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  • cusps
  • End-stage disease, eg, calcific aortic stenosis, is characterized pathologically by large nodular calcific masses within the aortic cusps that protrude along the aortic surface into the sinuses of Valsalva, interfering with opening of the cusps. (ahajournals.org)
  • The aortic valve (AV) provides a paradigm for valvular structural specialization and tissue dynamics, as viewed by echocardiography and bioreactor models ( Figure 1 A). The direction of flow during systole allows the valve cusps to open as the blood flows across the open AV leaflets. (ahajournals.org)
  • Individual AV cusps attach to the aortic wall in a semilunar fashion, ascending to the commissures and descending to the basal attachment of each cusp. (ahajournals.org)
  • early aortic
  • One early study identified male gender, triglycerides, and smoking as independent risk factors for early aortic valve replacement in AS patients. (ahajournals.org)
  • While clinical interventions with statins have failed to retard AS progression, there is substantial evidence linking activity of the renin-angiotensin system with early aortic valve disease. (ahajournals.org)
  • risk of aortic
  • 1 Correlations also were found between elevated levels of lipoprotein(a) [Lp(a)] and low-density lipoprotein cholesterol (LDL) and increased risk of aortic sclerosis, 1 though the relative risks appeared to be lower than those typically reported for atherosclerosis. (ahajournals.org)
  • People who have long-term raised blood pressure have an increased risk of aortic valve disease (AVD) - problems with the valve that controls how blood is pumped from the left ventricle of the heart out into the main artery, the aorta. (eurekalert.org)
  • stenotic
  • When an aortic valve becomes stenotic, it does not open properly, thus affecting the amount of oxygen-rich blood that leaves the heart with each beat. (medtronic.com)
  • Determination of the stenotic aortic valve area in adults using Doppler echocardiography. (springer.com)
  • Objectives This study sought to describe the natural history of combined stenotic and regurgitant aortic valve disease. (onlinejacc.org)
  • Data on combined stenotic and regurgitant aortic valve disease are scarce, both with regard to its epidemiological prevalence and even more importantly with regard to its natural history ( 3 ). (onlinejacc.org)
  • left ventricle
  • In particular, the aortic valve controls the flow of oxygenated blood pumped out of the heart from the left ventricle into the aorta, the main artery leading to the rest of the body. (healthcentral.com)
  • One of these valves, the aortic valve , guards the passageway between the left ventricle and the aorta , your primary supply artery for oxygen-rich blood. (howstuffworks.com)
  • AS is a condition in which the valve that opens and closes when blood is pumped out of the left ventricle becomes narrowed and stiff due to calcium building up. (eurekalert.org)
  • AR occurs when the valve doesn't close properly, allowing some blood to leak back into the left ventricle. (eurekalert.org)
  • Progression
  • In the current study we have evaluated the occurrence and correlates of development and progression of early ASc in an ageing population, utilizing the technique of aortic valve backscatter (AVBS), which facilitates quantification of early valve disease. (ahajournals.org)
  • No conventional coronary risk factors were associated with disease progression. (ahajournals.org)
  • interstitial cells
  • Consistent with the in vivo data, Notch signaling inhibition in porcine valve interstitial cells led to downregulation of HEY1 transcription, activation of osteogenic markers, and increased calcified nodule formation. (ahajournals.org)
  • Genetic
  • and (3) identification of cell-signaling pathways and genetic factors that may participate in valve disease pathogenesis. (ahajournals.org)
  • 21 Also, an emerging body of literature is investigating how genetic factors might influence disease development. (ahajournals.org)
  • In an accompanying editorial comment , Himanshu J. Patel, MD, FACC, writes that "the fundamental lack of knowledge regarding bicuspid aortic valve disease suggests that there is a need for a prospectively-collected, clinically-robust database to further evaluate the natural history and genetic underpinnings of this complex, heterogeneous pathology. (acc.org)
  • We investigated whether mice with genetic inactivation of the Notch signaling pathway are prone to develop valve disease when exposed to a predisposing diet. (ahajournals.org)
  • close tightly
  • In the echo, you can see that the leaves of my aortic valve do not close tightly, due to some irregularity on the edges (deposits of some kind, maybe calcium, maybe protein) and there's a bit of backflow into the heart. (medhelp.org)
  • semilunar
  • The semilunar valves , however, serve as the exit doors that blood pulses through as it leaves the ventricles on its way to the fuel lines (your arteries). (howstuffworks.com)