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  • Protocols
  • In Vaccinia Virus and Poxvirology: Methods and Protocols, internationally recognized experts and leaders in poxvirology describe in step-by-step detail the successful techniques they have perfected to study and work with vaccinia virus and other poxviruses. (springer.com)
  • Comprehensive and timely, Vaccinia Virus and Poxvirology: Methods and Protocols offers virologists and vaccinologists an unequaled source of proven techniques for understanding poxviruses and developing defenses against their use as bioterrorist agents. (springer.com)
  • infectious
  • One of the most promising new vaccine developments uses infectious vaccinia virus as a vector and produces recombinants through the insertion of genes as protective antigens of disease agents into the vaccinia virus DNA. (fao.org)
  • As compared to whole virus vaccines, there are a number of advantages to infectious vaccinia virus recombinant vaccines. (fao.org)
  • With the infectious vaccinia virus recombinant system, it is possible to make a polyvalent vaccine which expresses several genes representing various serotypes of the same agent or a number of unrelated agents (see Fig. 2). (fao.org)
  • Subsequently, the same approach has been used to generate recombinant avian infectious bronchitis coronavirus and, recently, recombinant mouse hepatitis virus, representing group III and group II coronaviruses, respectively. (nih.gov)
  • inhibition
  • Inhibition of 40S--Met--tRNAfMet ribosomal initiation complex formation by vaccinia virus. (biomedsearch.com)
  • A similar inhibition is found in reticulocyte lysates incubated with purified vaccinia cores, confirming the hypothesis that the factor associated with the viral cores is responsible for the inhibition observed in vaccinia virus-infected cells exposed to inhibitors of transcription. (biomedsearch.com)
  • genes
  • The candidate (prototype/vaccinia vector rinderpest vaccine, HA and F genes) was developed by Prof. Yilma. (fao.org)
  • Recombinant DNA technology has made it possible to insert and express heterologous genes in a variety of different viruses. (fao.org)
  • vaccines
  • A remarkable new generation of vaccines was developed recently, including subunit, synthetic peptide and virus vector vaccines. (fao.org)
  • genetic
  • Although the relatively small size of these viruses facilitates genetic engineering, this property also restricts the amount of DNA that can be inserted into the virus particle. (fao.org)
  • host
  • Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). (uniprot.org)
  • Needed for fusion and penetration of the virus core into host cell. (uniprot.org)
  • Phase
  • This is a randomized Phase 3 study to determine whether treatment with vaccinia virus based immunotherapy (Pexa-Vec) followed by sorafenib increases survival compared to treatment with sorafenib in patients with advanced hepatocellular carcinoma who have not received prior systemic therapy. (clinicaltrials.gov)
  • conditions
  • Vaccinia virus has protected hundreds of millions of people worldwide from smallpox, with minimal side effects and no adverse environmental impact despite the release of the vaccinia virus on thousands of occasions because of poor hygienic conditions. (fao.org)