Vaccines glycoconjugates. Medical search. Frequent questions

Menactra®, Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, is a sterile, intramuscularly administered vaccine that contains Neisseria meningitidis serogroup A, C, Y and W-135 capsular polysaccharide antigens individually conjugated to diphtheria toxoid protein. (mesvaccins.net)
Cases of meningococcal disease caused by serogroups C and Y among persons who were vaccinated with meningococcal conjugate vaccine have been reported. (cdc.gov)
In 2010, CDC received 12 reports of serogroup C or Y meningococcal disease among persons who had received a meningococcal conjugate vaccine. (cdc.gov)
1% w/ introduction of conjugate vaccine. (hopkinsguides.com)
at one time, expansion of serotype coverage, effectiveness in special populations, and issues relating to conjugate vaccine use in the developing world. (wnt-pathway.com)

Immunization with glycoconjugates successfully induced long term immune memory against carbohydrates antigens. (wikipedia.org)
Here, we examine and discuss the impact of glycan chain length on the efficacy of glycoconjugate vaccines and report the methods employed to size polysaccharide antigens, while highlighting the underlying reaction mechanisms. (jenner.ac.uk)
Kabanova, Anna (2010) Evaluation of glycoconjugate antigens as vaccine candidates against group A Streptococcus and human immunodeficiency virus infections , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
Based on GAS-PS structural analysis, the study evaluates the potential to exploit a synthetic design approach to GAS vaccine development and compares the efficiency of synthetic antigens with the long isolated GAS polysaccharide. (unibo.it)
The outer polysaccharide capsule and lipopolysaccharide (LPS) antigens are key targets for novel control strategies targeting Klebsiella pneumoniae and related taxa from the K. pneumoniae species complex (KpSC), including vaccines, phage and monoclonal antibody therapies. (microbiologyresearch.org)
Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines. (biomedcentral.com)
Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen. (biomedcentral.com)
These findings provide six novel immunogenic Shigella proteins that could serve as candidate vaccine antigens, species-specific carrier proteins, or targeted adjuvants. (biomedcentral.com)
Many vaccine development attempts stand to benefit from these novel approaches to generating glycoconjugates to target immunity to eukaryotic glycan antigens. (ebat2018.org)
These findings have important implications for the rational design of glycoconjugate vaccines using eukaryotic glycan antigens in the future. (ebat2018.org)

Coupled with carrier proteins, these molecules are effective vaccines that are much simpler to prepare in the laboratory than the isolation of conventional vaccines from bacteria. (mpg.de)
However, despite the success of these glycoconjugate vaccines they have major drawbacks in terms of the technical difficulties in purifying the capsule material from bacterial cells and then conjugating the capsule to carrier proteins. (ukri.org)
This paper focuses on the use of CRM197 as a carrier protein, contrasting it to other carrier proteins used in single-antigen pediatric vaccines as well as identifying areas for future study. (wnt-pathway.com)

In order to keep the synthesis effort for the vaccine managable, the researchers identified the smallest possible sugar for immunization. (mpg.de)
Serogroup C Meningococcal Glycoconjugate Vaccine in Adolescents: Persistence of Bactericidal Antibodies and Kinetics of the Immune Response to a Booster Vaccine More Than 3 Years after Immunization ," Matthew D. SNAPE, Penny SALT , et al. (improbable.com)
This report updates the 2010 recommendations from the CDC Advisory Committee on Immunization Practices (ACIP) regarding prevention of Japanese encephalitis (JE) among U.S. travelers and laboratory workers (Fischer M, Lindsey N, Staples JE, Hills S. Japanese encephalitis vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). (cdc.gov)
Ensuring the stability of vaccines is crucial to successfully performing global immunization programs. (mdpi.com)
Increasing awareness regarding vaccines and immunization among the populace is expected to boost the growth of the Global Pediatric Vaccines Market over the forecast period. (verifiedmarketresearch.com)
The Meningococcal Vaccines Work Group of ACIP reviewed available data on immunogenicity in high-risk groups, bactericidal antibody persistence after immunization, current epidemiology, vaccine effectiveness (VE), and cost-effectiveness of different strategies for vaccination of adolescents. (cdc.gov)
In the 2009 National Immunization Survey-Teen, 53.6% of adolescents aged 13 through 17 years had received a dose of meningococcal vaccine ( 3 ). (cdc.gov)

By combining the beneficiaries' expertise in carbohydrate synthesis, bioconjugation, high throughput screening, structural glycobiology, vaccinology and immunology, together with the experience in project management, GLYCOVAX is creating a multidisciplinary environment where 14 young researchers are contributing to develop a novel route towards improved, safer and better characterized glycoconjugate vaccines, and contemporarily acquire transferable skills which will lead them to become the new leaders of academic or industrial research. (com.hr)
The synthesis of the ST8-effective sugar molecule is a further milestone on the way to a new generation of tailor-made vaccines. (mpg.de)
Our laboratory has over 20 years of experience working with these important bacterial pathogens and has gained significant expertise in areas relating to Burkholderia genetics, pathogenesis, host-pathogen interactions, carbohydrate purification/characterization, glycoconjugate synthesis and the analysis of humoral/cellular immune responses. (unr.edu)
Expeditious strategies for the synthesis of complex oligosaccharides and glycoconjugates: chemoselectivity and orthogonality of modern building blocks. (glyco-world.com)

Immunological evaluation of synthetic glycosylphosphatidylinositol glycoconjugates as vaccine candidates against malaria. (mpg.de)
The new recombinant glycoconjugates in E. coli will be ideal vaccine candidates that can be readily purified and tested. (ukri.org)
Our laboratory is currently funded by the Defense Threat Reduction Agency (DTRA) to develop and test i) melioidosis and glanders subunit vaccine candidates and ii) serological assays to rapidly diagnose active cases of melioidosis. (unr.edu)
Researchers are exploring many different types of platforms for the development of COVID-19 vaccines, from the more traditional live attenuated virus and inactivated virus approaches, to recombinant protein antigen candidates, to newer approaches such as nucleic acid vaccines, like mRNA, which are showing promise in early stage phase 1 and 2 clinical trials. (usp.org)

Immunogenicity and immune memory of a nonadjuvanted quadrivalent meningococcal glycoconjugate vaccine in infants. (ox.ac.uk)

The MenACWY vaccine was introduced in Ireland from September 2019. (meningitis.org)
According to National Centre for Disease Control (NCDC), In 2019, little over half of the children aged 60 days to 17 years had received a flu vaccine in the previous 12 months (53.1 percent). (verifiedmarketresearch.com)

Many interdependent parameters affect the immunogenicity of glycoconjugate vaccines, including the size of the saccharide antigen. (jenner.ac.uk)
A better understanding of the impact of key parameters on the immunogenicity of glycoconjugates is critical to developing a new generation of highly effective vaccines. (jenner.ac.uk)
We evaluated the immunogenicity and reactogenicity of a novel quadrivalent nonadjuvanted meningococcal glycoconjugate vaccine (MenACWY-CRM) in healthy infants. (ox.ac.uk)
Meningococcal conjugate vaccines were licensed in 2005 based on immunogenicity (because a surrogate of protection had been defined) and safety data. (cdc.gov)

or =1:4 against each of the serogroups C, W-135, and Y and more than 79% against serogroup A. The vaccine was well tolerated. (ox.ac.uk)
The four meningococcal components, present as individual serogroup-specific glycoconjugates, compose the final formulated vaccine. (mesvaccins.net)

Examples of successful vaccines include those against the deadly bacteria Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae. (ukri.org)

This PhD thesis discusses the rationale for design and use of synthetic oligosaccharides for the development of glycoconjugate vaccines and the role of physicochemical methods in the characterization of these vaccines. (unibo.it)
The preparation and characterization of homogeneous bivalent pneumococcal vaccines is reported. (univ-nantes.fr)

At 12 months of age, the Canadian infants received either MenACWY-CRM or a reduced dose of a licensed meningococcal polysaccharide vaccine. (ox.ac.uk)
The Group A Streptococcus cell membrane polysaccharide (GAS-PS) is an attractive vaccine antigen candidate based on its conserved, constant expression pattern and the ability to confer immunoprotection in a relevant mouse model. (unibo.it)
Potency of Menactra vaccine is determined by quantifying the amount of each polysaccharide antigen that is conjugated to diphtheria toxoid protein and the amount of unconjugated polysaccharide present. (mesvaccins.net)
Polysaccharide vaccines are essential for protection against infectious diseases, which remain an alarming cause of mortality. (bioprocessintl.com)

Each 0.5 mL dose of vaccine is formulated in sodium phosphate buffered isotonic sodium chloride solution to contain 4 mcg each of meningococcal A, C, Y and W-135 polysaccharides conjugated to approximately 48 mcg of diphtheria toxoid protein carrier. (mesvaccins.net)
The structural integrity of meningococcal native, micro-fluidized and activated capsular polysaccharides and their glycoconjugates - in the form most relevant to their potential use as vaccines (dilute solution) - have been investigated with respect to their homogeneity, conformation and flexibility. (hud.ac.uk)

From the building blocks of nature to disease-battling therapeutics and vaccines, carbohydrates have had a profound impact on evolution, society, economy, and human health. (glyco-world.com)
To list therapeutics based on glycans or glycoconjugates and vaccine development, correlating with clinical application. (unl.pt)

The cluster nature of the 2G12 epitope suggested that multivalent antigen presentation was important to develop a carbohydrate based vaccine candidate. (unibo.it)
Glycoconjugate-bearing polymers, which have been shown to bind to Bacillus spores, were tested for recognition and binding of protective antigen (PA), lethal factor (LF), and edema factor (EF) toxins. (listlabs.com)
They furthermore suggest therapeutic options using competitive glycan-binding agents such as IVM and may help elucidate rare serious adverse effects (AEs) associated with COVID-19 mRNA vaccines which use spike protein as the generated antigen. (biorxiv.org)
The main goal of our research is to identify correlates of antigen-induced immunity against B. pseudomallei and B. mallei and use this information to develop safe, affordable and effective melioidosis/glanders vaccines. (unr.edu)
The primary strategy of developing an efficacious Shigella vaccine has been to elicit antibody responses targeting Shigella O-antigen [ 10 ]. (biomedcentral.com)
The nature of the sugar antigen, its length, its ratio per carrier protein and the conjugation chemistry impact on both structure and the immune response of a glycoconjugate vaccine. (univ-nantes.fr)
A synthetic vaccine comprising the Tn-antigen glycopeptide along with a T-cell epitope covalently linked to a Toll-like Receptor ligand, where no artificial linkages other than peptide bonds are created, exhibited very encouraging results in mice 18. (ebat2018.org)

Glycoconjugates are the classification family for carbohydrates - referred to as glycans - which are covalently linked with chemical species such as proteins, peptides, lipids, and other compounds. (wikipedia.org)

This oligomannose epitope has been a subject to the synthetic vaccine development. (unibo.it)
The production of conventional vaccines against ST8 is difficult,' explains Max Planck Director Peter Seeberger, 'therefore, the development of a synthetic vaccine would be an enormous medical advance. (mpg.de)

No vaccine against Shigella species exists yet, however, several are under development. (medscape.com)
Shigella is a major diarrheal pathogen for which there is presently no vaccine. (biomedcentral.com)
There is currently no licensed vaccine against Shigella [ 10 ]. (biomedcentral.com)
This challenge may be overcome by a vaccine that elicits either a broadly reactive immune response or numerous species-specific responses against the globally dominant Shigella species (i.e. (biomedcentral.com)

Professor Snape conjures up combination glyco-conjugate vaccines. (improbable.com)

Addition of the synthetic sugar molecule to the current pneumococcal vaccine Prevnar 13, expanded the protection in vaccinated animals from 13 to 14 serotypes including the dangerous ST8 pathogen. (mpg.de)

These results demonstrate that protective antibodies to schistosome infections in brown rats and rhesus monkeys include IgG responses to the core Xyl/Fuc epitopes in surface-expressed N-glycans, and raise the potential of novel glyco-based vaccines that might be developed to combat this disease. (bvsalud.org)

The MPI team has a long track record developing synthetic vaccines based on sugars. (mpg.de)
Our findings indicate the reducing end of the sugars is vital for generation of a glycan-specific response to some eukaryotic vaccine epitopes, and that there are species-specific variations in the ability to make a glycan-specific response to some glycoconjugates. (ebat2018.org)
These studies suggest that chemical methods requiring ring opening of the reducing-end sugars of glycoconjugates can create K 858 major alterations in glycan antigenicity, and may become unacceptable for making conjugate vaccines with relatively small eukaryotic glycan epitopes. (ebat2018.org)

The identification of this component can be tedious, and complicates the development of this new generation of synthetic vaccines. (mpg.de)
Irrespective of vaccine development, this new and emerging technology will be of direct importance to scientists interested in basic research and in applied research in glyco-biotechnology. (ukri.org)
This vaccine successfully reduced the incidence of invasive Hib disease in childhood and led to the further development of conjugate vaccines designed to prevent infection by other encapsulated bacteria (1). (bioprocessintl.com)
A comprehensive analysis of the market is provided by the Global Pediatric Vaccines Development Market study. (verifiedmarketresearch.com)
The scale and speed of the global vaccine research and development effort in response to COVID-19 is unprecedented. (usp.org)
There are many areas in vaccine development and manufacturing where existing public quality standards, such as the ones in the United States Pharmacopeia-National Formulary (USP-NF) Online , can help. (usp.org)
In addition, USP is actively exploring new standards, like RNA standards, which would be useful for development of some vaccine platforms. (usp.org)
I then specialized in glyco-vaccine development at Dr. Brendan Wren's lab (LSHTM). (vetvaccnet.ac.uk)
I am interested in new vaccine development, antimicrobial chemotherapy, pre-clinical drug development and immunotherapy. (vetvaccnet.ac.uk)

Researchers now aim to further develop it into a vaccine for humans. (mpg.de)
Currently, the researchers aim to develop a vaccine for humans together with Vaxxilon AG, a Max Planck Institute spin-off company. (mpg.de)
The first glycoconjugate vaccine for use in humans - a Haemophilus influenzae type b (Hib) conjugate - was licensed in the United States in 1987. (bioprocessintl.com)

Synthetic carbohydrate vaccines represent a paradigm shift within vaccine research,' says Seeberger. (mpg.de)

Solid phase and surface chemistry: application to stereoselective glycosylation and rapid assembly of complex oligosaccharides and glycoconjugates. (glyco-world.com)

In order to evoke an appropriate immune response, vaccines against these bacteria consist of capsule linked to a protein carrier forming a glycoprotein or glycoconjugate. (ukri.org)
Experimental findings for SARS-CoV-2 related to the glycan biochemistry of coronaviruses indicate that attachments from spike protein to glycoconjugates on the surfaces of red blood cells (RBCs), other blood cells and endothelial cells are key to the infectivity and morbidity of COVID-19. (biorxiv.org)
As with the recently published finding for Hib-TT complexes, it is the carbohydrate component that dictates the solution behaviour of these glycoconjugates, although the lower intrinsic viscosities suggest some degree of compaction of the carbohydrate chains around the protein. (hud.ac.uk)

In this highly multidisciplinary environment 14 Early Stage Researchers (ESRs) are trained in the growing field of glycoscience and vaccinology, enriching their skills and combining different state-of-the-art methodologies for the rational design of innovative glycoconjugates. (com.hr)
These findings warrant further investigation with regard to rational design of glycoconjugate vaccines. (ebat2018.org)

Glycoconjugate vaccines have contributed enormously to reducing and controlling encapsulated bacterial infections for over thirty years. (jenner.ac.uk)
The basis for these vaccines is a complex sugar structure, known as the capsule, which covers bacterial cells protecting them from immune attack. (ukri.org)
An inexpensive, rapid and flexible method for glycoconjugate vaccine production would enable a more effective response to the emergence of new pathogenic bacterial strains with different capsule structures. (ukri.org)

Furthermore, over the life cycle of a vaccine, process improvements will also likely be implemented to increase efficiency and reduce cost, but manufacturers need to consider how these changes affect the critical quality attributes for the vaccine to ensure its continued safety and potency. (usp.org)

Anti-PsaA antibody response induced in mice by the trivalent glycoconjugate was determined in comparison with corresponding monovalent and randomly functionalized conjugates. (univ-nantes.fr)

This emergence is of concern because GBS conjugate vaccines that are being developed to prevent invasive disease may protect only against serotypes Ia, Ib, II, III, and V, or combinations thereof ( 15 , 16 ). (cdc.gov)

Glycoconjugate vaccines represent the key for success of vaccination in children. (com.hr)
The decision about whether to vaccinate should be individualized and consider the 1) risks related to the specific travel itinerary, 2) likelihood of future travel to countries where JE is endemic, 3) high morbidity and mortality of JE, 4) availability of an effective vaccine, 5) possibility (but low probability) of serious adverse events after vaccination, and 6) the traveler's personal perception and tolerance of risk. (cdc.gov)
Moreover, shortening the vaccine schedule time can effectively increase the completion rate of vaccination and even stimulate earlier and faster hepatitis B surface antibody (anti-HBs) production [ 11 , 12 ]. (biomedcentral.com)
Thus as new disease strains emerge (e.g. from selective pressure by large scale vaccination regimes) the existing vaccines become ineffective. (ukri.org)
At that time, vaccination was recommended at age 11 or 12 years rather than at age 14 or 15 years because 1) more persons have preventive-care visits at age 11 or 12 years, 2) adding this vaccine at the 11 or 12 year-old visit would strengthen the pre-adolescent vaccination platform, and 3) the vaccine was expected to protect adolescents through the entire period of increased risk. (cdc.gov)

For some persons who might be at increased risk for JE, the vaccine can further reduce the risk for infection. (cdc.gov)
Mucins and pathogenic mucin-like molecules are immunomodulators during infection and targets for diagnostics and vaccines. (mpg.de)

Glycoconjugates are formed in processes termed glycosylation. (wikipedia.org)

One such approach is to produce glycoconjugate vaccines in the genetically tractable bacterium Escherichia coli. (ukri.org)
Young people of school age who missed out on getting their vaccine can approach their school or GP and ask about how to access the vaccine. (meningitis.org)
No matter which vaccines ultimately are approved and which approach(es) is found to be the most effective, several manufacturing challenges must be overcome to ensure these vaccines are widely available in a timely fashion. (usp.org)

Menactra n'est pas enregistré en Europe. (mesvaccins.net)
Menactra vaccine is manufactured as a sterile, clear to slightly turbid liquid. (mesvaccins.net)

Importantly, USP has a lot of experience developing and validating assays, and if new assays are needed for a vaccine platform, USP may be able to provide advice regarding a particular assay format. (usp.org)

Both pathogens possess distinctive carbohydrate structures that have been described as suitable targets for the vaccine design. (unibo.it)

Schistosomiasis is a globally prevalent, debilitating disease that is poorly controlled by chemotherapy and for which no vaccine exists. (bvsalud.org)

MenACWY vaccine directly protects vaccinated people from four different strains of meningococcal meningitis and septicaemia (groups A, C, W & Y) and also stops them from carrying the bacteria in the back of the nose and throat. (meningitis.org)

Some vaccines only include a little portion of a pathogen. (verifiedmarketresearch.com)

The report summarizes the epidemiology of JE, describes the JE vaccine that is licensed and available in the United States, and provides recommendations for its use among travelers and laboratory workers. (cdc.gov)

Outer Membrane Vesicles (OMV) are receiving great attention as vaccine platforms. (mdpi.com)
Novel manufacturing technologies like micro-modular platforms for manufacturing of vaccines with increased speed are also being fast-tracked to address the problem of producing hundreds of millions of doses of the vaccine(s) at affordable prices for the global population. (usp.org)
For example, USP can turn to the expertise of our staff and volunteers to convene an Advisory Expert Panel to offer solutions to specific challenges regarding novel vaccine platforms. (usp.org)

Polymeric GCs may suggest novel approaches to improve existing or develop new vaccines as well as immunotherapeutics. (listlabs.com)

METHODS: One hundred eighty infants (90 in Canada and 90 in the United Kingdom) received 2 doses of MenACWY-CRM at 2 and 4 months of age administered concomitantly with routine infant vaccines. (ox.ac.uk)

Anatomy2

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Chemicals and Drugs131

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20192

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