Vaccine highly immunogenic carrier protein carrier proteins. Medical search. Frequent questions

Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines. (biomedcentral.com)
Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen. (biomedcentral.com)
Using a reverse vaccinology approach, where genomic analysis informed the Shigella immunome via an antigen microarray, we aimed to identify novel immunogenic Shigella antigens. (biomedcentral.com)
A core genome analysis of Shigella species, pathogenic and non-pathogenic Escherichia coli , led to the selection of 234 predicted immunogenic Shigella antigens. (biomedcentral.com)
These findings provide six novel immunogenic Shigella proteins that could serve as candidate vaccine antigens, species-specific carrier proteins, or targeted adjuvants. (biomedcentral.com)
Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)
Although the assembled VLPs do not have S protein spikes, they could be developed as formulations that can improve the immunogenicity of vaccines including S antigens, and further could be used as platforms that can carry S antigens of concern for various mutations. (nature.com)
Conjugate vaccines in which polysaccharide antigens are covalently linked to carrier proteins belong to the most effective and safest vaccines against bacterial pathogens. (biomedcentral.com)
Two different periplasmic carrier proteins, AcrA from C. jejuni and a toxoid form of Pseudomonas aeruginosa exotoxin were glycosylated with Shigella O antigens in E. coli . (biomedcentral.com)
Indeed, hemocyanins have a multivalent nature as highly mannosylated antigens. (exeter.ac.uk)
Adjuvants are generally used with soluble protein antigens to increase antibody titers and induce a prolonged response with accompanying memory. (wikidoc.org)
Most complex protein antigens induce multiple B-cell clones during the immune response, thus, the response is polyclonal. (wikidoc.org)
Immune responses to non-protein antigens are generally poorly or enhanced by adjuvants and there is no system memory. (wikidoc.org)
The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
This article reviews recent studies on mucosal immune responses induced by polysaccharide based vaccines and some protein vaccine antigens against several pathogenic nasopharyngeal bacteria, and discusses the mechanisms and functions of these immune responses that may help our understanding of mucosal immune responses to both immunisation and infection. (bmj.com)
In addition to mutated proteins, NSCLC can over-express a number of non-mutated proteins that can induce both humoral and cytotoxic T cell responses [ 10 ], and also have the potential to serve as tumor rejection antigens [ 11 ]. (biomedcentral.com)
PRD-0038 S vaccination elicits greater titers of antibodies cross-reacting with vaccine-mismatched clade 2 and clade 1a sarbecoviruses compared with SARS-CoV-2 S due to broader antigenic targeting, motivating the inclusion of clade 3 antigens in next-generation vaccines for enhanced resilience to viral evolution. (uw.edu)
However, inclusion of protein antigens fromStreptococcus pneumoniaecombined with potent adjuvants and a suitable delivery system are expected to both extend protection to serotype strains not represented in the formulation and stimulate a broader immune response, thus more effective in young children, elderly, and immunocompromised populations. (univ-nantes.fr)

All Hib vaccines that are currently used are conjugate vaccine. (wikipedia.org)
Prior to introduction of the conjugate vaccine, Hib was a leading cause of childhood meningitis, pneumonia, and epiglottitis in the United States, causing an estimated 20,000 cases a year in the early 1980s. (wikipedia.org)
Since optimal contact between B cells and T cells is required (via MHC II) to maximize antibody production, it is reasoned that the conjugate vaccine allows B cells to properly recruit T cells, this is in contrast to the polysaccharide form in which it is speculated that B cells do not interact optimally with T cells leading to the TI interaction. (wikipedia.org)
These recommendations include information on two vaccines recently licensed for use among infants: Haemophilus b Conjugate Vaccine (PRP-T {ActHIB(TM), OmniHIB(TM)}), manufactured by Pasteur Merieux Vaccins, and TETRAMUNE{TM}, manufactured by Lederle Laboratories/Praxis Biologics. (cdc.gov)
On the basis of findings establishing comparable immunogenicity, a third conjugate vaccine, PRP-T (ActHIB{TM}, OmniHIB{TM}) has now been licensed for use among infants. (cdc.gov)
The first Hib conjugate vaccine was licensed in 1987. (cdc.gov)
In this study we describe the in vivo biosynthesis of two novel conjugate vaccine candidates against Shigella dysenteriae type 1, an important bacterial pathogen causing severe gastro-intestinal disease states mainly in developing countries. (biomedcentral.com)
Conjugate vaccine technology, where a polysaccharide antigen is coupled chemically to a protein carrier, either by direct linkage or by indirect coupling via diamino spacer molecules, can render the PS specific immune response T cell dependent. (bmj.com)

Most importantly, infection and current vaccines do not appear to effectively induce these antibodies in humans. (cdc.gov)
Current influenza virus vaccines attempt to induce strong antibody responses against the viral glycoproteins hemagglutinin (HA) and, with lesser emphasis, neuraminidase (NA) because their protective efficacy is well documented. (cdc.gov)
VLPs are highly immunogenic and can induce elevated titers of neutralizing antibodies, even without adjuvants, thanks to the maintenance of the native conformation of viral proteins presenting repetitive epitopes to the host immune system cells. (nature.com)
Strategies, which have been designed to overcome this lack of immunogenicity in infants, include the linking of the polysaccharide to large immunogenic proteins, which provide bystander T-cell help and which induce immunological memory against the polysaccharide antigen to which it is conjugated. (allindianpatents.com)
In contrast to isolated bacterial polysaccharides, conjugate vaccines induce a long-lasting T-lymphocyte dependent immunological memory [ 4 , 5 ]. (biomedcentral.com)
This optimism is built on recently published studies demonstrating the efficacy of mRNA vaccines in combatting several types of cancer and infectious pathogens where conventional vaccine platforms may fail to induce protective immune responses. (researchgate.net)
The inactivated vaccines consist of purified viral particle without or with only minor contaminants of NSP and thus induce antibody mainly against structural proteins of virus. (ncl.edu.tw)
The extent of this effect has been influenced by the fact that Haemophilus influenzae type b conjugate vaccines reduce nasopharyngeal carriage and induce herd immunity. (bmj.com)
Evidence has begun to accumulate that these new polysaccharide based conjugate vaccines can also reduce nasopharyngeal carriage and can induce immune responses at the local mucosal level, which may be responsible for these effects. (bmj.com)
Recent studies show that parenterally administered capsular polysaccharide (PS) based vaccines can induce mucosal immune responses. (bmj.com)
To be effective against colonisation, vaccines must induce local immune responses, which promote elimination of the pathogen, break the chain of transmission, and induce herd immunity. (bmj.com)
However, because they induce a T cell independent B cell response, they are poorly immunogenic in young children, and in adults only induce relatively short term protection. (bmj.com)
Most vaccines require several immunizations to induce robust immunity, and indeed, most SARS-CoV-2 vaccines require an initial two-shot regimen followed by several boosters to maintain efficacy. (uw.edu)

The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
The most promising approaches are based on antibodies specific for the relatively conserved ectodomain of matrix protein 2 and the intersubunit region of hemagglutinin. (cdc.gov)
While antibodies to the immunodominant, but highly variable, regions of HA and NA can provide potent virus strain-specific protection, the existence of weaker and more broadly protective immune activities directed to less variable regions of viral proteins has long been known ( 5 ). (cdc.gov)
Because of their potential for broadening vaccine-mediated protection in humans, they have been studied extensively in animals and found to be mediated predominantly by virus-specific memory T cells ( 6 , 7 ), antibodies ( 8 - 10 ), or a combination of both ( 11 - 13 ). (cdc.gov)
During this SARS-CoV-2 pandemic, many studies on the development of plant-derived vaccines and antibodies are underway. (nature.com)
For this purpose, we synthesized carcinogen-protein conjugates and prepared mono- and polyclonal antibodies to benzo[a]pyrene. (actanaturae.ru)
Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
Pharmaceutical Biotechnology, based entirely on modern biotechnological techniques, as to date encompass a wider range of altogether newer medicinal compounds, e.g., antibiotics, vaccines, and monclonal antibodies (MABs) that may now be produced commercially using well-defined, optimized, and improved fermentative methodologies. (123dok.com)

The current vaccination strategy against influenza A and B viruses is vulnerable to the unanticipated emergence of epidemic strains that are poorly matched by the vaccine. (cdc.gov)
There are 90 known serotypes of pneumococci, and the capsule is the principle virulence determinant for pneumococci, as the capsule not only protects the iimer surface of the bacteria from complement, but is itself poorly immunogenic. (allindianpatents.com)
Tumor-derived autophagosome vaccines (DRibbles) have the potential to broaden immune response to poorly immunogenic tumors. (biomedcentral.com)
However, the wP vaccine chosen by the CDC to be used in those trials, manufactured by Connaught, was later found to be one of the most poorly immunogenic of available wP vaccines [ 10 ]. (biomedcentral.com)

The Haemophilus influenzae type B vaccine, also known as Hib vaccine, is a vaccine used to prevent Haemophilus influenzae type b (Hib) infection. (wikipedia.org)
Hib vaccine is not effective against non-type B Haemophilus influenzae. (wikipedia.org)
However, non-type B disease is rare in comparison to pre-vaccine rates of Haemophilus influenzae type B disease. (wikipedia.org)
Most notably routine immunization of infants with conjugate vaccines against Haemophilus influenzae type B led to a fast and dramatic drop in respective disease incidents after implementation. (biomedcentral.com)
The introduction of Haemophilus influenzae type b conjugate vaccines during the 1990s was followed by dramatic decreases both in the incidence of Haemophilus influenzae type b related invasive disease and in nasopharyngeal carriage of the organism. (bmj.com)
Based on the success of Haemophilus influenzae type b conjugate vaccines, chemical conjugation has been applied to the development of pneumococcal and meningococcal polysaccharide conjugate vaccines. (bmj.com)

Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses toward type 1 T helper (Th1) polarization. (exeter.ac.uk)
It gives a full rundown of the current NP-based vaccines, their potential as adjuvants, and the ways they can be delivered to cells. (researchgate.net)
Compared to a clinically relevant prime-boost regimen with soluble vaccines formulated with CpG/alum or 3M-052/alum adjuvants, PNP hydrogel vaccines more rapidly generated higher, broader, and more durable antibody responses. (uw.edu)

SARS-CoV-2 is composed of four essential structural proteins: the spike (S) glycoprotein, membrane (M) protein, envelope (E) protein, and nucleocapsid (N) protein, as well as multiple accessory and non-structural proteins 1 . (nature.com)
As a result, effective vaccines must target the viral spike glycoprotein. (springeropen.com)

Screening the array with sera and ileal fluid samples from immunized pigs suggested cross-reactivity among homologous proteins and a general activation of immunity. (frontiersin.org)
Vaccines are critical in boosting immunity, lowering COVID-19-related illnesses, reducing the infectious burden on the healthcare system, and reducing economic loss, according to current data. (springeropen.com)
Among most immunosuppressive cells, TAMs, as crucial drivers of immunosuppressive TME, account for the largest proportion of immune cells in the TME (approximately 50% of tumor mass) [ 9 , 10 ], which possess highly heterogeneity and play a complex regulatory role in tumor immunity and immunotherapy due to helping tumor evade immune surveillance [ 11 ]. (thno.org)
There are four structural viral proteins, of which VP1 has been shown to elicit protective immunity in cattle ( Bachrach 1977 ). (wikisource.org)
In a rapidly evolving pandemic affected by the spread of immune-escaping variants, there is an urgent need to develop vaccines capable of providing robust and durable immunity. (uw.edu)
In this work, a single immunization SARS-CoV-2 subunit vaccine is developed that can rapidly generate potent, broad, and durable humoral immunity. (uw.edu)
Key amongst these is recent data indicating that the immune responses induced by aP vaccines differ fundamentally from those induced by the whole cell pertussis (wP) vaccines, and do not lead to mucosal immunity. (biomedcentral.com)
Part of this uncertainty rests in the limitations of our knowledge of pertussis disease pathogenesis and how natural or vaccine induced immunity impedes pathogen acquisition, replication, and movement through populations. (biomedcentral.com)

In each case, introduction of the vaccine led to a steep decline in clinical disease by vaccine serotypes/groups among those vaccinated, but also a significant decline among the non-vaccinated population, indicating herd effects. (biomedcentral.com)

PRP covalently linked to a protein carrier was found to elicit a greater immune response than the polysaccharide form of the vaccine. (wikipedia.org)
The primary strategy of developing an efficacious Shigella vaccine has been to elicit antibody responses targeting Shigella O-antigen [ 10 ]. (biomedcentral.com)
Additionally, these single-immunization hydrogel-based vaccines elicit potent and consistent neutralizing responses. (uw.edu)

Here, we demonstrate that non-infectious SARS-CoV-2 VLPs can be successfully assembled by co-expressing three important viral proteins membrane (M), envelop (E) and nucleocapsid (N) in plants. (nature.com)

Over one hundred vaccines using varied approaches including protein subunit, viral vector, RNA, DNA, inactivated virus, attenuated virus, and virus like particles (VLPs) platforms are in clinical trials. (nature.com)
Selection of particles and proteins for use as human cytomegalovirus subunit vaccines. (microbiologyresearch.org)

D. Pre-Pandemic Biodistribution Studies Provide Information -But Covid-19 mRNA Vaccine Consumers Never Saw It. (dailyclout.io)
K. Duty to Warn, obscured frequency of reactions statements -in non-pre-treated individuals administered PEGylated lipids, lipid nanomedicines, and nanomedicines- and missing warnings for countermeasures/pre-treatment premedication in similar lipids for Covid-19 mRNA vaccine labeling. (dailyclout.io)

Similar reductions in Hib disease occurred after introduction of the vaccine in Western Europe and developing countries. (wikipedia.org)

Although the vaccine was highly effective in trials in Finland among children greater than or equal to 18 months of age (3), postmarketing efficacy studies in the United States demonstrated variable efficacy (4,5). (cdc.gov)
Apart from their limited efficacy in the elderly, a major drawback of current vaccines is that the principal vaccine targets, most notably the distal region of HA, are subject to continuous alteration in circulating epidemic virus strains ( 2 , 3 ). (cdc.gov)
However, the appearance of an Omicron variant with 32 mutations in its spike protein raises questions about the vaccine's efficacy. (springeropen.com)
A 23-valent unconjugated pneumococcal vaccine has shown a wide variation in clinical efficacy, from 0% to 81% (Fedson et al, (1994) Arch Intern Med. (allindianpatents.com)

Accordingly, the influenza vaccine must be updated on a regular basis to reflect the antigenic changes that occur in the pool of circulating virus strains. (cdc.gov)
Live attenuated mucosal influenza vaccine has been licensed in the USA, but it will probably be some time before others go into general use. (bmj.com)

The hepatitis viruses include a range of unrelated and often highly unusual human pathogens. (medmuv.com)

The Hib vaccine is available by itself, in combination with the diphtheria/tetanus/pertussis vaccine, and in combination with the hepatitis B vaccine, among others. (wikipedia.org)
Current recommendations for universal vaccination of infants require parenteral administration of three different vaccines (diphtheria-tetanus-pertussis {DTP}, Hib conjugate, and hepatitis B) during two or three different visits to a health-care provider. (cdc.gov)
TETRAMUNE{TM} is the first licensed combination vaccine that provides protection against diphtheria, tetanus, pertussis, and Hib disease. (cdc.gov)
This single-chain 535 amino acid long protein causes the symptoms of acute diphtheria infection. (org.ua)
Several protein carriers have been used including tetanus toxoid (TT), diphtheria toxoid, mutant diphtheria toxin (CRM197), and the outer membrane protein of N meningitidis . (bmj.com)

VLPs self-assembled into empty shells can be used safely as vaccines without the risk of replication or infection due to the lack of viral nucleic acid. (nature.com)
A series of studies have revealed that exosomes-mediated intercellular transfer of proteins, nucleic acids, and metabolites plays a crucial role in the initiation and progression of HCC, hypoxia and angiogenesis, chemotherapy sensitivity, and cell death mode and regulates the immune microenvironment. (hindawi.com)
Regardless of the type or the physiological or pathological state of the originating cell, exosomes share common features as enriched with nucleic acids, lipids, and proteins [ 4 ]. (hindawi.com)
A film detection method for tritium-labeled proteins and nucleic acids in polyacrylamide gels. (microbiologyresearch.org)

A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)

Conjugation of the PRP polysaccharide with protein carriers confers T-cell- dependent characteristics to the vaccine and substantially enhances the immunologic response to the PRP antigen. (cdc.gov)
The sensitivity and specificity of the indirect ELISA using baculovirus expressed 3AB protein as the antigen were 62.4% and 86.8-91.7%, respectively. (ncl.edu.tw)
The sensitivity and specificity of the double-sandwich blocking ELISA using E. coli expressed 3AB protein as the antigen were 94% and 98-100%, respectively. (ncl.edu.tw)
A 64,000 dalton matrix protein of human cytomegalovirus induces in vitro immune responses similar to those of whole viral antigen. (microbiologyresearch.org)
Viral RNA polymerase, a nonstructural protein, has been termed "virus infection associated antigen" (VIAA) for diagnostic purposes but is more accurately termed "FMDV nonstructural protein 3D. (wikisource.org)

The processes are time-consuming and costly, and often large-scale cultivation of pathogenic bacteria is required for polysaccharide biosynthesis, making conjugate vaccines prohibitively expensive for vaccination campaigns in developing countries. (biomedcentral.com)

The CDC and the WHO recommend that all infants be vaccinated using a polysaccharide-protein conjugate Hib vaccine, starting after the age of six weeks. (wikipedia.org)

a: oligosaccharyltransferase PglB, b: carrier protein with signal sequence for secretion to the periplasm, c: undecaprenyl-pyrophosphate-linked polysaccharides. (biomedcentral.com)

currently who researchers are working on more potent anti-fertility vaccines using recombinant dna. (cognitive-liberty.online)

These protein subunits can assemble into virus particles without viral RNA genome in mammalian cells to study virus-cell entry 2 and to develop vaccines 3 . (nature.com)

This comprises of inactivated viruses, messenger RNA (mRNA), DNA vaccines, protein subunits, nonreplicating and replicating vector viral-like particles (VLP), and live attenuated vaccines. (springeropen.com)

The present invention provides an unproved vaccine for the prevention or amelioration of pneumococcal infection of the elderly (e.g., pneumonia) and/or in infants (e.g. (allindianpatents.com)

The vaccine has also been shown to be immunogenic in patients at high risk of invasive disease. (wikipedia.org)
In the pre-Hib-vaccine era, type b organisms accounted for 95% of all H. influenzae strains that caused invasive disease. (cdc.gov)

published research shows that by 1976 who researchers had conjugated tetanus toxoid (tt) with human chorionic gonadotropin (hcg) producing a 'birth-control' vaccine. (cognitive-liberty.online)

Multiple Sclerosis (MS) is an autoimmune disease, which features a highly complex pathogenic cascade and involves the infiltration of mononuclear cells into the brain and spinal cord. (listlabs.com)
Due to the appearance of the highly virulent strain of E. coli of serotype O157:H7 in the US and Canada in the 1980's, and subsequently in other Latin American countries, there is an increase need for accurate testing for this and other pathogenic E. coli strains, substantially enhancing detection of virulent strains and, therefore, facilitating identification of sporadic E. coli infections and outbreaks. (eurekaselect.com)

and c) provides updated recommendations from the Advisory Committee on Immunization Practices (ACIP) for use of conjugate Hib vaccines and TETRAMUNE{TM} for infants and children. (cdc.gov)
Refer to the Advisory Committee on Immunization Practices Vaccine Recommendations and Guidelines for the most updated vaccine-specific recommendations. (cdc.gov)
From the 1950's widespread immunization of children in the US with the whole cell (wP) pertussis vaccine led to a 99% reduction in pertussis cases, but not in complete elimination of the disease [ 8 ]. (biomedcentral.com)

Shigella is a major diarrheal pathogen for which there is presently no vaccine. (biomedcentral.com)
There is currently no licensed vaccine against Shigella [ 10 ]. (biomedcentral.com)
This challenge may be overcome by a vaccine that elicits either a broadly reactive immune response or numerous species-specific responses against the globally dominant Shigella species (i.e. (biomedcentral.com)

Specific characteristics of the four conjugate vaccines available for infants and children vary (e.g., the type of protein carrier, the size of the polysaccharide, and the chemical linkage between the polysaccharide and carrier) ( Table 1 ). (cdc.gov)
Studies have been performed with all four Hib conjugate vaccines to determine immunogenicity in infants 2-6 months of age. (cdc.gov)
In a related aspect, the present invention provides a vaccine for treating or ameliorating Otitis media in infants or pneumonia in the elderly. (allindianpatents.com)
In the pre vaccine era the disease was responsible for hundreds of thousands of pertussis cases a year with severe or fatal cases concentrated among very young infants. (biomedcentral.com)

pneumoniae serotype 14 capsular polysaccharide (CP14) linked to the Pneumococcal surface protein A (PsaA) using chitosan NPs (CNPs). (univ-nantes.fr)

by november 1993 catholic publications appeared saying an abortifacient vaccine was being used as a tetanus prophylactic. (cognitive-liberty.online)
three independent nairobi accredited biochemistry laboratories tested samples from vials of the who tetanus vaccine being used in march 2014 and found hcg where none should be present. (cognitive-liberty.online)
given that hcg was found in at least half the who vaccine samples known by the doctors involved in administering the vaccines to have been used in kenya, our opinion is that the kenya 'anti-tetanus' campaign was reasonably called into question by the kenya catholic doctors association as a front for population growth reduction. (cognitive-liberty.online)

However, there are worries about the vaccines' safety, the protection they provide, and whether future structural changes are required for these vaccines to be more effective. (springeropen.com)
RdRp is involved in viral genome replication and structural protein translation [ 6 ]. (springeropen.com)
Non-structural proteins (NSP) are produced during viral replication. (ncl.edu.tw)

Likewise, the elderly mount poor responses to pneumococcal vaccines [Roghmann et al, (1987), J. Gerontol. (allindianpatents.com)
The 23-valent vaccine does not demonstrate protection against pneumococcal pneumonia (in certain high risk groups such as the elderly) and Otitis media diseases. (allindianpatents.com)
However, there is still a need for improved pneumococcal vaccine compositions, particularly ones which will be more effective hi the prevention or amelioration of pneumococcal disease (particularly pneumonia) in the elderly and in young children. (allindianpatents.com)

Virus-like particles (VLPs) enable the construction of promising platforms in the field of vaccine development. (nature.com)

Glycoconjugate synthesis, in particular expression of oligosaccharyltransferase PglB, strongly inhibited growth of E. coli cells after induction, making it necessary to separate biomass growth and recombinant protein expression phases. (biomedcentral.com)
As a result, we prepared a recombinant protein composed of the benzo[a]pyrene immunomimetic peptide and pIII-encoding sequences. (actanaturae.ru)
Using ELISA, we demonstrated that the recombinant protein specifically interacts with the anti-benzo[a]pyrene monoclonal antibody (mAB B2). (actanaturae.ru)

Clinical trials and ongoing surveillance have shown Hib vaccine to be safe. (wikipedia.org)
Following a lengthy development process, in 1997 the US switched to acellular vaccines (aP), which are far less reactogenic, and, based on early head to head clinical trials comparing the aP with the wP vaccines, appeared to be as protective as the wP. (biomedcentral.com)

This research strongly supports future studies using a computational, comparative genomics/proteomics approach to produce an effective parasite vaccine. (frontiersin.org)
The described methodologies constitute an important step towards cost-effective in vivo production of conjugate vaccines, which in future may be used for combating severe infectious diseases, particularly in developing countries. (biomedcentral.com)
In the last few years, mRNA used as a vaccine with rapid, scalable, and cost-effective production during the corona pandemic [2]. (researchgate.net)
For example, 'Two mRNA vaccines developed by Pfizer-BioNTech and Moderna are effective against the coronavirus. (researchgate.net)
But while effective, the modest reactogenicity of wP vaccines and concerns about possible rare neurologic adverse events that might have been linked to wP vaccines prompted a need for a new, safer vaccine to replace it [ 9 ]. (biomedcentral.com)

Prediction of protein conformation. (microbiologyresearch.org)

VLPs constitute attractive vaccine platforms in view of their safety and ease of production. (nature.com)
Currently, seven SARS-CoV-2 vaccine platforms have been developed. (springeropen.com)

Organisms colonize the nasopharynx and may remain only transiently or for several months in the absence of symptoms (asymptomatic carrier). (cdc.gov)
[ 1 ] During the winter and spring in temperate climates, up to 20% of asymptomatic school-aged children may be group A streptococcus carriers. (medscape.com)
The transmission of these bacteria primarily between asymptomatic carriers is through droplet spread or contact with respiratory secretions. (bmj.com)

An immunogenic composition comprising 2 S. pneumoniae recombinant proteins wherein one of the proteins is selected from the Poly Histidine Triad family (PhtX) at a dose of between 1-100 µg and optionally comprising an adjuvant. (allindianpatents.com)

Controlling the biodistribution of protein- and nanoparticle-based therapeutic formulations remains challenging. (uw.edu)

In another preferred embodiment, one of the proteins is from the Choline Binding Protein family (CbpX), or CbpX truncates, or CbpX truncate-LytX truncate chimeric proteins. (allindianpatents.com)

Controlling the global COVID-19 pandemic depends, among other measures, on developing preventive vaccines at an unprecedented pace. (biorxiv.org)
The pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a public health emergency, and research on the development of various types of vaccines is rapidly progressing at an unprecedented development speed internationally. (nature.com)
and an introduction to the two significant pre-pandemic LNP development studies co-authored by the co-creators of the Pfizer Covid-19 mRNA-LNP vaccines. (dailyclout.io)

Several new mucosal vaccines against respiratory infections are under development. (bmj.com)

Most of our recombinant proteins are fluorescent derivatives of various DT and proHB-EGF. (org.ua)
The co-expression of Twitch and ∆NFAT protein required a set of fluorescent proteins (FP) that would have minimal bleed through in their emission channels. (listlabs.com)

These vaccines contained purified polyribosylribitol phosphate (PRP) capsular material from type b strains. (cdc.gov)
Because vaccines have to be manufactured before the actual epidemic strains are known, a failure to anticipate emergence of a strain with major antigenic drift or shift relative to the vaccine will result in a substantial reduction or abrogation of vaccine-mediated protection. (cdc.gov)
There are currently no vaccines to prevent disease caused by non-b encapsulated or nontypeable strains. (cdc.gov)

In general, adverse reactions to the vaccine are mild. (wikipedia.org)
F. Covid-19 vaccine adverse reactions are linked to documented autoimmune disease. (dailyclout.io)
More LNP details on the similar lipid 2018 LNP Nano lipid carrier drug Onpattro and EMA data on immune stimulation, complement activation, special cautions, and adverse reactions. (dailyclout.io)
N. After The mRNA Vaccines Were Approved and "Anaphylaxis" Adverse Reactions Were Seen, What Did The Pfizer LNP Experts Say? (dailyclout.io)

Autologous vaccine generated from tumor cells harvested from pleural effusions was administered to patients with advanced NSCLC with the objectives of assessing safety and immune response. (biomedcentral.com)
DRibble vaccine given with GM-CSF appeared safe and capable of inducing an immune response against tumor cells in this small, pilot study. (biomedcentral.com)
Tumor cells were cultured in vitro with the proteasome inhibitor bortezomib, which stabilizes SLiPs and DRiPs, shunting proteins into the autophagy pathway [ 12 ]. (biomedcentral.com)
The group identified a protein kinase MST4-dependant pathway that plays a tumor-promoting role in glioblastoma through increasing autophagic activity. (chicagobiomedicalconsortium.org)

Then the synthetic peptide vaccine application of peptides was reviewed. (intechopen.com)
The obtained benzo[a]pyrene immunomimetic peptide could only simulate chemical carcinogens in the frame of the pIII protein. (actanaturae.ru)

The presented data demonstrate that glycosylated proteins can be produced in recombinant E. coli at a larger scale. (biomedcentral.com)

Non-immunogenic, self-assembling and biodegradable nanomaterials carry a high promise to revolutionize regenerative medicine as vehicles to deliver therapeutic molecules to a site of injury. (chicagobiomedicalconsortium.org)
Early approaches were based on gene addition, where a new DNA copy of a gene is introduced to complement a genetic mutation: however, the advent of RNA-based products that can directly express a therapeutic protein or manipulate gene expression, together with the expanding range of tools for gene editing, has stimulated the development of alternative approaches. (bvsalud.org)

Anatomy5

Organisms16

Diseases1

Chemicals and Drugs163

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes39

Technology, Industry, Agriculture4

Information Science4

Health Care5

Antigens18

Conjugate vaccine8

Induce13

Antibodies8

Poorly4

Haemophilus6

Adjuvants3

Glycoprotein2

Immunity8

Serotypes1

Elicit3

Viral proteins1

Subunit2

MRNA vaccine2

Introduction of the vaccine1

Efficacy4

Influenza vaccine2

Pathogens1

Diphtheria5

Nucleic4

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Antigen5

Vaccination1

Polysaccharide-protein1

Polysaccharides1

Potent1

Develop vaccines1

Subunits1

Infection1

Invasive disease2

Toxoid1

Pathogenic2

Immunization3

Shigella3

Infants4

Capsular polysaccharide1

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Structural3

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Particles1

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Clinical trials2

Effective5

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