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  • NIAID
  • DESSAU, Germany & ROCKVILLE, Md.--( BUSINESS WIRE )-- IDT Biologika , a globally integrated manufacturer of vaccines and biopharmaceuticals, announced today that the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services, has awarded the company a new Task Order within the 10-year Indefinite Delivery, Indefinite Quantity (IDIQ) contract no. (businesswire.com)
  • Adjuvant discovery and development play critical roles in NIAID vaccine development efforts. (nih.gov)
  • Adjuvant discovery and development are critical to NIAID efforts to develop new and improved vaccines against infectious diseases. (nih.gov)
  • NIAID supports an array of adjuvant research, from basic studies on immune receptors to clinical testing of new adjuvant vaccine candidates. (nih.gov)
  • NIAID is studying various strategies to create a vaccine that elicits antibodies targeting the HA stem. (nih.gov)
  • For example, NIAID scientists designed an experimental vaccine featuring the protein ferritin, which can self-assemble into microscopic pieces called nanoparticles, as a key component. (nih.gov)
  • In another approach to a universal flu vaccine, NIAID scientists developed a vaccine incorporating four subtypes of the H protein into one vaccine. (nih.gov)
  • Today, NIAID and its global partners are continuing to learn from and build upon findings from this and other HIV vaccine trials. (nih.gov)
  • For example, in 2015, NIAID researchers and colleagues reported that antibodies stimulated by the vaccine used in the HVTN 505 clinical trial recognized HIV as well as microbes commonly found in the intestinal tract, providing a potential explanation for why the candidate vaccine was not protective against HIV infection. (nih.gov)
  • pathogens
  • Translate Bio , a clinical-stage messenger RNA (mRNA) therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction, announced today a multi-year research and development collaboration and exclusive licensing agreement with Sanofi Pasteur , the vaccines global business unit of Sanofi (NYSE: SNY), to develop mRNA vaccines for up to five undisclosed infectious disease pathogens. (biospace.com)
  • In total, Translate Bio is eligible to receive up to $805 million in payments, which also includes certain development, regulatory and sales-related milestones across several vaccine targets, and option exercise fees if Sanofi Pasteur exercises its option related to development of vaccines for additional pathogens. (biospace.com)
  • A new review summarizes the current status of research efforts to develop particulate vaccine delivery systems against bioterrorism agents and emerging infectious pathogens. (medicalnewstoday.com)
  • Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens , WIREs Nanomed Nanobiotechnology , doi: 10.1002/wnan.1403, published online 1 April 2016. (medicalnewstoday.com)
  • A new approach to preventing arboviral diseases is suggested by the observation that arthropod saliva facilitates transmission of pathogens, including leishmania parasites, Borrelia burgdorferi, and some arboviruses. (deepdyve.com)
  • There are as many as 19 million species of arthropods, many of which carry disease-causing pathogens that are transmitted via "bites" to humans and animals . (deepdyve.com)
  • Such vector-borne pathogens make up 17% of all communicable diseases in humans, causing 1 billion cases and 1 million deaths per year . (deepdyve.com)
  • vaccination
  • Although HPV vaccines are not recommended for pregnant women, pregnancy testing is not needed before vaccination. (merckmanuals.com)
  • A desired protein can be expressed from mRNA without the need to adjust the production process offering maximum flexibility in development, potentially enabling the development of vaccines for disease areas where vaccination is not a viable option today. (biospace.com)
  • Hundreds of children have died from an upsurge in measles cases, despite a series of local vaccination campaigns aimed at combating the disease. (nbcnews.com)
  • To evaluate the immune response to the pneumococcal polysaccharide vaccine in the elderly, samples from young adults and elderly were obtained before and one month after vaccination. (biomedcentral.com)
  • The response to the pneumococcal polysaccharide vaccine showed a similar response between adults and elderly when evaluated by the ELISA, however the functional activity of the antibodies elicited after vaccination were lower in the elderly group for more than half of the serotypes evaluated. (biomedcentral.com)
  • A randomized, placebo-controlled vaccine strategy for community-wide vaccination of adults is proposed: a large, simple trial with recipients stratified at enrollment by human immunodeficiency virus serologic status and purified protein derivative-skin test status. (oup.com)
  • outbreaks
  • In response to recent global outbreaks, such as the 2013-2016 West African Ebola epidemic, global partnerships have been formed to stimulate vaccine development with a blend of push and pull market incentives. (prnewswire.com)
  • Instead of requiring a single large, randomized Phase III trial for vaccine approval, new strategies include collecting and combining data across multiple outbreaks, and expanding avenues for post-marketing studies to evaluate safety and clinical benefit. (prnewswire.com)
  • With the recent outbreaks of Ebola virus and Zika virus, it is widely recognized that we need new strategies to prevent infectious disease outbreaks," said Dr. James Moon, author of the WIREs Nanomedicine and Nanobiotechnology article. (medicalnewstoday.com)
  • Flu pandemics and other disease outbreaks underscore the need for vaccines and public health infrastructures to protect individuals against global health threats, said leaders representing government, scientific societies and advocacy groups at a briefing hosted by Research!America and the American Society for Microbiology (ASM) at the Newseum in Washington, D.C. on May 21. (researchamerica.org)
  • Seventy-percent of Americans say the federal government should do more to educate the public about global disease outbreaks and the risk to the U.S., according to a new national survey commissioned by Research!America and ASM. (researchamerica.org)
  • There are no licensed vaccines against most of these viruses, and vaccine development and use has been complicated by the number of different viruses to protect against, by subtype and strain variation, and by the inability to predict when and where outbreaks will occur. (deepdyve.com)
  • Recent pertussis outbreaks are of concern, but should not overshadow a dramatic decrease in disease rates documented during the past three decades. (gideononline.com)
  • effectiveness
  • Adjuvants have several important benefits, including reducing the amount of antigen required, reducing the number of vaccines needed, enhancing the vaccine effectiveness in immunocompromised people, and many more. (nih.gov)
  • Although it has been reported to provide approximately 50-80% protection against invasive disease in the general elderly population, there is still controversy as to the effectiveness of the PPV in the elderly. (biomedcentral.com)
  • While the effectiveness of vaccine can be demonstrated by clinical studies directly, clinical studies may not be easy to perform. (biomedcentral.com)
  • Still, there is a lot of confusing information about the safety and effectiveness of vaccines and it can be difficult to discern fact from fiction. (healthcanal.com)
  • RV144 evaluated the safety and effectiveness of a prime-boost combination of two vaccine components given in sequence: ALVAC-HIV, which uses a canarypox virus as a vector-or carrier-to deliver HIV genes, and AIDSVAX B/E, which contains a protein found on the HIV surface. (nih.gov)
  • pediatric
  • Vaccine safety has come a long way since those early days and undergoes intense scrutiny and trials to ensure efficacy and safety before being approved," said Nadia Qureshi, MD , pediatric infectious disease physician at Loyola University Health System and assistant professor in the Department of Pediatrics at Loyola University Chicago Stritch School of Medicine . (healthcanal.com)
  • efficacy
  • Most traditional vaccines have safety and efficacy issues, whereas particulate vaccine delivery systems - which utilize nano- or micro-particulate carriers to protect and deliver antigens - are efficient, stable, include molecules to bolster immune responses, and minimize adverse reactions due to the use of biocompatible biomaterials. (medicalnewstoday.com)
  • Although there are no new tuberculosis vaccines currently available, it is possible to estimate the infrastructure needed for efficacy trials of such a vaccine. (oup.com)
  • Readiness for tuberculosis vaccine efficacy trials will require epidemiological field studies to identify potential trial sites and investment in local diagnostic, surveillance, and data management capabilities. (oup.com)
  • The landmark RV144 study in Thailand was the first, and to date only, large clinical trial to demonstrate efficacy for an investigational HIV vaccine. (nih.gov)
  • Researchers have gained insight into the types of immune responses that may help predict an HIV vaccine's efficacy, providing leads for new vaccine development strategies. (nih.gov)
  • Other HIV vaccine trials also have provided valuable information to help researchers improve vaccine efficacy. (nih.gov)
  • tuberculosis
  • The Bacillus Calmette GuĂ©rin (BCG) vaccine used to prevent tuberculosis (TB) for more than a century has been found to improve blood sugar levels to nearly normal levels in type 1 diabetes patients. (pharmaceutical-technology.com)
  • Developing effective tuberculosis (TB) vaccines is a high priority. (cdc.gov)
  • therapeutic
  • However, as the burden of non-communicable diseases, including cancer, diabetes and dementia, increases, and they become a leading cause of death worldwide, new therapeutic approaches are being investigated, including vaccines. (pharmaceutical-technology.com)
  • A leading authority on the therapeutic value of vitamin C, Dr. Levy has written many books, including "Death by Calcium," "Primal Panacea" and "Curing the Incurable: Vitamin C, Infectious Diseases and Toxins. (naturalhealth365.com)
  • investigational
  • Although all vaccine trials ultimately help contribute to scientific progress, historically, many investigational vaccines that initially seemed promising in laboratory and animal studies yielded disappointing results when tested in humans. (nih.gov)
  • The quest to develop a preventive HIV vaccine was reinvigorated in 2009 when results from the large RV144 trial showed for the first time that an investigational vaccine regimen could confer a modest degree of protection against HIV infection. (nih.gov)
  • infection
  • If administered within ____________ of exposure, varicella vaccine prevents varicella infection in exposed individuals. (mdedge.com)
  • Efforts to develop safe and effective vaccines increasingly involve the use of adjuvants - substances formulated as part of a vaccine to enhance its ability to induce protection against infection. (nih.gov)
  • An adjuvant is a substance that is formulated as part of a vaccine to enhance its ability to induce protection against infection. (nih.gov)
  • The risk of having a serious adverse reaction to a vaccine is 1 in a million, the risk of complications from a vaccine-prevent able infection is closer to 1 in 100 to 1in 1000," Qureshi said. (healthcanal.com)
  • Depending on the type of infection (and possibly their cellular origin), exosomes play a dual role with respect to their effect on disease progression. (frontiersin.org)
  • For example, in 2007, vaccinations were stopped in two large HIV vaccine clinical trials known as the STEP and Phambili studies after review of interim data by an independent data safety and monitoring board concluded that the vaccine candidate could not be shown to prevent HIV infection or affect the course of the disease in those who become infected with HIV. (nih.gov)
  • At the end of the 3.5-year study period, investigators observed a 31 percent reduction in HIV infection among vaccine recipients compared to those who received a placebo. (nih.gov)
  • The vaccine components, which individually had not protected recipients against HIV infection, were based on the HIV B and E subtypes common in Thailand. (nih.gov)
  • preparedness
  • Vaccine Preparedness: The current and future challenges face vaccine preparedness from a surveillance and infrastructure perspective. (prnewswire.com)
  • The available evidence indicates that particulate vaccine delivery systems should be strongly considered for public health preparedness and countermeasures against these threats. (medicalnewstoday.com)
  • research
  • Achieve quality results, meet deadlines, and maximize efficiencies by partnering with a full-service CRO that excels in designing and executing clinical research in antivirals, antibacterials, antifungals and vaccines. (medpace.com)
  • Under the agreement, Translate Bio and Sanofi Pasteur will jointly conduct research and development activities to advance mRNA vaccines during an initial three-year research term. (biospace.com)
  • Sanofi Pasteur is pursuing a variety of emerging technologies that will allow us to continue to lead in research and development of next-generation vaccines," said John Shiver, Senior Vice President, R&D, Sanofi Pasteur. (biospace.com)
  • Sanofi Pasteur is at the forefront of vaccine research and development which makes them an ideal partner as we expand upon our promising early efforts in vaccines," said Ronald Renaud, Chief Executive Officer, Translate Bio. (biospace.com)
  • This report covers current and future challenges for the development and deployment of vaccines for EIDs, focusing on vaccine platform technology and research, funding mechanisms, and collaborative global partnerships. (prnewswire.com)
  • We are improving human health by carrying out cutting-edge, fundamental basic and translational research focusing on the bacteria, viruses and parasites that cause human disease. (uab.edu)
  • In addition, let's not forget that recent (independent) laboratory research confirms that many commonly-used vaccines are contaminated with glyphosate - the toxic herbicide found in Roundup. (naturalhealth365.com)
  • Our review provides a timely overview on the current research efforts and presents future directions on particulate-based vaccine delivery systems that may address many of the technical challenges facing traditional vaccine design and development. (medicalnewstoday.com)
  • It's important for those who work with, and who oversee the government, to educate, surveil, and detect infectious diseases and communicate with the public what they need to know," said Mary Woolley, president and CEO, Research!America. (researchamerica.org)
  • Extensive research has been done to ensure the vaccine schedule is safe and effective. (healthcanal.com)
  • The purpose of this research study is to test the safety of an experimental vaccine, called PfSPZ Vaccine. (nih.gov)
  • Development
  • Because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration, mRNA vaccines represent a potentially innovative alternative to conventional vaccine approaches. (biospace.com)
  • Chief among these are advanced market commitments (AMCs) from health organizations to subsidize vaccine development by purchasing a vaccine before licensure. (prnewswire.com)
  • There is a wide gap in the stage of vaccine development for different EIDs. (prnewswire.com)
  • Pipeline Assessment for Key EIDs: What are the pipeline vaccine products in development for key EIDs. (prnewswire.com)
  • Funding and Market Incentives: How vaccine development is being incentivized in the public and private spaces. (prnewswire.com)
  • Global Collaborations: How global and public-private partnership organizations are supporting vaccine development. (prnewswire.com)
  • A DENV vaccine is now licensed in select countries, but its development has been more complicated given the presence of 4 circulating serotypes and controversies surrounding the phenomenon of possible vaccine-induced immune potentiation of more severe illness in children [2, (deepdyve.com)
  • An empirical approach to HIV vaccine development relies on observation and experimentation to quickly move vaccine candidates into human clinical trials. (nih.gov)
  • Approach
  • mRNA vaccines offer an innovative approach by delivering the nucleotide sequence encoding any protein associated with prevention or treatment of a pathogen. (biospace.com)
  • bacteria
  • In collaboration with Dr. Abraham Sonenshein's laboratory, this work aims to develop thermostable vaccines based on the natural thermostability of spore-forming bacteria. (tufts.edu)
  • formaldehyde
  • NaturalHealth365) Concerns over the safety of our current vaccine schedule appear to be growing every day, as well-educated health experts highlight the fact that vaccines contain toxins like, mercury, aluminum and formaldehyde. (naturalhealth365.com)
  • The level of formaldehyde found naturally in the body is greater than 100 times that which is found in a vaccine. (healthcanal.com)
  • A pear has 50 times more formaldehyde than a vaccine," said Qureshi. (healthcanal.com)
  • polio
  • In 2003, Islamic clerics claimed the United States was using polio vaccine to sterilize Muslims or contaminate them with the AIDS virus. (nbcnews.com)
  • But three powerful state governors in the north joined the polio boycott, and it dragged on 11 months before authorities persuaded the governors in July to accept vaccine bought from the predominantly Muslim nation of Indonesia. (nbcnews.com)
  • By then the number of polio cases in Nigeria had risen fivefold, and the crippling disease had spread to nine other African countries where it previously had been eradicated. (nbcnews.com)
  • Nasir Mohammed Nasir, imam of Kano's second-largest mosque, said Americans "can't be killing my brothers and children in Iraq and at the same time claim to want to save my children from polio and other diseases. (nbcnews.com)
  • protein
  • Recombinant DNA technology is used to prepare both vaccines from the major capsid (L1) protein of HPV. (merckmanuals.com)
  • Translate Bio is a clinical-stage mRNA therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction. (biospace.com)
  • The Company believes that its MRT platform is applicable to a broad range of diseases caused by insufficient protein production or where production of proteins can modify disease, including diseases that affect the lung, liver, eye, central nervous system, lymphatic system and circulatory system. (biospace.com)
  • widely
  • The simultaneous administration of inactivated and widely used live-virus vaccines is safe and effective. (mdedge.com)
  • Licensed and widely used arbovirus vaccines exist for tick-borne encephalitis virus, Japanese encephalitis virus, and YFV, although shortages occur with the YFV vaccine supply . (deepdyve.com)