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  • mammalian cells
  • If successful in preclinical and clinical trials, this will be the first recombinant subunit vaccine produced by large-scale TGE in mammalian cells. (epfl.ch)
  • Ricin's binding subunit, ricin toxin B subunit (RTB), is a galactose/N-acetyl galactosamine (Gal/GalNAc)-specific lectin that promotes toxin entry into mammalian cells, while ricin's enzymatic subunit, RTA, is an RNA N-glycosidase (EC 3.2.2.22) that, when successfully delivered into the cytoplasm, cleaves the sarcin-ricin loop (SRL) of 28S rRNA, thereby stalling ribosome translocation ( 6 , 7 ). (asm.org)
  • viral
  • This pH-responsive blend particle system represents a simple and promising delivery platform for subunit vaccine development against viral infections. (washington.edu)
  • The immunization protocol will be considered a success if the vaccine produces a significant and large reduction of viral loads. (grantome.com)
  • herpes zoster
  • During a mean follow-up of 3.2 years, herpes zoster was confirmed in 6 participants in the vaccine group and in 210 participants in the placebo group (incidence rate, 0.3 vs. 9.1 per 1000 person-years) in the modified vaccinated cohort. (uta.fi)
  • The HZ/su vaccine significantly reduced the risk of herpes zoster in adults who were 50 years of age or older. (uta.fi)
  • The study will evaluate humoral and cell mediated immunity in patients with IBD on vedolizumab who receive the two-dose herpes zoster vaccine. (clinicaltrials.gov)
  • SHINGRIX is a vaccine indicated for prevention of herpes zoster (shingles) in adults aged 50 years and older. (clinicaltrials.gov)
  • efficacious
  • Electroporation can increase the potency of DNA vaccines and is efficacious, safe, and well tolerated in human clinical trials;it represents a realistic product modality for a VZV/HZ vaccine destined for adults. (grantome.com)
  • immunity
  • The use of neutralizing antibodies to identify the most effective antigen has been proposed as a strategy to design vaccines capable of eliciting protective B-cell immunity. (pnas.org)
  • Lacking sufficient immunity, candidate HSV-2 vaccines that were protective in animal model, however, have not been successful in human clinical studies in decades. (washington.edu)
  • Subunit vaccines are made by removing the non-immunity producing components of microorganisms (nucleic acid in case of viruses and polysaccharides from bacteria) and retaining a part (specific protein subunit), which stimulates the immune system. (cmfenews.com)
  • To determine the effect of delivery route on induction of VP6-specific protective immunity, BALB/c mice were administered a vaccine containing RV rVP6 intramuscularly, intranasally or a combination of both, and challenged with murine RV. (uta.fi)
  • doses
  • Participants received two intramuscular doses of the vaccine or placebo 2 months apart. (uta.fi)
  • Vaccine induced immune response, mainly the Th1 type cytokine secretion, was evaluated in different age groups following booster doses at equal time intervals. (dtu.dk)
  • pentamer
  • Transgenic potatoes were engineered to synthesize a cholera toxin B subunit (CTB) pentamer with affinity for GMI-ganglioside. (nih.gov)
  • antibodies
  • In order to be used in a vaccine, these parts must be the very specific parts of the antigen that antibodies or T cells recognize and bind to. (thevaccinemom.com)
  • immunization
  • Live oral rotavirus (RV) vaccines are part of routine childhood immunization but are associated with adverse effects, particularly intussusception. (uta.fi)
  • mucosal
  • The successful development of a mucosal vaccine depends critically on the use of a safe and effective immunostimulant and/or carrier system. (frontiersin.org)
  • This review describes the effectiveness and mode of action of an immunostimulating particle, derived from bacteria, used in mucosal subunit vaccines. (frontiersin.org)
  • AIDS
  • With the spread of AIDS still rampant in many parts of the world, there is a global urgency to develop a vaccine against HIV-1. (eurekaselect.com)
  • peptides
  • Of course this would also have to be factored in the sequence for the antigen vaccine, as each immune cell can bind to certain lengths of antigen peptide specifically (B-cell is usually smaller and less bulky peptides, while the T-cell can take longer peptides and bulky R- group amino acids). (biology-online.org)
  • particles
  • We have developed a non-live combined RV - norovirus (NoV) vaccine candidate consisting of human RV inner-capsid rVP6 protein and NoV virus-like particles. (uta.fi)
  • affinity
  • Molecular docking and molecular dynamics simulations studies were carried out to confirm the stable affinity between the vaccine protein (3D) and TLR3 receptor. (ncbs.res.in)
  • silico
  • 2013). T-cell vaccine design for Streptococcus pneumoniae: an in silico approach. (jbsdonline.com)
  • At last, in silico cloning was executed to get the subunit vaccine restriction clone into pET28a vectro to express it in microbial expression system. (ncbs.res.in)
  • prevention
  • Biomolecule Surface Display and Uses Thereof - A vaccine for the treatment or prevention of a disease in a subject, wherein said disease is associated with an avian influenza virus, and wherein said vaccine comprises an expression vector comprising a nucleic acid encoding a hemagglutinin peptide, such that in use said hemagglutinin peptide is expressed by said expression vector in said subject. (patentsencyclopedia.com)
  • delivery
  • In this short review, we report on the recent research findings highlighting the versatility and potential of such systems in vaccine delivery. (mdpi.com)
  • A polymer nanoparticle system made of the mixture of pH-insensitive polymer, such as poly(lactic-co-glycolic acid) (PLGA) and pH-sensitive polymer has been developed in our lab for vaccine delivery. (washington.edu)
  • Now the mode of delivery and where you place this vaccine is where you can manipulate the immune response to the antigen the vaccine is producing. (biology-online.org)