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  • biological
  • The use of host-derived microRNAs (miRNAs) to attenuate viruses has been accomplished in an array of biological contexts. (mdpi.com)
  • Presently, a polyvalent, live, attenuated vaccine (LAV) against AHSV (AHSV-LAV), which is produced by Onderstepoort Biological Products (Pretoria, South Africa) and provides broad protection against all 9 AHSV types (10), is used widely in South Africa and adjacent countries. (thefreelibrary.com)
  • Specifically, the Committee is asked to indicate if the new test method described above applied to identify viral genomic nucleic acid fragments should be considered, if validated, for the development/qualification and/or routine testing of biological medicinal products, and particularly live attenuated vaccines. (gmp-compliance.org)
  • 4. Depending on the outcome of these investigations, the Committee should consider the need for appropriate guidance for other vaccines and other biological products. (gmp-compliance.org)
  • viruses
  • Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. (mdpi.com)
  • While escape is always a concern, effective strategies have been developed to improve the safety and stability of miRNA-attenuated viruses. (mdpi.com)
  • In this review, we discuss the various approaches that have been used to engineer miRNA-attenuated viruses, the steps that have been taken to improve their safety, and the potential use of these viruses as vaccines. (mdpi.com)
  • Given that continuing antigenic shift and drift of influenza A viruses result in the escape from previous vaccine-induced immune protection, a universal influenza vaccine has been actively sought. (medworm.com)
  • Two H5N2/NS1-LAIV viruses (H5N2/NS1-86 and H5N2/NS1-101) were highly attenuated compared with the full-length and remaining H5N2/NS-LAIV viruses in a mouse model. (deepdyve.com)
  • Furthermore, viruses containing NS1 modifications were found to induce more IFN-β activation than viruses with full-length NS1 proteins and were correspondingly attenuated in mice. (deepdyve.com)
  • This study clearly demonstrates that the modified H5N2/NS1-LAIV viruses attenuated through the introduction of mutations in the NS1 coding region display characteristics that are desirable for live attenuated vaccines and hold potential as vaccine candidates for mammalian hosts. (deepdyve.com)
  • Fluenz Tetra vaccine viruses are grown in chicken eggs. (medicines.org.uk)
  • On that note, if I might speculate a little bit," she said, "This might even explain why vaccines would lead to autism in some children, because these viruses live and divide and grow in lymphocytes - the immune response cells, the B and the T cells. (leftbrainrightbrain.co.uk)
  • Marian Nicholson, Director of the Herpes Viruses Association commented, "We have been keeping an eye on the progress of ImmunoVEX HSV2 for a while and are looking forward to knowing if this vaccine shows promise in the clinic as a protection for people who have not caught the virus and potentially as a therapy for people with frequent outbreaks of herpes simplex type 2. (news-medical.net)
  • LAIV
  • Few observational studies have evaluated the relative effectiveness of live attenuated (LAIV) and inactivated (IIV) influenza vaccines against medically attended laboratory-confirmed influenza. (aappublications.org)
  • We analyzed US Influenza Vaccine Effectiveness Network data from participants aged 2 to 17 years during 4 seasons (2010-2011 through 2013-2014) to compare relative effectiveness of LAIV and IIV against influenza-associated illness. (aappublications.org)
  • In this large observational study conducted over 4 influenza seasons, LAIV was less effective than inactivated vaccines for preventing A/H1N1pdm09 influenza among children and adolescents. (aappublications.org)
  • dose
  • This randomized, double-blinded, Phase I study in healthy is designed to investigate the safety, clinical tolerability, and immunogenicity in a dose escalating fashion of a live, oral, attenuated S. Paratyphi A at four dose levels (10^6, 10^7, 10^8, and 10^9 CFU). (clinicaltrials.gov)
  • While the two vaccines contain the same immunological components and provide protection against the same virus, Zostavax contains a higher dose and is used in older adults to prevent the development of shingles and post-herpetic neuralgia. (drugbank.ca)
  • Reactogenicity in Terms of Solicited Symptoms After Dose 1 of the Dengue Vaccine vs. Control Vaccine. (clinicaltrials.gov)
  • Are the local reactions to a third dose of the vaccine similar to what your child experienced after the first two doses? (clinicaltrials.gov)
  • Occurrence of any grade 2 or 3 fever, vomiting or diarrhea [ Time Frame: Within the 15-day solicited follow-up period after any dose of study vaccine. (clinicaltrials.gov)
  • The third dose of IPV vaccine (IPOL) may be given at visit 3, 4 or another time, at the investigator's discretion. (clinicaltrials.gov)
  • Chickenpox
  • Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. (drugbank.ca)
  • market's
  • Veterinary vaccine market's substantial growth can be attributed to increasing husbandry practices and better management of farms. (medgadget.com)
  • This report, with focus on top players in the global and Japan, studies the Live Attenuated Vaccine market's development status and future trend in the global and Japan. (researchmoz.us)
  • viral
  • In 2010 EMA became aware of some scientific publications which presented new information regarding the possible presence of nucleic acid sequences from endogenous2 and adventitious3 viral agents in a few batches of different live attenuated viral vaccines tested by a new analytical technique. (gmp-compliance.org)
  • 1. Whilst the presence of endogenous ALV and SRV DNA fragments is potentially linked to the cell lines used for the manufacture of the individual vaccines, the finding of PCV-1 DNA pointed towards the presence of non-endogenous viral DNA. (gmp-compliance.org)
  • tularensis , and heterologous vaccines developed using viral or bacterial vectors to express F. tularensis immunoprotective antigens. (frontiersin.org)
  • strains
  • Control of the development of adverse reactions (coccidiosis disease) is achieved through the use of low numbers of oocysts in vaccine preparations and in some cases even by the use of anticoccidials to control the excessive spread of vaccine strains. (thepoultrysite.com)
  • since it is an attenuated vaccine, its replication is very fast with a peak at 21 dpv, leaving the digestive tract clear so that animals can continue to grow without interference linked to the vaccine strains (Figure 1). (thepoultrysite.com)
  • Fluenz Tetra will help to protect against the four virus strains contained in the vaccine, and other strains closely related to them. (medicines.org.uk)
  • Each year the vaccine targets four strains of influenza, following the annual recommendations by the World Health Organisation. (medicines.org.uk)
  • tularensis , the route of transmission and species of greatest concern in a bioterrorist attack, in this review, we focus on live attenuated tularemia vaccine candidates tested against respiratory challenge with virulent Type A strains, including homologous vaccines derived from mutants of subsp. (frontiersin.org)
  • target for vaccine
  • Therefore, VP1 is a potential target for vaccine and drug development. (frontiersin.org)
  • The causative agent of genital herpes, herpes simplex virus 2, is therefore a very important target for vaccine development, both from a preventive and therapeutic perspective," said Dr. Simon Barton of the Chelsea and Westminster Hospital, London. (news-medical.net)
  • immunity
  • However, there were very few vaccines capable of eliciting cross-group ant-influenza immunity. (medworm.com)
  • Heterologous immunity is believed to provide protection to the 2 AHSV types, 5 and 9, that are not included in the vaccine. (thefreelibrary.com)
  • There are two purposes for conducting this Vaccine Study to evaluate an experimental vaccine called CVD 1208S (Center for Vaccine Development 1208S): 1) to learn whether CVD 1208S causes side effects, and 2) to learn whether the CVD 1208S gives people immunity to Shigella. (clinicaltrials.gov)
  • Experimental
  • High-level protection in humans can be achieved by experimental immunization with Plasmodium falciparum sporozoites attenuated by radiation or under anti-malarial drug coverage. (elifesciences.org)
  • 2018
  • Pang H, Qiu M, Zhao J, Hoare R, Monaghan S, Song D, Chang Y & Jian J (2018) Construction of a Vibrio alginolyticus hopPmaJ (hop) mutant and evaluation of its potential as a live attenuated vaccine in orange-spotted grouper (Epinephelus coioides), Fish and Shellfish Immunology, 76, pp. 93-100. (stir.ac.uk)
  • Accepted refereed manuscript of: Pang H, Qiu M, Zhao J, Hoare R, Monaghan S, Song D, Chang Y & Jian J (2018) Construction of a Vibrio alginolyticus hopPmaJ (hop) mutant and evaluation of its potential as a live attenuated vaccine in orange-spotted grouper (Epinephelus coioides), Fish and Shellfish Immunology, 76, pp. 93-100. (stir.ac.uk)
  • replication
  • However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. (mdpi.com)