polymorphism were related to the phenotype and outcome of GBS. (eur.nl)

African Americans with a common genetic variation are at increased risk for developing Alzheimer's disease, while European Americans with the same variation are not, according to a study led by researchers at Rush University Medical Center. (eurekalert.org)
The study found that African Americans with this polymorphism are 30 percent more likely to develop Alzheimer's disease dementia than the African American without the genetic polymorphism. (eurekalert.org)
INTRODUCTION: This study aimed to investigate the influence of the overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and cerebrospinal fluid (CSF) biomarkers. (bvsalud.org)
The APOE 2/3/4 polymorphism is the greatest genetic risk factor for Alzheimer's disease (AD). (bvsalud.org)

To their surprise, the brains of the healthy donors who had the polymorphism displayed biomarkers that are known to play a role in neurodegenerative brain disease. (eurekalert.org)

If data of Asian and European countries were used for analysis, it seems that we would observe no correlation between the ACE Ins/Del polymorphism and the prevalence of COVID-19 infection or the mortality due to COVID-19. (degruyter.com)
Distinguishing genetic correlation from causation across 52 diseases and complex traits. (harvard.edu)

An individual inherits two alleles, one from each parent, for any given genomic location where such variation exists. (genome.gov)
Genomic variations such as addition or deletion of segments of DNA are commonly observed in a population. (jove.com)
Genomic variations in a population can arise due to single nucleotide changes in the DNA or structural changes to chromosomes. (jove.com)
Separately, the genomic analysis of individuals of African ancestry showed only one genetic variation associated with general addiction risk and one substance-specific variation for risk of alcohol use disorder. (medscape.com)

DNA polymorphisms are important markers in genetic analyses and are increasingly detected by using genome resequencing. (psu.edu)
Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. (routledge.com)
A number of markers are now available to detect nuclear DNA polymorphisms. (intechopen.com)
In genetic diversity studies, the most frequently used markers are microsatellites. (intechopen.com)
We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density ( r g = 0.15) and pancreatic β-cell function ( r g = 0.12). (nature.com)
Population genetic diversity and species relationships in the genus Rhinanthus L. based on microsatellite markers, 495-502. (usd.edu)
A total of 720 individuals of 12 indigenous chicken populations, geographically localized in Southern China were genotyped for 30 microsatellite markers in polymerase chain reaction (PCR) to evaluate the genetic variation and genetic distance between populations. (scialert.net)

Wing size was associated with the genetic structure in all species, highlighting the functional importance of this trait. (frontiersin.org)
Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (snpedia.com)
PMID 17482701 ] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population. (snpedia.com)

We offer an alternative interpretation of the sequencing data of meiotic products, including the number and type of recombination events, to illustrate the potential for mistakes in single-nucleotide polymorphism calling. (psu.edu)
These variations can be a single nucleotide or a larger chromosomal variation. (jove.com)
The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1% of the population. (jove.com)
To determine whether genetic variations of IGF modify pancreatic cancer risk, we compared the frequency of six single nucleotide polymorphisms of IGF1 and IGF2 in a large-scale case control study. (aacrjournals.org)
Single nucleotide polymorphisms were investigated using the TaqMan method in 892 patients with pancreatic ductal adenocarcinoma and 783 healthy controls who were recruited from The University of Texas M. D. Anderson Cancer Center from 2000 to 2007. (aacrjournals.org)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
WGS revealed a 0-10 single-nucleotide polymorphism variation between isolates. (cdc.gov)

Based on molecular genetic polymorphisms 4 , these eight Groups are distributed equally into two subspecies, C. pepo subsp. (nature.com)
Because educational attainment is a complex phenomenon, there are many additional sources of molecular genetic variation to be discovered. (nih.gov)
Now, a study published in the journal Molecular Psychiatry is helping to quantify genetic influence. (bigthink.com)
2018). Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. (harvard.edu)
Laboratories that perform molecular genetic testing are subject to the general CLIA quality systems requirements for nonwaived testing and the CLIA personnel requirements for tests of high complexity. (cdc.gov)
Although many laboratories that perform molecular genetic testing comply with applicable regulatory requirements and adhere to professional practice guidelines,specific guidelines for quality assurance are needed to ensure the quality of test performance. (cdc.gov)
To enhance the oversight of genetic testing under the CLIA framework,CDC and the Centers for Medicare & Medicaid Services (CMS) have taken practical steps to address the quality management concerns in molecular genetic testing,including working with the Clinical Laboratory Improvement Advisory Committee (CLIAC). (cdc.gov)
This report provides CLIAC recommendations for good laboratory practices for ensuring the quality of molecular genetic testing for heritable diseases and conditions. (cdc.gov)
The recommended practices address the total testing process (including the preanalytic,analytic,and postanalytic phases),laboratory responsibilities regarding authorized persons,confidentiality of patient information,personnel competency,considerations before introducing molecular genetic testing or offering new molecular genetic tests,and the quality management system approach to molecular genetic testing. (cdc.gov)
These recommendations are intended for laboratories that perform molecular genetic testing for heritable diseases and conditions and for medical and public health professionals who evaluate laboratory practices and policies to improve the quality of molecular genetic laboratory services. (cdc.gov)
This report also is intended to be a resource for users of laboratory services to aid in their use of molecular genetic tests and test results in health assessment and care. (cdc.gov)
Genetic testing encompasses a broad range of laboratory tests performed to analyze DNA, RNA, chromosomes, proteins, and certain metabolites using biochemical, cytogenetic, or molecular methods or a combination of these methods. (cdc.gov)
Since that time, advances in scientific research and technology have led to a substantial increase both in the health conditions for which genetic defects or variations can be detected with molecular methods and in the spectrum of the molecular testing methods ( 1 ). (cdc.gov)
As the number of molecular genetic tests performed for patient testing has steadily increased, so has the number of laboratories that perform molecular genetic testing for heritable diseases and conditions ( 2,3 ). (cdc.gov)
With increasing use in clinical and public health practices, molecular genetic testing affects persons and their families in every life stage by contributing to disease diagnosis, prediction of future disease risk, optimization of treatment, prevention of adverse drug response, and health assessment and management. (cdc.gov)

The two possible nucleotide variations of this SNP - G or A - are called alleles. (wikipedia.org)
Generally, only a nucleotide variation that is found in more than 1% of the population is referred to as SNP. (jove.com)

The non-monophyly of the northern Tokara samples and the great genetic differences within these samples may have resulted from colonization from more than one source population by northeastward overseas dispersal. (bioone.org)
The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a population‐based, longitudinal birth cohort. (aaaai.org)
Once the statistical distribution of variation reaches homeostasis in a given environment, a human population can be described in terms of the maintained order and patterns of polymorphisms in the whole genome. (scirp.org)
We conducted a hypothesis-generating pilot study to examine if host genetic variants were associated with fatal influenza virus infection by comparing prevalence of selected host genetic variants among children and young adults who died of influenza with population-based prevalence estimates. (cdc.gov)
The epidemiological effect of ESR2 rs3020450 polymorphism was assessed by attributable risk percentage (ARP) and population attributable risk percentage (PARP). (cancerindex.org)
Scientists have identified thousands of genome variations that exist within a population. (jove.com)
It emerged that the risk of developing cardiovascular disease was approximately 21 percent higher if an individual belonged to the fifth of the population with the lowest score of genetic variants associated with educational attainment. (sciencedaily.com)
almost half the population are carriers of this polymorphism. (eurekalert.org)
The polymorphisms associated with warfarin sensitivity often differ by population and ethnic background. (medlineplus.gov)
PMID 17427186 ] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study. (snpedia.com)

A cohort of 1162 patients with coronary artery disease were genotyped for genetic polymorphisms in the renin-angiotensin system. (bmj.com)
Lack of association between the MTHFR (C677T) polymorphism and atopic disease. (aaaai.org)
However, to our knowledge, no published studies have examined the association between specific host genetic variants and severe influenza disease outcomes. (cdc.gov)
Study the HBS1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with β -thalassemia major and sickle cell disease and its relation to Hb F and severity of the disease. (scirp.org)
Also, a significant association was detected between polymorphisms and disease severity. (scirp.org)
In sickle cell disease patients, Genetic polymorphisms in HBS1L-MYB (rs9376090 & rs4895441) affect the level of Hb F which could improve the prognosis of these patients. (scirp.org)
Sickle cell disease is an inherited genetic disorder, resulting from homozygous and compound heterozygote mutation in the β globin gene as a single base-pair point mutation (GAG to GTG) results in the substitution of glutamic acid (hydrophilic) to Valine (hydrophobic) in the 6th position of the β-chain of hemoglobin resulting in hemoglobin S formation [7]. (scirp.org)
Huntington's disease is an example of an autosomal dominant genetic disorder. (genome.gov)
Our findings suggest that these genetic factors not only affect educational attainment to a certain extent, but also the risk of subsequently developing cardiovascular disease," explains Schunkert. (sciencedaily.com)
Prof. Schunkert explains the finding: "This protective effect against cardiovascular disease cannot be attributed to educational attainment alone -- it is clear that genetic make-up also has a strong influencing role. (sciencedaily.com)
Research from the University of Liverpool, published today in Lancet Respiratory Medicine , identifies a genetic variant that could improve the safety and effectiveness of corticosteroids, drugs that are used to treat a range of common and rare conditions including asthma, and chronic obstructive pulmonary disease (COPD). (news-medical.net)
His work will improve therapeutic approaches for tackling genetic and acquired heart disease. (swansea.ac.uk)
The use of genetic information, along with all of the other factors that contribute to occupational morbidity and mortality, will play an increasing role in preventing occupational disease. (cdc.gov)
Role of Genetic Information in Occupational Disease: The role of genetic information in occupational disease is being explored. (cdc.gov)
One major emphasis of genetic research in occupational disease has been in the area of response variability. (cdc.gov)
Cancer is a multifactorial disease brought on by a combination of causal and predisposing genetic factors, and which at a given moment and under favorable conditions may take effect in predisposed people 1 . (bvsalud.org)

To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)

The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. (medsci.org)

Using these examples, we propose that the detection of DNA polymorphisms using resequencing data needs to account for nonallelic homologous sequences. (psu.edu)
The detection of prenatal structural anomalies should lead to further genetic evaluation so that many of these conditions can be identified before birth. (medscape.com)

Research in crop genetic enhancement includes today from plant genetic resources conservation through use to breeding informatics, and with main focus on analysing genetic diversity and variation for further utilization in developing new cultivars or breeding lines and populations. (mdpi.com)
High genetic divergence characterizes populations of the endemic plant Lithophragma maximum (Saxifragaceae) on San Clemente Island. (usd.edu)
The topology of phylogenetic trees constructed showed general patterns of relationship and genetic differentiation among the indigenous populations studied, however, both trees from Neighbor-Joining method and Unweighted Pair Group method showed a similar topology. (scialert.net)
The results provided evidence of the applicability of microsatellite to determining the genetic relatedness among different Chinese indigenous chicken populations and evaluating of genetic variations. (scialert.net)

The experiment aimed to compare the effects of BA and mT on the regeneration from explants of Daphne mezereum , on the levels of several chemical components, the catalase activity, and to assess genetic diversity of microcuttings. (mdpi.com)
This research shows these accessions have diversity that could be useful for wheat breeders to integrate variation as well as nematode resistance into wheat cultivars. (usda.gov)
This diversity within this subset could be useful for wheat breeders to integrate genetic variation and resistance to both major pathogenic Pratylenchus spp. (usda.gov)
Minimum sampling intensity required to capture extant genetic diversity in ex situ seed collections: examples from the endangered plant Sibara filifolia (Brassicaceae). (usd.edu)
Do the island biogeography predictions of MacArthur and Wilson hold when examining genetic diversity on the near mainland California Channel Islands? (usd.edu)
Genetic diversity following demographic recovery in the insular endemic plant Galium catalinense subspecies acrispum. (usd.edu)

Since all tobacco products share the ability of stimulating the dopaminergic reward system, variation in the DRD2 genotype might be associated with waterpipe smoking addiction. (who.int)

Understanding how large-scale environmental variability may shape the distribution of phenotypic variation remains central to evolutionary biology. (frontiersin.org)
We found common and species-specific associations of climatic (precipitation, wind speed) and geographic (longitude, altitude) factors with the composite phenotypic variation. (frontiersin.org)
The environmental drivers associated with the phenotypic variation in S. aglaja and F. adippe were largely the same as those associated with their genetic structure, hinting at a genetic underpinning of the observed morphological variation due to local adaption. (frontiersin.org)

PMID 17363961 ] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment. (snpedia.com)

And would those who had a genetic predisposition toward lower achievement receive more resources or less? (bigthink.com)
Conversely, genetic variations have shown only a modest effect size and therefore cannot explain fully the predisposition to obesity. (medscape.com)

The rs2234762 polymorphism, sited in the NTS gene promoter, was statistically more frequent in the lowest pro-NTS level group. (lu.se)

AIM: This study aims to explore genetic variations in DRD2 gene and waterpipe smoking, motives and addiction in Egyptian rural males. (who.int)

Clear differences between subspecies pepo and ovifera in genetic variation and linkage disequilibrium are highlighted. (nature.com)
Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. (nature.com)

The Thr92AlaD2 polymorphism affects an enzyme that activates thyroid hormones. (eurekalert.org)

Many genetic disorders can be detected early in pregnancy using various noninvasive and invasive techniques. (medscape.com)
Autosomal dominant is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
Autosomal recessive is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
COMT genetic variation confers risk for psychotic and affective disorders: a case control study. (snpedia.com)
Substance use disorders (SUDs), including alcohol, tobacco, cannabis, or opioids, appear to share a common genetic signature, suggest new findings that researchers say could eventually lead to universal therapies to treat multiple and comorbid addictions. (medscape.com)
The shared genetic mechanisms between substance use and mental disorders revealed in this study underscore the importance of thinking about these disorders in tandem," Joshua A. Gordon, MD, PhD, director of the National Institute of Mental Health (NIMH), said in a news release. (medscape.com)

Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)

Codominance means that two different versions of the gene are active (expressed), and both versions influence the genetic trait. (medlineplus.gov)
Influence of COL2A1-G1405S polymorphism on mandibular skeletal malocclusions: A genetic association study and in silico analysis. (nih.gov)
This genetic variation may therefore also influence the chance to develop GBS. (eur.nl)
PMID 17006672 ] Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. (snpedia.com)
DISCUSSION: These data indicate that the AD genetic architecture influences cognitive and CSF phenotypes in DS adults, supporting common pathways that influence memory decline in both traits. (bvsalud.org)

We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determined their combined predictive value for rheumatoid arthritis (RA) in individuals who subsequently developed RA. (nih.gov)

In a previous study Lambert et al 3 sequenced the transcription factor LBP-1c / CP2 / LSF gene, which lies within the chromosome 12 AD locus, in order to identify any genetic variants that may modify the risk of developing AD. (bmj.com)
In this study we have typed for the 3′UTR polymorphism in a series of necropsy confirmed AD cases and age matched non-demented controls to see if we could confirm an association between this polymorphism and sporadic AD, and thus give further support for the role of this genetic variant as a risk factor in AD. (bmj.com)
NIH-funded study examines genetic influences on behavior. (nih.gov)
These study results will enable us to ask more refined questions about the genetic and environmental underpinnings of educational attainment and their health consequences," said Jonathan W. King, Ph.D., program director in NIA's Division of Behavioral and Social Research, which supports the SSGAC. (nih.gov)
With that information and a DNA sample, investigators can conduct additional GWAS of other racial and ethnic groups, which could allow identification of new variants and genetic pathways associated with educational attainment and further validate the contribution of loci from the study reported today. (nih.gov)
I read with great interest the study by Delanghe and his colleagues entitled "COVID-19 infections are also affected by human ACE1 D/I polymorphism" that was published in Clinical Chemistry and Laboratory Medicine [ 1 ]. (degruyter.com)
This study counters a previous one, using twins, which determined that 60% of individual academic achievement can be attributed to one's genetic makeup. (bigthink.com)
74 genetic variants associated with educational aptitude were identified in this study. (bigthink.com)
Prof. Heribert Schunkert and his team have now examined this link in a major study that has focused on the genetic dimension for the first time. (sciencedaily.com)
The aim of this study was to determine the possible genetic regulation of plasma pro-NT. (lu.se)
In a genome-wide association study (GWAS), the investigators looked for variations in the genome that were closely associated with SUDs in more than 1 million people of European ancestry and 92,630 people of African ancestry. (medscape.com)
This study aimed to identify new genetic variants affecting plasma ApoE level as well as to test if baseline ApoE level is associated with cognitive function and incident dementia in a longitudinally followed cohort of the Ginkgo Evaluation of Memory (GEM) study. (bvsalud.org)

Individual genetic variations lead to different responses of patients to a single treatment regimen. (researchsquare.com)

Funded by the NIA, the SSGAC is a cooperative enterprise among biomedical researchers and social scientists that coordinates genetic association studies for social science outcomes and provides a platform for interdisciplinary collaboration. (nih.gov)
Surprisingly, the association between genetic variants and the risk of heart attack remained significant. (sciencedaily.com)
PMID 16525418 ] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder. (snpedia.com)

These are variations in single DNA bases, which account for most of the genetic differences between people. (newscientist.com)

Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait. (nature.com)

Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. (who.int)

The team was able to prove statistically that individuals with a lower score of genetic variants associated with educational attainment were more likely to smoke, be overweight and suffer from high blood pressure. (sciencedaily.com)

However, this locus accounts for less than half the genetic variance. (bmj.com)

THE era of personalised medicine, when patients will be prescribed drugs tailored to their precise genetic make-up, has come a step closer. (newscientist.com)
Patients are initially counseled on the basis of their age and genetic and family history. (medscape.com)
Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls. (snpedia.com)
Understanding gene polymorphisms will help us move toward personalized medicine and determine which patients will actually benefit from therapies for HNSCCs. (researchsquare.com)
Therefore, knowing the genetic variations (polymorphisms) will be effective in predicting the response to treatment, and accordingly, we can determine which patients will benefit from chemo- or radiotherapy (Ansell et al. (researchsquare.com)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
Improvements in the quality and use of genetic laboratory services should improve the quality of health care and health outcomes for patients and families of patients. (cdc.gov)
RÉSUMÉ Les polymorphismes mononucléotidiques du gène de l' Interleukine (IL)-28B , en l'occurence le rs12979860, permettent de prédire la réponse au traitement par interféron- pégylé associé à la ribavirine chez des patients infectés par le virus de l'hépatite C de génotype 1. (who.int)

Our findings highlight the importance of comparative assessments of variation, and demonstrate that the relative effects of drivers of variability may vary between sister species. (frontiersin.org)
Has herbivory negatively impacted genetic variability in the flora of the California Channel Islands? (usd.edu)

Chris' primary research focus is on using experimental and clinical data to predict how heart cells, the engine of every heartbeat, respond to genetic mutations and to drugs. (swansea.ac.uk)

Across-species comparisons of trait variation alongside environmental gradients may offer valuable insights into how different species may respond to similar selective pressures. (frontiersin.org)

Genetic variants which had been linked to educational attainment in other studies were observed in the subjects. (sciencedaily.com)
The historical approach to setting OELs has in- genetic information extensively, but to date such factors have not volved investigators observing workers as well transmitted between been used to protect workers by incorpora- as conducting laboratory and animal studies. (cdc.gov)

Whole genome sequencing (WGS) was performed to characterise the genetic relatedness of isolates among the four outbreak-associated pulsed-field gel electrophoresis (PFGE) patterns. (cdc.gov)

PMID 15956988 ] COMT polymorphisms and anxiety-related personality traits. (snpedia.com)
PMID 16786032 ] Impact of complex genetic variation in COMT on human brain function. (snpedia.com)

The Applied Biosystems SeqStudio Genetic Analyzer is a low-throughput, easy-to-use, and convenient benchtop system that delivers gold-standard Sanger sequencing technology and fragment analysis by capillary electrophoresis with a simple click. (thermofisher.com)
The SeqStudio Genetic Analyzer offers data quality, usability, service, and support at an affordable price. (thermofisher.com)
Like the SeqStudio instrument, our SeqStudio Flex Genetic Analyzer is an easy-to-use, flexible system for Sanger sequencing and fragment analysis, but with higher throughput. (thermofisher.com)
The SeqStudio Genetic Analyzer is designed for both new and experienced users who need simple and affordable Sanger sequencing and fragment analysis, without compromising performance or quality. (thermofisher.com)
The SeqStudio Genetic Analyzer uses an innovative all-in-one cartridge that includes the capillary array, anode buffer, and a reservoir containing polymer for both sequencing and fragment analysis applications. (thermofisher.com)
Individual cartridges can be designated for different experimental designs or different researchers, enabling multiple users to share a single SeqStudio Genetic Analyzer. (thermofisher.com)

The CYP2C19 gene is particularly important for the activation of clopidogrel, and certain common variations (polymorphisms) in this gene have been associated with clopidogrel resistance. (medlineplus.gov)
The two most common CYP2C19 gene polymorphisms associated with clopidogrel resistance (known as CYP2C19*2 and CYP2C19*3 ) result in the production of a nonfunctional CYP2C19 enzyme that cannot convert clopidogrel to its active form. (medlineplus.gov)
These are the most common genetic variations people have. (bigthink.com)

The information is incorporated within a mostly fixed template, as well as within the structure of human genome sequence variation. (scirp.org)
The ongoing Human Genome Project, which aims to have a working draft of our entire genetic blueprint by February next year, will produce a "consensus" sequence for the typical human. (newscientist.com)
A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genetic information encoding a particular amino acid. (genome.gov)
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. (jove.com)
A total of seven sequence variations across the NTS gene, none of them located in coding regions, were identified. (lu.se)

CYP2C19 gene polymorphisms account for most of the variation in clopidogrel activation due to genetic factors. (medlineplus.gov)
Previous research has shown that genetic factors account for about 20 percent of variation in educational attainment. (nih.gov)
In this review, we focus primarily on inherited genetic factors and their role in occupational health standard setting. (cdc.gov)

Some people with clopidogrel resistance have a reduced ability to convert the drug to its active form because of a polymorphism in one copy of the CYP2C19 gene that results in decreased enzyme activity. (medlineplus.gov)

Anatomy3

Organisms4

Diseases14

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment61

Psychiatry and Psychology1

Phenomena and Processes93

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena3

Information Science10

Named Groups6

Health Care40

Geographicals19

SNPs24

Genes17

Susceptibility11

Determinants4

Genetics5

Allele6

Alzheimer's4

Biomarkers1

Correlation2

Genomic4

Markers7

Functional4

Single nucleotide7

Molecular15

Nucleotide2

Population10

Disease16

Investigate1

Risk of various human diseases1

Detection2

Populations4

Diversity6

Genotype1

Phenotypic3

Severity1

Predisposition2

Gene promoter1

Egyptian1

Linkage disequilibrium2

Affects1

Disorders6

Metabolism1

Influence5

Rheumatoid1

Study12

Regimen1

Association3

Differences1

Phenotype1

Several genetic1

Associated with educational attainment1

Variance1

Patients8

Variability2

Clinical1

Trait1

Studies2

Patterns1

PMID2

Analyzer6

Common3

Sequence5

Factors3

Enzyme1