Vaccines in clinical trials. Medical search. Frequent questions

The global clinical trials market size reached USD 48,680 million in 2022 and is estimated to hit around USD 83,550 million by 2032, expanding at a CAGR of 5.6% from 2023 to 2032, As per the study by Towards Healthcare. (biospace.com)
Vaccine;41(35): 5159-5181, 2023 08 07. (bvsalud.org)

Developing a universal vaccine requires that researchers identify conserved regions of the influenza virus that do not exhibit antigenic variability by strain or over time. (wikipedia.org)
To conduct a clinical trial, researchers must first develop a study plan, or protocol , in which they describe the study's aims, the characteristics of the participants, the scientific approach, the outcome measures, and the plan for statistical evaluation of the data. (britannica.com)
Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. (mayo.edu)
The researchers send the data to the trial sponsor, who then analyzes the pooled data using statistical tests. (disabled-world.com)
The vaccine candidate under investigation, FluMos-v2, was designed by researchers at NIAID's Vaccine Research Center (VRC). (eurekalert.org)
The researchers anticipate that this will further broaden vaccine recipients' immunity, providing protection against a wider variety of influenza viruses. (eurekalert.org)
The researchers searched for clinical trials of antiretroviral medications (of any phase) that were published in eight major medical journals. (aidsmap.com)
The researchers also examined 53 clinical trials of vaccines for HIV prevention. (aidsmap.com)
Researchers are beginning to test younger and younger kids to make sure COVID-19 vaccines are safe and work for each age. (smh.com.au)
Instead researchers are measuring whether the vaccines rev up youngsters' immune systems much like they do adults' - suggesting they'll offer similar protection. (smh.com.au)
The researchers plan to begin clinical trials of the Alzheimer's vaccine after this year or early in 2006, depending on the outcome of discussions with the US Food and Drug Administration. (pharmatimes.com)
Clinical studies then pass through a series of steps referred to as phases, which provide important data for clinical researchers on the effectiveness and risks of the treatment. (news-medical.net)
Phase 1 trials: Researchers study whether a new treatment is safe. (healthywomen.org)
Phase 2 trials: Researchers look at whether a new treatment works for a specific disease and if the new treatment is better than available treatments. (healthywomen.org)
Phase 3 trials: Researchers confirm the effectiveness of the treatment and compare it with an existing treatment (if one exists) or a placebo (a substance with no physical effect). (healthywomen.org)
Phase 4 trials: Researchers continue to track safety and optimal use after a drug is approved by the FDA. (healthywomen.org)
Clinical trials provide the essential testing ground for these novel therapeutic approaches, allowing researchers to validate their efficacy and safety. (biospace.com)
The large number of candidates, as well as the various types of vaccines that researchers are proposing, increase the likelihood of success. (bgr.com)
Researchers are already trialing several drugs that can speed up the recovery of patients as well, and they're devising several vaccines that can help eradicate the disease in the coming years. (bgr.com)
Researchers will administer the vaccine candidate in up to 100 healthy volunteers between 18 and 55 years old, reports Ed Cara for Gizmodo . (smithsonianmag.com)
Researchers found that the shot protected small mammals from lethal doses of six different flu strains, showing the promise of a universal vaccine against the flu. (smithsonianmag.com)
The phase I trials allow researchers to see if the vaccine can induce a wide and durable response against the flu virus in people, per Gizmodo , as opposed to the often incomplete protection offered by traditional vaccines that need to be received every year . (smithsonianmag.com)
Through clinical trials, researchers learn which approaches are more effective than others and is the best way to test a new treatment. (bidmc.org)
The NIAID Partnership for Access to Clinical Trials (PACT) is a collaboration in the Washington, D.C., metropolitan area that connects health care providers and their patients with researchers at NIAID who are conducting clinical trials at the NIH Clinical Center in Bethesda, Maryland. (nih.gov)
Researchers discovered accidentally that the vaccine attacked cancerous tissue when it was inadvertently placed in a Petri dish of tumor cells. (scienceblog.com)
The vaccine candidate was developed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID). (nih.gov)

Clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. (disabled-world.com)
A vaccine in development at Canadian firm ID Biomedical, designed to block the production of beta amyloid plaques in the brains of Alzheimer's disease patients, has shown preliminary efficacy in animal studies. (pharmatimes.com)
A new experimental Ebola vaccine displayed 100 percent efficacy in a clinical trial involving thousands in Guinea, Africa, according to a new study published in The Lancet . (beckershospitalreview.com)
The earlier Phase II trial, an initial test of the vaccine's efficacy, included 50 patients with metastatic melanoma, or melanoma that had spread to other parts of the body, who had failed to respond to conventional treatment, including chemotherapy and immunological drugs such as interleukin-2. (scienceblog.com)
Existing ethics guidance and regulatory requirements emphasize the need for pregnancy -specific safety and efficacy data during the development of vaccines in health emergencies . (bvsalud.org)
Based on controlled efficacy trials conducted in the 1940s and on subsequent observational efficacy studies, a primary series comprising four doses of whole-cell DTP vaccine is considered 70%-90% effective in preventing serious pertussis disease (1-4). (cdc.gov)
Defining surrogate serologic tests with respect to predicting protective vaccine efficacy: Poliovirus vaccination. (who.int)
Recommendations to assure the quality, safety and efficacy of live attenuated poliomyelitis vaccine (oral). (who.int)

Harrison Ford is spreading the word about the dire need for volunteers in coronavirus vaccine trials. (eonline.com)
Sept 6 (Interfax) - The clinical trials of Kazakhstan's first coronavirus vaccine, QazVac, have been successful, General Director of the Kazakh Research Institute for Biological Safety Problems Kunsulu Zakarya said. (interfax.com)
As reported earlier, Phase III of the clinical trials of Kazakhstan's QazVac coronavirus vaccine took place at three clinics in Almaty and Taraz, involved 3,000 volunteers, and ended on July 9, 2021. (interfax.com)
The QazVac coronavirus vaccine (formerly known as QazCovid-in) was developed by the Research Institute for Biological Safety Problems of the Committee of Science of the Kazakh Ministry of Education and Science. (interfax.com)

In June 2006, the National Institutes of Health (NIH) began enrolling participants in a Phase 1 H5N1 study of an intranasal influenza vaccine candidate based on MedImmune's live, attenuated vaccine technology. (wikipedia.org)
Interventional trials assign participants to a procedure or treatment and then measure the effects of that intervention. (britannica.com)
Observational trials collect a group of participants with a specific condition who receive a procedure or treatment as part of routine care and then measure the outcome results in this group. (britannica.com)
In both types of trials, the outcome in the participants undergoing the procedure or treatment is often compared with another group called the control. (britannica.com)
Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. (disabled-world.com)
For 40 weeks after their first vaccination, participants will receive regular follow-up phone calls and examinations to track their responses to the experimental vaccine. (eurekalert.org)
During these clinical trials, some participants will receive an adjuvant, called AS03, along with the test vaccine, to confirm that the adjuvant can boost the immune response to the vaccine, as previously shown for other influenza viruses of pandemic potential. (enewspf.com)
If a clinical trial fails to include a broad range of participants, the results of the trial are not generalizable across a broad population. (news-medical.net)
Clinical trials insurance covers all types of trial participants, diseases and products. (chubb.com)
It will have about 100 participants soon and get over by December, while the Phase III trials, with 1,500 participants, could be completed as early as March. (thehindu.com)
In one group for the vaccine trials, participants will receive the first dose of the candidate vaccine intramuscularly and then receive a placebo nasal spray. (smithsonianmag.com)
Another group of participants will receive a placebo shot and the actual vaccine as a nasal spray. (smithsonianmag.com)
Among the 5,837 participants who received a vaccine, none contracted Ebola after 10 or more days. (beckershospitalreview.com)
1 "A clinical trial is defined by WHO as any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. (who.int)
Successful clinical trials may improve the length and quality of life for study participants. (bidmc.org)
The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) randomized participants without blinding to immediate or deferred (18-24 weeks postenrollment) vaccination. (cdc.gov)
Enrollment and vaccination period for 84 participants in Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE). (cdc.gov)

In a new PSA, Harrison Ford urged Americans to sign up for the COVID-19 vaccine trials in order to move science forward. (eonline.com)
The nine-year-old twins didn't flinch as each received test doses of Pfizer's COVID-19 vaccine - and then a sparkly Band-Aid to cover the spot. (smh.com.au)
Alejandra Gerardo, 9, looks up to her mother, Dr Susanna Naggie, as she gets the first of two Pfizer COVID-19 vaccinations during a clinical trial for children at Duke Health in North Carolina. (smh.com.au)
Most COVID-19 vaccines being used around the world were first studied in tens of thousands of adults. (smh.com.au)
Clinical trials into finding vaccines and treatments for COVID-19 have also highlighted this issue. (news-medical.net)
This brief discusses the existing obstacles in developing international clinical trials that are critical to fight the COVID-19 pandemic. (oecd.org)
The urgent quest for safe and effective COVID-19 treatments requires international co-operation for conducting clinical trials to test and compare existing and new therapeutics. (oecd.org)
In order to accelerate the rigorous testing of COVID-19 treatments, governments and regulatory authorities are encouraged to share information internationally and co-ordinate policies for COVID-19-related clinical trial approvals. (oecd.org)
Since the global outbreak of SARS‑CoV‑2 (COVID-19) in early 2020, many research institutions, supported by public and private funders, have taken action to accelerate R&D on vaccines and treatments. (oecd.org)
As a result, many new pre-clinical research studies and clinical trials have been launched, and hundreds of clinical trials related to COVID-19 have been registered. (oecd.org)
Information on these clinical trials can be found on the World Health Organisation (WHO) website and in the OECD brief Treatments and a vaccine for COVID-19: the need for co-ordinating policies on R&D, manufacturing and access . (oecd.org)
Many of the clinical trials for COVID-19 treatments and vaccines have been launched at the national level, and are being conducted by health research institutions within a single country, having only to fulfil the (often accelerated and streamlined) regulatory requirements of a single national regulatory authority. (oecd.org)
Moleculin Biotech has received authorisation to begin a Phase Ia clinical trial of its drug, WP1122, in the UK to treat Covid-19. (pharmaceutical-business-review.com)
EnGeneIC has started dosing in Phase I clinical trial of the world's first nanocellular technology-based anti-Covid-19 vaccine in healthy adults. (pharmaceutical-business-review.com)
WHO's table lists all 70 COVID-19 candidates, complete with details about the phase they're in, the type of vaccine, the developer, and the platform used. (bgr.com)
The fact that so many laboratories have rushed to make a COVID-19 vaccine so quickly is excellent news and can help to make up for the slow start. (bgr.com)
committed to fast track clinical development of COVID vaccine candidates, says DBT Secratary Renu Swarup. (thehindu.com)
Sputnik V, the vaccine for COVID-19 developed by Russian company RDIF. (thehindu.com)
DBT Secretary and BIRAC Chairperson Renu Swarup said the government is committed to fast track clinical development of COVID vaccine candidates and provide facilitation to accelerate market readiness of a suitable vaccine. (thehindu.com)
Sputnik V vaccine, registered by the Ministry of Health of Russia in August, is the world's first registered vaccine against COVID-19 based on the human adenoviral vector platform. (thehindu.com)
The world could soon have another vaccine option in its fight against Covid-19 . (cnn.com)
A nurse fills up a syringe with the Moderna COVID-19 vaccine at a vaccination site at a senior center on March 29, 2021 in San Antonio, Texas. (cnn.com)
Because they rely on more familiar technology, there's hope that people who've declined other kinds of Covid-19 vaccines may find these kinds of vaccines more palatable. (cnn.com)
Today, the partners in the COVID-19 Therapeutics Accelerator announced grants of $20 million to three institutions-the University of Washington, University of Oxford, and La Jolla Institute for Immunology-to fund clinical trials in order to identify highly potent immunotherapies for the COVID-19 pandemic. (mastercard.com)
The trials aim to determine whether the drugs are effective as pre- and post-exposure preventive therapy for COVID-19. (mastercard.com)
The University of Washington will conduct a multi-site clinical trial in Western Washington and the New York City area, in collaboration with New York University's School of Medicine, investigating whether hydroxychloroquine can effectively prevent COVID-19 in people already exposed to the infection. (mastercard.com)
The trial will enroll up to 2,000 asymptomatic men and women who are close contacts of persons with confirmed or pending COVID-19 diagnoses. (mastercard.com)
A capsule version of the Covid-19 vaccine could be a "game changer" in countries with a low immunization rate, its developer has said. (rt.com)
Existing Covid-19 vaccines are administrated via one or two injections. (rt.com)
Oramed CEO Nadav Kidron told the Times of Israel the trial for the Covid vaccine pill is expected to start next month, once it gains the final approval from the Health Ministry. (rt.com)
Randomized clinical trials have repeatedly found that ivermectin does not benefit COVID-19 patients. (factcheck.org)
Paxlovid was found in a randomized, double-blind, placebo-controlled clinical trial to reduce COVID-19-related hospitalization or death from any cause by 86% compared with a placebo after 28 days of follow-up. (factcheck.org)
It was approved in October 2020 for hospitalized patients 12 years and older based on randomized, controlled clinical trials that found faster recovery times and statistically significant odds of improving conditions among hospitalized patients with mild to severe COVID-19 who received the drug, compared with those who got a placebo plus standard care. (factcheck.org)
Another key drug in the arsenal is the steroid dexamethasone, which was found in a large randomized controlled trial in the U.K. to provide a mortality benefit in hospitalized COVID-19 patients who were ventilated or receiving supplemental oxygen. (factcheck.org)
The latest results of several large , randomized controlled trials show no benefit in using the antiparasitic drug ivermectin to treat COVID-19, the disease caused by the coronavirus, or SARS-CoV-2. (factcheck.org)
CDC's COVID-19 clinical call center is available 24 hours a day at 770-488-7100. (cdc.gov)
Eastern, where the topic will be clinical management of critically ill adults with COVID-19. (cdc.gov)
Morris, a medical epidemiologist from the COVID-19 Response Clinical Team at CDC. (cdc.gov)
Planning for COVID-19 vaccines, see link. (who.int)
How will we know if a COVID-19 vaccine is safe? (who.int)
There are many strict protections in place to help ensure that COVID-19 vaccines will be safe. (who.int)
Like all vaccines, COVID-19 vaccines should go through a rigorous, multi- stage testing process, including large (phase III) trials that involve tens of thousands of people. (who.int)
After a COVID-19 vaccine is introduced, WHO will support monitoring for any safety concerns on an ongoing basis. (who.int)

Enrollment in a Phase 1 trial of a new investigational universal influenza vaccine candidate has begun at the National Institutes of Health's Clinical Center in Bethesda, Maryland. (eurekalert.org)
The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH, and will evaluate the investigational vaccine for safety and its ability to elicit an immune response. (eurekalert.org)
Many of the innovative therapies available at MSK Kids for children with neuroblastoma are investigational treatments being assessed in clinical trials. (mskcc.org)
Our clinical research team is highly experienced in selecting the children who are most likely to benefit from a particular investigational therapy. (mskcc.org)
The US Food and Drug Administration (FDA) has granted clearance for Skyline Therapeutics' investigational new drug (IND) application for Phase I/IIa clinical trial of gene therapy SKG0106 to treat neovascular age-related macular degeneration (nAMD). (pharmaceutical-business-review.com)
During the outbreak, clinical trials of the investigational Ebola vaccine rVSVΔG-ZEBOV-GP (Merck, https://merck.com ) were rapidly implemented. (cdc.gov)

Early results from H5N1 clinical trials showed poor immunogenicity compared to the 15-mcg dose that induces immunity in a seasonal flu vaccine. (wikipedia.org)
Getting this data, for all the vaccines being rolled out, is critical because countries must vaccinate children to achieve herd immunity, noted Duke pediatric and vaccine specialist Dr. Emmanuel Walter, who is helping to lead the Pfizer study. (smh.com.au)
The new version of the vaccine candidate uses an inactivated form of H7N9 influenza virus collected in 2017, to increase the likelihood that the vaccine will provide immunity against a newly-evolved strain of H7N9, which is currently circulating in the wild. (enewspf.com)
Once a large number of the population has acquired immunity via a vaccine or by surviving the disease, the spread of the virus will be slowed down significantly, and it could ultimately disappear. (bgr.com)
With the BPL-1357 vaccine, especially when given intranasally, we are attempting to induce a comprehensive immune response that closely mimics immunity gained following a natural influenza infection," says Matthew Memoli, a NIAID investigator leading the vaccine trial, in a statement. (smithsonianmag.com)
This is very different than nearly all other vaccines for influenza or other respiratory viruses, which focus on inducing immunity to a single viral antigen and often do not induce mucosal immunity. (smithsonianmag.com)
New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)

The trials will likely be held through March of 2021. (eonline.com)
It is an adaptation of an earlier universal flu vaccine candidate, FluMos-v1, which began first-in-human testing in 2021 and is still undergoing trials. (eurekalert.org)
An article about the QazVac vaccine, including the results of Phase I and Phase II of the vaccine's clinical trials, was published in the EClinical Medicine medical journal of The Lancet Group on August 14, 2021. (interfax.com)

Two diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccines -- ACEL-IMUNE{Registered} * and Tripedia{Registered} ** -- have been licensed for several years, but (until recently) only for administration of the fourth and fifth doses in the series to children aged 15 months-6 years who previously had received three or more doses of diphtheria and tetanus toxoids and whole-cell pertussis (DTP) vaccine. (cdc.gov)
Four diphtheria and tetanus toxoids combined with whole-cell pertussis (DTP) vaccines are presently licensed for use in the United States. (cdc.gov)

Vidprevtyn is a protein subunit vaccine, which means it uses harmless protein fragments that teach the immune system how to spot and fight off the SARS-CoV-2 virus. (cnn.com)

citation needed] The National Institute of Allergy and Infectious Diseases (NIAID) awarded H5N1 vaccine contracts to Aventis Pasteur (now Sanofi Pasteur) of Swiftwater, Pennsylvania, and to Chiron Corporation of Emeryville, California. (wikipedia.org)
With each new universal influenza vaccine candidate and clinical trial, we take another step closer to that goal," said Acting NIAID Director Hugh Auchincloss, M.D. (eurekalert.org)
The Phase 2 studies, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), will test different dosages of the inactivated influenza vaccine candidate (called 2017 H7N9 IIV) as well as different vaccination schedules. (enewspf.com)
NIAID funded previous research on the earlier version of the vaccine. (enewspf.com)
Both clinical trials will be conducted by the NIAID-funded network of Vaccine and Treatment Evaluation Units (VTEUs). (enewspf.com)
The vaccine, known as BPL-1357, was developed by experts at the National Institute of Allergy and Infectious Diseases (NIAID) and contains four strains of non-infectious, chemically inactivated avian influenza, thought to be not highly pathogenic. (smithsonianmag.com)
Influenza vaccines that can provide long-lasting protection against a wide range of seasonal influenza viruses, as well as those with pandemic potential, would be invaluable public health tools," says NIAID director Anthony S. Fauci in a statement. (smithsonianmag.com)
Watch the video " Participating in an NIAID HIV Clinical Trial " at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland. (nih.gov)
Mire el video " Participando en un Estudio Clínico del VIH del NIAID " en el Centro Clínico de los Institutos Nacionales de la Salud (NIH por sus siglas en inglés) en Bethesda, Maryland. (nih.gov)
Order or download materials available at no cost to patients, family members, and healthcare professionals who want to learn more about infectious diseases and NIAID clinical trials. (nih.gov)
The NIAID PACT team can answer questions and facilitate entry into many clinical trials. (nih.gov)
The single-site trial can enroll up to 100 people aged 18 to 55 years and is led by NIAID investigator Matthew J. Memoli, M.D. (nih.gov)
Influenza vaccines that can provide long-lasting protection against a wide range of seasonal influenza viruses as well as those with pandemic potential would be invaluable public health tools," said NIAID Director Anthony S. Fauci, M.D. "The scientific community is making progress on this pressing global health priority. (nih.gov)
A study in animals , led by NIAID investigator Jeffery K. Taubenberger, M.D., Ph.D., and posted online as a pre-print, found that all mice receiving two doses of BPL-1357 vaccine delivered either intramuscularly or intranasally survived later exposure to lethal doses of each of six different influenza virus strains, including subtypes that were not included in the vaccine. (nih.gov)

ACRP honors the 2022 Certification Milestone Achievers, an exclusive group of nearly 1,700 professionals who have consistently proven their commitment to conducting clinical trials safely, ethically, and to the highest standard. (acrpnet.org)

They come with obstacles-immunologic, regulatory, and commercial-but they also have generated more excitement than any other type of vaccine thus far. (wikipedia.org)
It's a more traditional type of vaccine than mRNA or adenovirus vector vaccines, which carry the genetic instructions for making the spike protein into cells, where they can then be built and displayed like mug shots for the immune system find and defend against. (cnn.com)

Ideally, before new drugs and other treatments, diagnostic tests, or preventive measures are accepted for general use, they should be studied in clinical trials to determine whether they have advantages over existing methods in health benefits, safety, or cost. (britannica.com)
To put it very simply, using Bayesian considerations, in which the plausibility of a hypothesis and hence its prior probability of producing a positive clinical trials are considered, testing treatments like homeopathy, which has about as low a pre-trial probability or plausibility as I can imagine, can be very good at producing false positive trials. (scienceblogs.com)
NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (eurekalert.org)
Clinical trials evaluate the safety and effectiveness of new drugs or combinations of treatments. (mskcc.org)
Clinical trials are a vital part of the process of introducing pharmaceutical treatments and interventions to the commercial market. (news-medical.net)
Clinical trials are studies of new treatments, procedures or behavioral interventions in people. (healthywomen.org)
After treatments, procedures or interventions have been tested in the lab and on animals, those that show promise are moved into clinical trials. (healthywomen.org)
Diversity in clinical trials is essential because people with different characteristics may experience the disease differently and react to treatments and procedures differently. (healthywomen.org)
Standard treatments are the best approaches that are currently available, while clinical trials are looking for even better ones. (healthywomen.org)
To get into a clinical trial, you will have to meet certain criteria, such as your age, specific diagnosis, genetic profile or response to other treatments. (healthywomen.org)
Adopting harmonised risk categories - as provided for in the OECD Recommendation on the Governance of Clinical Trials - is a critical step in harmonising clinical trial regulations across countries, and accelerating the rigorous testing of potential treatments. (oecd.org)
The clinical trials market is experiencing a surge in demand for innovative therapies, and this trend is driven by various factors that underscore the critical role of clinical trials in advancing medical knowledge, developing new treatments, and addressing unmet medical needs. (biospace.com)
Clinical trials are pivotal in identifying patient populations most likely to benefit from specific therapies, leading to treatments that are more effective, targeted, and tailored to the unique needs of patients. (biospace.com)
This demand, driven by factors ranging from complex diseases and unmet needs to patient engagement and regulatory support, highlights the pivotal role of clinical trials in bringing novel treatments from research labs to patients in need, ultimately improving healthcare outcomes on a global scale. (biospace.com)
Other innovative offerings include treating adults with acute lymphoblastic leukemia by applying the principles used in successful pediatric treatments of this condition and clinical trials and treatments specialized for older adults. (dana-farber.org)
The Phase III trial will enroll a total of 430 patients at centers across the U.S. As with the earlier trial, the vaccine will be injected directly into tumor nodules every two weeks for up to 24 treatments. (scienceblog.com)

The debate centers on whether it's still valid - or even ethical - to do research on products called nosodes, which are marketed as homeopathic "vaccines. (scienceblogs.com)
Austin, Texas (PRWEB) March 23, 2015 -- Benchmark Research, Miami Research Associates(MRA), and Piedmont Medical Group(PMG) are pleased to announce the formation of VaxCorps, a network of highly experienced, geographically diverse clinical research centers specializing in the conduct of vaccine trials in healthy adult, elderly, and pediatric populations. (prweb.com)

No one who contracted Ebola within the first nine days post-vaccination were counted against the vaccine, because it was assumed they had already been infected prior to immunization. (beckershospitalreview.com)
This Phase I study is an exciting milestone for Matrivax, and a major step forward in the development of a vaccine that has potential to be a technological breakthrough in vaccination options against pneumococcal disease," said Enda Moran, chief executive officer of Matrivax. (ou.edu)
Eight of the 50 patients were free of disease by the end of the trial period, which consisted of vaccination every two weeks, for a total of up to 24 injections or until disease disappeared. (scienceblog.com)
"Our oral vaccine, which doesn't rely on a deep-freeze supply chain unlike other coronavirus vaccines, could mean all the difference between a country being able to emerge from the pandemic or not," Kidron said, adding that an oral vaccine could be a "game changer" in counties with a low vaccination rate. (rt.com)
Volunteers must not have received any type of flu vaccination in the eight weeks prior to enrollment and must agree to forego seasonal flu vaccination for approximately two months after the second vaccine (or placebo) dose. (nih.gov)
The vaccine, a live-attenuated recombinant vesicular stomatitis virus (rVSV) vaccine, was found to be protective when used in a ring vaccination strategy in Guinea ( 2 ). (cdc.gov)
However, little information on the safety of the vaccine for pregnant women is available, making decisions about vaccination during pregnancy challenging. (cdc.gov)
In the Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) ( 10 , 11 ), some women were enrolled who were inadvertently vaccinated early in pregnancy, and some women became pregnant ≤60 days after enrollment or vaccination. (cdc.gov)
Tripedia{Registered}, ACEL-IMUNE{Registered}, and Infanrix TM are now recommended for routine vaccination of infants and young children, although whole-cell pertussis vaccines remain acceptable alternatives. (cdc.gov)
Tripedia{Registered}, ACEL-IMUNE{Registered}, and Infanrix TM are recommended for all remaining doses in the schedule for children who have started the vaccination series with one, two, three, or four doses of whole-cell pertussis vaccines. (cdc.gov)
Vaccines of this type, prepared from suspensions of inactivated Bordetella pertussis bacterial cells, have been licensed for routine vaccination of infants since the mid-1940s. (cdc.gov)

The World Health Organization listed 70 vaccine candidates for the novel coronavirus, a significant increase from the figure announced three weeks ago. (bgr.com)
It was just three weeks ago that the World Health Organization (WHO) announced that 20 vaccines for the novel coronavirus were in development. (bgr.com)
Documents are being drafted and validation of the vaccine production technology is being carried out consistent with good manufacturing practice requirements in order to register the vaccine with the World Health Organization. (interfax.com)
The vaccine received conditional marketing approval from the European Medicines Agency and World Health Organization prequalification in November 2019 ( 4 ). (cdc.gov)
Data were extracted from clinical trial protocols identified in the following registries ClinicalTrials.gov, Pan African Clinical Trial Registry (PACTR), and all primary registries indicated by the World Health Organization 's International Clinical Trials Registry Platform (ICTRP). (bvsalud.org)

So far in the US, teen testing is furthest along: Pfizer and Moderna expect to release results soon showing how two doses of their vaccines performed in the 12 and older crowd. (smh.com.au)
In the first phase of the Pfizer study, a small number of children receive different doses of vaccine as scientists winnow out the best dosage to test in several thousand kids in the next phase. (smh.com.au)
Roslin Cells inked a contract with the Neusentis research unit of Pfizer to support the manufacture of retinal pigment epithelium cells to be used in a cell therapy clinical trial. (genengnews.com)
Pfizer has dosed the first subjects in a Phase I clinical trial to test an influenza vaccine which is developed using mRNA technology. (pharmaceutical-business-review.com)
Pfizer alone recently said it plans to work on as many as four candidates of its own, although just one of them is listed in the table - it's an mRNA vaccine like Moderna's. (bgr.com)
Valneva and Pfizer have developed a Lyme disease vaccine candidate, VLA15, that is currently in Phase 3 human trials. (cdc.gov)

Moderna's mRNA test and a vaccine candidate being worked on in Hong Kong and China. (bgr.com)

Pregnant people are underrepresented in vaccine clinical trials conducted during outbreaks , resulting in underreporting of pregnancy -related outcomes and a lack of protection for pregnant people and neonates from infectious diseases . (bvsalud.org)

Experts disagree on whether whole-cell pertussis vaccine causes lasting brain damage, but agree that if the vaccine causes such damage it does so only rarely (7). (cdc.gov)

In a YouTube PSA titled 'My Reason,' Americans of all different backgrounds, ethnicities and professions revealed why they decided to participate in the vaccine research. (eonline.com)
Clinical trials are defined as research studies that test how well new medical approaches work in people. (disabled-world.com)
AMA President Susan R. Bailey welcomes three physician leaders from the Food and Drug Administration (FDA) to discuss the state of therapeutic clinical trials worldwide, the challenge of obtaining robust therapeutic data and what the future holds based on current research. (ama-assn.org)
The two clinical trials will test the experimental 2017 H7N9 inactivated influenza vaccine developed by Sanofi Pasteur, based in Lyon, France, supported by the Biomedical Advanced Research and Development Authority (BARDA), a component of the U.S. Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response. (enewspf.com)
One clinical trial, led by principal investigator Lisa A. Jackson, M.D., of the Kaiser Permanente Washington Health Research Institute in Seattle, will test the vaccine candidate at different dosages, both with and without the AS03 adjuvant. (enewspf.com)
Designing trials that include diverse groups of people is a vital research direction. (news-medical.net)
When you participate in clinical research, you're helping scientists find new ways to treat your disease. (healthywomen.org)
From new clinical research professionals just starting out to industry veterans looking for ways to move ahead in their careers, ACRP is where success starts - and grows. (acrpnet.org)
FREE for ACRP Members-Gain the foundational knowledge clinical research professionals need to implement digital health components in clinical trials. (acrpnet.org)
Interested in a career in clinical research? (acrpnet.org)
Explore career options, resources, and more to help you find your first opportunity in clinical research. (acrpnet.org)
Through our gold-standard education, the most rigorous certification process in the industry, and strong comment connections - ACRP prepares clinical research professionals to be the study team members employers can trust to get it right. (acrpnet.org)
Turn your organization's most important initiatives into its biggest successes with clinical trial insights research. (acrpnet.org)
This new solution from Continuum and ACRP combines best-in-class market research capabilities with unprecedented access to clinical research professionals, who will provide valuable, actionable insights into elements that will ultimately make or break your clinical trial: study design, patient behavior, recruitability, retention initiatives, and so much more. (acrpnet.org)
With more than 16,500 members, the Association of Clinical Research Professionals (ACRP) is the only non-profit organization solely dedicated to representing, supporting, and advocating for clinical research professionals. (acrpnet.org)
The growth of the clinical trials market is significantly influenced by the increasing trend of outsourcing and collaborative partnerships between pharmaceutical companies and Contract Research Organizations (CROs). (biospace.com)
The clinical research mission of the Adult Leukemia Program is to develop and bring new and better therapies to patients. (dana-farber.org)
At any given time, the program offers patients a wide array of opportunities to participate in clinical research studies relating to all stages and types of leukemia and related disorders. (dana-farber.org)
Dr. Reddy's Laboratories has announced a collaboration with Biotechnology Industry Research Assistance Council (BIRAC) to receive advisory support for the clinical trials of Russia's Sputnik V vaccine that the company plans to start soon in the country. (thehindu.com)
The company and Russia's sovereign wealth fund RDIF, which is supporting development of the vaccine by the Moscow-based Gamaleya National Research Institute of Epidemiology and Microbiology, had in September announced a collaboration for clinical trials and distribution of the vaccine in India. (thehindu.com)
As you consider treatment options for yourself or a loved one, you may consider participating in a clinical trial or research study. (bidmc.org)
New medical techniques, drug discoveries, and device inventions are created every day to help improve our quality of life from clinical research. (bidmc.org)
Clinical research is research involving people that is intended to add to medical and scientific knowledge. (bidmc.org)
The information and links below will provide you with more information about clinical research and other resources that may be available to you. (bidmc.org)
Why participate in clinical research? (bidmc.org)
People choose to participate in clinical research for reasons as individual as they are. (bidmc.org)
Why is clinical research important? (bidmc.org)
Clinical research studies also provide more information about how the human body or mind works and helps expand scientific knowledge. (bidmc.org)
Who sponsors clinical research? (bidmc.org)
The primary goal of the collaboration is to increase access to research by people who may be underrepresented in clinical trials. (nih.gov)
The research that created the vaccine candidate comes from the laboratory of Rodney Tweten, Ph.D., a George Lynn Cross Professor of Research in the Department of Microbiology and Immunology in the OU College of Medicine. (ou.edu)
This clinical trial is a result of my research team's deep understanding of how these toxins work," Tweten said. (ou.edu)
Darrin Akins, Ph.D., vice president of research at OU Health Sciences, said the clinical trial for Tweten's vaccine candidate underscores the importance of basic science research in making discoveries that may ultimately save lives. (ou.edu)
Rush is noted for bringing together clinical care and research to address major health problems, including arthritis and orthopedic disorders, cancer, heart disease, mental illness, neurological disorders and diseases associated with aging. (scienceblog.com)
Currently leading Clinical Operations at Tenax Therapeutics, Kevin M. Crawford is a 23-year clinical research veteran, having held leadership posts under such leading brands as GlaxoSmithKline (GSK), Johnson & Johnson, and United Therapeutics. (arena-international.com)
Co-Founder, Clinical Research Innovation Hub, Microsoft Corporation The Clinical Research Innovation Hub (CRIH) is the first industry focused internal startup in Microsoft. (arena-international.com)
CRIH is enabling Microsoft and its partners to conceptualize, incubate, and ultimately deliver the technology innovations that will drive the adoption of new clinical research paradigms. (arena-international.com)
CDC is currently conducting research to understand what concerns healthcare providers and the public may have about any potential Lyme disease vaccines. (cdc.gov)
and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious and immune-mediated diseases. (cdc.gov)

A Phase 1 clinical trial of a novel influenza vaccine has begun inoculating healthy adult volunteers at the National Institutes of Health Clinical Center in Bethesda, Maryland. (nih.gov)

Exclusion of pregnant people from emergency vaccine clinical trials: A systematic review of clinical trial protocols and reporting from 2009 to 2019. (bvsalud.org)
We searched for Phase II and Phase III vaccine clinical trials initiated during the H1N1 influenza , Middle East Respiratory Syndrome Coronavirus ( MERS-CoV ), Zika, and Ebola virus disease (EVD) outbreaks from 2009 to 2019. (bvsalud.org)

To this end, this brief describes the existing OECD Recommendation on the Governance of Clinical Trials issued in 2012 and how its implementation could greatly facilitate and streamline the registration and conduct of international clinical trials. (oecd.org)
In short, the sponsor is the entity or person that initiates, organises and supports the clinical trial and takes responsibility for the overall conduct of the trial, including liability for injuries that may be suffered by patients. (chubb.com)
Further, it will have access to Good Clinical Laboratory Practice (GCLP) labs to conduct immunogenicity assay testing of the vaccine, the pharma major said in a statement on Thursday. (thehindu.com)
Earlier this month, Dr. Reddy's and RDIF had received approval from the Drugs Controller General of India (DCGI) to conduct an adaptive phase 2/3 human clinical trial for the vaccine. (thehindu.com)
Our objective was to conduct a systematic review of vaccine clinical trials during active epidemic periods. (bvsalud.org)

We need to register a million more volunteers to complete the studies that will possibly get a safe and effective vaccine to hundreds of millions of Americans,' Ford explained in the PSA. (eonline.com)
The new clinical trial is expected to enroll 24 healthy volunteers, aged 18-50 years, who will receive two intramuscular injections of the FluMos-v2 vaccine candidate. (eurekalert.org)
Two new clinical trials testing an experimental vaccine to prevent influenza caused by an H7N9 influenza virus are now enrolling volunteers at sites across the United States. (enewspf.com)
Three of the groups (at least 480 volunteers in total) will receive the adjuvanted vaccine candidate, at different dosages (3.75 micrograms (mcg), 7.5 mcg or 15 mcg). (enewspf.com)
The two remaining groups (at least 160 volunteers in all) will receive unadjuvanted vaccine (15 mcg or 45 mcg). (enewspf.com)
Jerusalem-based Oramed Pharmaceuticals has received approval from the Tel Aviv Sourasky Medical Center to start a clinical trial on 24 unvaccinated volunteers for a single-dose capsule version of a vaccine that is being developed by Indian firm Premas Biotech. (rt.com)
In the Phase 1 trial, volunteers will be randomized in a 1:1:1 ratio into three groups and will receive two doses of placebo or vaccine spaced 28 days apart. (nih.gov)
In addition to the two clinic visits to receive vaccine (or placebo), volunteers will be asked to return to the clinic seven times to provide blood and nasal mucosal samples that will be used by the investigators to detect and characterize immune responses. (nih.gov)

Inactivated and trivalent oral poliovirus vaccines contain either formalin- inactivated or live, attenuated poliovirus, respectively, of the three serotypes. (who.int)

Trials in 2006 and 2007 using two 30-mcg doses produced unacceptable results while a 2006 trial using two doses of 90 mcg each achieved acceptable levels of protection. (wikipedia.org)
And in September, Sanofi Pasteur reported in a press release that an inactivated vaccine adjuvanted with the company's own proprietary formula induced EU-accepted levels of protection after two doses of 1.9 mcg. (wikipedia.org)
The vaccine was administered to the mice once a week for six weeks, after an initial 'loading' regimen of four doses was given in the first week. (pharmatimes.com)
The vaccine is given in two doses delivered about three weeks apart. (cnn.com)
While the vaccine has not yet earned approval from any regulatory body, an emergency stockpile of 300,000 doses has been created to quell an outbreak should one flare up. (beckershospitalreview.com)
A third DTaP vaccine (Infanrix TM) *** was licensed in January 1997 for the initial four doses of the series. (cdc.gov)
More severe systemic events (e.g., convulsions {with or without fever} and hypotonic hyporesponsive episodes) occur less frequently (ratio of one case to 1,750 doses administered) among children who receive whole-cell DTP vaccine (5). (cdc.gov)

This study will evaluate the immunogenicity and tolerability of V503 in preadolescent and adolescent subjects between 9 and 15 years old and demonstrate the consistency of the manufactured vaccine through assessment of 3 different final manufacturing process lots of V503. (sanevax.org)

Currently available seasonal influenza (or "flu") vaccines are effective at preventing specific strains of influenza. (eurekalert.org)
Each year, the vaccines are re-evaluated and changed to best match the strains of flu predicted to be the most dominant in the upcoming flu season. (eurekalert.org)
Most seasonal flu vaccines are designed to train the immune system to defend against three or four different common strains of flu, but a "universal" influenza vaccine might someday provide protection against many more. (eurekalert.org)
An ideal universal influenza vaccine could be taken less frequently than once a year and protect against multiple strains of influenza virus. (eurekalert.org)
While the FluMos-v1 vaccine candidate displays HA from four strains of influenza virus, FluMos-v2 displays HA from six: four influenza A viruses and two influenza B viruses. (eurekalert.org)
BPL-1357 is a whole-virus vaccine made up of four strains of non-infectious, chemically inactivated, low-pathogenicity avian flu virus. (nih.gov)
This vaccine is designed to protect people against North American and European strains of the Lyme disease bacterium. (cdc.gov)
History of Sabin attenuated poliovirus oral live vaccine strains. (who.int)
The ful data concerning the history of attenuated poliovirus strains developed by one of us (Sabin, 1965) for vaccine production do not appear in a single journal. (who.int)
Over the past few years we have had frequent requests for the details such as isolation and attenuation and accordingly we felt that bringing the data together in the report below would be both helpful and informative to those involved in the production and control of poliovirus vaccine (oral) prepared from these strains. (who.int)

The phase 3 trials to test the vaccine enrolled more than 10,000 adults in the US, Asia, Africa and Latin America. (cnn.com)

A universal vaccine, ACAM-FLU-A, is being developed by the British company Acambis and is being researched by others as well. (wikipedia.org)
The universal vaccine is made through bacterial fermentation technology, which would greatly speed up the rate of production over that possible with culture in chicken eggs, plus the vaccine could be produced constantly, since its formulation would not change. (wikipedia.org)

They are intended to discover pharmacological effects and identify any adverse reactions the vaccines may achieve in humans. (wikipedia.org)
Adverse side effects reported with the vaccine were headaches (reported by 25.4 percent of those vaccinated), fatigue (18.9 percent) and muscle pain (13.7 percent). (beckershospitalreview.com)
Pregnancy was an exclusion criterion for all rVSVΔG-ZEBOV-GP clinical trials, not only because so little was known about the safety of the vaccine generally but also because adverse effects on pregnancy were biologically plausible ( 5 , 6 ). (cdc.gov)
A phase 1 trial was paused because of concerns about postvaccination arthritis associated with dissemination of the vaccine rVSV into the joints, raising concerns that other adverse reactions could occur consequent to vaccine viremia ( 7 - 9 ). (cdc.gov)
71 serious adverse events pertaining to pregnancy were reported from all clinical trials with results. (bvsalud.org)
Concerns about the safety of whole-cell pertussis vaccines prompted development of acellular vaccines that are less likely to provoke adverse events because they contain purified antigenic components of Bordetella pertussis. (cdc.gov)
Published reports indicate that, when administered to infants aged 2, 4, and 6 months, acellular pertussis vaccines are effective in preventing pertussis disease and associated with fewer local, systemic, and certain more serious adverse events than whole-cell pertussis vaccines. (cdc.gov)
Concerns about safety prompted the development of more purified (acellular) pertussis vaccines that are associated with a lower frequency of adverse events and are effective in preventing pertussis disease. (cdc.gov)
What does it mean when a vaccine trial is halted due to an adverse event? (bvsalud.org)
Vaccine- associated paralytic poliomyelitis (VAPP) is a rare adverse event associated with oral poliovirus vaccine (OPV). (who.int)

All aspects of a clinical trial are explained to you thoroughly, and your decision to enroll your child is entirely voluntary. (mskcc.org)
Why would you want to enroll in a clinical trial? (healthywomen.org)
The trial will enroll patients 18 to 65 years old with newly diagnosed glioblastoma multiforme brain cancer who will receive standard primary treatment with surgery followed by radiation with concurrent chemotherapy. (science20.com)

Project on Controlled Therapeutic Trials. (who.int)
5 records were excluded in screening for irrelevant abstracts, 7 were excluded in full-text assessment (1 for a therapeutic drug trial, 3 for enrolling elderly adults only, 3 for enrolling children / adolescents only). (bvsalud.org)

Current flu vaccine manufacturing plants can not produce enough pandemic flu vaccine at this high dose level. (wikipedia.org)
A separate study is assessing a third dose of the vaccine as a booster. (cnn.com)

When tested in animals, the experimental vaccine resulted in robust antibody responses. (eurekalert.org)

Candidate vaccines were developed in the United States and the United Kingdom during 2003 for protection against the strain that was isolated from humans in Hong Kong in February 2003 but the 2003 strain died out in 2004 making the vaccine of little use. (wikipedia.org)
As of July 2007, phase I clinical trials on humans are underway in which a vaccine that focuses on the M2 viral protein "is being administered to a small group of healthy people in order to verify the safety of the product and to provide an initial insight into the vaccine's effect on the human immune system. (wikipedia.org)
In March 2006, Hungarian Prime Minister Ferenc Gyurcsány reported that Omninvest developed a vaccine to protect humans against the H5N1 influenza strain. (wikipedia.org)
OKLAHOMA CITY - A new vaccine candidate to provide broad protection against pneumonia, developed by a researcher at the University of Oklahoma College of Medicine, is being given to humans for the first time in a Phase I clinical trial. (ou.edu)

But we still need to continue working on Ebola vaccines. (beckershospitalreview.com)
Little information exists regarding Ebola vaccine rVSVΔG-ZEBOV-GP and pregnancy. (cdc.gov)
This result spurred subsequent use of this vaccine under expanded use protocols as part of the public health response to Ebola outbreaks. (cdc.gov)

Search clinical trials for adult and pediatric cancers and blood disorders offered through Dana-Farber and our clinical partners. (dana-farber.org)

The placebo-controlled trial will test the safety of a candidate vaccine, BPL-1357, and its ability to prompt immune responses. (nih.gov)

Now, Accentia Biopharmaceuticals and Biovest International have developed a non-Hodgkin's lymphoma (NHL) vaccine that teaches the body's immune system to identify and destroy tumor cells while leaving healthy tissue intact. (singularityhub.com)
What results is a patient-specific vaccine, which teaches the body's own immune system how to separate the good cells from the bad. (singularityhub.com)
Currently approved vaccines are carbohydrate-based, meaning they prompt the immune system to recognize part of the sugar coating found on Streptococcus pneumoniae , thereby protecting against infection. (ou.edu)
Tweten's vaccine, in contrast, uses a genetically modified, inactive version of a Streptococcus pneumoniae toxin called pneumolysin, against which the immune system makes antibodies. (ou.edu)
Unlike the current vaccines, which prompt the immune system to respond to specific variants, we believe our vaccine will protect against the majority of Streptococcus pneumoniae serotypes. (ou.edu)
A brain cancer vaccine is intended as a kind of immunotherapy, which means that it primes the patient's own immune system to kill proteins found in cancer cells. (science20.com)

The Phase 3 vaccines from Astra Zeneca/ OxfordUniversity, Moderna, GSK, Johnson & Johnson, and Novovax are currently being tested, as are monoclonal antibody treatment and prevention programs from Astra Zeneca, Regeneron, and Eli Lilly, Ellison wrote. (eonline.com)
Moderna recently began a study similar to Pfizer's new trial, as both companies hunt the right dosage of each shot for each age group as they work toward eventually vaccinating babies as young as 6 months. (smh.com.au)
At best, a vaccine-like Moderna might be approved for emergency use this fall. (bgr.com)

On April 17, 2007 the US FDA approved "Influenza Virus Vaccine, H5N1" by manufacturer Sanofi Pasteur Inc for manufacture at its Swiftwater, PA facility. (wikipedia.org)

Oct 2012 Novavax, Inc. pandemic influenza vaccine Phase I trials meet primary objectives. (wikipedia.org)
Adjuvanted vaccines appear to hold the greatest promise for solving the grave supply-demand imbalance in pandemic influenza vaccine development. (wikipedia.org)
VaxCorps clinical sites have successfully conducted over 500 phase I-IV vaccine clinical trials, with extensive experience in seasonal and pandemic influenza as well as a vast array of other infectious and biodefense vaccine indications. (prweb.com)

The scientists behind the study, reported in the online edition of the Journal of Clinical Investigation, note that their vaccine is an immunological approach to resolving amyloid in the brain that does not rely on the production of an antibody-based response. (pharmatimes.com)

Clinicians and other decision makers in healthcare use results from clinical trials to inform practice. (nih.gov)
Interpretation of clinical trial results can be challenging, as weaknesses in trial design, data collection, analysis or reporting, can compromise the usefulness of results. (nih.gov)
A good working knowledge of clinical trial design is essential to expertly interpret and determine the validity and generalizability of the results. (nih.gov)
The vaccine has already passed Phase I and II clinical trials with promising results: previous studies have shown that BiovaxID significantly increases both the time interval between relapses (44.2 months, as compared with 30.6 months in a placebo group) as well as patients' overall survival rates. (singularityhub.com)
European drug makers Sanofi and GSK announced positive results from late-stage clinical testing of a new vaccine that will be named Vidprevtyn, according to a Sanofi spokesperson. (cnn.com)
An earlier Phase II trial of the experimental drug involving 50 patients with metastatic melanoma had stunning results. (scienceblog.com)
The results were reported last December in the Journal of Clinical Oncology . (scienceblog.com)
These are the best results to date for any vaccine developed for melanoma, but they need to be confirmed in a larger population. (scienceblog.com)
of these, 3 were completed trials with published results. (bvsalud.org)

Available at http://www.who.int/biologicals/vaccines/BS2185_OPV_Post_ECBS_DB_TZ_DBFinal12Feb2013.pdf, accessed February 2016. (who.int)

These subtypes also exhibit cell surface markers that can be exploited by the vaccine. (singularityhub.com)

Industry players must navigate regulatory challenges, embrace innovative trial designs, and adopt digital solutions to optimize efficiency and patient outcomes in this dynamic landscape. (biospace.com)
These trials give patients and their families a chance for improved health outcomes and a better quality of life. (biospace.com)

Last month at the Active Immunotherapeutics Forum, Accentia's chief science officer Dr. Carlos Santos reported positive findings in Phase II clinical trials to treat mantle cell lymphoma . (singularityhub.com)
The Hyderabad-headquartered company's CEO Erez Israeli, during a media interaction on Wednesday, had said the phase II trials were expected to begin soon. (thehindu.com)

In the final episode, experts at UCSD and La Jolla Institute discuss current clinical trials of a cancer vaccine and future directions for neoantigen vaccines. (medscape.com)
In addition to funding drug trials, the Accelerator will provide $1.73 million to the La Jolla Institute for Immunology to establish a Coronavirus Immunotherapy Consortium, known as CoVIC. (mastercard.com)

In the USA, African Americans account for 20% of all Multiple Myeloma sufferers, but only 6% of individuals in trials are from this group. (news-medical.net)
Other B-cell lymphomas could also potentially be treated using the vaccine, including multiple myeloma and chronic lymophocytic leukemia. (singularityhub.com)

It was shown in a randomized, double-blind, placebo-controlled clinical trial to reduce hospitalization or death from any cause by 30% compared with a placebo after 29 days. (factcheck.org)

Trials may be separated into two main types: interventional or observational. (britannica.com)
Clinical trials may also be referred to as interventional trials. (who.int)

The 9-valent HPV vaccine (Gardasil 9 [9vHPV]) is available in the United States to decrease the risk of certain cancers and precancerous lesions in males and females. (medscape.com)

Interference among the three attenuated poliovirus serotypes was minimized with a 'balanced- formulation' vaccine, and serologic responses after IPV were optimized by adjusting the antigenic content of each inactivated poliovirus serotype. (who.int)

Clinical trials are key to finding new and safe ways to fight and/or prevent diseases. (healthywomen.org)
For rare diseases or conditions with limited treatment options, clinical trials offer a beacon of hope by providing a platform to develop innovative therapies. (biospace.com)
Any detectable titer of neutralizing antibody against poliovirus is considered protective against clinical paralytic diseases. (who.int)

The vaccine focuses on the M2 viral protein, which does not change, rather than the surface hemagglutinin and neuraminidase proteins targeted by traditional flu vaccines. (wikipedia.org)
Live viral vaccines should be avoided, such as oral polio and measles, mumps, and rubella (MMR). (lu.se)

The vaccine, a nasal spray which delivers ID Biomedical's proteasome-based adjuvant Protollin (IVX-908) and glatiramer acetate, the active ingredient in Teva Pharmaceutical Industries' multiple sclerosis treatment Copaxone, has been shown to stimulate a type of immune cell in the central nervous system - called a microglial cell - to break down the amyloid deposits. (pharmatimes.com)

The vaccine includes an oncolytic virus, a reprogrammed virus that has been converted into a cancer-fighting agent that attacks tumor cells while leaving healthy cells undamaged. (scienceblog.com)
When a patient's tumor is removed during surgery it will be shipped to a laboratory where the tumor cells will be broken up to prepare the first component of the vaccine. (science20.com)

Describes the nature of a clinical study. (mayo.edu)
Blood samples will be taken during study visits to measure any immune responses to the vaccine candidate. (eurekalert.org)
Looking for our work on the SUPPORT study , an unethical trial involving premature infants? (citizen.org)
Last month in Britain, AstraZeneca began a study of its vaccine among 6- to 17-year-olds. (smh.com.au)
A study published in 2013 explored the barriers to inclusion for older adults in Non-Hodgkin's Lymphoma trials. (news-medical.net)
For organizations who want to provide their clinical study teams with continuous, ongoing education and professional development resources, Organization Membership is a turnkey and scalable solution. (acrpnet.org)
A Study of V503 (Multivalent HPV Vaccine) in Preadolescents and Adolescents. (sanevax.org)
The study will evaluate the addition of the vaccine following standard therapy with surgery and chemotherapy in patients with glioblastoma multiforme, a deadly form of brain cancer. (science20.com)
The study underway at NYU Medical Center is an expansion of an earlier phase I trial of the vaccine. (science20.com)

Anatomy5

Organisms15

Diseases22

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment72

Psychiatry and Psychology2

Phenomena and Processes17

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture3

Humanities1

Information Science7

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Health Care52

Geographicals1

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Researchers26

Efficacy8

Coronavirus vaccine4

Participants17

COVID43

Investigational6

Immunity7

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Diphtheria and tetanus toxoids2

Protein subunit vaccine1

NIAID14

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Type of vaccine2

Treatments16

Centers2

Vaccination11

World Health Organ5

Pfizer6

MRNA1

Infectious Diseases1

Pertussis vaccine1

Research39

Center in Bethesda1

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Conduct5

Volunteers8

Live-attenuated1

Doses7

Immunogenicity1

Strains10

Test the vaccine1

Universal vaccine2

Adverse10

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Therapeutic2

Dose2

Experimental vaccine1

Humans4

Ebola3

Pediatric1

Candidate vaccine1

Immune system6

Moderna3

Sanofi Pasteur1

Pandemic influenza3

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Phase II2

Jolla Institute2

Multiple Myeloma2

Placebo-controlled1

Interventional2

Gardasil1

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Diseases3

Viral2

Nasal spray1

Tumor cells2

Study9