The Veterans Affairs Diabetes Trial (VADT) previously reported that intensive glucose lowering, compared to standard therapy, did not significantly reduce major cardiovascular events in 1,791 Veterans. (va.gov)
Ethnicity, race, and clinically significant macular edema in the Veterans Affairs Diabetes Trial (VADT). (wisc.edu)
Association of PAI-1 and fibrinogen with diabetic retinopathy in the Veterans Affairs Diabetes Trial (VADT). (eesa-journal.com)
Similarly, the Veterans Affairs Diabetes Trial (VADT) mTOR inhibitor-2 and the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial failed to show benefits in cardiovascular endpoints [31,32]. (acusticavisual.net)
Glucose1
VADT participants were randomly assigned to receive either intensive or standard glucose control. (va.gov)
Glycemic Control1
The top randomized scientific examples you to definitely considering facts support rigorous glycemic control (Agreement , Get better , and you may VADT ) together with verified the importance of adequate, comprehensive remedy for aerobic risk what to avoid macrovascular issue , which aspect of diligent management try insufficiently treated throughout the customers associated with the pooled studies. (nghebabe.net)
Events1
In patiënten met type 2 diabetes mellitus en vastgestelde atherosclerose, had intensieve glucosebeheersing geen significant effect op de frequentie van ernstige cardiovasculaire (CV) events, en volgens sommige data nam mortaliteit zelfs toe [1,2]. (cvgk.nl)
ACCORD8
Commenting on the results for heart wire , Dr Roger Blumenthal (Johns Hopkins, Baltimore, MD) pointed out that tight glycemic control earlier in the disease process - ACCORD, ADVANCE, and VADT were carried out in individuals with established disease for a mean duration of eight to 11 years - might have been more successful. (medscape.com)
Publication: Fasting Glucose Variation Predicts Microvascular Risk in ACCORD and VADT. (nih.gov)
Zhou JJ, Koska J, Bahn G, Reaven P. Fasting Glucose Variation Predicts Microvascular Risk in ACCORD and VADT. (nih.gov)
We investigated this relationship using both Action to Control Cardiovascular Risk in Diabetes (ACCORD) and the Veteran Affairs Diabetes Trial (VADT). (nih.gov)
RESULTS: In both ACCORD and the VADT, the CV and ARV of FPG were associated with development of future microvascular outcomes even after adjusting for other risk factors, including measures of average glycemic control (ie, cumulative average of HbA1c). (nih.gov)
He cites ACCORD, ADVANCE and VADT studies all of which appear to be T2D studies. (ydmv.net)
A systematic review of the Action to Control Cardiovascular Risk in Type 2 Diabetes (ACCORD) trial and the Veteran's Affairs Diabetes Trial (VADT) 5 showed modest protection against macrovascular disease and myocardial infarction from tight FPG control in T2DM. (racgp.org.au)
An early highlight came from researchers on the ORIGIN, ACCORD and VADT studies which examined the relationship between hypoglycaemia and cardiovascular disease. (biomedcentral.com)
Intensive8
December 19, 2008 - Results of the Veterans Affairs Diabetes Trial (VADT), a long-term study of US veterans with type 2 diabetes receiving intensive blood glucose control, is now published online December 17, 2008, in the New England Journal of Medicine [1]. (medscape.com)
First presented at the American Diabetes Association (ADA) 2008 Scientific Sessions in San Francisco, CA, and reported by heart wire at that time, the VADT showed that intensive blood glucose lowering in patients with elevated glycated hemoglobin A 1c (HbA 1c ) levels despite medical treatment had no significant effect on the rates of cardiovascular events, death, or microvascular complications. (medscape.com)
In VADT, investigators randomized 1791 military veterans with diabetes, mean age 60 years, who had a suboptimal response to medical therapy to intensive glucose control or standard glucose control. (medscape.com)
Treatment assignment (intensive versus standard) within the VADT did not influence CAC or AAC progression, irrespective of baseline calcium category. (diabetesjournals.org)
Intensive glycemic control during the VADT did not reduce progression of calcified atherosclerosis. (diabetesjournals.org)
Using the Veterans Affairs Diabetes Trial (VADT), we investigated the association between variation in fasting glucose and glycated hemoglobin (HbA1c) over time and the incidence of cardiovascular disease (CVD) and assessed whether this is influenced by intensive or standard glycemic control.During the VADT, fasting glucose and HbA1c were measured every 3 months for up to 84 months in 1,791 individuals. (nih.gov)
The ACCORDION and the VADT studies both found reductions in the primary CVD composite associated with intensive glycemic control, though the difference is not statistically significant. (cdc.gov)
Still, nearly 10 years after the vets signed up for VADT, those who received intensive therapy were 17 percent less likely to suffer major cardiovascular events than their standard therapy counterparts. (nih.gov)
Blood glucose2
To assess blood glucose control, the Veterans Affairs Diabetes Trial (VADT) used a common laboratory blood test for glycosylated hemoglobin A1C, often simply referred to as A1C. (nih.gov)
When the VADT results are considered along with those from three previous major clinical trials of blood glucose control, the researchers say the data underscore the importance of encouraging everyone with diabetes to strive for at least a moderate level of blood glucose control. (nih.gov)
Cardiovascular Events1
Speaking with heart wire , Duckworth said that when the VADT was initiated nearly five years ago, there was little to no evidence that glucose control altered the risk of cardiovascular events. (medscape.com)
Trials1
In this study, we used Bayesian analysis to reanalyze results from the ACCORDION and VADT-15 trials. (cdc.gov)
Type 2 diabet1
As part of the Risk Factors, Atherosclerosis, and Clinical Events in Diabetes (RACED) substudy of the Veterans Affairs Diabetes Trial (VADT), 197 and 189 individuals with type 2 diabetes received baseline and follow-up computed tomographic scans for measurement of coronary and abdominal artery calcium, respectively. (diabetesjournals.org)
Veterans1
We picked the toughest group of patients we could find because we figured if we could do some good there the benefit would be pretty obvious," lead VADT investigator Dr William Duckworth (Phoenix Veterans Affairs Health Care Center, AZ) told heart wire . (medscape.com)
Risk1
Interestingly, no HbA1c measures were associated with CVD after adjusting for multiple baseline risk factors.Our analysis indicates that in the VADT, variability of fasting glucose plays a role in the development of CVD complications beyond the influence of standard fasting glucose measures. (nih.gov)
Individuals1
In the VADT, FPG was measured every 3 months for up to 87 months in 1791 individuals. (nih.gov)