Prevalence2016HypoglycaemiaEpidemiologyHyperglycemiaInsulin therapyAdults with typeProgressionVascularGlycemicPatients with DiabetesStudieIntensiveClinicalMetabolic SyndromeMetforminMedscapeGlucose ControlControlEndocrinologistsDiabetic PatientsMicrovascularVeteransTypuAmerican Diabetes AsImplicationsHypertensionPeopleCareRiskSchemeManagementHbA1cCardiovascular diseaseIndividualsEpisodesDiabetuStudyEvidenceDisease
Prevalence1
- Estimates of the incidence and prevalence of diabetic neuropathies vary greatly, but several large observational cohorts and other studies suggest that they occur in at least 20% of people with type 1 diabetes after 20 years of disease. (medscape.com)
20161
- MATERIALS AND METHODS: Using 2016-2019 Medical Expenditure Panel Surveys data, we identified participants ≥65 years with diabetes. (cdc.gov)
Hypoglycaemia6
- Hypoglycaemia is a frequent adverse effect of treatment of diabetes mellitus with insulin and sulphonylureas. (nature.com)
- Fear of hypoglycaemia alters self-management of diabetes mellitus and prevents optimal glycaemic control. (nature.com)
- Mild (self-treated) and severe (requiring help) hypoglycaemia episodes are more common in type 1 diabetes mellitus but people with insulin-treated type 2 diabetes mellitus are also exposed to frequent hypoglycaemic events, many of which occur during sleep. (nature.com)
- Whereas coma and seizures are well-recognized neurological sequelae of hypoglycaemia, much interest is currently focused on the potential for hypoglycaemia to cause dangerous and life-threatening cardiac complications, such as arrhythmias and myocardial ischaemia, and whether recurrent severe hypoglycaemia can cause permanent cognitive impairment or promote cognitive decline and accelerate the onset of dementia in middle-aged and elderly people with diabetes mellitus. (nature.com)
- Prevention of hypoglycaemia is an important part of diabetes mellitus management and strategies include patient education, glucose monitoring, appropriate adjustment of diet and medications in relation to everyday circumstances including physical exercise, and the application of new technologies such as real-time continuous glucose monitoring, modified insulin pumps and the artificial pancreas. (nature.com)
- Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia. (cvgk.nl)
Epidemiology3
- Comparison of digital and film grading of diabetic retinopathy severity in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. (wisc.edu)
- Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. (wisc.edu)
- Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. (wisc.edu)
Hyperglycemia3
- Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes. (eesa-journal.com)
- Type 2 diabetes mellitus consists of an array of dysfunctions characterized by hyperglycemia and resulting from the combination of resistance to insulin action, inadequate insulin secretion, and excessive or inappropriate glucagon secretion. (medscape.com)
- This altered glucose metabolism state is associated with an increased risk of developing T2DM (Figure 1), although other parameters including excess adiposity, inflammation and dyslipidemia are risk factors associated with the development of insulin resistance, loss of pancreatic function, worsening of hyperglycemia and progression to diabetes (1). (ddw-online.com)
Insulin therapy1
Adults with type2
- The purpose of this study is to prevent major cardiovascular events (heart attack, stroke, or cardiovascular death) in adults with type 2 diabetes mellitus using intensive glycemic control, intensive blood pressure control, and multiple lipid management. (drugpatentwatch.com)
- The aim of the present study was to determine the effect of vitamin D supplementation on simvastatin-mediated changes in cardiorespiratory fitness and skeletal muscle mitochondrial content after exercise in adults with type 2 diabetes mellitus (T2DM). (vitad.org)
Progression2
Vascular3
- See Clinical Findings in Diabetes Mellitus, a Critical Images slideshow, to help identify various cutaneous, ophthalmologic, vascular, and neurologic manifestations of DM. (medscape.com)
- Other risk factors should also be controlled with a more ambitious strategy applied in the younger patients with shorter diabetes duration, but a more cautious approach in the elderly and frail patients with a number of vascular or non-vascular co-morbidities. (zju.edu.cn)
- Glucose control and vascular complications in veterans with type 2 diabetes. (cvgk.nl)
Glycemic3
- This study is a prospective, 2-arm, randomized controlled trial to determine whether glycemic control, achieved through intensification of treatment, is effective in preventing clinical macrovascular complications in patients with type 2 DM who are no longer responsive to oral agents alone. (drugpatentwatch.com)
- HbA1c is measured primarily to determine the three-month average blood sugar level and can be used as a diagnostic test for diabetes mellitus and as an assessment test for glycemic control in people with diabetes. (wikipedia.org)
- Efficacy and safety of sitagliptin as add-on therapy on glycemic control and blood glucose fluctuation in Japanese type 2 diabetes subjects ongoing with multiple daily insulin injections therapy. (cvgk.nl)
Patients with Diabetes4
- There is overwhelming evidence that hypertension is an important risk factor for both macrovascular and microvascular complications in patients with diabetes , but the problem remains to identify appropriate goal s for preventive therapies. (zju.edu.cn)
- Medscape spoke with the lead author, Rodica Pop-Busui, MD, PhD, about how these recommendations can assist primary care providers (PCPs) in the prevention, early recognition, and appropriate management of neuropathies in patients with diabetes. (medscape.com)
- Are there any new strategies-beyond the recognized importance of adequate glucose control-that PCPs should be instituting in patients with diabetes or prediabetes? (medscape.com)
- Patients with diabetic foot ulceration may be at considerably higher risk of all-cause mortality compared with those patients with diabetes but no history of foot ulceration. (forumdiabetologicum.sk)
Studie4
- In deze multicenter, gerandomiseerde studie werd het effect van sitagliptine ten opzichte van gebruikelijke behandeling op carotis intima-media dikte (IMT) onderzocht, in insulinebehandelde type 2 diabetes mellitus patiënten. (cvgk.nl)
- DE resultaten van deze studie onderschrijven de hypothese volgens welke vroege en effectieve interventie met DPP-4-remmers voor de ontwikkeling van atherosclerose gunstig kan zijn voor de preventie van carotis IMT progressie in deze patiënten. (cvgk.nl)
- Jak je patrné ze studie EURODIALE (European Study Group on Diabetes and the Lower Extremity), standardní péče byla suboptimální pro mnoho pacientů, a to dokonce i ve specializovaných podiatrických centrech. (forumdiabetologicum.sk)
- Navíc studie ACCORD, ADVANCE a VADT poukázaly na skutečnost, že snaha o snížení rizika chronických komplikací může být vyvážena negativním rizikem hypoglykemie. (remedia.cz)
Clinical3
- The recommendations can be accessed at American Diabetes Association DiabetesPro Professional Resources Online, Clinical Practice Recommendations - 2015. (medscape.com)
- Drs. Aron and Pogach are Co-Clinical Coordinators for VA/HSR&D's Diabetes Mellitus Quality Enhancement Research Initiative (DM-QUERI). (va.gov)
- In this study, we aim to identify the clinical parameters that modulate plasma CTGF levels measured longitudinally in type 1 diabetic patients over a period of 10 years. (biomedcentral.com)
Metabolic Syndrome2
- 3. Serdyuk VN, Ishсhenko VA. [Morphometrial and biochemical clusters of metabolic syndrome in patients with type 2 diabetes mellitus at different stages of diabetic retinopathy]. (eesa-journal.com)
- Plasma Fibrinogen in Type 2 Diabetic Patients with Metabolic Syndrome and its Relation with Ischemic Heart Disease (IHD) and Retinopathy. (eesa-journal.com)
Metformin2
- 4. Strowig SM, Avil ´ es-Santa ML, Raskin P. Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and troglitazone in type 2 diabetes. (cvgk.nl)
- The authors conducted an electronic search for publications in the PubMed/MEDLINE and Google Scholar databases using the keywords "amyloid beta", "Alzheimer type-3-diabetes", "intranasal insulin", "metformin", "type 2 diabetes mellitus", "incretins" and "PPARy agonists¼. (bvsalud.org)
Medscape3
- Medscape: What types of diabetic neuropathy should PCPs be aware of, and how common are they? (medscape.com)
- Medscape: What type of exercise? (medscape.com)
- Medscape: According to the statement, enhanced glucose control is very effective in preventing diabetic peripheral neuropathy in patients with type 1 diabetes, but is less successful in those with type 2. (medscape.com)
Glucose Control1
- All of these factors have been shown to be important in inducing nerve fiber damage, and may explain in part why glucose control alone has not been as effective in preventing diabetic neuropathy in patients with type 2 diabetes. (medscape.com)
Control3
- In conclusion, the current strategy is to have a more individualized approach to risk factor control in patients with type 2 diabetes , also relevant for blood pressure control. (zju.edu.cn)
- Whether the brain participates in the physiological control of circulating glucose levels therefore remains a matter of controversy, and the possibility that a dysfunctional central control system contributes to the pathogenesis of diabetes is only beginning to be explored. (silverchair.com)
- Hemoglobin A1c control is an important intermediate outcome for measuring quality of care provided to more than 20 million Americans with diabetes. (va.gov)
Endocrinologists1
- DIABETES MANAGEMENT Seventeenth edition 2011/12 supporting the education programs of Diabetes Australia Gratitude is expressed to everybody who has contributed to these guidelines: The Health Care and Education Committee of Diabetes Australia, The Australian Diabetes Educators Association, Australian Diabetes Society, Dietitians Association of Australia, The Australian Podiatry Council, many general practitioners, endocrinologists, dietitians, diabetes educators and podiatrists. (hmamedicalclinic.com)
Diabetic Patients1
- To gain insights into the factors that modulate plasma CTGF levels, circulating levels of CTGF were measured longitudinally in type 1 diabetic patients over a period of 10 years. (biomedcentral.com)
Microvascular2
- Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. (zju.edu.cn)
- Diabetes mellitus is a progressive disease of the vasculature, leading to increased risk of both microvascular complications such as diabetic nephropathy (DN) and retinopathy (DR), and cardiovascular disease (CVD), including myocardial infarction and stroke [ 1 , 2 ]. (biomedcentral.com)
Veterans3
- Association of PAI-1 and fibrinogen with diabetic retinopathy in the Veterans Affairs Diabetes Trial (VADT). (eesa-journal.com)
- Ethnicity, race, and clinically significant macular edema in the Veterans Affairs Diabetes Trial (VADT). (wisc.edu)
- Veterans Affairs Diabetes Trial Study Group. (wisc.edu)
Typu1
- typu) může být až 25% [2]. (forumdiabetologicum.sk)
American Diabetes As3
- The American Diabetes Association has released condensed recommendations for Standards of Medical Care in Diabetes: Abridged for Primary Care Providers, highlighting recommendations most relevant to primary care. (medscape.com)
- A number of guidelines (the European Society of Cardiology (ESC)/European Association for the Study of diabetes (EASD) 2007, the Joint National Committee (JNC)-VII 2003, the American diabetes Association (ADA) 2011) have for example advocated a blood pressure goal of less than 130/80 mmHg, but this suggestion has been challenged by findings in recent trials and meta-analyses (2011). (zju.edu.cn)
- The American Diabetes Association recently released a new position statement on diabetic neuropathy . (medscape.com)
Implications1
- Finally, we discuss the implications of these concepts for the future of diabetes treatment. (silverchair.com)
Hypertension1
- Target blood pressure in diabetes patients with hypertension -What is the accumulated evidence in 2011? (zju.edu.cn)
People3
- According to the International Diabetes Federation, more than 285 million people (6.4% of the world population) are currently estimated to suffer from diabetes, a figure which is expected to rise to 438 million (7.8%) by 2030. (ddw-online.com)
- 13 Diabetes australia 14 National Diabetes services scheme (NDss) 15 Royal australian College of General Practitioners Further resources internet resources Goals for management 4 Diabetes Management in General Practice ForewordGeneral practitioners continue to provide most of the medical care to people with type 2 diabetes. (hmamedicalclinic.com)
- AIMS: To quantify the incremental health and economic burden associated with cognitive impairment (CI) among non-institutionalized people with diabetes ≥65 years in the United States. (cdc.gov)
Care4
- Diabetes Care. (eesa-journal.com)
- Diabetes Care 2011;34(Suppl. (cvgk.nl)
- National Publications Manager State and Territory Diabetes Organisations Appreciation is expressed to Dr Michael d'Emden, Chair of the Health Care and Education Committee of Diabetes Australia and to Dr Evan Ackermann, Chair of the RACGP National Standing Committee - Quality Care. (hmamedicalclinic.com)
- Diabetes Care vol. 30 no. 09 (Sep. (atmajaya.ac.id)
Risk1
- Type 2 diabetics, but also prediabetics, are at increased risk for a wide range of debilitating diseases and diabetes is the leading cause of new cases of kidney failure and blindness and of nontraumatic lower limb amputation. (ddw-online.com)
Scheme1
- Simplified scheme for the pathophysiology of type 2 diabetes mellitus. (medscape.com)
Management3
- This booklet is intended to provide information about the management of type 2 diabetes in Australian general practice. (hmamedicalclinic.com)
- General practitioners seeking information about the management of type 1 diabetes should consult other sources. (hmamedicalclinic.com)
- The current guide, in its seventeenth edition, plays an important role in providing a readable summary of current guidelines and recommendations from various sources on the management of type 2 diabetes in adults in the general practice setting. (hmamedicalclinic.com)
HbA1c1
- The naming of HbA1c derives from hemoglobin type A being separated on cation exchange chromatography. (wikipedia.org)
Cardiovascular disease1
- Moreover, cardiovascular disease (CVD) is 2-4 times higher in diabetics (2). (ddw-online.com)
Individuals2
- Comparison of film and digital fundus photographs in eyes of individuals with diabetes mellitus. (wisc.edu)
- During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. (cdc.gov)
Episodes1
- Deze resultaten worden deels verklaard door frequente hypoglycemische episodes en gewichtstoename, veroorzaakt door de intensieve insulinebehandeling [3]. (cvgk.nl)
Diabetu1
- Nová antidiabetika působící na bázi inkretinového systému ovlivňují homeostázu glukózy u diabetu zvýšením sekrece inzulinu glukózodependentním způsobem a korigují i další metabolické abnormality u pacientů s diabetem mellitem 2. (remedia.cz)
Study4
- VADT Study Group. (eesa-journal.com)
- Effect of ruboxistaurin (RBX) On visual acuity decline over a 6-year period with cessation and reinstitution of therapy: results of an open-label extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2). (wisc.edu)
- This study was funded by HSR&D (IIR 06-091) and through VA/HSR&D's Diabetes Mellitus Quality Enhancement Research Initiative (DM-QUERI). (va.gov)
- In this study, we designed and synthesized new benzylidene-thiazolidine-2,4-diones while keeping the acidic thiazolidinedione (TZD) ring at the center, which is in contrast with the typical pharmacophore of PPAR-γ agonists. (bvsalud.org)
Evidence1
- The Editors have considered and included relevant information within guidelines and evidence recognised by the medical profession, including the NHMRC and the Australian Diabetes Society. (hmamedicalclinic.com)
Disease4
- Despite beneficial effects of current glucose-lowering treatments, disease-related morbidity and mortality remain considerable in T2DM patients, galvanising the search for innovative medications that target the multiple metabolic abnormalities as well as inflammatory processes and other pathways predisposing to diabetes-associated disorders. (ddw-online.com)
- Importantly, this edition again includes specific issues relating to treating diabetes in the Aboriginal and Torres Strait Islander population which reflect the burden of this disease within this group. (hmamedicalclinic.com)
- Distal symmetrical polyneuropathy (DSPN) may affect at least 10%-15% of patients with newly diagnosed type 2 diabetes , with rates increasing to 50% after 10 years of disease. (medscape.com)
- Patients with type 2 diabetes may also live with the disease for years without it being clearly diagnosed. (medscape.com)