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  • effect of vanadium
  • We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. (nih.gov)
  • Toxicological effect of vanadium on the macrophage response to Listeria challenge. (cdc.gov)
  • anticancer
  • This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. (nih.gov)
  • Like titanocene dichloride, this organovanadium compound is currently being investigated as a potential anticancer drug (currently in clinical trials). (wikipedia.org)
  • potent
  • Ten molecules inhibited over the 50% of the activity of the PTP1B, the three most potent molecules were selected for its characterization, reporting Ki values of 5.2, 4.2 and 41.3 µM, for compounds 1 , 2 , and 3 , respectively. (mdpi.com)
  • The data reported here support these compounds as hits for the design more potent and selective inhibitors against PTP1B in the search of new antidiabetic treatment. (mdpi.com)
  • protein
  • In the present work, a chemical library of 250 compounds was evaluated to determine their inhibition capability on the protein PTP1B. (mdpi.com)
  • diabetes
  • These compounds have been found to exert anti-diabetic effects in rodent models of type 1 and type 2 diabetes mellitus as well as in a limited number of studies in human diabetic subjects. (springer.com)
  • Thus, vanadium compounds have emerged as agents for potential use in diabetes therapy. (springer.com)
  • vitro
  • Compounds of the trace element vanadium have been shown to mimic insulin in in vitro and in vivo systems. (springer.com)
  • Vanadium, a trace metal known to accumulate in bone and to mimic insulin, has been shown to regulate mammalian bone formation using in vitro and in vivo systems. (springer.com)