DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. (nih.gov)
Intracellular1
changes of intracellular Na + concentrations ([Na + ] i ) induced by readmission of different external K + concentrations ([K + ] o ) to tissues depleted of K + by 4‐h exposure to K + ‐free solution. (comprehensivephysiology.com)
Metabolism1
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. (nih.gov)
Differentiating patients1
Results The cumulative chloride secretory response of ΔI sc,carbachol , ΔI sc,cAMP/forskolin and ΔI sc,histamine was the best diagnostic ICM parameter (cut-off 34 μA/cm 2 between patients with known PS-CF and controls), differentiating patients with questionable CF into PS-CF (n=6) and 'CF unlikely' (n=55) groups. (bmj.com)
Reference2
Objectives To describe reference values and validate ICM for the diagnostic classification of questionable CF at all patient ages. (bmj.com)
Follow-up information at ages 4 to 12 years was obtained on all 26 subjects. (nih.gov)
Function1
Conclusions This comprehensive investigation of CFTR function and genotype underlines the diagnostic value of ICM, especially for confirmation of CF in the absence of two disease-causing CFTR mutations, exclusion of CF despite intermediate sweat test and age groups unsuitable for nasal potential difference measurements. (bmj.com)