The model suggests that simple differences in the impact of antibiotic exposure does not differ according to the natural history of colonization, interhuman contact, and expo- mechanism of resistance and do not consider the particular nat- sure to -lactam antibiotics explain major differences in the epi- ural history of the colonization of the bacterial species. (cdc.gov)
Therefore, -lactam antibiotics, such as penicillin G, bind to PBPs in better understanding of S. pneumoniae resistance selection and the bacterial cell wall. (cdc.gov)
Therapeutic Drug Monitoring of Beta-Lactam Antibiotics" Encyclopedia , https://encyclopedia.pub/entry/45749 (accessed November 29, 2023). (encyclopedia.pub)
Beta-lactam antibiotics are small hydrophilic molecules with a low volume of distribution (V d ) characterized by tissue distribution limited to the extracellular space, i.e., plasma and interstitial compartment. (encyclopedia.pub)
The PK/PD characteristics of beta-lactam antibiotics are summarized in Table 1. (encyclopedia.pub)
Treatment of clinically relevant S . epidermidis infections frequently requires the use of glycopeptides, oxazolidinones or lipopeptide antibiotics, as resistance to beta-lactams is widespread among S . epidermidis strains [ 4 ]. (biomedcentral.com)
Clinical2
Here describes various aspects of beta-lactams use in the critical care, focusing on clinical antibiotic stewardship in the ICU. (encyclopedia.pub)
The clinical effectiveness of beta-lactams is based on the time that their unbound fraction spent above the minimum inhibitory concentrations (MICs) of the susceptible microorganisms [ 1 ] [ 2 ] . (encyclopedia.pub)
Resistance2
The model suggests that simple differences in the impact of antibiotic exposure does not differ according to the natural history of colonization, interhuman contact, and expo- mechanism of resistance and do not consider the particular nat- sure to -lactam antibiotics explain major differences in the epi- ural history of the colonization of the bacterial species. (cdc.gov)
Therefore, -lactam antibiotics, such as penicillin G, bind to PBPs in better understanding of S. pneumoniae resistance selection and the bacterial cell wall. (cdc.gov)
Bacteria1
Opportunities for improved study design are apparent, as existing studies are limited by their inclusion of heterogeneous patient populations, including patients that may not even have infection, small sample size, variability in the types of beta-lactams included, infections caused by highly susceptible bacteria, and varied sampling, analytical and dosing algorithm methods. (bvsalud.org)
Patients3
Additionally, pharmacokinetic variability and difficulty in treating patients, especially those who are critically ill or those with renal dysfunction, necessitate TDM to ensure optimal cefepime concentrations. (betasciencepress-publishing.com)
Critically ill patients have increased variability in beta-lactam antibiotic (beta-lactam) exposure due to alterations in their volume of distribution and elimination. (bvsalud.org)
Use caution when CAYSTON is administered to patients with a known allergic reaction to beta-lactams. (nih.gov)