In 1937, Elixir sulfanilamide, a medicine consisting of sulfanilamide dissolved in diethylene glycol, poisoned and killed more than 100 people as a result of acute kidney failure, prompting new US regulations for drug testing. (wikipedia.org)
Sulfonamide (medicine) Nazi human experimentation - Sulfonamide experiments Elixir sulfanilamide Sulfanilamides at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Actor P, Chow AW, Dutko FJ, McKinlay MA. (wikipedia.org)
Elixir sulfanilamide was an improperly prepared medicine that poisoned and killed nearly one hundred people . (listverse.com)
A second example is Elixir Sulfanilamide , an anti-infective drug which was considered a wonder drug when it arrived on the market in 1937. (fda.gov)
Antibiotic2
Examples include: Furosemide, a loop diuretic Sulfadiazine, an antibiotic Sulfamethoxazole, an antibiotic As a sulfonamide antibiotic, sulfanilamide functions by competitively inhibiting (that is, by acting as a substrate analogue) enzymatic reactions involving para-aminobenzoic acid (PABA). (wikipedia.org)
In late 1937, hundreds of children were poisoned and died after being given the antibiotic, Sulfanilamide, a medicine used for strep throat that was dissolved in a toxic solvent to make it easier for children to take. (prospect.org)
Sulfonamide1
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. (wikipedia.org)
Sulfa drugs1
Sulfanilamide is one of the sulfa drugs which were widely used as antibacterials in the early 20th century . (wikidoc.org)
19371
After elixir of sulfanilamide , a drug used to treat streptococcal infections, killed 107 people in 1937, Congress created the Food, Drug, and Cosmetic Act. (cnn.com)
Sulfonamides2
Sulfanilamide is rarely if ever used systemically due to toxicity and because more effective sulfonamides are available for this purpose. (wikipedia.org)
The Sulfanilamide Rapid Test (tissue) is based on the Colloidal Gold Immunochromatography to detect the Sulfonamides residues in aquaculture products. (ballyabio.com)
PABA1
CAUTION: Do not take with sulfanilamide drugs since PABA interferes with the activity of these drugs. (vitacost.com)
Sulfamethazine1
Sulfamethazine [N1-(4,6-dimethylpyrimidin-2-yl)sulfanilamide] is an antimicrobial drug that possesses functional groups capable of acting as hydrogen-bond donors and acceptors, which make it a suitable supramolecular building block for the formation of cocrystals and salts. (bvsalud.org)
Antibacterial1
also known as sulphapyridine) is a sulfanilamide antibacterial medication. (david-cook.org)
For example, sulfonation of aniline produces sulfanilic acid, which can be converted to sulfanilamide . (wikidoc.org)
Tablet1
It was only the solvent and not the sulfanilamide that was the problem, as sulfanilamide was widely and safely used at the time in both tablet and powder form. (wikipedia.org)
Sodium1
Cells were also exposed to the irritants sodium dodecyl sulfate (SDS) and sulfanilamide (SFA). (cdc.gov)
Infection1
Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to previous wars. (wikipedia.org)
Interactions1
Watkins, S.L. and Pichler, W.J. (2013) Activating interactions of sulfanilamides with T cell receptors. (scirp.org)
Reactions1
Since sulfanilamide is used almost exclusively in topical vaginal preparations these days, adverse effects are typically limited to hypersensitivity or local skin reactions. (wikipedia.org)
Treatment4
however, sulfanilamide remains in use today in the form of topical preparations, primarily for treatment of vaginal yeast infections mainly vulvovaginitis which is caused by Candida albicans. (wikipedia.org)
Public Health Reports, December 11, 1942: Sulfanilamide in the treatment of leprosy. (cdc.gov)
1975). Public Health Reports, December 11, 1942: Sulfanilamide in the treatment of leprosy. (cdc.gov)
Faget, G H and Johansen, F A and Ross, H "Public Health Reports, December 11, 1942: Sulfanilamide in the treatment of leprosy. (cdc.gov)
Application1
A small amount of sulfanilamide is absorbed following topical application or when administered as a vaginal cream or suppository (through the vaginal mucosa). (wikipedia.org)
Sulfa1
Sulfa drugs such as sodium sulfanilamide work because they resemble PABA. (quizlet.com)
Vaginal5
however, sulfanilamide remains in use today in the form of topical preparations, primarily for treatment of vaginal yeast infections mainly vulvovaginitis which is caused by Candida albicans. (wikipedia.org)
Since sulfanilamide is used almost exclusively in topical vaginal preparations these days, adverse effects are typically limited to hypersensitivity or local skin reactions. (wikipedia.org)
A small amount of sulfanilamide is absorbed following topical application or when administered as a vaginal cream or suppository (through the vaginal mucosa). (wikipedia.org)
US FDA Label: AVC (sulfanilamide) Vaginal Cream 15%" (PDF). (wikipedia.org)
Sulfanilamide has been a useful ingredient of vaginal formulations for about four decades. (nih.gov)
Cream1
They are the sole suppliers of sulfanilamide cream. (ashp.org)
Dihydrochloride1
The nitrite (that originally present plus reduced nitrate) is determined by diazotizing with sulfanilamide and coupling with N-(1-naphthyl)-ethylenediamine dihydrochloride to form a highly colored azo dye which is measured, spectrophotometrically. (caslab.com)
Serum1
Epidemic cerebrospinal meningitis (meningococcic): the treatment of 113 patients with antimeningococcus serum, meningococcus antitoxin and sulfanilamide. (jameslindlibrary.org)
Reduction1
Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to previous wars. (wikipedia.org)
Products1
On the heels of the Elixir Sulfanilamide scandal, in which a medicine manufactured with antifreeze killed scores of children, Congress passed the Food, Drug and Cosmetic Act of 1938, requiring for the first time that pharmaceutical manufacturers prove the safety of their products before marketing them," he continued. (wnd.com)
Approximately1
Sulfanilamide Melting Point Standard (1 g) (Approximately 165 degrees). (chromachemie.co.in)
The fishermen suffered from oxidative stress and had high levels of the urinary metabolite sulfanilamide [mean (μg/mg creatinine): Lake Edku 20.7, Mediterranean 14.5, controls 5.3]. (who.int)
Term1
The term "sulfanilamides" is also sometimes used to describe a family of molecules containing these functional groups. (wikipedia.org)
Base3
Nous avons réalisé une estimation de la pollution dans le lac Edkou et en Méditerranée (région d'El-Maadiya), sur la base de trois amines aromatiques (1-naphthylamine, 2-naphthylamine et benzidine) dans les tissus musculaires de poissons. (who.int)
In AVC, the sulfanilamide is in a specially compounded base buffered to the pH (about 4.3) of the normal vagina to encourage the presence of the normally occurring Döderlein's bacilli of the vagina. (nih.gov)
Last year when I was sick [John D. explained], the doctor on the base gave me sulfanilamide. (beyondweird.com)
Drug2
In 1937, Elixir sulfanilamide, a medicine consisting of sulfanilamide dissolved in diethylene glycol, poisoned and killed more than 100 people as a result of acute kidney failure, prompting new US regulations for drug testing. (wikipedia.org)
After successfully using Prontosil, a sulfanilamide, to cure a patient who was going to die from puerperal fever, Colebrook began experiments with the drug. (asu.edu)
White2
Sulfanilamide is a yellowish-white or white crystal or fine powder. (wikipedia.org)
Sulfanilamide occurs as a white odorless crystalline powder with a slightly bitter taste and sweet aftertaste. (nih.gov)