Vamp snap proteins n ethylmaleimide sensitive proteins. Medical search. Frequent questions

Its molecular weight has been found to be 47167 M. SNARE complex (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) includes syntaxin proteins, VAMP proteins and SNAP proteins. (wikipedia.org)
and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)
An abundance of soluble N-ethylmaleimide-sensitive factor adaptor protein receptors. (kegg.jp)
To achieve this, the neuronal SNARE (i.e., soluble N -ethylmaleimide-sensitive factor attachment protein receptor) complex brings the vesicle and presynaptic membranes in close proximity, thereby, mediating the fusion of the two membranes resulting in exocytosis of neurotransmitters. (nature.com)
Fusion of synaptic vesicles with the presynaptic membrane occurs in the presence of the NSF (N-ethylmaleimide-sensitive-factor) / α-SNAP (α-soluble NSF attachment protein) disassembly machinery. (nature.com)

VAMP (Vesicle-associated membrane protein), SNAP-25 (Synaptosome associated protein of 25 kDa) and Syntaxin constitute the basic SNARE complex. (biomedcentral.com)
The SNARE complex assembles from the vesicular protein Synaptobrevin-2 as well as SNAP25 (synaptosome-associated protein of 25 kDa) and Syntaxin-1, which are both anchored to the presynaptic membrane 2 . (nature.com)

Since many SNAP proteins do not have trans-membrane domains, these are common way of attachment. (wikipedia.org)

Using this framework to analyze the SM (Sec1/Munc18)-SNARE ( N -ethylmaleimide-sensitive factor activating protein receptor) system in exocytic membrane fusion in yeast and neurons, we find that the SM-SNARE network motifs of yeast and neurons show distinct dynamical behaviors. (biomedcentral.com)

Synaptosome-associated protein, 47 kDal (SNAP47) is a human protein encoded by the SNAP47 gene. (wikipedia.org)
SNAP47 protein is a synaptosome associated protein. (wikipedia.org)

SNARE proteins are generally known to be related to vesicle fusion - mediating exocytosis or neurotransmitter release. (wikipedia.org)
More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)
The specificity of vesicle trafficking: coat proteins and SNAREs. (kegg.jp)

SNAP proteins are t-snare proteins that are a component of SNARE complex. (wikipedia.org)
SNARE proteins are believed to form compact four-helix complex with membranes. (wikipedia.org)
Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
Although the members of Q-SNARE proteins are characterized in somatic cells, it is not known whether related proteins function in the sperm acrosome reaction. (ommegaonline.org)
Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. (biomedcentral.com)

The protein abundance is about average when compared to all the other proteins in humans. (wikipedia.org)
In vitro translation of inosine-containing luciferase RNA reduces resulting luciferase activity, which is only partly explained by reduced abundance of the luciferase protein produced. (bvsalud.org)

Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)

These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
As for many essential biological processes, intracellular membrane fusion is mediated by interactions among a series of evolutionarily conserved proteins. (biomedcentral.com)

By capturing the evolutionary dynamics of target biological systems, the comparative modeling framework is empowered to (i) identify the functional roles of poorly characterized proteins and interactions and (ii) further decipher the underlying regulatory mechanisms of complicated cellular processes. (biomedcentral.com)

Consistent with a role for RAB18 in regulating membrane contact sites, interactors included groups of microtubule/membrane-remodeling proteins, membrane-tethering and docking proteins, and lipid-modifying/transporting proteins. (bvsalud.org)
EBP is a Δ8-Δ7 sterol isomerase, and ORP2 is a lipid transport protein. (bvsalud.org)
Another distinction that has been drawn contrasts the constitutive and the regulated pathways to distinguish the ongoing transport of protein and lipid to the cell surface from the ability to secrete hormones and transmitters in response to specific stimuli. (sdbonline.org)

This protein causes ubiquitous expression in testis, ovary, and many other tissues The gene is located at 1q42.13, meaning on chromosome 1 on the long arm of the chromosome in region 42, sub region 13. (wikipedia.org)

60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)

In this paper, we show that Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster . (rupress.org)
sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)

SP1 or Stimulating protein 1 had a matrix similarity of 1.0 and is a ubiquitous zinc finger transcription factor and is on the minus strand. (wikipedia.org)
TATAB is a TATA binding protein factor with a similar matrix of 0.945. (wikipedia.org)
Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. (shengsci.com)

Seeking ovarian cancer related SNAP proteins may help to reveal new mechanisms of invasion and metastasis of ovarian cancer, and provide new ideas for clinical diagnosis and treatment. (biomedcentral.com)

The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)

Protein Kinase C plays a role in several signal transduction cascades including calcium release. (wikipedia.org)
Therefore this study provides a new method to solve the discrepancies and to generalize the functional role of SM proteins. (biomedcentral.com)

SNAP47 is a member of the SNAP protein family. (wikipedia.org)

This may suggest that there is a larger expression rate but the protein is used up quickly for its function. (wikipedia.org)

Mutations of a gene sequence can modify the interfaces or domains of its protein product and lead to the emergence of new or loss of existing protein interaction patterns [ 11 ]. (biomedcentral.com)
Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)

SNAP47 is a synaptosome protein which is associated with the protein coding in multiple diseases, including non small cell lung cancer and schizophrenia. (wikipedia.org)

Two Palmitoylation sites were predicted at the beginning of SNAP47 protein at Cys6 and Cys12. (wikipedia.org)

Synaptic vesicle fusion is driven by the formation of a four-helical bundle composed of soluble N- ethylmaleimide sensitive factor (NSF) attachment protein receptors (SNAREs). (jneurosci.org)
18. Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling. (nih.gov)

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. (novusbio.com)
Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (VAMP) 1, 2 and 3, but at a novel site (Arg66-Ala67 in VAMP2). (nature.com)

Since many SNAP proteins do not have trans-membrane domains, these are common way of attachment. (wikipedia.org)
These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. (novusbio.com)
Herein, we investigated the effects of glucose on the subcellular localization and spatial distribution on the plasma membrane (PM) of t-SNAREs (SNAP-25 and STX-1A) using a live-cell confocal microscope and the single-molecule localization imaging technique. (bvsalud.org)
This process takes place at the trans -Golgi network (TGN) and is thought to involve selective protein aggregation and protein-membrane interactions. (medscape.com)
[ 8 , 9 ] These complexes exhibit distinct protein compositions and contain certain zymogens in association with nonenzyme proteins, which have been proposed to act as 'helper' proteins in complex formation, aggregation and/or sorting to the membrane. (medscape.com)
[ 8 , 10 ] The protein complexes progressively aggregate at the mildly acidic pH and high Ca 2+ levels within the TGN and form dense core aggregates that are supposed to interact with the TGN membrane. (medscape.com)
However, the retention of the granule-specific membrane components is likely to involve their interaction with regulated secretory proteins. (medscape.com)
however, some information is beginning to emerge regarding the proteins that mediate the exocytotic membrane fusion event. (medscape.com)

HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)

These condensing vacuoles (CVs), the initial stage of ZGs, then pinch off as immature granules, which mature into ZGs by the selective removal of nonsecretory granule proteins (via a clathrin-mediated process called 'constitutive-like secretion') and further condensation of the aggregated proteins occurs, as well as a reduction in granule size. (medscape.com)

Western Blot: VAMP3/Cellubrevin Antibody [NB300-510] - Analysis of recombinant rat VAMP-3. (novusbio.com)
confirmed using commercial and recombinant proteins. (pharmaceuticalintelligence.com)

The common ribosome-inactivating proteins gelonin, saporin and ricin have been investigated when coupled to antibodies against neuroblastoma-enriched receptors, e.g. gangliosides GD2 and GD3 [ 6 - 8 ]. (oncotarget.com)

In Alzheimer's disease, all VAMP isoform levels appear to be significantly reduced. (novusbio.com)

in the absence of any other cytosolic proteins. (pharmaceuticalintelligence.com)

In an alternative, passive model ('sorting by retention'), aggregation of regulated secretory proteins is the primary sorting event. (medscape.com)

We sought to investigate the structure-function relationship of SNAP-25 in functional mammalian CNS synapses by combining the specificity of clostridial neurotoxin cleavage with the ability to transfect organotypic hippocampal slices with mutated forms of SNAP-25. (jneurosci.org)
The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. (novusbio.com)
4. Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases. (nih.gov)

Figure 1D & E highlights the pH-dependent aggregation of ZG proteins in an in vitro condensation-sorting assay after processing for electron microscopy. (medscape.com)

A series of protein-protein interaction cascades have been proposed to lead to vesicle docking and fusion (1-3). (pharmaceuticalintelligence.com)

We found that an intramolecular interplay between the N-terminal Rab-binding domain and C-terminal C2AB domain enables Rabphilin 3A to strongly bind the SNAP-25 N-peptide region via its C2B bottom α-helix. (bvsalud.org)
AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)

Some of the ZG enzymes form protein complexes already within the lumen of the endoplasmic reticulum. (medscape.com)

Two Palmitoylation sites were predicted at the beginning of SNAP47 protein at Cys6 and Cys12. (wikipedia.org)

M. mulatta, a monkey, was aligned with the Homo sapiens protein transcript and a 67.1% identical amino acids were found. (wikipedia.org)

This protein causes ubiquitous expression in testis, ovary, and many other tissues The gene is located at 1q42.13, meaning on chromosome 1 on the long arm of the chromosome in region 42, sub region 13. (wikipedia.org)

Live-cell confocal and dSTORM imaging first revealed that SNAP-25 was mostly localized to the PM as clusters under the basal glucose concentration condition and demonstrated significant colocalization with STX-1A clusters. (bvsalud.org)

Sythetic peptide corresponding to residues M(1) S T G V P S G S S A A T G S N R R(18) C of mouse VAMP-3. (novusbio.com)

It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)

Soluble5

Syntaxin2

Attachment1

Receptor1

Synaptosome associated protein2

Vesicle4

SNARE5

Abundance2

Exocytosis1

Membrane fusion2

Regulatory1

Lipid3

Ovary1

Genes1

Drosophila2

Factor3

Reveal1

Complex1

Role2

Family1

Function1

Domains2

Small1

Sites1

Soluble N-ethylmaleimide-sensitive2

Vesicle associated membrane proteins2

Membrane8

Eukaryotes1

Secretion1

Recombinant2

Receptors1

Isoform1

Cytosolic1

Secretory1

Specificity3

Assay1

Interaction1

Bind2

Endoplasmic reticulum1

Palmitoylation1

Amino1

Gene1

Concentration1

Mouse1

Levels1