Vaginal microbial communities. Medical search. Frequent questions

In the recent years our knowledge of those vaginal bacteria communities has expanded rapidly as a consequence of using modern molecular (cultivation-independent) methods for species identification. (news-medical.net)
Generally, this condition is characterized by a shift in microbial composition from an abundance of lactobacilli in healthy women, to an increase of commensal anaerobic bacteria (such as Gardnerella , Atopobium , Prevotella and a panoply of other species). (news-medical.net)
Women with this condition are characterized by heterogeneous communities of bacteria that exhibit increased richness and diversity of existent bacterial species. (news-medical.net)
Only supraphysiologic concentrations of exogenous H2O2 (0.34% w/v, 100 mM) were sufficient to inactivate BV-associated bacteria at which concentration it more potently inactivated vaginal lactobacilli (L. crispatus, L. gasseri, L. iners and L. jensenii). (wikipedia.org)
Traditionally, scientists have considered healthy vaginal microbial communities to be those dominated by this type of bacteria. (popsci.com)
Now, research suggests that certain vaginal bacteria can actually their hosts more vulnerable to HIV. (popsci.com)
Women whose bacterial communities were dominated by microbes known to cause inflammation were four times more likely to get HIV than those who hosted bacteria traditionally associated with a healthy vaginal microbiome. (popsci.com)
A lot has been written and said about the gut microbiome - the community of bacteria, viruses, fungi and archaea that lives in our intestines. (theconversation.com)
In females, the vaginal microbiome is mainly composed of bacteria, particularly Lactobacillus species. (theconversation.com)
This microbiome helps maintain a healthy vagina by creating an acidic environment that prevents the growth of harmful bacteria and promotes a balanced microbial community. (theconversation.com)
A study of men with and without sexually transmitted infections (STIs) found that bacteria associated with STI but also with vaginal dysbiosis can be found in STI-positive patients [ 15 ]. (biomedcentral.com)
Horizontal gene transfers are common within communities of bacteria - they contribute greatly to the spread of antibiotic-resistant genes in a variety of pathogens, for example - and they've also been found to occur in multicellular organisms . (quantamagazine.org)
Bacterial Vaginosis - Caused by an overgrowth of bad bacteria, BV leads to vaginal inflammation and thinning of the lining. (gynelogic.co.uk)
An optimal vaginal microbiome results in the production of lactic acid and hydrogen peroxide, maintaining a level of acidity that keeps pathogenic bacteria at bay. (gynelogic.co.uk)
We now know that intestinal flora is made up of a veritable microbial community, comprising bacteria, yeasts and phages 2 . (lesaffre.com)
Other vaginal discharge is the fluid that comes out of the vagina and is made up of cells from the cervix and vagina, bacteria, mucus, and water. (hannahpearn.com)
Lactobacillus are common bacteria in the vaginal tract of healthy females. (vagibiom.com)
Unprotected sexual activity can introduce foreign bacteria into the vaginal tract, increasing the risk of microbiome disruption. (vagibiom.com)
Maintaining good hygiene practices, such as regular washing with mild soap and warm water, can help prevent the overgrowth of harmful bacteria while preserving a healthy vaginal microbiome. (vagibiom.com)
Here, we review the literature on culture-independent analysis of microbial diversity in the BE and explore what it tells us about the dynamics and distribution of bacteria and fungi in these environments. (biomedcentral.com)
This is the reason for the ingestion of probiotic bacteria affecting nasal and vaginal health. (cultureforgood.com)
The vaginal microbiome is the ecosystem of bacteria, yeasts and other microorganisms that live inside your vagina. (yourdaye.com)
These are the good bacteria in your vaginal microbiome, responsible for warding off infections. (yourdaye.com)
Bacterial vaginosis (BV) is the most common genital tract disorder in reproductive aged women and is characterized by a shift from a healthy vaginal microbiome - one dominated by acid-producing bacteria (the healthy bacteria, such as lactobacillus) - to a vagina dominated by unhealthy bacteria. (my-fertility-blog.com)
Vaginal health correlates to the presence of good bacteria and antibiotics kill off the good bacteria along with the ones that they are intended to kill. (my-fertility-blog.com)
Science has shown that any foods that help promote gut health can also help promote a healthy balance of vaginal bacteria. (my-fertility-blog.com)
and datamining publicly available metagenomic datasets from the human vaginal tract, to identify protein-coding gene clusters in the bacteria that make up the majority of the microbiome of the vagina. (lu.se)
Linked to an overgrowth of harmful microorganisms that then can crowd out "healthier" vaginal bacteria, BV can increase a woman's chance of contracting sexually transmitted diseases and developing pelvic inflammatory disease. (florajen.com)
A vaginal microbiome test is a diagnostic tool that allows you to analyze the composition of the bacteria and yeast in your vagina. (ombrelab.com)
Identify vaginal microbiome imbalances and address harmful bacteria associated with infertility and pregnancy complications. (ombrelab.com)
Provides a vaginal microbiome health report with bacteria description, health benefits/effects, associated imbalances/disease, risks and actionable insights. (ombrelab.com)

A nurse, midwife, or clinician collected maternal vaginal swabs of the posterior fornix and lateral vaginal wall at first presentation to the labor and delivery area. (medscape.com)
Gathering a cohort of 2,000 largely African American pregnant women, whose mean age was 28, investigators collected vaginal swabs and took anthropometric measurements during three different points in the pregnancy to establish immunological profiles and characterize cervicovaginal microbiota using a unique Bayesian model. (aacc.org)
We aimed to evaluate if patient- and provider-collected vaginal swabs in pregnant women reflect similar bacterial community characteristics. (biomedcentral.com)
Ninety-four vaginal swabs from 47 women were analyzed. (biomedcentral.com)
We demonstrate that bacterial communities defined from patient- and provider-collected vaginal swabs in pregnant women are similar, validating utilization of patient-collected swabs for vaginal bacterial microbiome sampling during pregnancy. (biomedcentral.com)
However, data are not currently available regarding the representation of microbial species composition in patient-collected swabs compared to provider-collected swabs among pregnant women. (biomedcentral.com)
Considering the maternal physiologic changes in pregnancy, including the gravid abdomen and increased physiologic vaginal discharge, we aimed to evaluate if patient-collected swabs of the mid-vagina in pregnancy reflect the same microbial community characteristics as provider-collected swabs obtained during speculum exam. (biomedcentral.com)
Samples of vaginal swabs were collected and stored at -70℃ until assayed. (researchsquare.com)
In the present study, the researchers enrolled 749 women from diverse ethnicities in the last trimester of their pregnancy, and vaginal swabs were obtained from all the participants for microbial analyses. (mypharmacynews.com)
Taxonomic profiling using over 600 human samples comprising vaginal, fecal, oral, and breast milk samples were used to create a customized database, which was then used to assign the sequences obtained from the vaginal swabs taxonomically. (mypharmacynews.com)
Diagnostic tests, such as vaginal swabs or DNA sequencing, can help identify abnormal vaginal microbiota and guide appropriate treatment strategies. (vagibiom.com)

O'Hanlon and Baeten found that 96% of Lactobacillus species from a healthy vaginal ecosystem produced H2O2 (L. jensenii and L. vaginalis produce the highest levels of H2O2), whereas only 6% of the lactobacilli recovered from women with BV produced H2O2. (wikipedia.org)
Only about 10 percent of these women had a Lactobacillus -dominated vaginal microbiome. (popsci.com)
Not only do they have more inflammation, but they're actually acquiring HIV at fourfold rates over women who have the sort of Lactobacillus -dominant, 'classically healthy' vaginal communities," Kwon says. (popsci.com)
If diverse vaginal microbiomes can be shifted to become Lactobacillus -dominated, women could become less susceptible to HIV. (popsci.com)
Eubiotic effect of estrogen and Lactobacillus species in the vaginal milieu. (frontiersin.org)
Glycogen from exfoliated and lysed epithelial cells is catabolized by α-amylase in the vaginal lumen to smaller polymers that are subsequently metabolized to lactic acid by Lactobacillus spp. (frontiersin.org)
The normal physiological vaginal microbiota was initially described in 1892 by Albert Döderlein as homogenous, consisting of only Gram-positive bacilli (Doderlein's bacilli) ( 6 ), believed to originate from the gut and currently known to be a part of the genus Lactobacillus ( 7 ). (frontiersin.org)
Eight different community types, so called urotypes (UT), were identified in healthy humans, all of which were shared between men and women, except UT 7, dominated in relative abundance by Lactobacillus crispatus , which was found in healthy women only. (biomedcentral.com)
Community sequence types based on the species of Lactobacillus or the abundance of G. vaginalis over Lactobacillus species also vary across ethnicities. (mypharmacynews.com)
The results reported that Lactobacillus species play a major role in maintaining the low diversity in the vaginal microbial community, and the decrease in the abundance of these species is associated with preterm delivery. (mypharmacynews.com)
The vaginal microbial analyses corroborated the findings from previous studies about the presence of distinct community sequence types represented by the abundance of specific Lactobacillus species. (mypharmacynews.com)
The two prominent Lactobacillus species in the community sequence types were L. crispatus and L. iners , and a reduction in the levels of these species was linked to a higher risk of preterm delivery. (mypharmacynews.com)
Furthermore, the co-occurrence of Ureaplasma species and C. albicans in samples with a low abundance of Lactobacillus species highlighted the protective effects of Lactobacillus species in the vaginal microbiome during pregnancy. (mypharmacynews.com)
For the normally less diverse vaginal microbiome, live biotherapeutics are under development to treat bacterial vaginosis, a disorder associated with increased diversity and loss of the normal, healthy mono-dominance by Lactobacillus spp. (cdc.gov)
Pregnancy is accompanied by a shift in the bacterial community structure of the vagina to a composition that is typically dominated by one or two species of Lactobacillus. (vagibiom.com)
Using Lactobacillus treatment instead of direct antimicrobial therapies to restore a healthy vaginal microbiome may promote fertility. (vagibiom.com)
Certain strains of Lactobacillus can be taken as probiotic supplements to restore and maintain a healthy vaginal microbiome. (vagibiom.com)
Vaginal environments in which Lactobacillus gasseri dominate, for example, are more likely to clear HPV infections. (advocatesaz.org)
The human vaginal microbiota impacts HIV risk, and young women in the South African FRESH study with a vaginal microbiota deficient in Lactobacillus crispatus had a 4-fold higher rate of HIV acquisition compared to their peers. (ucsf.edu)
In this population, we demonstrated that women with vaginal microbial communities dominated by Lactobacillus crispatus had a 4-fold lower rate of HIV acquisition, reduced numbers of mucosal CD4+ T cells and lower levels of genital tract proinflammatory cytokines compared with women with communities deficient in Lactobacillus species. (ucsf.edu)
This common syndrome of vaginal dysbiosis, characterized by a diverse, non- Lactobacillus dominant microbial community, is known as bacterial vaginosis (BV). (ucsf.edu)
Given the apparent protection from infections afforded by a Lactobacillus- dominant vaginal microbiota, an intervention strategy using live biotherapeutic products (LBP) is a logical approach. (ucsf.edu)
In 60 young South African women with a non-Lactobacillus-dominant microbiota, we plan to assess whether this intervention a) reduces proinflammatory cytokines and HIV target cells in the lower genital tract, b) leads to a persistent Lactobacillus-dominant vaginal microbial community and c) is safe and acceptable in this population of young women at high risk for HIV. (ucsf.edu)
Indeed, studies have shown that several probiotics , including oral Lactobacillus acidophilus (which is included in Florajen Women probiotics) can play a role in maintaining vaginal pH and increasing vaginal lactobacilli for a more stable microbiome. (florajen.com)

As the aforementioned loss of lactobacilli results in reduced lactic acid production, the pH in the vaginal lumen increases. (news-medical.net)
Since the first description of lactobacilli by Döderlein, lactobacilli have been generally considered the gatekeepers of the vaginal ecosystem. (wikipedia.org)
Moreover, lactobacilli normally help to prevent long-term colonization of the vagina by adhering to vaginal epithelial cells. (wikipedia.org)
Vaginal colonization by H2O2-producing lactobacilli has been associated with a decrease in the occurrence of bacterial vaginosis (BV). (wikipedia.org)
In contrast, under optimal anaerobic growth conditions, physiological concentrations of lactic acid inactivated the BV-associated pathogens without affecting the vaginal lactobacilli. (wikipedia.org)
In summary, although the hydrogen peroxide production of lactobacilli has been considered as an important antimicrobial component, contributing to the colonization resistance provided by lactobacilli, and although there seems to be a link between H2O2-producing lactobacilli and normal vaginal microflora, recent data do not support this role for H2O2. (wikipedia.org)
Lactobacilli from a vaginal swab. (popsci.com)
A glycogen-rich vaginal milieu is a haven for the proliferation of Lactobacilli facilitated by the production of lactic acid and decreased pH. (frontiersin.org)
Lactic acid acidifies the vaginal milieu favoring the proliferation of Lactobacilli and inhibiting the growth of infection-associated organisms. (frontiersin.org)
Lactobacilli work by strengthening the vaginal microbiome so it can fight infections all by itself. (yourdaye.com)
Should LACTIN-V be able to sustainably replenish vaginal lactobacilli and reduce genital inflammation, it could become a safe, effective, self- renewing, female-controlled product that promotes vaginal health and provides protection from HIV and potentially other STIs. (ucsf.edu)

Understand your risk of vaginal infections like yeast infections or BV, STIs, fertility im. (yourdaye.com)
By identifying imbalances in your vaginal microbiome, you can take steps to correct them and reduce your risk of vaginal infections and other complications. (ombrelab.com)

By forming a mutual relationship with the host, the vaginal microbiome ( i.e. various kinds of vaginal microbial communities present in healthy women) has a significant impact on women's health and disease. (news-medical.net)
so it sounds intuitive that different kinds of vaginal microbiomes could end up influencing the development of a baby's gut microbiome in different ways. (medscape.com)

Vaginal discharge and why it's important for your fertility. (hannahpearn.com)
Most people with a vagina will at some point in their life suffer with problematic vaginal discharge. (hannahpearn.com)
Problematic vaginal discharge means that there is an imbalance of the microbes in the vagina. (hannahpearn.com)
Cervical mucus, a vaginal discharge made by the cervix and is normal and essential part of the menstrual cycle and women's fertility. (hannahpearn.com)
This discharge helps to protect the vaginal and urinary tract against infections and provides lubrication to the vaginal tissues. (hannahpearn.com)
Problematic discharge can happen when the vagina's microbial community gets out of balance. (hannahpearn.com)
The 3 most common causes of problematic discharge are, Bacterial Vaginosis, Vulva/Vaginal Candida (thrush) and Trichomoniasis. (hannahpearn.com)
Bacterial vaginosis and thrush are common causes of unusual vaginal discharge. (yourdaye.com)
The most prominent and often the most disconcerting symptom of BV is a strong fishy vaginal odor, but some women with BV also see increased amounts of discharge that is gray in color. (my-fertility-blog.com)
Normal vaginal discharge helps to cleanse the vagina, forms a protective barrier, and boosts natural fertility. (my-fertility-blog.com)
Increased vaginal discharge that may be thin, white, or gray, sometimes with a fishy odor. (florajen.com)
Many women report an abnormal vaginal discharge. (medscape.com)

This is an in-depth assessment of the health of the vaginal microbiome as a whole. (hannahpearn.com)
Clearly, understanding and promoting the health of the vaginal microbiome can help protect and promote a more fertile environment. (vagibiom.com)

The potential impact of vaginal dysbiosis on reproduction is also outlined. (frontiersin.org)

Healthy young women in this African community that we've been studying have much more diverse [bacterial] communities within their genital tract," says coauthor Douglas Kwon, an immunologist at the Ragon Institute in Cambridge, Massachusetts. (popsci.com)
This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. (frontiersin.org)
This study was undertaken to determine whether the vaginal microbes of women at childbearing age is different among groups defined by urogenital tract infections, childbearing history and menstrual cycle, respectively. (researchsquare.com)
We tested the hypothesis of whether the relative abundance of microbial species in vaginal microbiota was different between women with different urogenital tract infections, childbearing history and menstrual cycle. (researchsquare.com)
We showed that the vaginal microbial richness(Alpha diversity measured by PD_whole tree) was decreased in normal women(without reproductive tract infections) than in those with bacterial vaginosis (BV), and decreased in pregnant women than in other groups of non-pregnancy. (researchsquare.com)
Woman genital tract is one of the natural niches that harbor the most amount of body microbes[1].The normal structure of vaginal microbiome plays a pivotal role in maintaining the healthy microecosystem, especially for those in childbearing age. (researchsquare.com)
Biogeographical Differences in the Influence of Maternal Microbial Sources on the Early Successional Development of the Bovine Neonatal Gastrointestinal tract. (montana.edu)
They naturally make their way to the vaginal tract after excretion from your GI system when you have a bowel movement. (florajen.com)
Support vaginal health, fertility, immunity, and urinary tract health all year long with an at-home vagina microbiome test subscription. (ombrelab.com)
The colonic microbiome view is controversial, some people Metagenomics of the Human Intes- is the most diverse and also the best consider the gut microbiota to be tinal Tract (MetaHIT) consortium re- characterized microbial community. (who.int)
In the upper tract, a number of microbial and host factors appear to influence the degree of inflammation that occurs and, thus, the amount of subsequent scarring that develops. (medscape.com)

Sure enough, the team found that the study subjects with more diverse vaginal microbiomes had a higher risk of HIV infection. (popsci.com)
A principal component analysis of infant stool microbiomes showed no significant clustering of microbiome profiles at 10 days or 3 months by maternal community state types (that is, microbial species). (medscape.com)
The microbial diversities of vaginal microbiomes were analyzed concerning adverse pregnancy outcomes. (mypharmacynews.com)
They learned that women who have cervical cancer or precancerous abnormalities have drastically different vaginal microbiomes. (advocatesaz.org)

The substantial changes in estrogen levels during pregnancy also result in changes in the vaginal microbial community, which protect the fetus against pathogens. (mypharmacynews.com)
However, we found no changes in the vaginal microbiota composition. (eco-vector.com)

Diagnostics "could include rapid polymerase chain reaction and enzyme-linked immunosorbent assay testing," Michal Elovitz, MD, the study's principal investigator and professor of obstetrics and gynecology at Penn, told CLN Stat . "Testing could be performed on a noninvasive, self-collected vaginal swab. (aacc.org)
Pregnant patients performed a self-collected vaginal swab, then underwent a provider-collected swab via speculum exam. (biomedcentral.com)

Vaginal flora, vaginal microbiota or vaginal microbiome are the microorganisms that colonize the vagina. (wikipedia.org)
Urethra and bladder thus harbor microbial communities distinct from the vagina. (biomedcentral.com)
The population of microbes that live in your vagina are known collectively as the vaginal microbiome. (advocatesaz.org)
The vagina is a very strong, tube-like, extremely elastic muscular organ that connects the external vaginal organs to the uterus. (my-fertility-blog.com)
Candida is a normal part of the vaginal microbiome, a collection of microorganisms in the vagina. (customprobiotics.com)

The microbes present in the vaginal environment of women with endometrial cancer are also different from the microbes present in the vaginal environment of women without endometrial cancer. (mayoclinic.org)
The premature disruption of the amniotic membrane and preterm delivery have also been associated with specific microbes present in the vaginal microbiome. (mypharmacynews.com)

We thus postulate that gynecological infections as well as the normal physiological cycle may affect the structural profile of vaginal microbiota of women in childbearing age. (researchsquare.com)
Methods and analysis We are conducting a community-based birth cohort study to examine interactions between gut microbiome conditions and enteric infections, and how environmental conditions affect the development of the gut microbiome. (bmj.com)
We will follow 360 newborns from 3 sites along a rural-urban gradient in northern coastal Ecuador, characterising enteric infections and gut microbial communities in the children every 3 to 6 months over their first 2 years of life. (bmj.com)
Yeast Infections - Candida fungus irritates the vaginal tissue, causing itchiness and redness. (gynelogic.co.uk)
While usually not severe, vaginal infections should always be treated properly. (gynelogic.co.uk)
My preferred options are at a local sexual health clinic, making sure that also include a test for BV, or I can order the Vaginal Ecologix test for you, and you can gain a comprehensive picture of your vaginal microbiome and identify specific infections. (gynelogic.co.uk)
Leading an active sex life or suffering from recurrent vaginal infections? (yourdaye.com)
The human vaginal microbiota has long been considered a factor impacting women's risk for acquiring sexually transmitted infections (STIs) including HIV, but the extent of this contribution and the underlying mechanisms have not been well defined. (ucsf.edu)
An American study from 2018 has revealed that women who smoke show alterations in vaginal microbiome and may have increased susceptibilities to urogenital infections. (my-fertility-blog.com)
Oral antifungal agents may be used for a variety of skin or vaginal infections . (infectiontalk.net)
Vaginal yeast infections are usually caused by a type of yeast called Candida albicans . (infectiontalk.net)
Some illnesses increase the risk of vaginal yeast infections. (infectiontalk.net)
Other factors that increase the risk of vaginal yeast infections include stress, washing your genitals with soap, wearing synthetic and tight clothes, sweating and using non-breathable panty liners or sanitary pads. (infectiontalk.net)
This undermines the effectiveness of the available treatment options and thus contributes to the persistence of microbial infections. (who.int)
This test detects imbalances in the vaginal microbiome, which can lead to a variety of issues such as recurrent vaginal infections, yeast infections, bacterial vaginosis and other discomforts. (ombrelab.com)
Uncover any deficiencies in your vaginal microbiome that can leave the body prone to pathogens that can cause recurrent infections, like UTIs, Candida overgrowth, bacterial vaginosis, and more. (ombrelab.com)
Les micro-organismes mis en évidence par coloration de Gram ont donné une sensibilité de 96,6 %, une spécificité de 88,9 %, une valeur prédictive positive de 97,7 % et une valeur prédictive négative de 84,2 % lorsqu'ils étaient utilisés pour prévoir les résultats de culture positifs pour les infections bactériennes des plaies. (who.int)

This condition, which is highly dependent on resident microbial flora, is linked to some severe sequelae such as pelvic inflammatory disease, preterm labor, as well as increased sensitivity to infection with various sexually-transmitted agents. (news-medical.net)
Research Links Vaginal Flora and Fertility! (vagibiom.com)
Research increasingly demonstrates that within each discrete microbial environment (e.g., the skin, gut, vaginal flora), unique compositions of microbiota correspond to various healthy and diseased states. (ddw-online.com)
Screen one-off and make sure your vaginal flora isn't inhibiting your fertility. (yourdaye.com)
Receive food and lifestyle recommendations that promote digestive health, support mental wellness, and nourish healthy vaginal flora. (ombrelab.com)

High estrogen states, as seen during puberty and pregnancy, promote the preservation of a homeostatic (eubiotic) vaginal microenvironment by stimulating the maturation and proliferation of vaginal epithelial cells and the accumulation of glycogen. (frontiersin.org)
At puberty and during pregnancy, elevated levels of estrogen promote the maturation of and deposition of glycogen in vaginal epithelial cells. (frontiersin.org)

This usually reduces pathogens from infecting to the vaginal epithelium. (wikipedia.org)
The urinary microbiota is similarly complex as the vaginal and penile microbiota, yet its role as a reservoir for pathogens and for recurrent polymicrobial biofilm diseases like bacterial vaginosis (BV) is not clear. (biomedcentral.com)

Furthermore, the findings suggested that specific species in the vaginal microbiome are not the best indicator of the risk of adverse outcomes during pregnancy. (mypharmacynews.com)

Low pH is generally accepted to be the main mechanism controlling the composition of the vaginal microflora. (wikipedia.org)
The composition of the vaginal microbiota/microbiome is dynamic and undergoes changes corresponding with hormonal fluctuations throughout the woman's reproductive life, i.e., from puberty to menopause, and during pregnancy ( 5 ). (frontiersin.org)

In a recent study published in the Scientific Reports Journal, researchers examined the diversity, community-type prevalence, and role of the vaginal microbiota in various pregnancy outcomes. (mypharmacynews.com)
Microbial diversity in the vaginal microbiota and its link to pregnancy outcomes. (mypharmacynews.com)
The vaginal microbiome has relatively lower microbial diversity as compared to the intestinal microbiome, and the composition changes across phases starting from birth till menopause. (mypharmacynews.com)
Still, the overall diversity of the vaginal microbial community does provide a better understanding of the risk. (mypharmacynews.com)
The role of the overall diversity of the microbial community, and not that of single species, in determining the risk of preterm birth was further emphasized by the fact that women who had a high abundance of G. vaginalis did not show any symptoms of bacterial vaginosis and had normal pregnancies. (mypharmacynews.com)
Here we show that spared nerve injury-induced neuropathic pain alters gut microbial diversity in mice. (biomedcentral.com)
In summary, our results provide novel experimental evidence that spared nerve injury-induced neuropathic pain reshapes gut microbial diversity, and alters the stability and key microbes in the gut. (biomedcentral.com)
The most commonly used molecular approach for exploring microbial diversity is based on the PCR amplification and sequencing of genes encoding small subunit ribosomal RNA (16S rRNA) directly from environmental sources [ 16 ]. (biomedcentral.com)
This approach readily determines several orders of magnitude more microbial diversity than culture-based methods, often discovering novel organisms with no known growth conditions, and has dramatically altered our understanding of global microbial diversity [ 14 ]. (biomedcentral.com)
This 'alpha diversity', or microbial diversity within a sample, can include taxonomic assignment. (ddw-online.com)
Furthermore, researchers examine 'beta diversity' (microbial diversity between samples) to establish the significance of an individual's microbial profile across population-wide references. (ddw-online.com)
In addition to relying upon NGS and algorithms built for diversity profiling and association mapping, therapeutic development requires bioinformatic platforms uncovering how microbes operate within biological pathways, and how microbial (im)balances contribute to disease root cause and symptom alleviation. (ddw-online.com)
Findings present technical considerations in the characterization of microbial diversity and composition associated with gestational diabetes as a model pregnancy-associated pathology. (rmmj.org.il)

We studied whether vaginal microbiome community state types (CSTs) are associated with high-grade precancer and/or invasive cervical cancer (HSIL/ICC). (biomedcentral.com)
To date, there are no works devoted to the assessment of changes in vaginal microbiocenosis after the cervical pessary insertion. (eco-vector.com)
The insertion of the Dr. Arabin cervical pessary under conditions of vaginal normocenosis is a microbiologically safe way to correct short cervix and prevent preterm birth, and does not disrupt the vaginal microflora in pregnant women before delivery. (eco-vector.com)
The first stage is acquisition of a vaginal or cervical infection. (medscape.com)
Although cervical mucus provides a functional barrier against upward spread, the efficacy of this barrier may be decreased by vaginal inflammation and by hormonal changes that occur during ovulation and menstruation. (medscape.com)

You can further support vaginal health by avoiding processed foods, sugars, as well as too much meat and dairy products. (my-fertility-blog.com)

A complex community of microorganisms lives on our skin's surface and deeper layers. (theconversation.com)
These simple cells, which journey from mother to baby at birth and in the months of intimate contact that follow, form the first seeds of the child's microbiome - the evolving community of symbiotic microorganisms tied to the body's healthy functioning. (quantamagazine.org)
These microorganisms make their way onto the newborn's skin, eyes, and mouth as the baby pushes through the vaginal walls. (cultureforgood.com)

A good Vaginal Microbiome is an essential part of supporting your fertility. (hannahpearn.com)
Can Vaginal Microbiome Imbalance Reduce Fertility Success? (vagibiom.com)
The vaginal microbiome plays a crucial role in maintaining reproductive health and fertility. (vagibiom.com)
However, recent research has shown that the vaginal microbiome can influence fertility even without apparent inflammation. (vagibiom.com)
What probiotics promote an optimal microbial environment for fertility and the health and survival of the next generation? (vagibiom.com)
Maintaining a healthy vaginal microbiome is essential for promoting fertility and reproductive health. (vagibiom.com)
Research has increasingly underlined the important influence of the composition and structure of the inhabiting vaginal microbial communities on reproductive health and fertility outcomes. (my-fertility-blog.com)
Paying attention to your vaginal health is an important facet of a lifestyle that promotes healthy fertility. (my-fertility-blog.com)

It was highest in UT 1 in acute BV (59% of samples), but after metronidazole treatment, only 3 out of 35 women showed a significant correlation between their urinary and vaginal microbiota composition. (biomedcentral.com)
The study of the vaginal microbiota composition and the need for its routine correction after the pessary insertion remain to be investigated. (eco-vector.com)

Bacterial vaginosis represents the most prevalent type of vaginal infection that occurs among reproductive-age women, and also the most common condition that prompts women to seek medical care. (news-medical.net)
In recent years, culture-independent, phylogenetic characterization of microbial communities using 16S ribosomal RNA (16S rRNA) gene sequences directly extracted from biological samples has provided a broad understanding of vaginal microbial communities among reproductive age women [ 1 ]. (biomedcentral.com)

Identify and correct imbalances in the vaginal microbiome through food, lifestyle, and probiotic recommendations. (ombrelab.com)

Also, there are a few simple steps to maintain vaginal health and prevent problems in the first place. (my-fertility-blog.com)

Despite these advances, manipulating complex microbial communities for a particular outcome still presents challenges. (cdc.gov)
Over the last two decades, advanced molecular genetics technology has enabled analysis of complex microbial communities and the study of microbial genomics. (rmmj.org.il)
2 Recently developed molecular microbiology techniques have enabled culture-independent analysis of complex microbial communities in the human body. (rmmj.org.il)

The ovarian steroid hormone cycle and the changes in estrogen levels associated with the availability of glycogen change the vaginal microbiota of women of reproductive age. (mypharmacynews.com)

However, the relationship between sPTB and a woman's vaginal microbiome has not been extensively researched. (aacc.org)

Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women. (uidaho.edu)
It's unclear why some vaginas-all of them apparently healthy-host more diverse bacterial communities than others. (popsci.com)
Although individual urine microbial profiles strongly responded to the antibiotic, the healthy community could not be restored. (biomedcentral.com)
What constitutes a "healthy" vaginal microbiome? (vagibiom.com)
Both projects also share similar end goals, in that I hope to be able to contribute to better medical care for people infected by P. aeruginosa , as well as contribute to a greater understanding of how healthy (or unhealthy) vaginal microbial communities develop or are maintained. (lu.se)
That can upset the healthy balance and increase the likelihood of developing a vaginal yeast infection. (infectiontalk.net)
Cerumen microbial community shifts between healthy and. (joyfulhealthcare.org)
Under healthy conditions, the in- nomes obtained from individuals crobiota resembles the mother's skin testinal microbiota is considered to on three continents, including 760 microbial community, composed of be a stable community, influenced samples from Europe. (who.int)

human microbiota The bacterial community in the human body. (mpkb.org)
Utilizes our proprietary liquid buffer that holds the bacterial cells in stasis, resulting in a precise representation of the vaginal bacterial community. (ombrelab.com)

With 100-fold the number of genes in the human genome 1 , this microbial collection is a rich genetic signature of clinical significance that we have only recently gained the tools to explore. (ddw-online.com)

Quite few reports dealt with the impact of a natural menstrual cycle on bacterial growth, colonization, and community structure. (researchsquare.com)
As the project develops, Lawrenz also hopes to explore the relationship of Y.pestis and microbial communities of the flea, which may impact colonization and transmission. (louisville.edu)

In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. (frontiersin.org)
Discover which of Ombre's science-backed probiotics for vaginal health is best for your unique microbiome. (ombrelab.com)
Our clinically studied and peer-reviewed vaginal probiotics have proven to reach the vaginal biome, correct imbalances, and provide health benefits. (ombrelab.com)

In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. (frontiersin.org)
The vaginal microbial community is distinct in its composition and has a specific function in women's reproductive health. (mypharmacynews.com)

demonstrated that the vaginal microbiome of pregnancy uniquely differs compared to the non-pregnant state. (biomedcentral.com)
Examination of community membership, behavior, and community dynamics of the vaginal microbiome over pregnancy may further elucidate mechanisms that predispose women to preterm birth. (biomedcentral.com)
For the millions of women who hope to conceive a child but cannot, a recently published study may shed some light on vaginal microbiome composition and pregnancy outcomes. (vagibiom.com)
It is known the vaginal microbiome in pregnancy plays an important role in both maternal and neonatal health outcomes. (vagibiom.com)
An imbalance of the vaginal microbiome is also associated with pregnancy complications, particularly an increased risk of preterm birth. (vagibiom.com)
Finding a new vaginal "bad guy" was exciting, and Sneathia had previously been linked to other gynecological problems, ranging from bacterial vaginosis to pregnancy complications. (advocatesaz.org)

The physiological status of the vaginal milieu is important for the wellbeing of the host as well as for successful reproduction. (frontiersin.org)
This microbial community exerts numerous physiological functions. (customprobiotics.com)

But in some cases, it can indicate an underlying vaginal infection needs treatment. (gynelogic.co.uk)
In most cases, vaginal infection-related bleeding is short-lived once treated. (gynelogic.co.uk)
Bacterial vaginosis (BV) is the most common vaginal infection in women of childbearing age, occurring in 30% of women ages 15 to 44 in the United States. (florajen.com)
The recent success gut microbial genes, obtained after has fantastic potential, it has only of faecal microbiota transplantation, sequencing whole faecal microbiota been about 10 years since the sci- especially in the context of Clostridi- metagenomes from 124 European indi- entific community first realized its im- um difficile infection, argues for such viduals [4]. (who.int)

The vaginal mucosal ecosystem is comprised of a stratified squamous non-keratinized epithelium overlaid by a mucosal layer continuously lubricated by cervicovaginal fluid (CVF). (frontiersin.org)
Interestingly, at a higher resolution, our results showed that spared nerve injury-induced neuropathic pain altered both the stability of the microbial community and the key microbes in a gut micro-ecosystem. (biomedcentral.com)

These biological factors are believed to impact the two key determinants of HIV transmission risk: the HIV viral load in the PLHIV's blood and genital secretions, and the number and density of HIV-susceptible cells in the sex partner (generally within their penile, vaginal, or anal mucosa) who is a person not living with HIV (non-PLHIV) [ 13 , 14 ]. (biomedcentral.com)

The process is about as seamless as a pair of Skims knickers, and a good deal more comfortable than a vaginal swab via a speculum. (yourdaye.com)

Our findings demonstrate that maternal vaginal microbiome composition at delivery does not affect infant stool microbiome composition and development, suggesting that practices to amend infant stool microbiome composition focus on factors other than maternal vaginal microbes," the authors conclude. (medscape.com)

Heading further south, we have the vaginal microbiome in females and the penile microbiome in males. (theconversation.com)

A visit to the gynecologist is recommended for annual screening and any time a woman has concerns about symptoms such as pelvic, vulvar, and vaginal pain or abnormal bleeding from the uterus. (labroots.com)
Testing the vaginal microbiome has been found helpful for diagnosing abnormal vaginal microbiota. (vagibiom.com)

Moreover, a thorough analysis of the vaginal microbiome may predict the recurrence of bacterial vaginosis if changes in the resident microflora are compared. (news-medical.net)
In agreement with this, L. iners, most frequently associated with disturbed vaginal microflora, is a poor producer of H2O2. (wikipedia.org)

A longitudinal, prospective cohort study of more than 600 pregnant Canadian women and their newborns showed significant differences in an infant's stool composition by delivery mode at 10 days post partum, but the differences could not be explained by the mother's vaginal microbiome, and they effectively disappeared by 3 months. (medscape.com)
The others were about the comparison of vaginal microbial composition of non-pregnant with pregnant women by the case-control longitudinal study but these designs did not reflect on the real menstrual cycle[9,10]. (researchsquare.com)
We also describe our analysis of microbiome samples from the oral, vaginal, and rectal compartments in a cohort of pregnant women. (rmmj.org.il)

Why certain specific microbes or microbial communities colonize in black women is unclear, said Elovitz. (aacc.org)

Even more remarkable, the addition of only 1% vaginal fluid blocked the microbicidal activity of 1 M H2O2. (wikipedia.org)
The correlation between urinary and vaginal fluid microbiota was generally weak and depending on UT and BV status. (biomedcentral.com)
There is an increased blood flow to your genitals, including the vaginal walls, which causes fluid to pass through them. (hannahpearn.com)

Jill Steinbach-Rankins, Ph.D., will investigate a new nanotherapeutic approach to treat bacterial vaginosis (BV), a dysbiotic condition where vaginal microbial communities are disrupted. (louisville.edu)

This microbial metagenome acts as our "other genome" and like our own genes, is unique to the individual. (frontiersin.org)
7) The human gut alone contains on average: 40,000 bacterial species, 8) 9 million unique bacterial genes and 100 trillion microbial cells. (mpkb.org)

The relative abundance of dominant bacterial taxa in vaginal microbial communities of women at childbearing age, characterized with 16S rRNA gene sequence and QIIME based analysis, were not different among groups of childbearing history and menstrual cycle. (researchsquare.com)

Here, we show that antibiotic-induced reduction of gut microbial populations leads to an enrichment of nutrients and depletion of inhibitory metabolites, which enhances CRE growth. (imperial.ac.uk)
In another example of CDC-funded work with a simpler human microbiome, Dr. Sam Brown's lab at Georgia Tech is examining the microbiota in the lungs of cystic fibrosis patients to better understand these microbial communities and subsequently tailor antibiotic treatment to the patient and their specificdisease state. (cdc.gov)

MSM), there are limited data available regarding the prevalence of STIs in Black communities. (biomedcentral.com)
The FRESH / LACTIN-V project will provide critical data to assess if LACTIN-V could have the potential to offer women a safe, effective, durable, self-renewing, coitally independent, multi- purpose prevention product that promotes vaginal health and provides protection from HIV and potentially other STIs. (ucsf.edu)

Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. (frontiersin.org)

The Independent Medicines and Medical Devices Safety Review, led by Julia Cumberlege and announced by then-health secretary Jeremy Hunt in 2018, has involved two years of data gathering from women who received vaginal and other pelvic mesh implants, mostly to treat stress urinary incontinence and prolapse that developed after childbirth. (gynelogic.co.uk)

Anatomy5

Organisms29

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology1

Phenomena and Processes47

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Information Science3

Named Groups1

Health Care44

Geographicals7

Bacteria31

Swabs11

Lactobacillus24

Lactobacilli11

Risk of vaginal infections2

Kinds of vaginal2

Discharge12

Health of the vaginal microbiome2

Dysbiosis1

Tract11

Microbiomes4

Changes in the vaginal2

Self-collected vaginal swab2

Vagina5

Microbes present in the vaginal2

Infections17

Flora5

Epithelial cells2

Pathogens2

Species in the vaginal1

Composition of the vaginal2

Diversity13

Cervical5

Support vaginal health1

Microorganisms3

Fertility8

Microbiota composition2

Among reproductive-age women2

Probiotic1

Maintain vaginal1

Complex microbial communities3

Availability of glycogen1

Woman's1

Healthy8

Bacterial community2

Human genome1

Colonization2

Probiotics3

Reproductive health2

Pregnancy6

Physiological2

Infection4

Ecosystem2

Genital1

Swab via1

Microbiome composition1

Penile1

Abnormal2

Microflora2

Pregnant3

Specific microbes1

Fluid3

Treat bacterial vaginosis1

Genes2

Taxa1

Antibiotic2

STIs2

Genomes1

Urinary1