Variants osteosarcoma. Medical search. Frequent questions

At age 17, she underwent limb-sparing surgery for a left leg (femur) periosteal osteosarcoma. (biomedcentral.com)
9,10,12 Although signs of periosteal osteosarcoma may appear subtle on knee radiographs, magnetic resonance imaging (MRI) typically reveals a large, extraosseous soft-tissue mass with intramedullary invasion in some cases. (appliedradiology.com)
9-11 The absence of the more obvious cloud-like osseous matrix, sclerosis, and bone destruction usually associated with conventional osteosarcoma makes periosteal osteosarcoma a diagnostic challenge. (appliedradiology.com)

Osteosarcoma is one of more than 50 kinds of sarcoma. (sarcomahelp.org)
Patients with osteosarcoma are best treated at a cancer center where an expert sarcoma team and resources are available to provide specialized and responsive care. (sarcomahelp.org)
The term "sarcoma" identifies a heterogeneous group of rare tumors comprising over 60 different histologic variants ( 1 ). (frontiersin.org)
Indeed, the identification of histotype-specific (pathognomonic) gene alterations is of paramount importance in the differential diagnosis among sarcoma variants, between malignant and benign mimics, as well as between sarcoma and other tumor types ( 1 - 3 ). (frontiersin.org)
The Collier Lab strives to ask thoughtful questions pertaining to the musculoskeletal oncology patient, ranging from the origins of sarcoma to the development of epigenetic therapies for osteosarcoma to understanding the significance of oligometastatic disease to bone. (iu.edu)
Furthermore, a minor splice variant lacking a part of exon 1 that would encode residues corresponding to transmembrane domain M1 was relatively more abundant in two of seven sarcoma cell lines, one of which was derived from a rhabdomyosarcoma, and the other was derived from an osteosarcoma. (aacrjournals.org)
Osteosarcoma (OS), referred to as osteogenic sarcoma, is the most common primary malignant bone tumor excluding plasma cell tumors. (ijofb.org)
Ewing's sarcoma and osteosarcoma are treated by surgery combined with chemotherapy. (bvsalud.org)
Osteosarcoma is the commonest primary bone sarcoma arising in the young adult population, with a peak incidence in the second and third decade. (orthoracle.com)
A variant, telangiectatic where when you cut through the bone of a telangiectatic sarcoma it's markedly vascular. (cancerstreatment.com)
A paraostial and periosteal sarcoma, which are the surface variants, which I'll show you. (cancerstreatment.com)
Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes. (cdc.gov)
Osteosarcoma (osteogenic sarcoma) Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults. (msdmanuals.com)

Frontal radiograph of the distal femur in a patient with telangiectatic osteosarcoma. (medscape.com)
Case report 700: Primary intracortical osteosarcoma of femur, sclerosing variant, grade 1 to 2 anaplasia. (understandinginterventions.org)
Bone scan of a low-grade central osteosarcoma of the distal femur. (medscape.com)
Magnetic resonance image (MRI) of low-grade central osteosarcoma of the distal femur. (medscape.com)
The most common sites for osteosarcoma are the distal femur and proximal tibia, followed by the proximal humerus and distal radius. (orthoracle.com)

Osteosarcomas range from low grade tumors that only require surgery to high grade tumors that require an aggressive treatment regimen. (sarcomahelp.org)
To investigate the genomic evolution of metastatic pediatric osteosarcoma, we performed whole-genome and targeted deep sequencing on 14 osteosarcoma metastases and two primary tumors from four patients (two to eight samples per patient). (nih.gov)
For example, recent whole-genome sequencing suggests that osteosarcomas are driven by a relatively small number of mutations compared to adult tumors - frequently in genes encoding epigenetic regulators - while copy number alterations and structural variants predominate. (iu.edu)
[ 14 ] Many of these induced tumors are well-differentiated osteosarcomas, including low-grade central osteosarcomas. (medscape.com)
Osteosarcoma (OS) arising from the jaw comprises 2.1% of all malignant oral and maxillofacial tumors. (ijofb.org)
some are malignant primary tumors (eg, osteosarcoma. (msdmanuals.com)
The remaining sarcomas are made up of heterologous tumors-tumors that contain histologic components foreign to the uterus, such as rhabdomyosarcomas , osteosarcomas , and chondrosarcomas . (medscape.com)

The overall prognosis for patients with osteosarcoma depends on the stage of the tumor at presentation. (medscape.com)
Intraosseous low-grade osteosarcoma generally has a good prognosis. (medscape.com)
[ 9 ] Low-grade central osteosarcoma has a better prognosis than that of high-grade osteosarcoma. (medscape.com)
Postradiation osteosarcoma, which connotes somewhat of a worse prognosis. (cancerstreatment.com)
Whole-exome sequencing in osteosarcoma with distinct prognosis reveals disparate genetic heterogeneity. (cdc.gov)

We found that cisplatin treatment can potentially double the mutational burden in osteosarcoma, which has implications for optimizing therapy for recurrent, chemotherapy-resistant disease. (nih.gov)
The Clinical Implications of Tumor Mutational Burden in Osteosarcoma. (cdc.gov)

However, it is believed that about 80% of patients with high grade osteosarcoma already have metastatic disease that is not yet visible on imaging tests. (sarcomahelp.org)
Histopathology sections (Fig. 3) showed features of osteoblastic type (high grade) osteosarcoma. (annalsofafricansurgery.com)

Dr. Kyle Walsh, of Duke University, had a theory that the genes that determine height might have something to do with the development of osteosarcoma, the most common type of childhood bone cancer. (alexslemonade.org)
Cross-species target mining identified two genes, interleukin-8 ( IL-8 ) and solute carrier family 1 (glial high affinity glutamate transporter), member 3 ( SLC1A3 ), which were uniformly expressed in dog but not in all pediatric osteosarcoma patient samples. (biomedcentral.com)
Expression of these genes in an independent population of pediatric osteosarcoma patients was associated with poor outcome (p = 0.020 and p = 0.026, respectively). (biomedcentral.com)
Effect of TIMP2/TIMP3 genes on the risk of osteosarcoma in Zhejiang population. (cdc.gov)
Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)
Request curation for specific Genes, Variants, or PubMed publications. (jax.org)
In this podcast we learn about the research that is refining the genes and gene signatures associated with osteosarcoma and how this may lead to better treatments. (libsyn.com)
Changes in your genes are also called gene variants or mutations. (medlineplus.gov)

Osteosarcoma is the most common primary malignant tumor of bone, excluding plasma cell myeloma . (medscape.com)
Histologically, the tumor was a sclerosing variant of OS with extensive "normalization" of nuclei. (understandinginterventions.org)
Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. (medscape.com)
The biopsy will also show whether the tumor is high grade (highly malignant, which is the case for most osteosarcomas) or low grade. (sarcomahelp.org)
By examining the relationship between the genetic variants and childhood growth, he has found evidence that increased birthweight is associated with tumor extension, higher tumor stage, and metastatic disease. (alexslemonade.org)
In addition to studying the heritable causes of osteosarcoma, we also seek to identify genetic variants that are associated with poor prognostic factors, such as larger tumor size and presence of distant metastases. (alexslemonade.org)
Extraskeletal osteosarcoma (EOS) is a malignant tumor of soft tissue origin comprising tumor cells that produce osteoid matrix. (researchsquare.com)
Given the accelerated biology of canine osteosarcoma, we hypothesized that a direct comparison of canine and pediatric osteosarcoma expression profiles may help identify novel metastasis-associated tumor targets that have been missed through the study of the human cancer alone. (biomedcentral.com)
Osteosarcoma is the most common primary bone tumor in children and young adults. (biomedcentral.com)
Similarly, in 112 osteosarcomas who underwent exome or whole genome sequencing, another report found a median of 38 mutations per tumor. (biomedcentral.com)
Osteosarcoma (OS) is a malignant tumor that induces formation of osteoid or immature bone and rarely occurs in maxilla. (ac.ir)
Osteosarcoma (OS) is a primary malignant tumor of bone which is characterized by formation of osteoid tissue. (ac.ir)
Osteosarcoma is the most common malignant bone tumor which predominantly affects adolescents and young adults, accounting for almost 45% of all bone sarcomas [ 1 ]. (biomedcentral.com)
Integrated analyses of an RNA binding protein-based signature related to tumor immune microenvironment and candidate drugs in osteosarcoma. (cdc.gov)
among which embryonal and alveolar RMSs are the most common ones under the age of 20, while pleomorphic and spindle cell variants of the tumor may also occur in adults, with a peak at the 4th-5th and 6th -7th decades of lifetime, respectively. (biomedcentral.com)

Telangiectatic osteosarcoma (as shown in the images below) has been considered more aggressive than classic osteosarcoma, but studies of long-term survival after optimum treatment now indicate that the aggressiveness of telangiectatic osteosarcoma is similar to that of the classic type. (medscape.com)
Coronal short-tau inversion recovery (STIR) magnetic resonance imaging (MRI) scan of the same patient (patient with telangiectatic osteosarcoma). (medscape.com)
Axial T2-weighted magnetic resonance imaging (MRI) scan of the same patient (patient with telangiectatic osteosarcoma). (medscape.com)

The latter exhibits histologic atypias that sometimes make it difficult to distinguish between this entity and low-grade osteosarcoma. (bvsalud.org)
clinical presentation and histologic variants.This may form the basis for further research and management inorder to reduce the morbidity and mortality associated with it. (bvsalud.org)

Therefore, our study showed that the AA and CA+AA genotypes of the VEGF -2578C/A polymorphism might modify the risk of osteosarcoma in a Chinese population. (geneticsmr.com)

Scientists have not discovered the cause of most cases of osteosarcoma. (sarcomahelp.org)
The above-mentioned study by Kurt and coauthors revealed low-grade central osteosarcoma accounts for 1.2-1.9% of all cases of osteosarcoma. (medscape.com)
Internationally, low-grade central osteosarcoma accounts for 0.7% of all cases of osteosarcoma, as reported by the Instituto de Rizzoli at the University of Bologna, Italy. (medscape.com)

What are the symptoms of osteosarcoma? (sarcomahelp.org)
Patients and their families should be educated regarding the potential signs and symptoms of osteosarcoma such as bone pain, swelling, or an enlarging lesion on a limb. (medscape.com)

Biological pathways related to childhood growth and development likely play an important role in the development of osteosarcoma, but congenital causes remain poorly understood. (alexslemonade.org)
The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. (geneticsmr.com)

As we recently reported, analysis of 77 FHWT by whole genome sequencing (WGS, 58 patients) or whole exomic sequencing (WES,19 patients) identified 825 high-quality somatic, non-synonymous variants, with an average of 11 candidate mutations/case (range 2-42) (ref. 6 ). (nature.com)

Low-grade central osteosarcoma is a rare variant of osteosarcoma that is often mistaken for fibrous dysplasia. (medscape.com)
Low-grade central osteosarcoma is a rare variant of osteosarcoma that originates within the medullary cavity of bone. (medscape.com)
The exact etiology of low-grade central osteosarcoma is unknown. (medscape.com)
Patients with low-grade central osteosarcoma are approximately 1 decade older than patients with traditional osteosarcoma, although cases have been reported in patients aged 9-83 years. (medscape.com)

Note: this finding does not indicate that tall individuals are more likely to develop osteosarcoma. (alexslemonade.org)
Pet dogs naturally develop osteosarcoma providing a novel opportunity to model metastasis development and progression. (biomedcentral.com)

These results reveal extensive clonal heterogeneity in metastatic osteosarcoma, much of which is likely cisplatin-induced. (nih.gov)
Herein, we describe a patient with treatment-refractory metastatic osteosarcoma who was successfully managed long-term with a genomically matched (chemotherapy-free) combination strategy. (biomedcentral.com)
A 30-year-old woman with recurrent, refractory metastatic osteosarcoma was referred. (biomedcentral.com)

Extraskeletal osteosarcoma (EOS) is a rare malignant soft tissue neoplasm. (researchsquare.com)

Epigenetics may also be critical in osteosarcoma metastases, which are accompanied by a shift in the cancer epigenome despite minor changes in the mutational landscape. (iu.edu)
Maxillofacial sarcomas have a biological behaviour that differs from that of the long bones: the average age of onset is 10-20 years later than their skeletal variants, distant metastases are rarer and survival rates are more favourable (9). (annalsofafricansurgery.com)

The current research is aimed at assessing the correlation between two functional GAS5 variants (rs145204276 and rs55829688) and susceptibility to IS in a Han Chinese population. (hindawi.com)
Retraction: Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma. (cdc.gov)
Epidemiological Evidence for Associations Between Genetic Variants and Osteosarcoma Susceptibility: A Meta-Analysis. (cdc.gov)

RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome. (medscape.com)

His dream was to cure pediatric cancers, and the organization has raised nearly $40,000 for osteosarcoma research. (sarcomahelp.org)

Dr. Walsh has been investigating how genetic variation contributes to pediatric osteosarcoma risk. (alexslemonade.org)
Pediatric osteosarcoma is more common in boys and in children who are tall for their age. (alexslemonade.org)
Pediatric osteosarcoma is associated with increased birth weight, taller stature and male gender. (alexslemonade.org)
Validation of IL-8 and SLC1A3 protein expression in pediatric osteosarcoma tissues further supported the potential value of these novel targets. (biomedcentral.com)
Osteosarcoma is a highly metastatic cancer of bone seen primarily in pediatric patients. (biomedcentral.com)
Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk. (cdc.gov)

The histopathologic subtypes varied between osteoblastic, fibroblastic and chondroblastic highgrade variants. (annalsofafricansurgery.com)
The most common histological variant of osteosarcoma is a high grade osteoblastic variant. (orthoracle.com)

These functions are especially important when discussing bone cancer, particularly osteosarcoma development, that can be attributed to aberrant cell proliferation control. (wikipedia.org)
An x-ray is often the first diagnostic test that osteosarcoma patients receive, and an experienced radiologist may recognize immediately that bone cancer is the likely diagnosis. (sarcomahelp.org)

Osteosarcoma, an aggressive bone malignancy that primarily affects children and young adults, is notable for widespread genetic and epigenetic instability. (iu.edu)
One patient was diagnosed with an aggressive telangiectatic/ vascular type of osteosarcoma while another had a discordant diagnosis: initial histological diagnosis was osteoblastoma, later revised to osteosarcoma after review by a panel of pathologists. (annalsofafricansurgery.com)

Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. (nih.gov)
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. (medscape.com)
Rothmund-Thomson Syndrome: novel pathogenic mutations and frequencies of variants in the RECQL4 and USB1 (C16orf57) gene. (medscape.com)

Frontal radiograph of the mandible in an adult with gnathic osteosarcoma. (medscape.com)
The mandible and maxilla are the predominant sites of head and neck osteosarcoma (HNOS), although extragnathic bone as well as soft tissue sites may be affected [6]. (annalsofafricansurgery.com)
Osteosarcoma of the jaw, mandible maxillary area where again you may not be able to achieve very wide margins, and here you may use radiation therapy. (cancerstreatment.com)

Although height genetics are unable to be changed, this finding may shed some light on the genetic and biological factors that drive both height and osteosarcoma. (alexslemonade.org)

Our study supports a model wherein the rs145204276 variant in the GAS5 lncRNA is associated with IS risk, thus representing a potentially viable biomarker for IS prevention and treatment. (hindawi.com)
CDK4 overexpression is a predictive biomarker for resistance to conventional chemotherapy in patients with osteosarcoma. (cdc.gov)
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. (uni-muenster.de)

His finding: children that developed osteosarcoma had a genetic propensity to become taller adults. (alexslemonade.org)
Ultimately, this finding could guide future research efforts to identify specific genetic targets for prevention or treatment of osteosarcoma. (alexslemonade.org)
He continues to incorporate genetic data into his study to gain more specific understanding of osteosarcoma, the third most common cancer in adolescents. (alexslemonade.org)
By leveraging a large multi-ethnic patient population drawn from the California Birth Cohort, we will compare the genomes of 545 children with osteosarcoma to the genomes of 3545 cancer-free individuals to identify genetic risk factors underlying this disease. (alexslemonade.org)
Genetic variants and risk of cervical cancer: epidemiological evidence, meta-analysis and research review. (cdc.gov)

[ 3 ] (See also Osteosarcoma Variant Imaging and Parosteal Osteosarcoma . (medscape.com)

Association of ERCC gene polymorphism with osteosarcoma risk. (cdc.gov)

Osteosarcoma is often treated with a combination of therapies that can include surgery, chemotherapy and radiation therapy. (sarcomahelp.org)
and the efficacy and mechanistic basis for epigenetic therapies in osteosarcoma. (iu.edu)
Collectively, these data support the strong similarities between human and canine osteosarcoma and underline the opportunities provided by a comparative oncology approach as a means to improve our understanding of cancer biology and therapies. (biomedcentral.com)

Initial findings have been published in the open access journal Genome Biology , entitled " Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B . (libsyn.com)

All four patients harbored ancestral (truncal) somatic variants resulting in TP53 inactivation and cell-cycle aberrations, followed by divergence into relapse-specific lineages exhibiting a cisplatin-induced mutation signature. (nih.gov)
In a preclinical study, TP53 R280M resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment ( PMID: 21643018 ). (jax.org)

A series of factors have been reported in literatures to have predictive or prognostic values for osteosarcoma, including the traditionally established prognostic factors and the newly identified predictive factors. (biomedcentral.com)

Fourteen histopathologic types were found of which osteosarcoma (28%), chondrosarcoma (17%), rhabdomyosarcoma (12%) and fibrosarcoma (12%) were predominant. (bvsalud.org)

Trichorhinophalangeal syndrome (TRPS) comprises TRPS I (caused by a heterozygous pathogenic variant in TRPS1) and TRPS II (caused by contiguous gene deletion of TRPS1, RAD21, and EXT1). (beds.ac.uk)

Conclusion: In Northern Nigeria, sarcomas account for 20% of all maxillofacial malignancies with the osteosarcoma as the predominant type. (bvsalud.org)

Osteosarcoma is a type of cancer that produces immature bone. (sarcomahelp.org)
Then, using data from the California Cancer Registry, Dr. Walsh studied only the blood spots from children who were later diagnosed with osteosarcoma. (alexslemonade.org)
Dr. Walsh plans to investigate how environmental exposures and dietary factors might interact with established osteosarcoma risk factors, like height, to modify cancer risk in children. (alexslemonade.org)

With an incidence of 1:100,000 (1,2), osteosarcoma is the most common primary neoplasm of bone. (annalsofafricansurgery.com)

Because this study utilizes biologic specimens collected at birth, years prior to diagnosis, its powerful design enables identification of potential biomarkers of future osteosarcoma risk. (alexslemonade.org)
Initial diagnosis of osteosarcoma is often difficult. (medscape.com)

ADCK1 is a potential therapeutic target of osteosarcoma. (nih.gov)

Axial computed tomography (CT) scan obtained with bone window settings, in the same patient (adult with gnathic osteosarcoma). (medscape.com)

Lung lesion resection confirmed osteosarcoma, and was followed by adriamycin and cisplatin and later adriamycin and ifosfamide administration (total = 6 cycles). (biomedcentral.com)

The patient was treated by en bloc resection without preoperative or systemic chemotherapy and is without evidence of disease with 15 months' follow-up. (understandinginterventions.org)

Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. (biomedcentral.com)

Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. (biomedcentral.com)

Transcript variants of the gene that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. (wikipedia.org)
Alternative splicing results in multiple transcript variants. (nih.gov)
Alternative splicing of this gene results in two transcript variants encoding different isoforms. (thermofisher.com)

The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. (thermofisher.com)

Compared to normal osteoblast cell line MC3T3-E1, the oscillations of Runx2 in osteosarcoma ROS and SaOS cell lines are aberrant when compared to the oscillations of Runx2 levels in normal osteoblasts, suggesting that deregulation of Runx2 levels may contribute to abnormal cell proliferation by an inability to escape the cell cycle. (wikipedia.org)
Correlation between TRAIL and caspase-8 expression and their relationship with cell proliferation and apoptosis in human osteosarcoma. (geneticsmr.com)

Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study. (cdc.gov)

Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis. (nih.gov)

Approximately 75% of all osteosarcomas are of the classic or conventional type, and the remaining 25% constitute the osteosarcoma variants. (medscape.com)
Gnathic osteosarcoma (as shown in the images below) is less frequently associated with metastatic spread than is conventional osteosarcoma, but local disease recurrence is often problematic. (medscape.com)

This study genotyped the two GAS5 variants in 1086 IS patients as well as 1045 age-matched healthy controls by using an improved multitemperature ligase detection reaction (iMLDR-TM) genotyping technology. (hindawi.com)
Unlike osteosarcoma, which frequently occurs in teenagers, the onset age of EOS is generally older, most of the victims being middle-aged and elderly patients 2 , 5 . (researchsquare.com)
Low-grade central osteosarcomas typically develop de novo in the long bones of patients aged 20-30 years. (medscape.com)
A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. (geneticsmr.com)
This study aimed to evaluate the clinical significance of pre-treatment Naples prognostic score (NPS) in patients with osteosarcoma. (biomedcentral.com)
The clinical data of 133 osteosarcoma patients between January 2011 and February 2018 in our hospital was retrospectively collected and analyzed. (biomedcentral.com)
NPS was a novel, reliable, and multidimensional prognostic scoring system with favorable predictive performance for patients with osteosarcoma. (biomedcentral.com)
However, all these factors usually covered only one aspect of clinical or pathological characteristics of osteosarcoma patients and thus might be inherently inaccurate and inadequate for prognostic prediction. (biomedcentral.com)
FAT1 and MSH2 Are Predictive Prognostic Markers for Chinese Osteosarcoma Patients Following Chemotherapeutic Treatment. (cdc.gov)

The medullary and periosteal subtypes are more common in the jaw bones, while the cortical variant is frequently observed at extragnathic sites 2-3 . (bvsalud.org)

Osteosarcoma can develop as a result of radiation to an area of the body. (sarcomahelp.org)

The mainstay of treatment for osteosarcoma of the jaws is complete surgical excision with free margins as well as reconstruction to improve function and quality of life post-treatment. (annalsofafricansurgery.com)

Anatomy6

Diseases11

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes15

Information Science3

Periosteal osteosarcoma3

Sarcoma13

Femur5

Tumors7

Prognosis5

Mutational burden in osteosarcoma2

High grade osteosarcoma2

Genes8

Tumor15

Telangiectatic osteosarcoma3

Histologic2

Risk of osteosarcoma1

Cases of osteosarcoma3

Symptoms of osteosarcoma2

Development of osteosarcoma2

Whole-genome1

Central osteosarcoma4

Develop osteosarcoma2

Metastatic osteosarcoma3

Extraskeletal Osteosarcoma1

Metastases2

Susceptibility3

Heterogeneity1

Cancers1

Pediatric6

Osteoblastic2

Bone cancer2

Aggressive2

Mutations3

Mandible3

Genetics1

Biomarker3

Genetic5

Parosteal1

Polymorphism1

Therapies3

Heritable1

TP532

Prognostic factors1

Chondrosarcoma1

Pathogenic1

Malignancies1

Cancer3

Primary1

Diagnosis2

Potential therapeutic target1

Computed Tomography1

Lesion1

Chemotherapy1

Survival1

Metastasis1

Transcript variants3

Protein1

Cell proliferation2

Polymorphisms1

Prevalence1

Conventional2

Patients9

Extragnathic1

Radiation1

Jaws1