Vancomycin susceptible. Medical search. Frequent questions

We report characterization of a methicillin-susceptible, vancomycin-resistant bloodstream isolate of Staphylococcus aureus recovered from a patient in Brazil. (cdc.gov)
Acquisition of high-level vancomycin resistance by Staphylococcus aureus represents a major public health risk because this antimicrobial drug continues to be the first-line and most inexpensive therapy to treat methicillin-resistant S. aureus (MRSA) despite concerns about its clinical efficacy. (cdc.gov)
Using non-β-lactam antibiotics in certain infections has been shown to be less efficacious including vancomycin monotherapy for Staphylococcus aureus bacteraemia, which is associated with higher mortality rates. (bmj.com)
Vancomycin, the first line antibiotic for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, is often administered inappropriately when MIC is greater than 2 µg/mL, including 'susceptible' strains. (peerj.com)
This study assessed the discordance of vancomycin minimum inhibitory concentration (MIC) for methicillin-resistant Staphylococcus aureus (MRSA). (peerj.com)
In September 1999, the U.S. Food and Drug Administration labeled quinupristin-dalfopristin (Synercid) for use in the treatment of serious or life-threatening infections associated with vancomycin-resistant Enterococcus faecium bacteremia and complicated skin and skin structure infections caused by methicillin-susceptible Staphylococcus aureus and Streptococcus pyogenes (group A streptococcus). (aafp.org)
Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and ‑resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (druglib.com)
Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (druglib.com)
Methicillin-Susceptible Staphylococcus aureus Endocarditis Isolates Are Associated With Clonal Complex 30 Genotype and a Distinct Repertoire of Enterotoxins and Adhesins. (medscape.com)
To analyse the concentration of serum level in the voucher (one hour before the next administration of the drug dose) of vancomycin in newborns with Staphylococcus aureus infection or oxacillin-resistant coagulase-negative. (bvsalud.org)
We selected 30 patients who had staphylococcus aureus and coagulase-negative sepsis and used vancomycin as a treatment. (bvsalud.org)
The Food and Drug Administration (FDA) approved vancomycin for use in the United States in 1958 to treat penicillin-resistant1 Staphylococcus aureus infection. (bvsalud.org)

Occurrence of vancomycin-resistant and -susceptible Enterococcus spp. (nebraska.edu)
Dive into the research topics of 'Occurrence of vancomycin-resistant and -susceptible Enterococcus spp. (nebraska.edu)
Zyvox (linezolid) has received Federal Drug Administration approval for treatment of Vancomycin Resistant Enterococcus (VRE) infections, nosocomial pneumonia, community-acquired pneumonia, and various skin/skin structure infections. (ny.gov)
ABSTRACT: Vancomycin-resistant Enterococcus (VRE) is a major cause of hospital-acquired infections in the United States. (uspharmacist.com)
Infections caused by vancomycin-resistant Enterococcus (VRE) have rapidly emerged as a predominant concern, particularly among vulnerable patient populations. (uspharmacist.com)
This rise was predominantly due to E. faecium , but E. faecalis accounted for 11% of vancomycin-resistant Enterococcus (VRE) bacteraemias in the UK and Ireland (UK&I) between 2001 and 2013 ( http://www.bsacsurv.org ). (nature.com)
Resende M, Caierão J, Prates JG, Narvaez GA, Dias CAG, d'Azevedo PA (2014) Emergence of vanA vancomycin-resistant Enterococcus faecium in a hospital in Porto Alegre, South Brazil. (jidc.org)
Quinupristin-dalfopristin, the first formulation of a distinct class of antibiotics known as the streptogramins, has activity against a range of gram-positive bacteria that are usually resistant to other agents, including vancomycin-resistant Enterococcus faecium . (aafp.org)
The use of gloves and gowns did not affect vancomycin-resistant enterococcus (VRE) rates in that study, however. (infectioncontroltoday.com)

Both isolates were susceptible to daptomycin (MIC 0.5 μg/mL). (cdc.gov)
Thirteen days earlier, 2 MRSA isolates, 1 of which was resistant to vancomycin (VR-MRSA), were recovered from the blood of the same patient ( Technical Appendix ) ( 1 ). (cdc.gov)
Historically, isolates resistant to oxacillin (commonly referred to as MRSA) were resistant to most agents other than vancomycin, but these isolates were limited to nosocomial infections. (medscape.com)
isolates with an increased minimum inhibitory concentration (MIC) to vancomycin are becoming more common and include both MRSA and MSSA. (medscape.com)
Daptomycin retains potency against antibiotic-resistant Gram-positive bacteria, including isolates resistant to methicillin, vancomycin, and linezolid. (globalrph.com)
Fifty-three percent of the human EC isolates were pan susceptible, 26% were singly resistant, and 21% were resistant to 2 or more antimicrobials. (usda.gov)
One S. epidermidis and one S. haemolyticus isolates were resistant to teicoplanin and susceptible to vancomycin. (scielo.br)
Methodology: Twenty-nine isolates from inpatients of Mãe de Deus Hospital that were identified and characterized for their susceptibility profile, vancomycin genotype, presence of esp gene, biofilm production, and clonal relationship were collected. (jidc.org)
Results: All isolates were identified as vancomycin/ampicillin resistant E. faecium carrying the vanA gene. (jidc.org)
In addition, this enhanced dose would deal with the relative resistance of enterococcal isolates that have been previously exposed to vancomycin. (medscape.com)
According to data from the National Nosocomial Infection Surveillance System (1989 to 1993), 1 the percentage of nosocomial enterococcal isolates that are resistant to vancomycin (Vancocin) has increased from 0.3 percent to 8 percent. (aafp.org)
Even more strikingly, the percentage of vancomycin-resistant enterococcal isolates in intensive care units has increased from 0.4 percent to almost 14 percent. (aafp.org)

In a small study (40 subjects) with MRSA bacteremia, the combination of ceftaroline plus daptomycin was found to have lower in-hospital mortality rate as compared to vancomycin or daptomycin monotherapy. (medscape.com)
We screened the Nebraska Transposon Mutant Library of 1920 single-gene inactivations in S. aureus strain JE2, for increased susceptibility to the anti-staphylococcal antimicrobials (ciprofloxacin, oxacillin, linezolid, fosfomycin, daptomycin, mupirocin, vancomycin, and gentamicin). (frontiersin.org)
It appears that combining various beta-lactam antibiotics with daptomycin may result in synergy against vancomycin-resistant E faecalis and E faecium . (medscape.com)
1 however, few randomised trials have evaluated its efficacy compared to current standard treatment options (vancomycin, daptomycin, linezolid). (bmj.com)
In addition, infected wax moth larvae were treated with daptomycin, penicillin or vancomycin to examine whether these agents were effective against S. aureus and MRSA infections in vivo. (stir.ac.uk)
After larvae were infected with S. aureus, larval survival was enhanced by administering the antistaphylococcal antibiotics daptomycin or vancomycin. (stir.ac.uk)
Daptomycin and vancomycin were also effective when administered to the larvae prior to infection with bacteria. (stir.ac.uk)

A drug called linezolid is more successful at treating a deadly form of pneumonia than the standard treatment, vancomycin, according to data presented Jan. 30 at the 32nd Critical Care Congress of the Society of Critical Care Medicine in San Antonio. (scienceblog.com)
These results are based on data from two identical phase III clinical trials comparing linezolid to vancomycin in the treatment of pneumonia cases that develop in the hospital. (scienceblog.com)
These data demonstrate that critically-ill patients taking linezolid were more likely to live than those taking vancomycin. (scienceblog.com)
Patients received intravenous linezolid or vancomycin twice daily for seven to 21 days. (scienceblog.com)
The team found that the patients were significantly more likely to survive when treated with linezolid compared with those treated with vancomycin. (scienceblog.com)
Linezolid vs vancomycin: Predictors of survival in patients with ventilator-associated pneumonia. (scienceblog.com)
Of the study participants, 122 linezolid-treated patients and 103 vancomycin-treated patients were clinically evaluable. (renalandurologynews.com)
The cure rates were 57% for linezolid-treated patients and 60% for vancomycin-treated patients. (renalandurologynews.com)
The cure rates in patients with ventilator-associated pneumonia were 47% for linezolid-treated patients and 40% for vancomycin-treated patients. (renalandurologynews.com)
The cure rates in the MITT analysis were 57% in linezolid-treated patients and 46% in vancomycin-treated patients. (renalandurologynews.com)

During this study, 17 vancomycin-resistant E. faecium (VRE) were isolated from human wastewater from multiple geographic locations. (usda.gov)
Quinupristin-dalfopristin has been shown to be effective in the management of documented severe infections caused by vancomycin-resistant E. faecium , nosocomial pneumonia, and infections related to the use of intravascular catheters. (aafp.org)
3 When resistance has emerged during the treatment of vancomycin-resistant E. faecium infections, it has been to both components of the formulation. (aafp.org)
Susceptible vancomycin-resistant E. faecium (VREF) infections, nosocomial and community-acquired pneumonia, complicated skin and skin structure infections (including diabetic foot infections) without osteomyelitis, uncomplicated skin and skin structure infections. (renalandurologynews.com)

In particular, no previous studies have evaluated the occurrence of vancomycin-resistant enterococci (VRE) in reclaimed water used at spray irrigation sites in the United States. (nebraska.edu)
To address this knowledge gap, we investigated the occurrence, concentration, and antimicrobial resistance patterns of VRE and vancomycin-susceptible enterococci at three U.S. spray irrigation sites that use reclaimed water. (nebraska.edu)
Since 1989, a rapid increase in the incidence of infection and colonization with vancomycin-resistant enterococci (VRE) has been reported by U.S. hospitals. (cdc.gov)
From 1989 through 1993, the percentage of nosocomial enterococcal infections reported to CDC's National Nosocomial Infections Surveillance (NNIS) system that were caused by vancomycin-resistant enterococci (VRE) increased from 0.3% to 7.9% (1). (cdc.gov)
Vancomycin resistance in enterococci has coincided with the increasing incidence of high-level enterococcal resistance to penicillin and aminoglycosides, thus presenting a challenge for physicians who treat patients who have infections caused by these microorganisms (1,4). (cdc.gov)
Vancomycin is the first-line antimicrobial drug for enterococci with high-level resistance to ampicillin or for patients with penicillin allergy. (nature.com)
Conclusions: An important change in vancomycin-resistant enterococci was observed. (jidc.org)

Emergence of vancomycin resistance in methicillin-susceptible S. aureus would indicate that this resistance trait might be poised to disseminate more rapidly among S. aureus and represents a major public health threat. (cdc.gov)
We characterized a clinical isolate of vancomycin-resistant, methicillin-susceptible S. aureus (VR-MSSA) and document the in vivo transfer of the vanA gene cluster to 2 unrelated S. aureus strains causing bacteremia within the same patient. (cdc.gov)
Treatment of methicillin-susceptible S aureus (MSSA) bacteremia with cefazolin has been shown to improve survival rates and decrease toxicity in comparison to antistaphylococcal penicillins. (medscape.com)
Preferred therapy for methicillin-susceptible S aureus (MSSA) staphylococci infections. (medscape.com)
2 , 3 A single randomised controlled trial conducted more than two decades ago suggested that TMP-SMX may be a useful alternative to vancomycin for treatment of severe S aureus infections. (bmj.com)
It is indicated for the treatment of pneumonia infections caused by S. aureus (both methicillin-susceptible and resistant strains) and S. pneumoniae (penicillin-susceptible strains only). (scienceblog.com)
Moreover, penicillin improved survival of larvae infected with a penicillin-susceptible methicillin-susceptible S. aureus (MSSA) strain, but it was ineffective at similar doses in larvae infected with MRSA (penicillin resistant). (stir.ac.uk)
Unfortunately, the suspected cases of ear, wound and urinary tract report of emergence of vancomycin intermediate infections at both tertiary (UUTH) and secondary sensitive S. aureus (VISA) and vancomycin (GHIA) healthcare facilities in Akwa Ibom State. (who.int)
resistant S. aureus (VRSA) in clinical samples The study was approved by the Health Ethics impacted negatively on the efficacy of vancomycin Committee of the State Ministry of Health and the 6 leading to treatment failures. (who.int)

Transferable vancomycin resistance in a community-associated MRSA lineage. (cdc.gov)
Recently, we described vancomycin-resistant MRSA (VR-MRSA) recovered from the bloodstream of a patient in Brazil ( 1 ). (cdc.gov)
In the 1990s, many reports appeared describing community-acquired MRSA infections that were susceptible to various non-beta-lactam antibiotics. (medscape.com)
Although many strains of MRSA that cause community-acquired infection are susceptible to trimethoprim-sulfamethoxazole, treatment with trimethoprim-sulfamethoxazole has been associated with clinical failure, especially in the presence of significant tissue damage. (medscape.com)
In a study of 296 consecutive MRSA bacteremia episodes, several factors were predictive of high vancomycin MIC, including age older than 50 years, prior vancomycin exposure, history of MRSA bacteremia, history of chronic liver disease, and presence of a nontunneled catheter. (medscape.com)
3) MRSA-vancomycin MICs at a cutoff of 2 µg/mL obtained using Vitek II exhibited a higher sensitivity level and negative predictive value than those obtained using E -test in the prediction of categorical agreement with standard broth microdilution. (peerj.com)
Patients in the comparator group could also be treated with vancomycin 1g every 12 hours IV if MRSA was isolated from the foot infection. (renalandurologynews.com)
This was a cross sectional hospital- vancomycin as the drug of choice in the treatment of based study involving 300 patients of all ages with 6 infections caused by MRSA. (who.int)

Although some species are inherently resistant to vancomycin, they are far less common than species that acquire resistance through transfer of genetic material. (uspharmacist.com)

The second isolate (VR-MSSA) had a vancomycin MIC of 256 µg/mL and was also resistant to gentamicin ( Table 1 ). (cdc.gov)
Almost all were susceptible to gentamicin and streptomycin. (jidc.org)
Combination therapy with a cell wall-active agent (eg, ampicillin, vancomycin) and an aminoglycoside (eg, gentamicin, streptomycin) has long been regarded as the standard of care for E faecalis native valve endocarditis. (medscape.com)

All strains were susceptible to vancomycin. (inspq.qc.ca)

and their susceptibility to 20 antibiotics was tested by disk diffusion and to vancomycin by agar dilution. (bvsalud.org)
Reduced susceptibility (MIC = 4mg/L) to vancomycin was shown by both oxacillin-resistant and susceptible CoNS species. (bvsalud.org)

This increase poses important problems, including a) the lack of available antimicrobial therapy for VRE infections, because most VRE are also resistant to drugs previously used to treat such infections (e.g., aminoglycosides and ampicillin), and b) the possibility that the vancomycin-resistant genes present in VRE can be transferred to other gram-positive microorganisms (e.g. (cdc.gov)
Ampicillin is the drug of choice for monotherapy of susceptible E faecalis infection . (medscape.com)

C. jeikeium is usually susceptible to vancomycin and tetracycline. (wikipedia.org)
Resistance to nafcillin by mecA gene which is located on chromosome, resistance to vancomycin (vancomycin and nafcillin resistance genes exist in these strains) and plasmid resistance to tetracycline, erythromycin and aminoglycosides are the types of resistance mechanisms [ 5 , 6 ]. (alliedacademies.org)

Efficacy and safety of tigecycline monotherapy compared with vancomycin-aztreonam in the treatment of complicated skin and skin structure infections in patients from India and Taiwan. (druglib.com)
BACKGROUND: To compare the monotherapy of tigecycline with vancomycin-aztreonam in hospitalized patients from India and Taiwan with complicated skin and skin structure infections (cSSSIs). (druglib.com)

For treatment of infections caused by penicillinase-producing staphylococci susceptible to methicillin (MSSA). (medscape.com)
Vancomycin Hydrochloride is indicated for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant staphylococci. (fda.gov)
It is used in penicillin- allergic patients, and also for patients who cannot receive or who have failed to respond to other antimicrobials, including penicillin or cephalosporin agents, and for infections caused by vancomycin-susceptible organisms that are resistant to other antimicrobials. (fda.gov)

Plasmid-mediated gene complexes confer high-level resistance to vancomycin and are often used as targets for molecular detection of VRE. (uspharmacist.com)

Patients with pre-existing moderate/severe renal impairment (CrCl ≤50 mL/min)who were treated with VIBATIV for hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia had increased mortality observed versus vancomycin. (nih.gov)

Of the human EF, 3% were pan susceptible, 9% were singly resistant, and 88% were resistant to 2 or more antimicrobials. (usda.gov)
Of the EC, 12% were pan susceptible, 37% were singly resistant, and 51% were resistant to 2 or more antimicrobials. (usda.gov)
Conclusion: The test strains were resistant to amoxicillin and susceptible to all antimicrobials tested. (bvsalud.org)

Patients were randomly assigned 1:1 to receive either Zyvox IV Injection (n=203) 600mg every 12 hours or vancomycin (n=193) IV 1g every 12 hours for 7 to 21 days. (renalandurologynews.com)

The actual increase in the incidence of VRE in U.S. hospitals might be greater than reported because the fully automated methods used in many clinical laboratories cannot consistently detect vancomycin resistance, especially moderate vancomycin resistance (as manifested in the VanB phenotype) (9-11). (cdc.gov)

The monitoring of serum levels in the vancomycin valley is of great importance as it minimises nephrotoxic effects, thus increasing the efficacy of the drug. (bvsalud.org)

5,6 Additional risk factors include prolonged stay in a hospital or healthcare facility, presence of invasive devices such as bladder catheters, and exposure to certain antibiotics, such as vancomycin, third-generation cephalosporins, and antianaerobic agents. (uspharmacist.com)
Treatment is usually with penicillinase-resistant beta-lactams, but because antibiotic resistance is common, vancomycin or other newer antibiotics may be required. (merckmanuals.com)

Vancomycin is a glycopeptide antibiotic considered the gold standard in the treatment of staphylococcal infections that are oxacillin-resistant. (bvsalud.org)

One MSSA isolate was susceptible to all antimicrobial drugs tested (VS-MSSA). (cdc.gov)

An increased risk for VRE infection and colonization has been associated with previous vancomycin and/or multiantimicrobial therapy, severe underlying disease or immunosuppression, and intraabdominal surgery. (cdc.gov)
This report presents recommendations of the Hospital Infection Control Practices Advisory Committee for preventing and controlling the spread of vancomycin resistance, with a special focus on VRE. (cdc.gov)
Each of the three main lineages contained a mixture of vancomycin-resistant and -susceptible E. faecalis (VSEfs), which has important implications for infection control and antibiotic stewardship. (nature.com)
Clostridium difficile infection (CDI) is a relatively common and refractory infection, often acquired in hospitals and nursing homes by susceptible elderly patients. (patentdocs.org)

Vancomycin should be used in patients with a penicillin allergy or infections with strains that have high-level penicillin resistance due to altered PBPs. (medscape.com)

[ 51 ] but instead recommend dosing vancomycin based on the area under the curve over 24 hours to minimum inhibitory concentration (AUC/MIC) with a target of 400-600 mg*hour/L. (medscape.com)

This combination results in synergistic bactericidal activity against susceptible enterococcal strains. (medscape.com)

2) Physicians should incorporate this information and consider a complementary test to verify the appropriateness of the decision of shifting vancomycin to second-line antibiotic treatment to improve patients' prognosis. (peerj.com)

Vancomycin Hydrochloride is effective in the treatment of staphylococcal endocarditis, septicemia, bone infections, lower respiratory tract infections, and skin and skin-structure infections. (fda.gov)

Several situations require the monitoring of serum levels and adjustment of vancomycin doses. (bvsalud.org)

To reduce the development of drug-resistant bacteria and maintain the effectiveness of TYGACIL and other antibacterial drugs, TYGACIL should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. (druglib.com)

VIBATIV should be used with caution in patients with known hypersensitivity to vancomycin. (nih.gov)
therefore, this option should be reserved for patients in whom other therapeutic options, including metronidazole and vancomycin, have failed. (druglib.com)
Harris is also studying which pre-existing conditions make patients more susceptible for developing HAIs. (infectioncontroltoday.com)
In seven patients (23.34%), the first serum level in the Vancomycin valley collected was adequate, but in nine (30%) and 14 (46.67%) patients, the serum concentration in the valley was respectively below and above the correct values. (bvsalud.org)
The dosage adjustment of vancomycin in severely ill patients admitted to an intensive care unit is important and requires more studies related to this area, as the work of a multidisciplinary body makes the treatment better and more specific. (bvsalud.org)

Penicillin-resistant staphylococci have emerged since the 1980s, and currently both types are sensitive to vancomycin only. (bvsalud.org)

[ 52 ] .The results of such testing are often delayed .Because of these drawbacks and the availability of less nephrotoxic and more effective alternatives , vancomycin has a very limited role in treating staphylococcal infections. (medscape.com)

Anatomy1

Organisms11

Diseases10

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes8

Staphylococcus12

Enterococcus9

Isolates12

Daptomycin7

Linezolid10

Faecium4

Enterococci7

Aureus9

MRSA8

Resistant to vancomycin1

Gentamicin3

Strains were susceptible to vancomycin1

Susceptibility2

Ampicillin2

Tetracycline2

Monotherapy2

Infections caused3

Resistance to vancomycin1

Versus vancomycin1

Antimicrobials3

ZYVOX1

Clinical1

Efficacy1

Antibiotics2

Oxacillin1

Antimicrobial drugs1

Infection4

Penicillin allergy1

Minimum inhibitory co1

Bactericidal activity1

Antibiotic1

Endocarditis1

Doses1

Bacteria1

Patients5

Staphylococci1

Staphylococcal1