Uveal diseases. Medical search. Frequent questions

The uveal tract and retinal pigment epithelium contain pigment cells. (medscape.com)
In the remaining 19 globes, COX-2 expression was detected in areas also labeled in globes without disease and globes with nonneoplastic disease, especially the aqueous outflow tract and ciliary body. (avma.org)
Diseases of the uveal tract -- v. 10. (who.int)
Metastatic tumors to the uveal tract are the most common intraocular tumors in adults when eyes have been examined in large autopsy series. (aao.org)
Ocular melanocytosis, also referred to as melanosis oculi , is a unilateral congenital condition characterized by hyperpigmentation of the episclera and uveal tract due to the presence of increased numbers of plump melanocytes. (vin.com)
2 Finally, panuveitis affects all three sections of the uveal tract and is responsible for 7-38% of all cases. (touchophthalmology.com)
Crohn disease is an inflammatory bowel disease where chronic inflammation typically involves the lower part of the small intestine, the large intestine, or both and may affect any part of the digestive tract. (merckmanuals.com)
Most commonly, Crohn disease occurs in the last portion of the small intestine (ileum) and in the large intestine, but it can occur in any part of the digestive tract, from the mouth to the anus and even in the skin around the anus. (merckmanuals.com)
The disease may affect some segments of the intestinal tract while leaving normal segments (called skip areas) between the affected areas. (merckmanuals.com)
Uveal melanoma (UM) is a uncommon ocular malignancy which originates within the uveal tract, and infrequently provides rise to metastases. (aabioetica.org)
Primary ciliary body melanoma arises from melanocytes in the uveal tract. (medscape.com)

Establishing clinical validity and utility of ctDNA analysis for diagnosis, prognosis and monitoring intraocular disease in retinoblastoma. (chla.org)
Uveal melanoma is the most common intraocular cancer in adults and represents 3% to 5% of all melanomas, with an annual incidence in Europe and the United States at approximately 6 per 1 million individuals annually. (pharmacytimes.com)
A new article from Liverpool ocular researchers demonstrates that small uveal (intraocular) melanomas are not always harmless, as the current paradigm suggests. (oullins-patriote.com)
Uveal melanoma is a rare intraocular tumour. (aldryn.io)
Uveal melanomas are the most common primary intraocular malignancies and the second most common type of primary malignant melanoma in the body. (medscape.com)
Intraocular melanomas can involve two uveal structures simultaneously, such as in ciliochoroidal melanoma. (medscape.com)

The FDA recently approved tebentafusp-tebn (Kimmtrak) as a treatment option for adult patients with unresectable or metastatic uveal melanoma whose disease harbors HLA-A*02:01. (oncnursingnews.com)
This approval was particularly significant, Paul Nathan, PhD, explained, because it represents both the first FDA-approved therapy to treat unresectable or metastatic uveal melanoma, as well as the first FDA-approved T-cell receptor therapeutic. (oncnursingnews.com)
Immunocore) for the treatment of adult patients with human leukocyte antigen (HLA)-A*02:01-positive unresectable or metastatic uveal melanoma. (pharmacytimes.com)
Tumor first detected at the stage of advanced unresectable or metastatic disease, or disease progressing during or recurring after previous radical therapy. (who.int)

However, only globes with uveal malignant melanomas had detectable COX-2 expression in the iris. (avma.org)
Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas. (cdc.gov)
In humans, uveal melanomas most commonly arise from the choroid and demonstrate spindle and epithelioid morphologic variants that allow for reasonable predictability of biologic behavior. (vin.com)
This is the first study to show that over a quarter of these smaller uveal melanomas have lethal genetic mutations, and suggests that we may be able to influence patient survival and mortality outcomes with earlier treatment of these small melanomas. (oullins-patriote.com)
Despite affecting the same organ, uveal melanomas and conjunctival melanomas are very different in their nature. (aldryn.io)
They can be classified as anterior uveal melanomas when the tumor arises in the iris and as posterior uveal melanomas when it arises in either the choroid or the ciliary body. (medscape.com)
Although uveal melanomas may grow de novo, most develop from a preexisting melanocytic nevus. (medscape.com)
Three distinct cell types are recognized in uveal melanomas: spindle A, spindle B, and epithelioid. (medscape.com)

This results in recruitment and activation of polyclonal T cells through CD3 to release cytokines and cytolytic mediators against the target uveal melanoma tumor cells. (pharmacytimes.com)
Moffitt researchers, in collaboration with scientists from the UF Health Cancer Center and Sylvester Comprehensive Cancer Center, wanted to determine how this resistance develops and identify additional drugs that could be used in combination with MEK inhibitors to target uveal melanoma cells for destruction. (pharmaceutical.report)

Prevalence of retinal scar lesion types in a case-control study of ocular signs in Ebola virus disease survivors, Sierra Leone, 2016. (cdc.gov)
Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors. (harvard.edu)
I was interested in retinal diseases and got attracted to the inflammations of the posterior segment because unlike the medical retinal diseases, posterior uveitis was a major challenge then and has remained so even now. (eophtha.com)

The four topics of discussion at this meeting were: advances in molecular profiling and novel biomarkers, combination therapies, novel concepts toward integrating biomarkers and therapies into contemporary clinical management of patients with melanoma across the entire spectrum of disease stage, and the knowledge gained from the biology of tumor microenvironment across different tumors as a bridge to impact on prognosis and response to therapy in melanoma. (biomedcentral.com)
The research of the group "Cell Biology" focuses on the development of cellular models to understand human imprinting diseases and the development of tumors of the eye, retinoblastoma and uveal melanoma. (dsmz.de)
The paper shows that uveal melanoma patients with small tumors, when treated within a certain time frame in Liverpool, do indeed have improved outcomes. (oullins-patriote.com)

When these lesions are identified clinically, they most often involve the choroid, but metastatic disease can affect any part of the uvea. (aao.org)
While cats share with humans a significant risk for metastatic disease and tumor-related mortality, the most common clinical syndrome involves diffuse transformation of melanocytes on the anterior iris surface with a prolonged pre-malignant phase. (vin.com)
However, nearly half of uveal melanoma patients will develop metastatic disease that migrates to other part of the body, primarily the liver. (pharmaceutical.report)
First author Dr. Rumana Hussain, of Liverpool Ocular Oncology Center, said: "Uveal melanoma is a potentially lethal disease, with a 50% mortality rate from metastatic disease. (oullins-patriote.com)

Uveitis and systemic inflammatory markers in convalescent phase of Ebola virus disease. (cdc.gov)
Uveitis is a disease that affects over 2 million people around the globe, and can ultimately lead to blindness. (clinicaltrials.gov)
However the diagnosis and treatment of such diseases as uveitis remains a challenge for veterinary ophthalmologists. (cnshb.ru)
My chief Prof Jain was among the first who showed HLAB27 positivity in acute anterior uveitis (IJO 1979), viral uveitis in 1974, a VKH disease series in 1978, fungal endophthalmitis in 1965, APMPPE in 1982, Wegner's granulomatousus in 1988. (eophtha.com)
Uveitis is an inflammatory eye disease affecting the iris, ciliary body, and choroid that can lead to symptoms ranging from redness, pain, and blurred vision to markedly diminished acuity in the setting of severe or chronic disease. (touchophthalmology.com)
2 The broad disease entity of uveitis can be further classified into the anatomical divisions of anterior, intermediate, posterior, and panuveitis. (touchophthalmology.com)

During the past 50 years, treating liver metastases in uveal melanoma has been a journey, she explained, from systemic chemotherapy in the 1970s to transarterial chemoembolization (TACE) with 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), drug-eluting beads with doxorubicin, immunoembolization, and radioembolization. (medscape.com)
He indicated that newer systemic therapies under investigation, such as IMCgp100, which have shown potential survival benefit, could be combined with the liver-directed therapies to further improve the outcome of uveal melanoma patients with hepatic metastases. (medscape.com)
2 Additionally, up to 50% of patients with uveal melanoma will have metastases, predominantly in the liver. (pharmacytimes.com)
Exclusion criteria for the patient population during the trial included symptomatic central nervous system metastases, active autoimmune disease and receiving steroids, or active systemic immunosuppressive treatment. (pharmacytimes.com)

Molecular and immunohistochemical analyses of uveal melanoma patient cohort. (cdc.gov)

Atropine is used to controls pain due to corneal and uveal disease. (petsupplies.com)
Her profession focuses on 1) corneal transplantation, 2) regenerative medicine in limbal deficient disease, and 3) the relation of gut microbiota to the autoimmune dry eye disease. (snuh.org)
The cells of the cranial neural crest migrate into adjacent primary mesenchyme to give rise to secondary mesenchyme that in turn differentiates into the corneal stroma and uveal tissue, including the uveal melanocytes, as well as other ocular tissues. (vin.com)

2019) Marburg virus disease outbreak in Kween District Uganda, 2017: Epidemiological and laboratory findings. (cdc.gov)

Chicago - For patients with uveal melanoma, the most common eye cancer in adults, survival outcomes have improved in recent years, after treatment modalities shifted from systemic to liver-directed therapies. (medscape.com)
The paper concluded that tebentafusp is the first systemic treatment to show a survival benefit in mUM and should become a new treatment option for this poor prognosis disease. (checkorphan.org)
Immunocore's most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. (checkorphan.org)
This was the first phase 3 study to show a survival benefit in uveal melanoma. (oncnursingnews.com)
First-line tebentafusp significantly improved overall survival (OS) when compared with immunotherapy or chemotherapy in patients with metastatic uveal melanoma in a phase 3 trial. (medscape.com)
This is the first randomized controlled trial to be positive for overall survival in uveal melanoma. (medscape.com)
This phase II study evaluated the overall response rate and safety of GV, glycoprotein NMB (GPNMB) expression, and survival in patients with metastatic uveal melanoma. (northwestern.edu)
This exploratory study was carried out to determine the expression levels of hepatocyte growth factor (HGF), insulin-like growth factor 1, thyroid-stimulating hormone (TSH), and leptin in serum and tumor samples from patients with uveal melanoma and to investigate the potential association of these expression levels with disease progression and patient survival. (elsevier.com)
Associations between protein levels and survival, disease progression, and other clinicopathological factors were analyzed statistically. (elsevier.com)
The prognosis for patients with metastatic uveal melanoma is very poor, with median survival of only 17 to 20 months. (pharmaceutical.report)
However, a recent phase 3 clinical trial in uveal melanoma revealed that patients treated with a MEK inhibitor plus chemotherapy had no improvement in survival over those patients treated with chemotherapy alone. (pharmaceutical.report)

These findings support the hypothesis that the clinical link between the 2 diseases results from immune responses to antigens shared by normal and malignant pigment cells. (medscape.com)
Objective -To determine whether cyclooxygenase-2 (COX-2) is expressed in benign or malignant canine uveal melanocytic neoplasms and whether expression correlates with malignancy. (avma.org)
Expression of COX-2 was detected in the ciliary body of more globes with uveal malignant melanoma (20/34) than in those without disease (1/4), with nonneoplastic disease (4/10), or with melanocytoma (3/15) or mixed neoplasms (3/8). (avma.org)
Differentiation of benign from malignant canine uveal melanocytic neoplasms was not possible. (avma.org)
The incidence of lymphoproliferative ocular diseases, especially malignant lymphoma, has increased over the years. (medscape.com)
Ciliary body melanoma is a subtype of uveal melanoma, the most common primary malignant tumor of the eye. (medscape.com)

Tebentafusp is the first investigational therapy in a phase 3 trial to improve OS in metastatic uveal melanoma, said Jessica Hassel, MD , of University Hospital Heidelberg in Germany, when presenting the results at the American Association for Cancer Research Annual Meeting 2021: Week 1 ( Abstract CT002 ). (medscape.com)

This further validates the potential of tebentafusp to provide a much needed treatment option for patients with metastatic uveal melanoma, making a meaningful difference to patients' lives. (checkorphan.org)
Tebentafusp has been granted Breakthrough Therapy Designation, Fast Track designation and orphan drug designation by the U.S. Food and Drug Administration (FDA) and Promising Innovative Medicine (PIM) designation under the UK Early Access to Medicines Scheme for metastatic uveal melanoma. (checkorphan.org)
Immunocore's biologics license application for approval of tebentafusp for the treatment of HLA-A*02:01-positive adult patients with metastatic uveal melanoma was recently accepted by the FDA. (checkorphan.org)
The disease control rate, defined as response or stable disease for 12 or more weeks, was 46% in the tebentafusp arm and 27% in the investigator's choice arm. (medscape.com)
Hassel pointed out that a landmark analysis of OS in patients with a best response of progressive disease, with patients continuing to receive treatment after progression, showed a hazard ratio of 0.4 (95% CI, 0.248-0.642) for those receiving tebentafusp vs. investigator's choice. (medscape.com)
She observed that the biology of uveal melanoma is distinct from that of cutaneous melanoma, and future research will have to address why tebentafusp doesn't work as well in cutaneous melanoma. (medscape.com)
Glycoprotein 100 is expressed via HLA-A*02:01 on the surface of most uveal melanoma tumor cells, and tebentafusp-tebn binds to the HLA-A*02:01-gp100 complex on the target cell surface. (pharmacytimes.com)
Patients should be treated with tebentafusp-tebn following the dosing schedule until unacceptable toxicity or disease progression occurs. (pharmacytimes.com)

Sarah Coupland , who leads the Liverpool Ocular Oncology Research Group at the University of Liverpool, a member of the UM CURE 2020 Consortium, explains what Uveal Melanoma is. (aldryn.io)

Our study is the largest, real-world data showing improvement of the outcomes of metastatic uveal melanoma patients over the last 50 years with newer liver-directed treatments, including radioembolization," lead author Rino S. Seedor, MD, told Medscape Medical News . (medscape.com)
For their study, Seedor and colleagues carried out a retrospective chart review of consecutive patients with uveal melanoma with liver metastasis who were treated at their institution. (medscape.com)
Liver enzyme levels are indicated in any patient with uveal melanoma, because the liver is the most common site of choroidal melanoma metastasis. (medscape.com)
Other concerns related to the equine digestive system include strangulation of the intestines, peritonitis, liver diseases, acute diarrhea and constipation. (equimed.com)
In breast invasive carcinoma (BRCA) and liver hepatocellular carcinoma (LIHC), high YIF1B expression correlated with a poor disease-free interval (DFI), indicating a role in malignancy progression. (silverchair.com)

Uveal melanoma (UM) is the most common primary tumor of the eye in adults. (atcc.org)
This cell line form the primary tumor is part of a panel This panel recapitulates the molecular and scape of the disease in terms of genetic alterations and mutations. (atcc.org)
Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role for PHF10/BAF45a. (cdc.gov)

Previous invasive malignancy with any evidence of the disease within the last 3 years. (who.int)

Conclusions and Clinical Relevance -Canine globes with uveal melanocytic neoplasia appeared to express COX-2 in similar sites and with similar intensity as globes without neoplasia. (avma.org)

Schnabolk G, Obert E, Banda NK, Rohrer B. Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease. (ucdenver.edu)

Eligible patients with metastatic uveal melanoma who had not previously been treated with chemotherapy received GV 1.9 mg/kg every three weeks. (northwestern.edu)

High-resolution 3-T MR imaging helps characterize orbital and ocular soft-tissue lesions, permitting superior delineation of orbital soft tissues, cranial nerves, blood vessels, and blood flow and detection of intracranial extension of orbital disease. (radiologykey.com)

His report that VKH disease and sympathetic ophthalmia were similar diseases was cited by Duke-Elder in System of Ophthalmology text book. (eophtha.com)

Although it's rare, it's an area of great unmet clinical need: When the disease does metastasize, it's associated with a very poor prognosis. (oncnursingnews.com)
During several prior studies investi-gating the role of HLA in uveal melanoma, investigators were able to confirm that a high HLA class I expression (including HLA-A) is associated with a poor prognosis. (pharmacytimes.com)
The bulbar conjunctiva is where this disease most frequently presents itself, and it may have a poor prognosis if it is not diagnosed and treated early. (ecancer.org)

This scoping review took a systematic approach to comprehensively search the electronic databases MEDLINE, EMBASE, PubMed, Web of Science, Scopus, Google Scholar, and the grey literature databases OpenGrey / GreyLit for journal articles pertaining to multi-omics and rare disease, written in English and published prior to the 30th December 2018. (biomedcentral.com)

Expanding the spectrum of Ebola-associated eye disease: a summary of ocular findings in a large cohort of Ebola survivors. (cdc.gov)

Metastatic uveal melanoma has no standard therapy, but there is evidence that both radiation therapy and immunotherapy may be helpful and may be synergistic. (clinicaltrials.gov)
Characteristics, management, and outcome of patients with uveal melanoma treated by Iodine-125 radioactive plaque therapy in a single tertiary cancer center in Jordan. (khcc.jo)

Adult patients with previously untreated HLA A*02:01-positive metastatic uveal melanoma, an ECOG score of 0 or 1 and at least 1 measurable lesion were included. (pharmacytimes.com)
Sutimlimab-jome, a hinge-stabilized, humanized IgG4k antibody that targets and inhibits complement component 1s (C1s), was approved by FDA in February 2022 as a treatment of hemolysis in adult patients with cold agglutinin disease (CAD). (antibodysociety.org)

In the phase 3 trial, investigators enrolled 378 treatment-naive HLA-A*02:01-positive patients with metastatic uveal melanoma. (medscape.com)
1 The FDA approval was based on results from the IMCgp100 102 trial (NCT02570308), a phase 3, open-label, multicenter trial that included 378 patients with metastatic uveal melanoma. (pharmacytimes.com)

Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study. (cdc.gov)
Leveraging its proprietary, flexible, off-the-shelf ImmTAX platform, Immunocore is developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs. (checkorphan.org)
Bis-choline tetrathiomolybdate is in clinical development for the treatment of Wilson's disease (WD). (nihr.ac.uk)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)

We conducted a case-control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. (cdc.gov)

A hitherto unknown infectious disease contracted from monkeys. (cdc.gov)
Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies called ImmTAX - Immune mobilizing monoclonal TCRs Against X disease - designed to treat a broad range of diseases, including cancer, infectious and autoimmune. (checkorphan.org)
Equines are susceptible to numerous infectious diseases as well as diseases and conditions that affect the major body systems. (equimed.com)
The cause of Crohn disease is not known for certain, but many researchers believe that a dysfunction of the immune system causes the intestine to overreact to an environmental, dietary, or infectious agent. (merckmanuals.com)
There is increasing evidence that it suppresses the immune system, which could lead to a reduction in the efficacy of immunization programmes and increase the spread of infectious diseases. (who.int)

The relationship of these diseases to various syndromes and/or known genetic mutations is also highlighted. (radiologykey.com)

Researchers report in the European Journal of Human Genetics that genome sequencing for rare disease diagnoses currently has similar benefits as less expensive exome analysis. (genomeweb.com)

Now we have a range of immunotherapy drugs [which use our own immune system to treat disease] so we can fight the cancer better. (medlineplus.gov)

In the arsenal of Veterinary Ophthalmologist have firmly taken their exact microsurgical instruments, operating microscopes, modern devices for the diagnosis and surgical treatment of eye diseases. (cnshb.ru)
Patients with rare diseases face unique challenges in obtaining a diagnosis, appropriate medical care and access to support services. (biomedcentral.com)
This scoping review emphasises the value of multi-omic analysis for rare disease research in several ways compared to single omic analysis, ranging from the provision of a diagnosis, identification of prognostic biomarkers, distinct molecular subtypes (particularly for rare cancers), and identification of novel therapeutic targets. (biomedcentral.com)
Obtaining a diagnosis has a significant impact on the development of a patients' defined care pathway as an accurate diagnosis can enable appropriate medical intervention, access to public services (such as financial support) and connection with vital rare disease support groups [ 5 , 6 , 7 ]. (biomedcentral.com)
The eye specialist hospital in Bangalore provides a well-equipped facility for the complete examination, diagnosis and treatment (both medically and surgically) of all ocular diseases. (specialisthospital.in)

Moreover, studies suggest that an association exists between a positive family history of vitiligo, autoimmune/endocrine diseases, leukotrichia, and an increased incidence of vitiligo in children. (medscape.com)

Unlike primary uveal melanoma, uveal metastatic lesions are often multiple and may be bilateral. (aao.org)

BACKGROUND AND OBJECTIVES: Skin diseases are a common reason for consultations in pediatric practice. (bvsalud.org)
Whereas Hodgkin lymphoma rarely causes ocular disease, non-Hodgkin lymphoma (NHL) is the most common type of ocular lymphoma. (medscape.com)
Yet while the type and definitions of a rare disease may vary, there are many common issues faced by patients falling under the 'rare' umbrella. (biomedcentral.com)
In the past few decades, Crohn disease has become more common worldwide. (merckmanuals.com)

She has published 224 SCI(E) articles in answering important scientific questions about these ocular immune reactions in variable ophthalmic disease. (snuh.org)
Although we have made huge advances for the treatment of [patients with] skin melanoma-when it unfortunately metastasizes, with treatments that are either targeting genetic abnormalities or stimulating the immune system to fight the disease-those types of treatments are relatively useless in uveal melanoma, and that's because [this disease] does not have the same genetic changes in it as skin melanoma. (oncnursingnews.com)
For patients who have an opportunity to be treated with this drug, obviously they have to have advanced uveal melanoma, but also their immune system needs to be of the right HLA type [for it to be effective]. (oncnursingnews.com)
Although the exact cause is unknown, an improperly triggered immune system may result in Crohn disease. (merckmanuals.com)

Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia. (cdc.gov)
While problems have rarely been noted in veterinary medicine, ophthalmic beta blockers should be used with caution in patients with bronchoconstrictive disease or congestive heart failure. (elephantcare.org)

Patients received futibatinib 20 mg/day PO until disease progression or unacceptable toxicity. (medscape.com)

Between October 2014 and June 2017, at the National Institute of Neoplastic Diseases (INEN) from Peru, 39 patients with squamous cell carcinoma of ocular conjunctiva, T1-T3, resected, were selected to receive adjuvant treatment. (ecancer.org)

Regulatory agencies in the US, Europe, Japan, as well as other countries, have 'orphan drug' programs, which incentivize the development of drugs to treat rare diseases. (antibodysociety.org)
We're getting more information on using drugs to treat early stage disease in order to prevent it from progressing to an incurable stage. (medlineplus.gov)

The two primary types of inflammatory bowel disease (IBD) are Crohn. (merckmanuals.com)

Posterior scleritis is an inflammatory disease that involves the sclera posterior to the ora serrata ( 1 ). (amegroups.com)
Enteritis, which is inflammatory disease of the small bowel, and enterocolitis, which involves the colon, are the results of infections or intestinal parasites. (equimed.com)
Overview of Inflammatory Bowel Disease (IBD) In inflammatory bowel diseases, the intestine (bowel) becomes inflamed, often causing recurring abdominal pain and diarrhea. (merckmanuals.com)
Ulcerative Colitis Ulcerative colitis is a chronic inflammatory bowel disease in which the large intestine (colon) becomes inflamed and ulcerated (pitted or eroded), leading to flare-ups (bouts or attacks) of. (merckmanuals.com)
Several reports suggest that people who were breastfed may be protected from developing inflammatory bowel disease. (merckmanuals.com)

Diseases4

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Disciplines and Occupations1

Health Care1

Tract11

Intraocular6

Unresectable or metastatic4

Melanomas8

Target uveal melanoma2

Retinal3

Tumors3

Metastatic disease4

Uveitis6

Metastases4

Melanoma patient1

Corneal3

20191

Survival11

Malignant6

20211

Tebentafusp8

20201

Liver5

Tumor3

Malignancy1

Neoplasia1

Systemic1

Treated with chemotherapy1

Tissue1

Ophthalmology1

Prognosis3

20181

Cohort1

Therapy2

Adult patients2

Phase2

Clinical3

Centers for Diseas2

Ocular signs in Ebola virus d1

Infectious5

Genetic mutations1

Genetics1

Immunotherapy1

Diagnosis5

Autoimmune1

Lesions1

Common4

Immune4

Ophthalmic2

Progression or unacceptable toxicity1

20171

Drugs2

Primary1

Inflammatory5