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  • polio vaccine
  • WASHINGTON - New research suggests a one-two punch could help battle polio in some of the world's most remote and strife-torn regions: Giving a single vaccine shot to children who've already swallowed drops of an oral polio vaccine greatly boosted their immunity. (recordonline.com)
  • Oral polio vaccine has played a critical role in the nearly three-decade effort to eradicate the paralyzing disease, as health workers have gone house-to-house, to refugee camps and to roadside checkpoints delivering the drops. (recordonline.com)
  • The United States and other wealthy countries have switched back to using only injected polio vaccine, which is made of "inactivated" or killed virus, for routine childhood immunizations after eradicating the disease within their borders. (recordonline.com)
  • measles vaccine
  • The Kitasato Institute Research Center for Biologicals (current Kitasato Daiichi Sankyo Vaccine) and JICA offered technical assistance to Vietnam's public corporation Center for Research and Production of Vaccines and Biologicals (POLYVAC) to produce the measles vaccine for four years between March 2006 and March 2010. (devex.com)
  • As a result of this cooperation, POLYVAC has acquired technology for domestic production of measles vaccine. (devex.com)
  • The 2013 technical cooperation project utilizes the rubella vaccine production technology of Kitasato Daiichi Sankyo Vaccine, in addition to the existing measles vaccine production technology of POLYVAC, to build a current Good Manufacturing Practice compliant measles-rubella combined vaccine production system that is expected to contribute to lowering the rate of measles and rubella cases in Vietnam. (devex.com)
  • epitope
  • 1. To assess the safety of repeated administration of the H3.3K27M epitope specific vaccine in HLA-A2+ children with H3.3K27M-positive DIPGs. (pnoc.us)
  • Induction of the H3.3K27M epitope-specific CTL response in post vaccine peripheral mononuclear cells (PBMC) in HLA-A2+ children with DIPG. (pnoc.us)
  • immunity
  • The shots acted as a better booster for the children's intestinal immunity than giving them yet more vaccine drops - and those youngsters shed far less virus, key to cutting transmission in an outbreak, Jafari's team reported. (recordonline.com)
  • therapeutic vaccine
  • Demonstrating that this therapeutic vaccine increased the complete response rate by 15% in this trial, without adding significant toxicities, represents an important scientific and medical advance. (marketwired.com)
  • The late-breaker poster (LB15) titled, "GI-5005 Therapeutic Vaccine Plus Peg-IFN/Ribavirin Improves End of Treatment Response at 48 Weeks Versus Peg-IFN/Ribavirin in Naive Genotype 1 Chronic HCV Patients" will be presented by Dr. McHutchison at the AASLD Meeting today from 1:00 - 2:30 p.m. in the Hynes Exhibit Hall C at the John B. Hynes Convention Center in Boston. (marketwired.com)
  • The MYASTERIX project will advance a therapeutic vaccine candidate (designated orphan drug) indicated for the autoimmune disease myasthenia gravis (MG) to clinical proof of concept studies. (europa.eu)
  • The objectives of the project are to manufacture toxicology and clinical batches of the vaccine human formulation based on already developed and tested standard operating procedures, to carry out stability and regulatory toxicity testing of the GMP product, to conduct phase I and subsequently phase II clinical trials to demonstrate safety, tolerability and proof of mechanism of action/concept of the therapeutic vaccine. (europa.eu)
  • meningococcal
  • Countries where meningococcal vaccine is recommended for travel are also areas where typhoid immunisation is advised. (bmj.com)
  • 1 Unpublished data from Merieux, which manufactures a typhoid and a meningococcal polysaccharide vaccine for injection, showed that the vaccines were compatible and stable in combination. (bmj.com)
  • We received responses from 40 in the combined groups A and B and 40 in group C. Antibody response to meningococcal A, meningococcal C, and typhoid Vi antigens was assessed by radioimmunoassay. (bmj.com)
  • antibodies
  • A strategy for control of IBD in chicks is to hyper-immunise dams with IBD inactivated vaccines so that they can transmit high levels of maternally derived antibodies (MDA) to the progeny. (thepoultrysite.com)
  • When the M. hyo component is grown, it likely contains PCV antibodies, which can affect the potency of the PCV fraction when the two fractions are combined. (pigprogress.net)
  • The vaccine candidate comprises two synthetic peptides designed to generate antibodies that bind to autoantibodies and T-cell receptors associated with MG. These peptides prevented or improved muscle fatigue in a rat model of MG and increased the remission rate to 75% in pet dogs (compared to 17% natural remission rate in historical controls). (europa.eu)
  • peripheral
  • Our aim was to demonstrate the ability of a CCR4 antagonist (a small chemical molecule identified in silico) when combined with vaccines to break peripheral tolerance controlled by Tregs, a prerequisite for the induction of CD8 + T cells against self Ags. (bloodjournal.org)
  • combination
  • Though both DNA-HIV-PT123 and AIDSVAX®B/E and the combination of the two vaccines have been evaluated in humans and have shown to be safe and well tolerated, this is the first time the combination regimen is being evaluated in HIV-1 uninfected African populations with and without S. mansoni. (clinicaltrials.gov)
  • With this M. hyo fraction, we can now produce a one-bottle combination vaccine. (pigprogress.net)
  • Previous studies estimated that vaccinating high-risk heterosexuals (HRH) with combination hepatitis A/B vaccine was a cost-effective alternative to vaccinating HRH against hepatitis B alone. (rti.org)
  • However, advances in our understanding of tumor immunology are rekindling interest in cancer vaccines, particularly in combination with breakthrough immunotherapies, such as immune checkpoint inhibitors. (drug-dev.com)
  • A novel combination vaccine designed to treat heroin addiction and target HIV was found to elicit immune responses in mice and dull their response to injected heroin in a recent preclinical trial. (drugabuse.gov)
  • Poultry
  • We alerted the Australian Pesticide and Veterinary Medicines Authority (APVMA) to our findings and they are now working closely with our research team, vaccine registrants and the poultry industry to determine both short and long term regulatory actions," she said. (melbourne.edu)
  • Live vaccines are used throughout the world to control ILT in poultry. (melbourne.edu)
  • viruses
  • Research from the University of Melbourne has shown that two different vaccine viruses- used simultaneously to control the same condition in chickens- have combined to produce new infectious viruses, prompting early response from Australia's veterinary medicines regulator. (melbourne.edu)
  • While recombination has been recognised as a potential risk associated with live virus vaccines for many years, the likelihood of it happening in viruses like this in the field has been thought to be so low that it was considered to be very unlikely to lead to significant problems," he said. (melbourne.edu)
  • Measures
  • Short-term measures include risk assessment of all live virus vaccines currently registered by the APVMA in regard to the risk of recombination and could include changes to product labels, which may result in restrictions on the use of two vaccines of different origins in the one animal population. (melbourne.edu)
  • Measures such as those now being taken for the ILT vaccines will need to be implemented. (melbourne.edu)
  • tumor
  • Due to these challenges, vaccines are unlikely to have a major anti-tumor effect without control of immune checkpoints. (drug-dev.com)
  • generate
  • Therefore, there is a potential that helminth infected populations may not generate the desired immune responses to vaccines designed to drive Th1-type and cytotoxic T-cell responses. (clinicaltrials.gov)
  • populations
  • The research found that when two different ILT vaccine strains were used in the same populations, they combined into two new strains (a process known as recombination), resulting in disease outbreaks. (melbourne.edu)
  • acute
  • The vaccines were used to control infectious laryngotracheitis (ILT), an acute respiratory disease occurring in chickens worldwide. (melbourne.edu)
  • safe
  • That's why we let science lead the way in developing an effective and safe vaccine all in one convenient bottle. (pigprogress.net)
  • Immunisation for travel could be made more acceptable by combining compatible vaccines in one injection, provided that the mixture conferred adequate protection and was safe. (bmj.com)
  • research
  • Daiichi Sankyo is a global pharmaceutical company engaged in the research and development, manufacturing, and sale and marketing of innovative and generic drugs, vaccines, and over-the counter. (devex.com)
  • Measles, Mumps and Rubella Combined Vaccine Market Report by Material, Application, and Geography - Global Forecast to 2021 is a professional and in-depth research report on the world's major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China). (medgadget.com)