Vaccine responses. Medical search. Frequent questions

After antibiotic treatment and vaccination, subjects were assessed for antibody response and viral shedding. (sciencedaily.com)
Reassuringly, most IBD medications do not prevent an initial antibody response after SARS-CoV-2 vaccination, and this is unlike other classes of immune suppression such as B-cell depletion therapy," Weaver concluded. (medscape.com)
The levels of neutralizing antibody response were similar to the immune response that people had after naturally recovering from Covid-19, according to the study. (cnn.com)
This interim analysis showed a robust neutralizing antibody response in both age groups,' Moderna said. (axios.com)
Given that vaccines against EVD have typically been administered during an outbreak to populations at risk for infection, it was important to investigate the early kinetics of the antibody response. (medpagetoday.com)
Participants were followed up to assess antibody response, reactions, and symptoms on days 7, 14, and 28 after dose 1. (medpagetoday.com)
The highest antibody response was seen after two doses of the Pfizer jab, while the highest T cell response was from AstraZeneca followed by Pfizer. (shieldsgazette.com)
Moderna says its new vaccine candidate, which fights both the original COVID-19 strain and the now-dominant omicron variant, shows a "superior neutralizing antibody response" against the coronavirus compared to its original vaccine. (wunc.org)
Because of the higher antibody response seen with the new vaccine candidate, Moderna predicts that people who get the booster will have protection that is "more durable over time" against omicron, compared to the original Moderna vaccine. (wunc.org)
People who reported experiencing side effects to the Pfizer/BioNTech and Moderna Covid-19 vaccines such as fever, chills or muscle pain tended to have a greater antibody response following vaccination, according to new research. (ktvz.com)
Nearly all study participants exhibited a positive antibody response after completing a two-dose Pfizer/BioNTech or Moderna vaccine series. (ktvz.com)
An original article in the January 2022 JALM Special Issue on Autoimmune Diagnostics described the evaluation of quantitative serologic antibody response in a cohort of 98 participants following the administration of either a single dose or both doses of an mRNA SARS-CoV-2 vaccine. (aacc.org)
Results showed within 14 days of the first dose of vaccination it provoked a T cell response - it could find and attack cells infected with the virus - and caused an antibody response within 28 days of the booster jab. (euronews.com)
In this study, using a live virus assay, we describe the neutralizing antibody response to the B.1.617.1 variant in serum from infected and vaccinated individuals. (biorxiv.org)
Overall, 85% of patients had either a T-cell response or an antibody response against survivin," said Locke. (medicalxpress.com)
The difficulties in stimulating a reliable antibody response has led to the attempts to develop a vaccine that stimulates a response by cytotoxic T-lymphocytes. (wikipedia.org)

Anti-receptor binding domain IgG antibodies specific to SARS-CoV-2 were detectable in 95% of patients, with "generally similar" results across vaccine type, age group, and medication class, apart from corticosteroid users, who had an 86% antibody detection rate, reported lead author Kimberly N. Weaver, MD , of the University of North Carolina at Chapel Hill, and colleagues. (medscape.com)
A Covid-19 vaccine developed and tested in Russia generated neutralizing antibodies in dozens of study subjects, and while the vaccine often caused side effects such as fever, those side effects were mostly mild, according to data published Friday in the medical journal The Lancet. (cnn.com)
In the Phase 1 and 2 studies of the vaccine, which is named Sputnik V, all 76 study participants developed antibodies to the virus that causes Covid-19, according to Friday's report in The Lancet. (cnn.com)
When Moderna released information about the interim Phase I data from its own COVID-19 vaccine, the company did provide at least some data about the number of patients that produced binding antibodies and neutralizing antibodies. (biospace.com)
This is because the vaccine can induce and stimulate both neutralizing antibodies and CD8+ T cells, which can kill the virus if it enters the cells. (news-medical.net)
A booster dose of the mRNA-1273 COVID-19 vaccine given to rhesus macaques about six months after their primary vaccine series significantly increased levels of neutralizing antibodies against all known SARS-CoV-2 variants of concern, according to a new study from National Institutes of Health scientists and colleagues. (nih.gov)
In the US study, nearly half of the patients with blood cancers-31 out of 67 patients (46%)- did not produce detectable antibodies to the SARS-CoV-2 spike protein following two doses of the Pfizer-BioNTech COVID-19 vaccine. (cancer.gov)
Another limitation was that the researchers did not determine whether antibodies from vaccine responders were able to neutralize SARS-CoV-2. (cancer.gov)
While vaccine-induced neutralizing antibody responses (that is, antibodies that directly bind the virus and "neutralize" infection) provide the primary protection against infection and severe disease, other, less well understood, multiple immune responses contribute to protection. (rtmagazine.com)
These additional immune responses which control viral replication are mediated by the so-called Fc receptor (a cell-surface molecule that recognizes the invariant part of antibodies, and can trigger the destruction of infected cells) and by T-cell responses, complementing the other antibody responses that directly neutralize the virus. (rtmagazine.com)
Antibodies that bind to a protein called platelet factor 4 may be behind rare, but dangerous, blood clots (one illustrated) that develop in some people vaccinated with AstraZeneca's or Johnson & Johnson's COVID-19 vaccines. (sciencenews.org)
Similar patterns were observed for spike protein-specific serum antibodies and T cells, but the magnitude of each of these responses was diminished relative to the control cohort. (nature.com)
For example, patients with autoimmune conditions or chronic lymphocytic leukemia treated with B cell-depleting antibodies have predictably diminished humoral responses to vaccination, whereas responses by patients on anti-TNF therapies are less affected 6 , 7 . (nature.com)
In conclusion, this study demonstrated that the AS03-adjuvanted H7N9 vaccines elicited high levels of homologous and heterologous antibodies and protected against H7N9 virus damage post-challenge. (nature.com)
Researchers found that participants who received the malaria vaccine developed antibodies against RH5 in their blood upon follow-up. (sciencedaily.com)
Both formulations of the chlamydia vaccine provoked an immune response in all participants, although the added liposomes proved more effective at producing antibodies. (zmescience.com)
Researchers found that using the Pfizer vaccine followed by AstraZeneca, or vice versa, induced high concentrations of antibodies against the spike protein of Covid-19 when doses were administered four weeks apart. (shieldsgazette.com)
The study also suggested that people who have received two doses of the AstraZeneca vaccine could have more antibodies if they were given a different jab as a booster. (shieldsgazette.com)
Administering the AstraZeneca vaccine followed by Pfizer induced higher antibodies and T cell responses than when Pfizer was followed by AstraZeneca. (shieldsgazette.com)
The company announced in April that a new version of its vaccine targeting the beta variant appeared to produce high levels of antibodies for months. (wunc.org)
One study found long-term, heavy drinkers produced fewer antibodies to the pneumococcal vaccine. (fox17online.com)
The vaccine is a self-assembling, germline-targeting HIV nanoparticle designed to prime a type of B cells that produce precursors to broadly neutralizing antibodies that target a protein on the surface of the virus. (scienceboard.net)
These results highlight the potential of this HIV-1 nanoparticle vaccine approach to induce the critical T-cell help needed for maturing antibodies toward the pathway of broadly neutralizing against HIV," McElrath said. (scienceboard.net)
McElrath called the data a first step, adding that heterologous booster vaccines will still be needed to eventually produce VRC01-class broadly neutralizing antibodies. (scienceboard.net)
Many of these tests provide quantitative detection of antibodies to the virus but further studies are needed to be able to better interpret these quantitative results in the context of vaccine response and immunity. (aacc.org)
Pre-existing antibodies due to natural exposure appeared to positively influence vaccine-induced antibody responses. (frontiersin.org)
Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. (gsk.com)
Adaptive immune responses were assessed based on receptor binding domain specific antibodies and neutralizing antibodies as well as memory B and T cells. (gsk.com)
It is thought that an HIV vaccine could either induce an immune response against HIV (active vaccination approach) or consist of preformed antibodies against HIV (passive vaccination approach). (wikipedia.org)
If blood tests show that you do not have antibodies to hepatitis A and B, you should have the hepatitis A and hepatitis B vaccines. (medlineplus.gov)

Together, these results demonstrate that an activated immune microenvironment prior to vaccination impedes efficacy of the YF-17D vaccine in an African cohort and suggest that vaccine regimens may need to be boosted in African populations to achieve efficient immunity. (nih.gov)
Although the data is positive, analysts and investors seem to think the company did not disclose enough information to be meaningful about the efficacy of the vaccine. (biospace.com)
Now, a new study published in the journal Science Immunology reports on the efficacy of a rapidly scalable, novel yeas expressed SARS-CoV-2 specific receptor-binding domain (RBD) based vaccine formulated with 3M-052-alum adjuvant. (news-medical.net)
The researchers paired Baylor's SARS-CoV-2 RBD recombinant protein formulation vaccine with IDRI's aluminum-based formulation of 3M's Toll-like receptor 7 and 8 agonist 3M-052 (3M-052/Alum) to enhance the immune response against SARS-CoV-2, increasing the vaccine's efficacy against COVID-19. (news-medical.net)
The findings provide some of the first data on the efficacy of COVID-19 vaccines in people with cancer, who were largely excluded from the initial trials testing the vaccines. (cancer.gov)
According to researchers at TIH, the specific vaccine has already established its safety and efficacy in the previous trials held in China with no serious adverse effects. (dawn.com)
According to Dr Naseem Salahuddin, the principal investigator of the research at TIH, it's a randomised placebo-controlled trial - the gold standard for evaluating the safety and efficacy of a new vaccine - which means a section of the volunteers would receive the vaccine while others an injection without the active components of the vaccine. (dawn.com)
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown high efficacy, but immunocompromised participants were excluded from controlled clinical trials. (nature.com)
Independent clinical trials demonstrated 94-95% vaccine efficacy against symptomatic disease caused by SARS-CoV-2 for both the Pfizer/BioNTech and Moderna mRNA-based vaccines 3 , 4 . (nature.com)
In addition, microscopic examination post-challenge showed animals immunized with the AS03-adjuvanted vaccines had the least signs of lung injury and inflammation, consistent with the greater relative efficacy of the adjuvanted vaccines. (nature.com)
Researchers in the United States have conducted a study showing the efficacy of the Moderna and Pfizer-BioNTech vaccines at eliciting a robust T cell response against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the agent that causes coronavirus disease 2019 (COVID-19). (news-medical.net)
To understand how complex genomic changes in these two vaccine vectors translate into antigen-specific systemic immune responses, we undertook a head-to-head vaccine immunogenicity and efficacy study in the pathogenic HIV type 1 (HIV-1) model of AIDS in Indian rhesus macaques. (nih.gov)
As noted in Part I, given the already dubious efficacy of these novel vaccines, the emerging adverse side effects weigh more heavily in the balance when assessing their utility, and thus the purported "grave necessity" justifying their use despite their "remote" origins in abortion. (lifesitenews.com)
We would like to inform you that for vaccines, as for any other medicinal product, a thorough evaluation of its quality, safety and efficacy is undertaken prior to approval. (sanevax.org)
In addition, the EMA takes very seriously its role in protecting public health by monitoring medicines already on the market, and as such, the quality, safety and efficacy of all medicines, including all vaccines, are continuously monitored. (sanevax.org)
As the B.1.617.1 variant continues to evolve, it will be important to monitor how additional mutations within the spike impact antibody resistance, viral transmission and vaccine efficacy. (biorxiv.org)
CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid ("mRNA"), and GSK today announced the publication of preclinical data investigating immune responses as well as the protective efficacy of CureVac's first-generation vaccine candidate, CVnCoV, and second-generation vaccine candidate, CV2CoV, against SARS-CoV-2 challenge in non-human primates. (gsk.com)

In the interim data in 40 healthy volunteers, 94% of the recipients demonstrated an overall immune response at Week 6 after two doses of the vaccine. (biospace.com)
Second doses of the vaccine tend to produce stronger side effects anyway, a signal that the body's immune system is activated. (fox17online.com)
McElrath and her collaborators found that recipients of two doses of the vaccine had robust polyfunctional CD4 T cells that were specific for eOD-GT8 and for a component of eOD-GT8 60-mer, lumazine synthase (LumSyn). (scienceboard.net)
39 of them had received only the first dose, while 49 of the 88 had received both doses of the vaccine. (aacc.org)

Two vaccines-Pfizer-BioNTech and Moderna-have already returned very encouraging preliminary data from their phase three trials, and now Britain's Oxford vaccine is also showing promising signs. (thedailybeast.com)
The mRNA COVID-19 vaccines (Moderna and Pfizer- for inclusion in this test-negative case-control assessment ( 1 , 3 ). (cdc.gov)
In their study, Dr. Irshad and her colleagues analyzed immune responses to the Pfizer-BioNTech COVID-19 vaccine-including antibody production, virus-neutralizing ability, and T-cell responses-in people with and without cancer. (cancer.gov)
On the basis of these data, in December 2020, both the Pfizer/BioNTech and Moderna vaccines were granted emergency use authorization by regulatory agencies in North America. (nature.com)
And the study looking at whether Oxford/AstraZeneca and Pfizer vaccine doses can be combined is to be expanded to include two additional jabs - Moderna and Novavax. (walesonline.co.uk)
SummaryThe mRNA-based BNT162b2 vaccine from Pfizer/BioNTech was the first registered COVID-19 vaccine and has been shown to be up to 95% effective in preventing SARS-CoV-2 infections. (ssrn.com)
Although the Pfizer-BioNTech and Moderna vaccines have proved highly effective at protecting against SARS-CoV-2 infection, concerns have arisen regarding the extent to which they can protect against the new variants that are now quickly spreading across the globe. (news-medical.net)
Three of the participants had received the Moderna mRNA-1273 vaccine, and the remaining five had received the Pfizer-BioNTech BNT162b2 vaccine. (news-medical.net)
People who have been vaccinated against Covid-19 with the AstraZeneca vaccine could have a stronger immune response if they are given the Pfizer jab as a booster, research suggests. (shieldsgazette.com)
An AstraZeneca jab followed by a Pfizer jab generated a stronger immune response than two doses of the AstraZeneca vaccine alone. (shieldsgazette.com)
Professor Matthew Snape, associate professor in paediatrics and vaccinology at the University of Oxford, and chief investigator on the trial, said: "The Com-COV study has evaluated 'mix and match' combinations of the Oxford and Pfizer vaccines to see to what extent these vaccines can be used interchangeably, potentially allowing flexibility in the UK and global vaccine rollout. (shieldsgazette.com)
From our study you have to be thinking that if you received AZ/AZ (Oxford), then maybe there would be advantages in getting an RNA vaccine next (Pfizer or Moderna). (shieldsgazette.com)
Pfizer and BioNTech are also testing a version of their vaccine that targets the omicron variant. (wunc.org)
NEW YORK & MAINZ, Germany--(BUSINESS WIRE)-- Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced positive data evaluating the safety, tolerability, and immunogenicity of two Omicron-adapted COVID-19 vaccine candidates: one monovalent and the other bivalent, a combination of the Pfizer-BioNTech COVID-19 Vaccine and a vaccine candidate targeting the spike protein of the Omicron BA.1 variant of concern. (pfizer.com)
And so, in terms of this study cohort, there were 10 patients, 5 of them had received 2 doses of the Pfizer vaccine and then 5 had received 2 doses of the Moderna vaccine. (aacc.org)
Late-stage trial results will show if the Astra-Oxford vaccine can meet the standard set by front-runners Pfizer-BioNTech and Moderna. (euronews.com)

Patients with IBD on immunosuppressive medications have the potential for attenuated response to the SARS-CoV-2 vaccination," Weaver said at the annual meeting of the American College of Gastroenterology. (medscape.com)
one demonstrated blunted antibody responses in IBD patients taking infliximab , while the other showed that full vaccination was less effective at preventing SARS-CoV-2 infection among patients with IBD than nonimmunosuppressed individuals. (medscape.com)
To better characterize antibody responses after receiving an mRNA vaccination series, Weaver and colleagues launched the PREVENT-COVID trial, including the present dataset of 787 patients with IBD older than 12 years, all of whom provided serum samples 8 weeks after completing an mRNA vaccine series. (medscape.com)
We measured the CD8+ T cell and B cell responses induced by YF-17D and correlated them with immune parameters analyzed by flow cytometry prior to vaccination. (nih.gov)
Additionally, memory T and B cell responses in preimmunized volunteers exhibited reduced persistence in the Entebbe cohort but were boosted by a second vaccination. (nih.gov)
Although the total number of persons who received vaccine from recalled lots of Fluogen{Registered} represent only 5%-7% of all persons nationwide who received a 1996-97 influenza vaccination, most doses of vaccine have been administered before the influenza season (October-mid-November), and all remaining supplies of 1996-97 vaccine are limited. (cdc.gov)
Their results support vaccine boosting in the elderly, people with pre-existing health conditions, those at high-risk exposure, and those who responded poorly to primary vaccination. (nih.gov)
Until more studies looking specifically at COVID-19 vaccines in patients with cancer are available, it is important for patients with cancer to continue to observe all public health measures in place, even after vaccination," Dr. Irshad said. (cancer.gov)
The research, into whether different coronavirus vaccines can be safely mixed for the first and second doses, aims to provide "flexibility" and "resilience" to the UK's vaccination programme, the trial's chief investigator has said. (walesonline.co.uk)
On the so-called mix-and-match trials - where people are being given doses of two separate jabs - Professor Anthony Harnden, deputy chairman of the Joint Committee on Vaccination and Immunisation (JCVI), said: "If we can mix and match, we'll get much better flexibility - we will be able to potentially use different vaccine booster campaigns in the autumn. (walesonline.co.uk)
After more available data on phase 3 clinical trials of candidate vaccines ( 7 ) became available and the vaccine was authorized for emergency use, the COVID-19 vaccination program in Hong Kong began in late February 2021. (cdc.gov)
In addition to psychobehavioral responses, unique to COVID-19 is its unprecedented massive epidemic size compared with other recent outbreaks, such that vaccination becomes the exit strategy. (cdc.gov)
But did you know that the same mechanisms involved during an effective immune response are also triggered following vaccination to generate immunity? (dsm.com)
The data in the phase 1b trial reported here confirm, for the first time, that substantial anti-RH5 immune responses can be achieved safely by vaccination in infants from a malaria-endemic area," say the authors. (sciencedaily.com)
Participants in both the control and treatment group reported pain at the injection site and a mild fever shortly after vaccination, but overall the vaccine was well tolerated and there were no safety concerns. (sciencedaily.com)
The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination, while fungi-induced cytokine responses were stronger. (ssrn.com)
We find a reassuringly unaltered T cell response against the variants, and a striking impact of prior infection on qualitative features of T cells elicited by vaccination," writes the team. (news-medical.net)
Here, a vial of the company's COVID-19 vaccine sits on a table at a vaccination clinic in San Rafael, California. (wunc.org)
At some level, vaccination is a way of presenting a fake pathogen to the body to stimulate an immune response. (fox17online.com)
One group in the UK recommends people avoid alcohol two days before vaccination and up to two weeks after to ensure the maximum immune response. (fox17online.com)
This was shown in Part I by the example of Chile, a world leader in vaccination rates, which has experienced a post-vaccination "surge" in positive PCR test results misleadingly denominated "cases" of COVID, showing that viral transmission and the development of herd immunity are proceeding despite the vaccine campaign. (lifesitenews.com)
Collectively, the findings show that the vaccine acts on the immune system in a way that may improve human immune responses, either to heterologous boost immunogens after the prime vaccination, or to other human vaccine immunogens. (scienceboard.net)
Having such symptoms after vaccination is associated with greater antibody responses compared with having only pain or rash at the injection site or no symptoms at all, suggests the paper published Friday in the journal JAMA Network Open . (ktvz.com)
However, questions still remain about the longevity and variability of antibody responses to vaccination in different individuals. (aacc.org)
The majority of the elderly subjects seroconverted for seasonal influenza upon vaccination, and importantly, influenza vaccination-induced humoral immune responses and seroprotection were similar across the frailty strata, indicating that frail individuals may also benefit from influenza vaccination. (frontiersin.org)
Ongoing actions are being undertaken for the implementation of initial response and containment measures in West and North Darfur, including case management, alert investigation, response vaccination campaigns and community health awareness. (who.int)
If you have not received a vaccine for hepatitis A or B or have not had these forms of hepatitis, you may need vaccination for them. (medlineplus.gov)

In the team's earlier field work in children in Ghana and Pakistan, they found that infants with good immunity to the rotavirus vaccine had specific bacteria in their intestine. (sciencedaily.com)
These data suggest that boosting triggers a strong immune memory response and potentially longer lasting immunity. (nih.gov)
These data provide critical insights in the context of the current pandemic, where emerging variants of concern have the capability of breaking through vaccine-mediated protection, but vaccine-induced immunity still elicits a response against several variants and provides some level of protection against severe disease and death. (rtmagazine.com)
Although these results add to the evidence for immunogenicity and safety of the Ad26-MVA regimen and the rVSVΔG-ZEBOVGP vaccine in adults and children, "there is no universally agreed-on correlate of protective immunity to EVD, and in this trial we were unable to assess protection from disease given that there were no incident cases of EVD," the team wrote. (medpagetoday.com)
The findings are encouraging as they show the vaccine is safe and produces the type of immune response that could potentially protect against chlamydia," said Professor Robin Shattock , Head of Mucosal Infection and Immunity within the Department of Infectious Disease at Imperial. (zmescience.com)
It is also not clear how booster doses and prior infection might influence the vaccine-elicited immunity. (news-medical.net)
However, "how this translates in the context of vaccine-elicited T cell immunity is not clear," says Roan and colleagues. (news-medical.net)
This suggests that protective immunity by the mRNA vaccines tested here are likely retained against the B.1.617.1 variant. (biorxiv.org)

The researchers initiated the study to see if they could corroborate that the microbiome is related to vaccine performance. (sciencedaily.com)
While the results from this study are limited since rotavirus is a childhood disease and the microbiome of infants and children is different in adults, the researchers are buoyed that their microbiome/vaccine response theory deserves further study. (sciencedaily.com)
Instead, the researchers view these results as a starting point with great potential for altering the microbiome to improve vaccine performance and ultimately better protect children in low-income settings from rotavirus, which continues to be a life-threatening disease. (sciencedaily.com)
The researchers also looked at responses from T cells, another component of the immune system. (cnn.com)
Outcomes from] the trial also suggest the vaccines also produce a T cell response within 28 days," the researchers wrote. (cnn.com)
The researchers from Yerkes National Primate Research Center at Emory University, Infectious Disease Research Institute (IDRI), 3M and Texas Children's Hospital's Center for Vaccine Development at Baylor College of Medicine were the first to show combining yeast-expression technology and a new adjuvant formulation to produce a COVID-19 vaccine candidate. (news-medical.net)
Together, these data show that a yeast expressed, RBD-based vaccine+3M-052-alum provides robust immune responses and protection against SARS-CoV-2, making it a strong and scalable vaccine candidate,' the researchers noted in the study. (news-medical.net)
The researchers also determined that both the mRNA-1273 vaccine developed to target the original SARS-CoV-2 virus and a slightly modified version of the vaccine targeting the Beta variant, were equivalent in their ability to boost antibody responses and protect. (nih.gov)
The researchers focused on the Beta variant because it has consistently shown the greatest ability to resist neutralization - by likely reducing vaccine effectiveness - according to the researchers. (nih.gov)
The researchers concluded that the 31 patients were "nonresponders" to the vaccine. (cancer.gov)
Those with B-cell chronic lymphocytic leukemia were the least likely to respond to the vaccine, the researchers found. (cancer.gov)
To better understand the protective role of each immune response mechanism, the researchers immunized five groups of five rhesus macaques with different doses of COVID-19 vaccine or a sham control. (rtmagazine.com)
The researchers found that the immune responses responsible for controlling viral replication following infection were dose dependent, indicating an important role in protection against severe illness and death. (rtmagazine.com)
The vaccine, the researchers say, may cause minor side effects such as pain at injection site and fever, which are common to other vaccines and that it cannot cause Covid-19 infection as it doesn't contain the live virus. (dawn.com)
The researchers used the PREVAC protocol, which compared the three vaccine regimens with placebo in adults and children separately. (medpagetoday.com)
However, in the results of the early-stage phase Ib trial, researchers find that targeting RH5 -- a protein that the malaria pathogen Plasmodium falciparum uses to invade red blood cells -- can generate a promising immune response that is most pronounced in an infant cohort. (sciencedaily.com)
However, in the results of the early-stage phase Ib trial conducted in Tanzania and published on August 11th in the journal Med , researchers find that targeting RH5 -- a protein that the malaria pathogen Plasmodium falciparum uses to invade red blood cells -- can generate a promising immune response that is most pronounced in an infant cohort. (sciencedaily.com)
For years, researchers have been chasing a vaccine for chlamydia in order to break the chain of reinfection -- a vaccine that might not be that far away. (zmescience.com)
According to recent findings reported by researchers at Imperial College London and the Statens Serum Institut in Copenhagen, a vaccine designed for preventing genital chlamydia provoked an immune response. (zmescience.com)
In the experiments, conducted in mice, the researchers used a typical vaccine regimen, priming the immune system with an experimental AAV vaccine against HIV and following it with a booster immunization using an HIV vaccine construct incorporating another viral vector called adenovirus, or Ad. (health.am)
In 2021, researchers reported that 97% of recipients of the vaccine had the hoped-for VRC01-class B cell response, leading to a collaboration with Moderna to develop a candidate based on its mRNA vaccine technology. (scienceboard.net)
CD4 T-cell help will be needed to develop the high-affinity neutralizing antibody responses that the researchers aim to induce to protect against HIV. (scienceboard.net)
In conclusion, these findings support reframing postvaccination symptoms as signals of vaccine effectiveness and reinforce guidelines for vaccine boosters in older adults," the researchers - from Columbia University in New York, University of Vermont and Boston University - wrote in their paper. (ktvz.com)
The researchers found that after either vaccine dose, 446 or 48% of participants reported systemic symptoms while 12% reported only local symptoms and 40% reported no symptoms at all. (ktvz.com)
To produce the vaccine, the researchers engineered the patients' own dendritic cells to express survivin and induce an immune response against the protein. (medicalxpress.com)

The residents were given the BNT162b2 mRNA vaccine between December 2020 and February 2021 at 4 nursing homes and were vaccinated at the same time as HCWs. (ajmc.com)
In this study, we compared immune responses to the BNT162b2 mRNA Coronavirus Disease 2019 vaccine in patients with solid tumors ( n = 53) who were on active cytotoxic anti-cancer therapy to a control cohort of participants without cancer ( n = 50). (nature.com)
Interestingly, however, the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. (ssrn.com)
In conclusion, the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines. (ssrn.com)

Professor Andrew Pollard, study lead from the University of Oxford, said he was "absolutely delighted" with the results and predicted they will be able to confirm whether or not the vaccine prevents people from getting COVID-19 within weeks. (thedailybeast.com)

2021. Among 234 U.S. veterans fully vaccinated with an vaccine were excluded from the analysis. (cdc.gov)
INO-4800 is one of the experimental vaccines included in the U.S. government's Operation Warp Speed that has a goal of having a vaccine available by January 2021. (biospace.com)

The COVID vaccine induces multiple immune responses in the body, including antibody responses and control of viral replication. (rtmagazine.com)
The phase 2 trial, which involved 560 adults including 240 over the age of 70, found that the vaccine causes few side effects and induces immune responses in both parts of the immune system in all age groups. (euronews.com)

In a proof-of-concept study in healthy adult men, scientists in the Netherlands found that microbiome manipulation with antibiotics influenced response to oral rotavirus vaccine. (sciencedaily.com)
The rotavirus vaccine is currently recommended for the general population, and according to some data, it appears to reduce the risk for the development of CD autoimmunity in the early years of life. (mdpi.com)
Discoveries at Wistar led to the creation of the rubella vaccine that eradicated the disease in the United States, human rabies vaccines used worldwide, and a new rotavirus vaccine approved in 2006. (health.am)

The scientists write that in people, an mRNA-1273 booster vaccine may improve the duration and potency of protection against upper and lower airway infection by any of the circulating SARS-CoV-2 variants, including Delta. (nih.gov)
Doctors have generally recommended that their patients with cancer receive vaccines to protect against infection with SARS-CoV-2, the virus that causes COVID-19. (cancer.gov)
A recent study found that a latent cytomegalovirus infection can have a negative effect on mRNA vaccine responsiveness to COVID-19 infection. (ajmc.com)
Health care workers (HCWs) had a lower vaccine response to COVID-19 infection when they had a latent cytomegalovirus (CMV) infection, according to a study published in Open Forum Infectious Diseases . (ajmc.com)
Residents of nursing homes were also found to have lower vaccine response with a latent CMV infection. (ajmc.com)
This study aimed to determine whether latent CMV or Epstein-Barr virus (EBV) affected vaccine antibody responses and whether there was an association with age or prior COVID-19 infection. (ajmc.com)
Given that both anti-sporozoite and blood-stage malaria vaccine strategies necessitate very high levels of antibody to protect against parasite infection, current efforts remain focused on infants and young children. (sciencedaily.com)
The team - from Gladstone Institute of Virology in San Francisco and the University of California - also provided evidence that individuals who receive one vaccine dose after having recovered from SARS-CoV-2 infection may not require a second dose. (news-medical.net)
Furthermore, studies of the antibody and B cell response to infection suggest that for COVID-19 convalescents, one dose of an mRNA vaccine is beneficial, but that a second booster jab is not necessary. (news-medical.net)
So I think it's theoretically plausible that alcohol could impair, ultimately, your ability to respond to the vaccine, or to any other infection for that matter. (fox17online.com)
Follow-up assays of the immune response showed that, in all cases, HIV-specific T cells induced by the AAV-vector only poorly protected from infection in a challenge model, failed to secrete adequate levels of important immune-system activating chemicals called cytokines, and most importantly were severely impaired in their ability to proliferate upon re-encounter with their antigen. (health.am)
Remarkably, vector-induced differences in CD4(+)/CD8(+) T-cell immune responses persisted for more than a year after challenge and even accompanied antigenic modulation throughout the control of chronic infection. (nih.gov)
Rushing to stamp out the fire of vaccine dissent, the left-leaning Politifact labelled Risch's statement "Pants on Fire" based on the CDC's report of only 7,157 "breakthrough cases" of infection among "87 million fully vaccinated people. (lifesitenews.com)
Therefore, elderly individuals above 65 years of age are considered to be at a greater risk of influenza infection and its complications, and it is hence recommended that they receive an annual administration of seasonal influenza vaccine ( 3 ). (frontiersin.org)
Objectives: To evaluate the impact of latent EBV and CMV infection on rubella- and measles-specific antibody responses as well as on the B-cell compartment in a prospective birth cohort followed during the first 10 years of life. (lu.se)
It is important to develop a broad-spectrum vaccine with conserved antigens to prevent variant infection . (bvsalud.org)

Additional data are forthcoming on a larger subset of participants in the PREVENT-COVID study which will allow for analysis of factors associated with humoral immune response and potential optimization of immunization strategies. (medscape.com)
At 1 week after a third immunization, 16 participants demonstrated a median threefold increase in neutralizing antibody responses, but no improvement was observed in T cell responses. (nature.com)
Notably, organ transplant recipients mount very poor antibody responses to the first mRNA immunization relative to healthy individuals 10 , which increase somewhat after the second immunization 8 . (nature.com)
Similarly, in patients with cancer with solid or hematological malignancies, antibody responses are markedly diminished after the first immunization but improve somewhat after the second 9 . (nature.com)
Serological analyses demonstrated that homologous hemagglutination inhibition and microneutralization antibody titers were detectable in the ferrets after the first immunization with the AS03-adjuvanted vaccines that were further boosted by the second immunization. (nature.com)
This system fully integrates the vaccine supply chain from purchasing and ordering to more than 64 participating state, local, and territorial health departments (referred to as "immunization awardees"), more than 44,000 health care providers, six vaccine manufacturers, and a centralized CDC distributor. (maximus.com)
Since the onset of the outbreak, enormous efforts have been undertaken to control the outbreak, including conducting response immunization campaigns. (who.int)
Between 19 and 23 January, Gedarif and Kassala states of Sudan (where the outbreak first started) conducted a response measles immunization campaign in 11 localities targeting children from 6 months to 15 years. (who.int)

No differences were found in antibody levels between the three treatment arms except a slight increase in early vaccine boosting in the narrow-spectrum arm, but higher viral shedding was noted in the antibiotic-treated groups compared with the control arm. (sciencedaily.com)
Supporting the immune system with optimal nutrition is one important way to facilitate a healthy immune response and reduce the risk and impact of viral infections. (dsm.com)
Recently, however, evidence has emerged that some of these so-called viral vector systems may undermine the immune system and should not be used for vaccine development. (health.am)
Now, a new study from scientists at The Wistar Institute provides strong support for the idea that some viral-vector vaccines may cause more harm than good. (health.am)
a) HPV vaccine (Gardasil) has been shown to contain viral DNA impurities that have been related to fatal adverse events (SAEs, Refs. (sanevax.org)
Vaccines may contain residual amounts of viral or cellular DNA fragments (depending on the manufacturing process) that originate from the processes used for their manufacture and this is not considered a contaminant but a residual substance. (sanevax.org)
During the evaluation of the manufacturing process for any medicinal product, including vaccines, the possibility of impurities and endogenous viral contaminants is always investigated. (sanevax.org)

Most patients with inflammatory bowel disease (IBD) develop a humoral immune response after completing an mRNA SARS-CoV-2 vaccine series, according to data from almost 800 patients. (medscape.com)
We are very encouraged by the positive interim safety and preliminary cellular and humoral immune response results to date as well as the inclusion of INO-4800 in Operation Warp Speed. (biospace.com)
A conserved N protein nano-vaccine of COVID-19 exerts potent and cross-reactive humoral and cellular immune responses in mice. (bvsalud.org)

Little is known about the broad effects of the new class of mRNA vaccines, especially whether they have combined effects on innate and adaptive immune responses. (ssrn.com)
Within two hours, the authors detected a drop in the number of circulating monocytes, a type of white blood cell that plays a role in both the innate and adaptive immune responses. (fox17online.com)

The formulation induced a robust immune response and protection against SARS-CoV-2 in rhesus macaques. (news-medical.net)
By testing the vaccine on rhesus macaques, the team found that the 3M-052/Alum formulation induced a significant and robust overall immune response than alum alone. (news-medical.net)

His team is also studying COVID-19 vaccine responses in people with HIV/AIDS, autoimmune conditions, and transplant recipients. (cancer.gov)

Moderna says its new bivalent vaccine is its "lead candidate for a Fall 2022 booster. (wunc.org)
The "bivalent" vaccine - meaning it targets two different antigens - is Moderna's leading candidate to have an effective booster ready for fall of 2022, the company said. (wunc.org)

When in the context of a global pandemic, this could simplify some of the supply chain logistics of delivering a vaccine to hundreds of millions, potentially billions of people around the world. (biospace.com)
Although non-pharmaceutical public health interventions have managed to control outbreaks in some countries, most of the global population will depend upon vaccines to mitigate the pandemic. (nature.com)
To access temporal changes in psychobehavioral responses to the coronavirus disease (COVID-19) pandemic, we conducted a 5-round (R1-R5) longitudinal population-based online survey in Hong Kong during January-September 2020. (cdc.gov)
Human infections with avian H7N9 subtype influenza viruses are a major public health concern and vaccines against H7N9 are urgently needed for pandemic preparedness. (nature.com)
A yearly booster shot would bring new relief to the public and to a health care system that's been stressed by the pandemic, including the need to administer millions of vaccine doses, followed by booster shots. (wunc.org)
Wistar Institute Vaccine Center scientists are creating new vaccines against pandemic influenza, HIV, and other diseases threatening global health. (health.am)
Those in vaccine-aware organizations have stopped pandemic agendas before and if we all take this threat seriously, we can do it again. (blogs.com)
The COVID-19 pandemic required the CDC to rapidly address its ability to provide access to its vaccine ordering system. (maximus.com)
Human papillomavirus (HPV) vaccine programmes, aimed at preventing cervical cancer, are often implemented within schools which in many countries are now closed because of the pandemic. (gavi.org)
In light of the protracted nature of the COVID-19 pandemic, countries may wish to conduct periodic reviews during the event so they can continue to reflect on the ongoing response and revise national and subnational response strategies and plans as needed. (who.int)

With the ongoing global COVID-19 vaccine rollout, ensuring a robust vaccine response is critical to protecting populations worldwide. (dsm.com)
And it's not going to give you the nice, robust response to that vaccine. (fox17online.com)
But even though some people may have small, localized side effects or no symptoms at all, the vaccine still elicits robust immune responses in them too. (ktvz.com)
Following this, the N- Ferritin elicited more robust and long-lasting antibody responses , which had better cross-reactivity with the SARS-CoV N protein . (bvsalud.org)

Since the COVID-19 outbreak first began in late December 2019, intense efforts to develop and clinically test vaccines against SARS-CoV-2 quickly resulted in the emergency use authorization of several mRNA-based vaccines. (news-medical.net)

The team believes that the vaccine containing a recombinant RBD protein with its novel 3M-052 adjuvant formulation may be potent against SARS-CoV-2, including the newly emerging variants. (news-medical.net)
News of Moderna's bivalent vaccine comes as even more contagious omicron variants are taking over in the U.S. (wunc.org)
The recent emergence of SARS-CoV-2 variants that are less sensitive to neutralization by convalescent sera or vaccine-induced neutralizing antibody responses has raised concerns. (biorxiv.org)
The current study shows that the immune responses and resulting protection produced by our second-generation candidate, based on our mRNA technology featuring targeted optimizations, are substantially improved in non-human primates against both, the original SARS-CoV-2 virus as well as the Beta and Delta Variants of Concern and the Lambda Variant of Interest. (gsk.com)
The optimised mRNA backbone that is being used in this collaboration also has the potential for a multivalent or combination approach to address multiple emerging variants in one vaccine. (gsk.com)
The conserved N-based nanoparticles could provide a promising vaccine developing strategy against SARS-CoV-2 variants and other coronaviruses . (bvsalud.org)

The results show that when given at a four-week interval both mixed schedules induce an immune response that is above the threshold set by the standard schedule of the Oxford/AstraZeneca vaccine. (shieldsgazette.com)
Therefore, we hypothesized that by targeting this protein, we could induce an immune response in patients who have the most aggressive disease and potentially keep them in remission for a longer period of time. (medicalxpress.com)

Three vaccine regimens for Zaire Ebola virus disease (EVD) produced antibody responses in adults and children, according to the results of two randomized trials conducted in West Africa. (medpagetoday.com)
Immune responses were elicited by 14 days after injection for these vaccine regimens and were maintained for 12 months," the authors wrote in the New England Journal of Medicine . (medpagetoday.com)
Two active vaccine regimens, studied in the RV 144 and Imbokodo trials, showed they can prevent HIV in some individuals. (wikipedia.org)

If that is so, which we believe it is, then one could potentially use the microbiome to improve vaccine performance," says Harris, whose research has focused on the potential correlation between the microbiome and oral vaccine performance. (sciencedaily.com)
If an anti-sporozoite and an anti-RH5 vaccine were used in combination in the future, individuals could potentially experience more effective protection against malaria for a longer period of time. (sciencedaily.com)
Put simply, they mean that AAV vaccines against HIV may potentially cause harm and that, without additional pre-clinical studies, they should not be used in humans. (health.am)
They were restarted again after the company had investigated whether a vaccine recipient's "potentially unexplained" illness was a result of receiving the jab. (euronews.com)
Dendritic cell vaccines have the potential to harness the patients ' own immune system to get them into remission and potentially keep the cancer from coming back. (medicalxpress.com)

She described a dataset of about 500 IBD patients in which booster vaccines overcame poor antibody responses to the initial vaccine series. (medscape.com)

COVID-19 vaccines might not stimulate effective immune responses in people with cancer, particularly those with blood cancers, according to several new studies. (cancer.gov)
Two of the studies found that COVID-19 vaccines might not stimulate effective immune responses in some people with blood cancers. (cancer.gov)
Just as it impacts immune function, nutritional status can influence vaccine effectiveness too, because vaccines stimulate the immune system in the same way that infections do. (dsm.com)
They take up foreign proteins, break them down, and present the fragments (peptides) to other immune cells to stimulate an immune response, Locke explained. (medicalxpress.com)

63 participants aged 6 months to 35 years were enrolled and randomized to receive either the experimental malaria vaccine, called "ChAd63-MVA RH5," or a control rabies vaccine. (sciencedaily.com)
Title : Cortisone and ACTH impairment of response to rabies vaccine Personal Author(s) : Burns, Kenneth F.;Shelton, Dorothy Fresenius;Lukeman, John M.;Grogan, Earl W. (cdc.gov)

Part I notes that not even the government or the pharmaceutical industry claims COVID vaccines will prevent community spread of the virus, as opposed to merely reducing individual symptoms. (lifesitenews.com)
On that score, since Part I appeared the Vaccine Adverse Event Reporting System (VAERS) has recorded (as of April 23) 86,080 adverse events following COVID vaccines, including 3,544 deaths and 12,619 serious injuries. (lifesitenews.com)
In a briefing Monday, the Biden Coronavirus Response Coordinator Jeffrey Zients announced that "it's time to impose some requirements" where COVID vaccines are concerned. (davidicke.com)

This study aimed to evaluate the contribution of the patient-specific immune microenvironment to the response to the licensed yellow fever vaccine 17D (YF-17D) in an African cohort. (nih.gov)
The impaired vaccine response in the Entebbe cohort associated with reduced YF-17D replication. (nih.gov)
In the vaccine cohort, 84% and 93% of participants had antigen-specific CD4 T helper responses to eOD-GT8 and LumSyn, respectively. (scienceboard.net)

This is the second bivalent vaccine Moderna has lauded as a success. (wunc.org)

One of the selling points of Inovio's vaccine, should it make it to the market as an approved vaccine or under an Emergency Use Authorization, is that it can be shipped and stored at room temperature. (biospace.com)
Moderna also announced that it has initiated submission for emergency use authorization of its COVID-19 vaccine in children ages 6 to 11 years old. (axios.com)

Prof Snape also said a pause in the rollout of the Johnson & Johnson vaccine to Europe emphasises the need for research. (walesonline.co.uk)

To understand how vaccine effectiveness (VE) might change health records. (cdc.gov)
The test-negative study design is commonly used to assess vaccine effectiveness in observational studies. (cdc.gov)
There are no published studies on whether alcohol decreases the effectiveness or intensifies the side effects of the COVID-19 vaccines. (fox17online.com)
Studies on alcohol and the effectiveness of other vaccines offer mixed results . (fox17online.com)
These results demonstrate the effectiveness of this novel and relatively simple means of generating carbohydrate-based vaccines. (rsc.org)

There's some suggestions from animal studies in mice that actually you may get a better immune response if you, for example, combine the AstraZeneca-type vaccines with an RNA-type vaccine, and that actually seems to generate in some aspects a better immune response. (walesonline.co.uk)
Prof Snape added: "These results are an invaluable guide to the use of mixed dose schedules, however the interval of four weeks studied here is shorter than the eight to 12-week schedule most commonly used for the Oxford/AstraZeneca vaccine. (shieldsgazette.com)
The university confirmed that the candidate vaccine it is developing with AstraZeneca showed similar safety and immunogenicity results in healthy older people (aged 56 and over) to those seen in adults aged 18-55 years. (euronews.com)

A WHO proposal to allocate US$ 3.9 million for response activities has been approved by the Measles and Rubella Initiative. (who.int)
Other challenges include: vulnerabilities in insecure and hard-to-reach areas, ensuring a high quality implementation of the campaign and response intervention and limited vaccine availability - the country measles vaccine reserve after the distribution for routine activities is about 500 000 doses. (who.int)
Methods: IgG titers against rubella and measles vaccines were measured in plasma obtained from the same donors at 2, 5, and. (lu.se)

To increase the number of survivin peptides presented to the immune system, and therefore the likelihood of triggering a survivin-specific response, Locke and team engineered the dendritic cells to express a version of the entire protein, with a mutation to increase safety without compromising immunogenicity. (medicalxpress.com)

In addition to the ongoing responses to the previously graded emergencies, WHO had 21 new graded emergencies in the period from 1 January to 31 December 2019. (who.int)

Robert A. Seder, M.D., chief of NIAID's Cellular Immunology Section in the Vaccine Research Center, is available to discuss this study. (nih.gov)
In DSM's latest webinar - 'Laying the nutritional foundation for optimal immune and vaccine responses' - we were joined by renowned immunology expert, Prof. Philip Calder, as well as DSM's Dr. Jim Richards and Dr. Geetika Saraswat, to explore why nutrition is key for an optimal vaccine response and the important role that dietary supplements may play in addressing nutrient gaps. (dsm.com)

Yeast expression is widely available for hepatitis B vaccines in low and middle-income countries and this shows the advantage for the fast development and manufacture of yeast-based SARS-CoV-2 vaccines. (news-medical.net)

Russia drew criticism when it announced the world's first approved coronavirus vaccine for public use in August - even before crucial Phase 3 trials had been completed. (cnn.com)
Scientists not involved in the study said that, while the results are a positive sign, only larger, Phase 3 trials can confirm whether the vaccine actually prevents illness with Covid-19. (cnn.com)
The vaccine was registered in Russia in August, before it had gone through large-scale trials. (cnn.com)
Our study supports the testing of an RBD-based immunogen adjuvanted with 3M-052-alum in human trials might offer as a cost-effective, scalable and thermostable SARS-CoV-2 vaccine,' the team concluded in the study. (news-medical.net)
The findings confirm what we have suspected all along, which is that immunocompromised people aren't going to have the same immune responses to COVID-19 vaccines as people in the initial clinical trials testing these vaccines," said study leader Ghady Haidar, M.D., of the University of Pittsburgh School of Medicine. (cancer.gov)
The next step is to take the vaccine forward to further trials, but until that's done, we won't know whether it is truly protective or not. (zmescience.com)
Phase 2 trials of Oxford University's COVID-19 vaccine in healthy older adults have found it is safe and provokes an immune response. (euronews.com)
Trials for the Astra-Oxford vaccine candidate were paused in September after a participant fell ill. (euronews.com)
Some vaccines based on the virus envelope have protected chimpanzees or macaques from homologous virus challenge, but in clinical trials, humans who were immunised with similar constructs became infected after later exposure to HIV-1. (wikipedia.org)

Hence, the S protein is the lead target for vaccine development. (news-medical.net)
Studies suggest that some inoculated people develop an immune response that attacks a protein called platelet factor 4 or PF4, which makes platelets form clots. (sciencenews.org)
Immune response to the mRNA vaccine was measured with immunoglobulin G (IgG) to spike protein and the anti-receptor binding domain (RBD). (ajmc.com)
He responded: "Ultimately, they are all actually generating an immune response against the spike protein and it's being delivered by different platforms. (walesonline.co.uk)
We have developed a simple, liposome-based approach to generate multivalent carbohydrate vaccines, and in place of an antigenic peptide or protein, we have used a potent antigen for natural killer T cells. (rsc.org)
The vaccine candidate, presently at a preclinical development stage, is a non-chemically modified mRNA, encoding the prefusion stabilized full-length spike protein of the SARS-CoV-2 virus, and formulated within Lipid Nanoparticles (LNPs). (gsk.com)
Locke and colleagues designed a dendritic cell vaccine targeting a protein called survivin and tested this vaccine in a phase I clinical trial involving 13 patients with multiple myeloma. (medicalxpress.com)
Anticytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a humanized antibody that overcomes CTLA-4-mediated T-cell suppression to enhance the immune response against tumors. (medscape.com)
Here we fused the SARS-CoV-2 N protein with Helicobacter pylori nonheme ferritin to construct a SARS-CoV-2 N- Ferritin nanoparticle vaccine . (bvsalud.org)

If you could introduce a protective vaccine, you could break that cycle. (zmescience.com)

A multivariable least squares linear regression model was used to measure the differences in antibody responses between the CMV- and CMV+ participants. (ajmc.com)
They noted that the peak proportion of participants with a response was observed at 3 months (28 days after the receipt of the second dose) in the Ad26-MVA group among both adults and children, at day 28 in the rVSV group for both, and at day 63 among adults and at 3 months among children in the rVSV-booster group. (medpagetoday.com)
The trial was also double-blinded, meaning that neither the participants nor the vaccine administrators knew who received the malaria vaccine or the control. (sciencedaily.com)
All participants were given the second dose of vaccine two months later and followed for four months after this. (sciencedaily.com)
We were quite impressed that this vaccine candidate produced such a vigorous T-cell response in almost all trial participants who received the vaccine. (scienceboard.net)

For the group of residents that received recalled vaccine, both geometric mean antibody titers and the percentage of residents with titers greater than or equal to 1:40 against the A/Nanchang/933/95(H3N2) vaccine component were significantly lower than for the group of residents that received vaccine from a different manufacturer ( Table 1 ). (cdc.gov)
For both groups of residents, antibody titers were similar for the B/Harbin/07/94 and A/Texas/36/91(H1N1) vaccine components. (cdc.gov)
In addition, heterologous antibody titers against older H7 subtype viruses of the North American lineage (H7N7, H7N3) and newer H7 subtype viruses of the Eurasian lineage (H7N9) were detected in the animals receiving the AS03-adjuvanted vaccines. (nature.com)

Unraveling the reasons behind vaccine hesitancy and monitoring its trends over time will support the design of interventions to boost COVID-19 vaccine uptake. (cdc.gov)

No statistically significant differences were observed between the frailty groups in vaccine-induced modulation of leukocyte populations, cytokine responses, and gene expression profiles of peripheral blood mononuclear cells (PBMCs). (frontiersin.org)

protection against COVID-19-associated hospitalization in Data on demographic characteristics, clinical history, and real-world settings, including by vaccine product, are limited. (cdc.gov)
Biotech company Inovio released positive interim data from its Phase I clinical trial of INO-4800, its experimental vaccine against COVID-19. (biospace.com)
Inovio expects to begin a Phase II/III clinical trial of the vaccine this summer, pending approval from the U.S. Food and Drug Administration (FDA). (biospace.com)
While the pathophysiologic profile of SARS-CoV-2 is not completely understood, research and clinical studies suggest that both T-cell and antibody immune responses will be important for protection in both mild and serious infections," said Kate Broderick, senior vice president of R&D at Inovio. (biospace.com)
Patients with blood-related cancers often have dysfunctional immune systems , and as a result they're just not able to respond as well to the COVID-19 vaccine as other people," said Elad Sharon, M.D., M.P.H., a senior investigator at NCI, who was not involved in the new studies but is leading a clinical trial testing COVID-19 vaccines in people being treated for cancer . (cancer.gov)
KARACHI: The Indus Hospital (TIH) - one of the five sites in Pakistan selected for the multi-country phase-III clinical trial of a potential Covid-19 vaccine - has seen a positive public response to the recent low-key launch of the trial, raising the hope that the effort would meet its target. (dawn.com)
May 26, 2023 -- An HIV nanoparticle vaccine has induced strong T-cell responses in a first-in-human clinical trial, marking a step toward the development of a product that protects against the virus. (scienceboard.net)
The clinical significance of the published data referred to in the question has not been addressed in the response. (sanevax.org)
The strong immune response and protection in pre-clinical testing of this second-generation mRNA backbone are very encouraging and represent an important milestone for its further development. (gsk.com)
A dendritic cell vaccine administered before and after autologous stem cell transplant (ASCT) was safe and immunogenic and was associated with durable clinical responses in patients with high-risk multiple myeloma, according to research published in Clinical Cancer Research . (medicalxpress.com)
Seven patients experienced an improved clinical response at 90 days post-transplant, all of whom showed survivin-specific immune responses. (medicalxpress.com)

Defining the parameters that modulate vaccine responses in African populations will be imperative to design effective vaccines for protection against HIV, malaria, tuberculosis, and dengue virus infections. (nih.gov)

The vaccine development against SARS-CoV-2 is focused on identifying stable, accessible, and cost-effective candidates for global use, particularly in low and middle-income countries. (news-medical.net)
International data suggests there are currently more than 100 Covid-19 vaccine candidates under development, with a number of these in the human trial phase in over 150 countries. (dawn.com)
RTS,S and many other vaccine candidates teach the immune system how to target the parasite at this sporozoite stage, before it invades the liver. (sciencedaily.com)
Recent reports reveal marked differences in the gene expression of human dendritic cells infected with two leading poxvirus-based human immunodeficiency virus (HIV) vaccine candidates, New York vaccinia virus (NYVAC) and modified vaccinia virus Ankara (MVA). (nih.gov)

Anatomy12

Organisms36

Diseases35

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes23

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science3

Named Groups1

Health Care10

Geographicals1

Antibody response16

Antibodies30

Efficacy17

Doses of the vaccine4

Pfizer16

Vaccination27

Immunity8

Researchers25

BNT162b24

Getting COVID-191

20212

Induces2

Rotavirus vaccine3

Infection16

Immunization8

Viral7

Humoral3

Innate and adaptive immune responses2

Rhesus macaques2

Studying COVID-19 vaccine1

20222

Pandemic10

Robust4

MRNA-based vaccines1

Variants6

Induce an immune response2

Regimens3

Potentially5

Poor antibody responses1

Stimulate4

Rabies vaccine2

COVID Vaccines3

Cohort3

Bivalent vaccine1

Emergency Use Authorization2

Rollout1

Effectiveness5

AstraZeneca3

Measles3

Immunogenicity1

20191

Immunology2

Hepatitis B vaccin1

Trials9

Protein9

Protective1

Participants5

Titers3

Hesitancy1

Cytokine responses1

Clinical11

Effective vaccines1

Candidates4