Variants contribute. Medical search. Frequent questions

The teams from Henri-Mondor AP-HP hospital and Paris-Est Créteil University, Inserm, CNRS, University of Paris, within the Necker-Enfants Malades Institute, and the Institut Pasteur analyzed the capacity of the immune memory generated after mRNA vaccination to recognize and neutralize SARS-CoV-2 variants. (pasteur.fr)
The teams from Henri-Mondor AP-HP hospital and Paris-Est Créteil University, Inserm, CNRS, University of Paris, within the Necker-Enfants Malades Institute, and the Institut Pasteur, studied the fate of memory B cells* in patients vaccinated with a messenger RNA vaccine and their capacity to recognize and neutralize SARS-CoV-2 variants. (pasteur.fr)
This study strongly suggests that the memory cells of people vaccinated with two doses of the vaccine (or just one for those who had previously contracted COVID-19) protect from severe forms of Covid-19 due to SARS-CoV-2 variants, in support of the protective antibodies present in the blood. (pasteur.fr)
This very encouraging result also suggests that in the event of strong viral circulation due to the SARS-CoV-2 variants, a third dose of vaccine, using currently available vaccines containing the original Wuhan Spike, should make it possible to rapidly generate antibodies neutralizing the Beta and Delta variants currently present and reducing viral circulation. (pasteur.fr)
Because SARS-CoV-2 can be detected in feces and urine of some infected persons ( 2 ), wastewater surveillance in airports and on aircraft has been proposed by the global public health community † as a low-cost mechanism to monitor SARS-CoV-2 variants entering the United States. (cdc.gov)
This investigation demonstrated the feasibility of aircraft wastewater surveillance as a low-resource approach compared with individual testing to monitor SARS-CoV-2 variants without direct traveler involvement or disruption to airport operations. (cdc.gov)

NEW YORK - A handful of germline gene variants contribute to the risk of developing aging-related clonal hematopoiesis, a new study has found. (genomeweb.com)
In summary, our analysis provides a better understanding of the genetic architecture of autism in isolated populations by highlighting the role of both common and rare gene variants and pointing at new autism-risk genes. (nature.com)
Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. (qxmd.com)

In England, the percentage of people with new variant compatible positives has decreased in London, the South East and East of England in the week ending 16 January 2021, while in other regions increases have generally levelled off. (finchannel.com)
Africa and P.1 in first identified in Brazil), and these have contributed significantly to resurgence in several countries between November 2020 and February 2021. (who.int)

On the contrary, in some cases, the genetic architecture is more complex and involves thousands of common genetic variants, each one with low impact but collectively increasing the susceptibility to autism. (nature.com)
The current research is aimed at assessing the correlation between two functional GAS5 variants (rs145204276 and rs55829688) and susceptibility to IS in a Han Chinese population. (hindawi.com)
These SNPs, however, are still thought to account for less than half of all genetic susceptibility to IS, with a number of yet to be discovered genes also contributing to the development of IS. (hindawi.com)
Genome-wide association studies (GWAS) and exome-sequencing analysis have been successfully implemented as approaches to identify genetic variants associated with disease susceptibility. (frontiersin.org)

Nonetheless, the association signal primarily arises from de novo protein-truncating variants, as opposed to the more common missense variants. (springer.com)
Despite their commonness in humans, determining which missense variants affect phenotypes and how remains a challenge. (springer.com)
We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
Utilizing our previous interactome perturbation predictor, we identify a set of missense variants that are likely disruptive to protein-protein interactions. (springer.com)
Extending earlier work, we show that de novo missense variants that disrupt protein interactions are enriched in individuals with ASD, often affecting hub proteins and disrupting hub interactions. (springer.com)
These missense variants are uncommon, 8.3% of all missense variants given a score. (springer.com)

Within a subset of this cohort, the researchers conducted a single-variant genome-wide association analysis to uncover germline variants linked to CHIP. (genomeweb.com)
Finding genes and variants for lipid levels after genome-wide association analysis. (medscape.com)

Data from SNP array and whole exome sequencing revealed that individuals with autism had a higher burden of rare exonic copy-number variants altering autism associated genes (deletions ( p = 0.0352) or duplications ( p = 0.0352)), higher inbreeding status ( p = 0.023) and a higher load of rare homozygous deleterious variants ( p = 0.011) compared to controls. (nature.com)
It also revealed three genes involved in synaptic plasticity, RIMS4 , KALRN , and PLA2G4A , carrying de novo deleterious variants in individuals with autism without intellectual disability. (nature.com)
We additionally performed exome-sequencing analysis in 960 individuals to investigate rare variants in candidate genes. (frontiersin.org)
The precise mechanism of how these genes may contribute to neutrophil function or the formation of NETs remains unclear and should be further investigated in experimental studies. (frontiersin.org)
We performed additional in silico analyses to identify more evidence for the associated variants and genes in relation to the plasma MPO-DNA complex levels. (frontiersin.org)
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. (medscape.com)

People testing positive for the new UK variant of the coronavirus (COVID-19) have been more likely to report some symptoms than those whose tests were not compatible with the new variant, but were less likely to report loss of taste or smell. (finchannel.com)
The delta variant of the coronavirus is here. (vox.com)
Pfizer plans to test a booster shot to address the South African coronavirus variant. (medpagetoday.com)
Scientists say vaccinating kids against COVID-19 should not only slow the spread of the coronavirus but also help prevent potentially-dangerous variants from emerging. (ktar.com)
AP) - Cadell Walker rushed to get her 9-year-old daughter Solome vaccinated against COVID-19 - not just to protect her but to help stop the coronavirus from spreading and spawning even more dangerous variants. (ktar.com)

The researchers homed in on a set of about two dozen likely causal variants, which they hypothesized affects a TET2 enhancer in hematopoietic stem cells. (genomeweb.com)

As SARS-CoV-2 testing declines worldwide, surveillance of international travelers for SARS-CoV-2 enables detection of emerging variants and fills gaps in global genomic surveillance ( 1 ). (cdc.gov)
Most countries are conducting genomic sequencing to identify new variants. (who.int)

This variant predisposes individuals to developing CHIP driven by a number of somatic mutations, suggesting the variant doesn't specifically predispose individuals to TET2-specific CHIP. (genomeweb.com)
By combining whole exome sequencing, machine learning, and network analysis, researchers have identified new, ultra-rare gene mutations within specific biological pathways that may contribute to eating disorders. (news-medical.net)
Variants (also known as mutations) in the GRIN2A gene can cause conditions in the epilepsy-aphasia spectrum. (medlineplus.gov)
The enormous variants and mutations found mean that we are still far from being able to concretely clarify a genotype-phenotype relationship. (bvsalud.org)

At least two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Alternative splicing results in multiple transcript variants. (nih.gov)

Previous genetic studies indicated that individuals from Scotland, Norway, Sweden, Ireland, Iceland, and British Isles have significantly contributed to the current gene pool of the Faroese population. (nature.com)
New evolving variants of malware are contributing significantly to cyberattacks globally. (itnext.in)

Today, with the delta variant fueling a nationwide surge in Covid-19 cases, ongoing fights over vaccines and masks, and yet another school year beginning with fear and uncertainty, you can see that same sentiment everywhere you look. (vox.com)
The highly transmissible Omicron variant was responsible for the biggest surge in COVID-19 cases in Puerto Rico. (cdc.gov)

Conclusions: A limited number of common and rare variants contribute to the risk of idiopathic pulmonary fibrosis in each of the resequencing regions, and these genetic variants focus on biological mechanisms of host defense and cell senescence. (qxmd.com)
It means your biological parents contributed identical variants. (healthline.com)
These new variants of concern have displayed biological properties such as increased transmissibility and some have potential for immune evasion, diminished vaccines efficacy (B.1.351 and B.1.1.7). (who.int)

A year from now, might there be an omega variant that's twice as transmissible as delta? (vox.com)
If a variant 50% more transmissible than delta showed up in late fall, 860,000 cases would be averted, "a big impact," said project co-leader Katriona Shea, of Pennsylvania State University. (ktar.com)

They each emphasized the importance of vaccines for stopping the delta variant in their opening remarks. (foxnews.com)

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)

In some cases, a single de novo causative variant can be detected. (nature.com)
The evidence, however, largely comes from protein-truncating variants (PTVs) as opposed to de novo missense (dnMis) variants. (springer.com)

Then, of course, came the delta variant. (vox.com)
Dr Tenpenny discusses the Delta Variant and how it is being used by Governments around the world to achieve their desired result. (beforeitsnews.com)
This work, coordinated by Prof. Matthieu Mahévas, Dr Claude-Agnès Reynaud, Prof. Jean-Claude Weill, Dr Pascal Chappert, Dr Félix Rey and Dr Pierre Bruhns, shows that people vaccinated with a messenger RNA vaccine against SARS-CoV-2 develop defenses against the Beta and Delta variants. (pasteur.fr)
This study demonstrates that patients infected during the first wave maintain a stable memory response for up to 12 months, and after one dose of vaccine develop excellent serological and cellular memory capable of recognizing and neutralizing the Beta and Delta variants of SARS-CoV-2. (pasteur.fr)
In patients "naive" from a former SARS-CoV-2 infection, that is to say who have never been infected with the virus, the quality of the serological response is initially less efficient with respect to the Beta and Delta variants. (pasteur.fr)
Will Covid-19 get worse than the delta variant? (vox.com)
The sobering news that you've already heard of is the fact that we are not challenged with a very difficult and problematic variant referred to as the Delta variant," Fauci said. (foxnews.com)
But worry over the Delta variant has led some in the U.S. to call for the return of strict health measures from the pandemic's height. (foxnews.com)
A variant even more dangerous than the contagious delta currently circulating. (ktar.com)
But some experts say children played a significant role this year spreading contagious variants such as alpha and delta. (ktar.com)
But there's also very good and growing evidence that delta is simply more fit, meaning that it's able to grow to higher levels faster than other variants that are studied. (ktar.com)
We have many lineages of delta that are circulating in many places with no clear winners," Ray said, adding that it's hard to know from genetic features which might have an edge, or which non-delta variants might dethrone delta. (ktar.com)

Marvel's "Guardians of the Galaxy #1" blasts into comic shops and online retailers on April 12, 2023 with variant covers by Derrick Chew, Aaron Kuder, Kael Ngu, and Scottie Young. (space.com)

1560-7917.ES.2019.24.45.1900140 ants, some of which have become variants of concern, 7. (cdc.gov)
The emergence of new variants of concern presents an additional risk for new waves of transmission. (who.int)
Some countries in the region have identified more than one new variant of concern. (who.int)
The significance of new variants of concern is immune escape, reduced vaccine efficacy resulting in resurgences and a high likelihood of a protracted or more severe COVID-19 outbreaks. (who.int)

The researchers used a somatic variant caller to identify individuals from the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine (TOPMed) program cohort with CHIP. (genomeweb.com)
We did not identify autosomal-recessive FBLIM1 variants. (biomedcentral.com)
Our approach has been piloted in the PrecisionFDA variant-calling challenges to identify the best-in-class variant-calling methods within high-confidence regions. (nature.com)
We performed a genome-wide association study (GWAS) and exome-sequencing analysis to identify common and rare genetic variants associated with plasma myeloperoxidase (MPO)-DNA complex levels, a biomarker for NETs, in the population-based Rotterdam Study cohort. (frontiersin.org)
We will use http://r12a.github.io/scripts/mongolian/variants to identify items that need discussion, and to record decisions. (w3.org)
To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. (bmj.com)
DNA microarrays can be used in genome-wide association studies (GWAS) to compare patient and control populations to identify DNA variants that can contribute to disease risk. (msdmanuals.com)

Among them, variants at 4q25, located upstream of PITX2 , far exceeded the preset threshold for genome-wide significance and demonstrate strong association with AF in both Europeans and Japanese popupations. (nature.com)

1 The heritability of autism is very high 2 and molecular genetic studies revealed that the genetic risk for autism is shaped by a combination of rare and common variants. (nature.com)
Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. (qxmd.com)
Objectives: To develop an integrated understanding of the rare and common variants located in multiple loci that have been reported to contribute to the risk of disease. (qxmd.com)
We tested for associations between disease and 1 ) individual common variants via logistic regression and 2 ) groups of rare variants via sequence kernel association tests. (qxmd.com)
In addition to identifying for the first time that rare variation in FAM13A is associated with disease, we confirmed the role of rare variation in the TERT and RTEL1 gene regions in the risk of IPF, and found that the FAM13A and TERT regions have independent common and rare variant signals. (qxmd.com)
Here, we are the first to apply these approaches to ascertain common and rare genetic variants associated with NETs using data from a population-based cohort study. (frontiersin.org)

In the case of the alpha variant, which started to make headlines around the start of the year , Goldstein says there is one mutation - a change to the virus's spike protein - that likely allowed it to bind more tightly to human cells. (vox.com)

But with the Omicron variant of the virus now spreading more quickly than any that came before, a number of big name tech and media companies have scrapped plans to attend in person. (liliputing.com)

The GWAS approach also demonstrated associations of common variants in HNF1A with levels of C-reactive protein, which is a potential biomarker of the condition. (cdc.gov)

These authors contributed equally to this work. (mdpi.com)

Here, we used resting-state functional magnetic resonance images from 47,276 individuals to discover and validate common genetic variants influencing intrinsic brain activity. (nih.gov)

Standardized benchmarking approaches are required to assess the accuracy of variants called from sequence data. (nature.com)

Variants in the GAS5 promoter region have been reported to be linked to mutiple diseases. (hindawi.com)

India accounted for as much as 3% of all new malware detected, and the country also registered the presence of many variants of common malware such as Mirai. (itnext.in)
Security researchers have discovered a new variant of the Duqu cyberespionage malware that was designed to evade detection by antivirus products and other security tools. (csoonline.com)
Researchers at Palo Alto Networks say earlier this month they discovered a new, more nasty variant of the Waledac malware that not only sends spam, but also steals passwords and other credentials: It can sniff for FTP, POP3, and SMTP user credentials, as well as pilfer .dat files for FTP and BitCoin. (darkreading.com)
Williamson says his team was able to discern the new malware was a fresh variant of Waledac because the C&C model was the same. (darkreading.com)

GWAS was performed using haplotype reference consortium(HRC)-imputed genotypes of common variants in 3,514 individuals from the first and 2,076 individuals from the second cohort of the Rotterdam Study. (frontiersin.org)
Genome-wide association studies (or GWAS) are large-scale genetic investigations of human disease that measure simultaneously hundreds of thousands of genetic variants scattered throughout the human genome. (cdc.gov)
For example, in type 1 diabetes (T1D), GWAS has the potential to substantially contribute to the identification of genetically high risk individuals. (cdc.gov)
GWAS variants could be used to stratify the population by level of risk in combination with age as a threshold for cancer screening. (cdc.gov)
A GWAS of change in hemoglobin levels during ribavirin treatment identified inosine triphosphatase (ITPA) variants that can protect against ribavirin-induced anemia. (cdc.gov)

Contributed equally. (nih.gov)

Every time the epidemic curve goes up, especially when it's variant-related, we just have a new injection of fear," Lindsey Leininger, a public health scientist at Dartmouth's Tuck School of Business who also co-writes the advice column Dear Pandemic , told Vox. (vox.com)

Although variant-calling tools and the metrics used to assess their performance continue to improve, important challenges remain. (nature.com)
MEM) to assess national surveillance data for respiratory navirus 2 variant derived from clade 19B (HMN.19B variant syncytial virus (RSV) in the Netherlands, 2005 to 2017. (cdc.gov)

Although, vaccine producers Pfizer's stock was up 6% and Moderna 26% , while Israel declared State of Emergency' after detecting the country's first case of a new faster mutating Covid Variant discovered in Africa. (beforeitsnews.com)

Through their analysis and subsequent replication, they uncovered one variant in TERT that was associated with a 1.3-fold increased risk of developing CHIP, as well as a variant near both KPNA4 and TRIM59 that was associated with a 1.16-fold increased risk and a variant near TET2 that was associated with a 2.4-fold increased risk of developing CHIP. (genomeweb.com)

Studies have shown that the longevity-associated variant (LAV) of the BPIFB4 gene is associated with a longer lifespan in humans and has protective effects in rodent models of cardiovascular disease. (medicalnewstoday.com)

Neutrophils contribute to host defense through different mechanisms, including the formation of neutrophil extracellular traps (NETs). (frontiersin.org)

Their immune system indeed produces memory cells capable of recognizing and neutralizing these worrisome variants. (pasteur.fr)
The fewer people who are infected, the less lottery tickets it has and the better off we're all going to be in terms of generating the variants," he said, adding that variants are even more likely to emerge in people with weakened immune systems who harbor the virus for a long time. (ktar.com)

Early research suggested they didn't contribute much to viral spread. (ktar.com)

The variant near TET2, the researchers noted, was specific to individuals with African ancestry, and had not previously been linked to disease, possibly due to the underrepresentation of individuals of African ancestry in genetic association studies. (genomeweb.com)

Measurements and Main Results: Statistically significant common variant association signals occurred in all 10 of the regions chosen based on genome-wide association studies. (qxmd.com)
The assessment of genetic variants in association with NETs might help to elucidate potential molecular mechanisms intervening in their formation and their downstream effect on other pathways. (frontiersin.org)

However, the genetic variants affecting brain function are largely unknown. (nih.gov)
Another big unknown: Dangerous variants may still arise in largely-unvaccinated parts of the world and make their way to America even as U.S. children join the ranks of the vaccinated. (ktar.com)

Our study supports a model wherein the rs145204276 variant in the GAS5 lncRNA is associated with IS risk, thus representing a potentially viable biomarker for IS prevention and treatment. (hindawi.com)

And as more people contract it, the odds of new variants rise. (ktar.com)

This study genotyped the two GAS5 variants in 1086 IS patients as well as 1045 age-matched healthy controls by using an improved multitemperature ligase detection reaction (iMLDR-TM) genotyping technology. (hindawi.com)
During August 1-September 9, 2022, the biotech company Ginkgo Bioworks, in collaboration with CDC, evaluated the feasibility of SARS-CoV-2 variant detection in aircraft wastewater from incoming international flights. (cdc.gov)

The genetic background and underlying mechanisms contributing to NET formation remain unclear. (frontiersin.org)

Our web-based app enables comparison of variant calls against truth sets to obtain a standardized performance report. (nature.com)

We provide guidance on how to match variant calls with different representations, define standard performance metrics, and stratify performance by variant type and genome context. (nature.com)

Nevertheless, the pool of memory cells generated after vaccination improves over time and contains cells capable of recognizing and neutralizing the current variants of SARS-CoV-2. (pasteur.fr)

Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach. (bvsalud.org)

In a series of assays, they found that individuals with this variant had decreased TET2 expression and that the reduction of TET2 activity was linked to increased self-renewal and proliferation of hematopoietic stem cells. (genomeweb.com)
A recent study published in Cardiovascular Research suggests that LAV-BPIFB4 , a gene variant that previous research ha shown to be highly expressed by individuals with an exceptionally long lifespan, could also protect cardiac and vascular function in old age. (medicalnewstoday.com)

The analysis concerns those of working age between 20 and 64 years, and deaths involving COVID-19 includes those where COVID-19 was the underlying cause of death or a factor that contributed to the death. (finchannel.com)

50 variants) are the highest known for any disease . (cdc.gov)

Fig. 2: Four examples of cases in which variants can be represented in multiple forms in VCF format. (nature.com)
The hub's latest estimates show that for this November through March 12, 2022, vaccinating 5- to 11-year-olds would avert about 430,000 COVID cases in the overall U.S. population if no new variant arose. (ktar.com)

Anatomy14

Organisms9

Diseases11

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology2

Phenomena and Processes108

Disciplines and Occupations8

Information Science9

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Health Care13

Geographicals4

SARS-CoV-2 Variants6

Gene variants3

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Susceptibility4

Missense variants6

Genome-wide association analysis2

Genes6

Coronavirus5

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Genomic2

Mutations4

Transcript variants2

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Surge in Covid-19 cases2

Biological3

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Vaccines1

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Novo2

Delta12

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Concern4

Identify7

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Rare6

Mutation1

Omicron1

Protein1

Authors contributed equally1

Functional1

Sequence1

Promoter1

Malware4

GWAS5

Equally1

Pandemic1

Assess2

Vaccine1

TERT1

Longevity1

Host defense1

Immune2

Viral1

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Largely2

Risk1

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Mechanisms1

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